| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Danielle M Gerhard, Nathaniel Tse, Francis S Lee, Heidi C Meye. Developmental age and fatty acid amide hydrolase genetic variation converge to mediate fear regulation in female mice. Developmental psychobiology. vol 65. issue 6. 2023-08-22. PMID:37607892. |
for this, we used knock-in mice containing a common human mutation in the gene for fatty acid amide hydrolase (faah), the primary catabolic enzyme for the endocannabinoid anandamide (faah-in). |
2023-08-22 |
2023-09-07 |
mouse |
| Joao P De Aquin. Fatty Acid Amide Hydrolase, Neurodevelopment, and Alcohol: Illuminating the Intricacies of the Endocannabinoid System in Addiction Susceptibility. Biological psychiatry. vol 94. issue 5. 2023-08-09. PMID:37558315. |
fatty acid amide hydrolase, neurodevelopment, and alcohol: illuminating the intricacies of the endocannabinoid system in addiction susceptibility. |
2023-08-09 |
2023-08-16 |
Not clear |
| Gina Granja-Galeano, Ana Paula Dominguez Rubio, C Daniel Zappia, Manuel Wolfson, Sara Sanz Blasco, Julieta Aisemberg, Maria Zorrilla Zubilete, Natalia Fernandez, Ana Franchi, Carlos P Fitzsimons, Federico Monczo. CB1 receptor expression and signaling are required for dexamethasone-induced aversive memory consolidation. Neuropharmacology. 2023-08-04. PMID:37541383. |
furthermore, we provide primary evidence for the mechanism responsible for this crosstalk between cannabinoid and glucocorticoid-mediated signaling pathways, showing that dexamethasone regulates endocannabinoid metabolism by inhibiting the activity of the fatty acid amide hydrolase (faah), an integral membrane enzyme that hydrolyzes endocannabinoids and related amidated signaling lipids. |
2023-08-04 |
2023-08-14 |
Not clear |
| Marta Kruk-Slomka, Bartlomiej Adamski, Tomasz Slomka, Grazyna Bial. Inhibitors of Endocannabinoids' Enzymatic Degradation as a Potential Target of the Memory Disturbances in an Acute N-Methyl-D-Aspartate (NMDA) Receptor Hypofunction Model of Schizophrenia in Mice. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511157. |
the ecs is comprised of cannabinoid (cb) receptors, endocannabinoids and enzymes responsible for the metabolism of endocannabinoids (fatty acid hydrolase (faah) and monoacylglycerol lipase (magl)). |
2023-07-29 |
2023-08-14 |
mouse |
| Takehito Terajima, Hirofumi Inoue, Kenji Shimomura, Fuki Iwasaki, Aya Sasaki, Yuki Ito, Michihiro Kamijima, Motohiro Tomizaw. Organophosphate agent action at the fatty acid amide hydrolase enhancing anandamide-induced apoptosis in NG108-15 cells. The Journal of toxicological sciences. vol 48. issue 7. 2023-07-02. PMID:37394655. |
op agent as an anticholinesterase also acts on the endocannabinoid (ec)-hydrolases, i.e., fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), to reveal unexpected adverse effects including adhd-like behaviors in adolescent male rats. |
2023-07-02 |
2023-08-14 |
human |
| Takehito Terajima, Hirofumi Inoue, Kenji Shimomura, Fuki Iwasaki, Aya Sasaki, Yuki Ito, Michihiro Kamijima, Motohiro Tomizaw. Organophosphate agent action at the fatty acid amide hydrolase enhancing anandamide-induced apoptosis in NG108-15 cells. The Journal of toxicological sciences. vol 48. issue 7. 2023-07-02. PMID:37394655. |
accordingly, faah inhibition by eopf suppresses aea-metabolism, and accumulated excess aea overstimulates both the cannabinoid receptor- and mitochondria-mediated apoptotic pathways. |
2023-07-02 |
2023-08-14 |
human |
| Tiziana Genovese, Andrea Duranti, Francesco Monaco, Rosalba Siracusa, Roberta Fusco, Daniela Impellizzeri, Ramona D'Amico, Marika Cordaro, Salvatore Cuzzocrea, Rosanna Di Paol. Inhibition of Fatty Acid Amide Hydrolase (FAAH) Regulates NF-kb Pathways Reducing Bleomycin-Induced Chronic Lung Inflammation and Pulmonary Fibrosis. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37373275. |
increasing endogenous levels of endocannabinoid by pharmacologically inhibiting faah results in numerous analgesic advantages in a variety of experimental models for pre-clinical pain and inflammation. |
2023-06-28 |
2023-08-14 |
Not clear |
| Hajar Mikaeili, Abdella M Habib, Charlix Wai-Lok Yeung, Sonia Santana-Varela, Ana P Luiz, Kseniia Panteleeva, Sana Zuberi, Alkyoni Athanasiou-Fragkouli, Henry Houlden, John N Wood, Andrei L Okorokov, James J Co. Molecular basis of FAAH-OUT-associated human pain insensitivity. Brain : a journal of neurology. 2023-05-24. PMID:37222214. |
here we report how the recently discovered brain and dorsal root ganglia-expressed faah-out long non-coding rna (lncrna) gene, which was found from studying a pain-insensitive patient with reduced anxiety and fast wound healing, regulates the adjacent key endocannabinoid system gene faah, which encodes the anandamide-degrading fatty acid amide hydrolase enzyme. |
2023-05-24 |
2023-08-14 |
human |
| Hernan Bazan, Surjyadipta Bhattacharjee, Madigan Reid, Bokkyoo Jun, Connor Polk, Madeleine Strain, Linsey St Pierre, Neehar Desai, Patrick Daly, Jessica Cucinello-Ragland, Scott Edwards, Julio Alvarez-Builla, James Cai, Nicolas Baza. Transcriptomic signature, bioactivity and safety of a non-hepatoxic analgesic generating AM404 in the mid-brain PAG region. Research square. 2023-05-19. PMID:37205420. |
single-cell transcriptomics of pag uncovered that srp-001 and apap also share modulation of pain-related gene expression and cell signaling pathways, including the endocannabinoid, mechanical nociception, and fatty acid amide hydrolase (faah) pathways. |
2023-05-19 |
2023-08-14 |
Not clear |
| Sumit S Rathod, Yogeeta O Agrawa. Phytocannabinoids as Potential Multitargeting Neuroprotectants in Alzheimer's Disease. Current drug research reviews. 2023-05-03. PMID:37132109. |
the present article also discusses the implications of cannabinoid receptors (cb1 and cb2) as well as cannabinoid enzymes (faah and magl) modulators in ad. |
2023-05-03 |
2023-08-14 |
Not clear |
| Sumit S Rathod, Yogeeta O Agrawa. Phytocannabinoids as Potential Multitargeting Neuroprotectants in Alzheimer's Disease. Current drug research reviews. