All Relations between fatty acid amide hydrolase and cannabinoids

Publication Sentence Publish Date Extraction Date Species
Marialuisa de Ceglia, Maria Vittoria Micioni Di Bonaventura, Adele Romano, Marzia Friuli, Emanuela Micioni Di Bonaventura, Ana L Gavito, Luca Botticelli, Silvana Gaetani, Fernando Rodríguez de Fonseca, Carlo Cifan. Anxiety associated with palatable food withdrawal is reversed by the selective FAAH inhibitor PF-3845: A regional analysis of the contribution of endocannabinoid signaling machinery. The International journal of eating disorders. 2023-02-25. PMID:36840536. currently, no pharmacological treatment is effective for obesity-related anxiety, so we investigated the endocannabinoid system (ecs), and specifically the fatty acid amide hydrolase (faah), as an interesting emerging target in this context because of its key role in the regulation of both energy homeostasis and emotional behavior. 2023-02-25 2023-08-14 Not clear
Rosiane Aparecida Miranda, Vanessa Silva Tavares Rodrigues, Thamara Cherem Peixoto, Alex C Manhães, Egberto Gaspar de Moura, Patricia Cristina Lisbo. Nicotine exposure during breastfeeding alters the expression of endocannabinoid system biomarkers in female but not in male offspring at adulthood. Journal of developmental origins of health and disease. 2023-02-23. PMID:36815400. we evaluated protein expression of n-acylphosphatidylethanolamide-phospholipase d (nape-pld), fatty acid amide hydrolase (faah), diacylglycerol lipase (dagl), monoacylglycerol lipase (magl) and cannabinoid receptors (cb1 and/or cb2) in lateral hypothalamus, paraventricular nucleus of the hypothalamus, liver, visceral adipose tissue (vat), adrenal and thyroid. 2023-02-23 2023-08-14 rat
Ashraf Duzan, Desiree Reinken, Timothy L McGomery, Nicholas M Ferencz, Jacob M Plummer, Mufeed M Bast. Endocannabinoids are potential inhibitors of glioblastoma multiforme proliferation. Journal of integrative medicine. 2023-02-22. PMID:36805391. cannabinoids promote atypical protein kinase c, deactivate fatty acid amide hydrolase enzymes, and activate transient receptor potential vanilloid 1 (trpv1) and trpv2 to induce pro-apoptotic signaling pathways without increasing endogenous cannabinoids. 2023-02-22 2023-08-14 human
Lakhan S Khara, Declan W Al. The endocannabinoid system's involvement in motor development relies on cannabinoid receptors, TRP channels, and Sonic Hedgehog signaling. Physiological reports. vol 11. issue 1. 2023-01-13. PMID:36636759. to investigate the involvement of canonical and non-canonical cannabinoid receptors, trp channels, and the shh pathway in the development of sensorimotor function in zebrafish, we treated developing animals with pharmacological inhibitors of the cb1r, cb2r, trpa1/trpv1/trpm8, and a smoothened (smo) agonist, along with inhibitors of the ecs catabolic enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) during the first ~24 h of zebrafish embryogenesis. 2023-01-13 2023-08-14 zebrafish
Meenakshi Ahluwalia, Hannah Mcmichael, Manish Kumar, Mario P Espinosa, Asamoah Bosomtwi, Yujiao Lu, Hesam Khodadadi, Abbas Jarrahi, Mohammad B Khan, David C Hess, Scott Y Rahimi, John R Vender, Fernando L Vale, Molly Braun, Babak Baban, Krishnan M Dhandapani, Kumar Vaibha. Altered endocannabinoid metabolism compromises the brain-CSF barrier and exacerbates chronic deficits after traumatic brain injury in mice. Experimental neurology. 2023-01-10. PMID:36627040. reductions in endocannabinoid (2-ag and aea) levels in plasma were supported by higher expression of their respective metabolizing enzymes, monoacylglycerol lipase (magl), fatty acid amide hydrolase (faah), and cyclooxygenase 2 (cox-2) in the post-tbi mouse brain. 2023-01-10 2023-08-14 mouse
Carmine Marco Morgillo, Antonio Lupia, Alessandro Deplano, Luciano Pirone, Bianca Fiorillo, Emilia Pedone, F Javier Luque, Valentina Onnis, Federica Moraca, Bruno Catalanott. Molecular Basis for Non-Covalent, Non-Competitive FAAH Inhibition. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555144. fatty acid amide hydrolase (faah) plays a key role in the control of cannabinoid signaling and it represents a promising therapeutic strategy for the treatment of a wide range of diseases, including neuropathic pain and chronic inflammation. 2022-12-23 2023-08-14 Not clear
Francesca Intranuovo, Leonardo Brunetti, Pietro DelRe, Giuseppe Felice Mangiatordi, Angela Stefanachi, Antonio Laghezza, Mauro Niso, Francesco Leonetti, Fulvio Loiodice, Alessia Ligresti, Magdalena Kostrzewa, Jose Brea, Maria Isabel Loza, Eddy Sotelo, Michele Saviano, Nicola Antonio Colabufo, Chiara Riganti, Carmen Abate, Marialessandra Contin. Development of Journal of medicinal chemistry. 2022-12-21. PMID:36542836. fatty acid amide hydrolase (faah) is an enzyme responsible for the degradation of the main endocannabinoid anandamide; thus, the simultaneous cb2r activation and faah inhibition may be a synergistic anti-inflammatory strategy. 2022-12-21 2023-08-14 Not clear
Mariarosaria Cammarota, Francesca Ferlenghi, Federica Vacondio, Fabrizio Vincenzi, Katia Varani, Annalida Bedini, Silvia Rivara, Marco Mor, Francesca Bosci. Combined targeting of fatty acid amide hydrolase (FAAH) and melatonin receptors promotes neuroprotection and stimulates inflammation resolution in rats. British journal of pharmacology. 2022-12-16. PMID:36526591. enhancing the endocannabinoid (ec) tone by inhibiting the catabolic enzyme faah or stimulating melatonin receptors have therapeutic potential to treat neuropathological states in which neuroinflammation plays a central role. 2022-12-16 2023-08-14 rat
Mariangela Pucci, Claudio D'Addario, Emanuela Micioni Di Bonaventura, Francesca Mercante, Eugenia Annunzi, Federico Fanti, Manuel Sergi, Luca Botticelli, Giacomo Einaudi, Carlo Cifani, Maria Vittoria Micioni Di Bonaventur. Endocannabinoid System Regulation in Female Rats with Recurrent Episodes of Binge Eating. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499556. we detected, in rats showing the be behavior, an up-regulated gene expression of cannabinoid type-1 receptor (cb1), sn-1-specific diacylglycerol lipase, as well as fatty acid amide hydrolase ( 2022-12-11 2023-08-14 rat
Meipeng Zhu, Qian Guo, Honglei Kang, Renpeng Peng, Yimin Dong, Yayun Zhang, Sibo Wang, Haiyang Liu, Hongjian Zhao, Zijian Dong, Kehan Song, Shimeng Xu, Pengju Wang, Liangxi Chen, Jian Liu, Feng L. Inhibition of FAAH suppresses RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss partially through repressing the IL17 pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 1. 2022-12-05. PMID:36468880. fatty amide hydrolase (faah) is a key degradation enzyme of the endocannabinoid system, mainly responsible for the hydrolysis of arachidonic acid ethanolamine (aea). 2022-12-05 2023-08-14 mouse
Alessandro Papa, Silvia Pasquini, Francesca Galvani, Mariarosaria Cammarota, Chiara Contri, Gabriele Carullo, Sandra Gemma, Anna Ramunno, Stefania Lamponi, Beatrice Gorelli, Simona Saponara, Katia Varani, Marco Mor, Giuseppe Campiani, Francesca Boscia, Fabrizio Vincenzi, Alessio Lodola, Stefania Butin. Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions. European journal of medicinal chemistry. vol 246. 2022-12-03. PMID:36462439. the neuroprotective performance against neuroinflammation of the endocannabinoid system (ecs) can be remarkably improved by indirect stimulation mediated by the pharmacological inhibition of the key ecs catabolic enzyme fatty acid amide hydrolase (faah). 2022-12-03 2023-08-14 mouse
Jamie L Myers, Hui Xia, Manuel Y Caballero, Sandra Valtier, G Jilani Chaudr. A Military Community Cohort Study Reveals Single Nucleotide Polymorphisms in Inflammation Mediator Genes That Associate With Type 2 Diabetes. Military medicine. 2022-11-24. PMID:36420960. the snps analyzed in this work occur in nine different genes, comprising six interleukin (il) genes (il1a, il1b, il4, il6, il10, and il18), fatty acid amide hydrolase (faah) gene, and cannabinoid receptors 1 and 2 genes (cnr1, cnr2). 2022-11-24 2023-08-14 human
Laura López-Gómez, Agata Szymaszkiewicz, Marta Zielińska, Raquel Abal. The Enteric Glia and Its Modulation by the Endocannabinoid System, a New Target for Cannabinoid-Based Nutraceuticals? Molecules (Basel, Switzerland). vol 27. issue 19. 2022-10-14. PMID:36235308. the endogenous cannabinoid system (ecs) includes endogenous classical cannabinoids (anandamide, 2-arachidonoylglycerol), cannabinoid-like ligands (oleoylethanolamide (oea) and palmitoylethanolamide (pea)), enzymes involved in their metabolism (faah, magl, cox-2) and classical (cb1 and cb2) and non-classical (trpv1, gpr55, ppar) receptors. 2022-10-14 2023-08-14 Not clear
Ana Clara Casadoumecq, José Javier Fernández-Solari, Juan Carlos Elverdin, Pablo Alejandro Rodríguez, Claudia Ester Moh. The role of the endocannabinoid system in tooth eruption: An ex vivo study. Australian endodontic journal : the journal of the Australian Society of Endodontology Inc. 2022-10-13. PMID:36226979. messenger rna expression of components of the ecs as cannabinoid receptors (cbr1 and cbr2), and anandamide synthetizing (nape-pld) and degradation (faah) enzymes were measured by rt-pcr. 2022-10-13 2023-08-14 Not clear
María Victoria Noya-Riobó, Constanza Ágata Miguel, Delia Beatriz Soriano, Pablo Rodolfo Brumovsky, Marcelo José Villar, María Florencia Corone. Changes in the expression of endocannabinoid system components in an experimental model of chemotherapy-induced peripheral neuropathic pain: Evaluation of sex-related differences. Experimental neurology. 2022-09-30. PMID:36179876. the mrna levels corresponding to cannabinoid receptors (cb1, cb2), cannabinoid-related receptors (gpr55, 5ht1a, trpv1) and to the main enzymes involved in the synthesis (dagl, dagl, nape-pld) and degradation (mgl, faah) of endocannabinoids were assessed in lumbar dorsal root ganglia (drgs) and spinal cord by using real time rt-pcr. 2022-09-30 2023-08-14 rat
Victoria Woyach, Katherine Sherman, Cecilia J Hillard, Francis A Hopp, Quinn H Hogan, Caron Dea. Fatty acid amide hydrolase activity in the dorsal PAG attenuates neuropathic pain and associated dysautonomia. American journal of physiology. Regulatory, integrative and comparative physiology. 2022-09-26. PMID:36154489. inhibition of fatty acid amide hydrolase (faah) increases brain concentrations of the endocannabinoid n-arachidonoylethanolamine (aea) and reduces pain-related behaviors in neuropathic pain models. 2022-09-26 2023-08-14 rat
Yangyang Zhu, Hao Zhang, Huawei Mao, Suqin Zhong, Yubing Huang, Sirong Chen, Kai Yan, Zhibin Zhao, Xiaohan Hao, Yue Zhang, Han Yao, Xiaowan Huang, Meimei Wang, Wenbin Zhang, Juan Li, Guangxun Meng, Xiaohua Qin, Zhiming Ye, Jiani Shen, Yang Song, Youcui Xu, Zhenyu Yang, Liansheng Wang, Yunjiao Zhang, Longping We. FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system. Cell death and differentiation. 2022-09-14. PMID:36104448. faah served a key membrane-anchoring and stabilizing role for nlrp3 protein independently of the endocannabinoid system. 2022-09-14 2023-08-14 mouse
Yangyang Zhu, Hao Zhang, Huawei Mao, Suqin Zhong, Yubing Huang, Sirong Chen, Kai Yan, Zhibin Zhao, Xiaohan Hao, Yue Zhang, Han Yao, Xiaowan Huang, Meimei Wang, Wenbin Zhang, Juan Li, Guangxun Meng, Xiaohua Qin, Zhiming Ye, Jiani Shen, Yang Song, Youcui Xu, Zhenyu Yang, Liansheng Wang, Yunjiao Zhang, Longping We. FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system. Cell death and differentiation. 2022-09-14. PMID:36104448. here, we show that fatty acid amide hydrolase (faah), the key integral membrane enzyme in the endocannabinoid system, unexpectedly served the critical membrane-anchoring and stabilizing role for nlrp3. 2022-09-14 2023-08-14 mouse
Kelsey Andreis, Jenna Billingsley, Kian Naimi Shirazi, Jim Wager-Miller, Clare Johnson, Heather Bradshaw, Alex Straike. Cannabinoid CB1 receptors regulate salivation. Scientific reports. vol 12. issue 1. 2022-08-19. PMID:35986066. we also found that fatty acid amide hydrolase (faah), the enzyme that metabolizes the endocannabinoid anandamide and related lipids, regulates salivation. 2022-08-19 2023-08-14 mouse
Vikram Thakur, Mohammad Bashashati, Josue Enriquez, Munmun Chattopadhya. Inhibiting Fatty Acid Amide Hydrolase Ameliorates Enteropathy in Diabetic Mice: A Cannabinoid 1 Receptor Mediated Mechanism. Veterinary sciences. vol 9. issue 7. 2022-07-25. PMID:35878381. inhibiting fatty acid amide hydrolase ameliorates enteropathy in diabetic mice: a cannabinoid 1 receptor mediated mechanism. 2022-07-25 2023-08-14 mouse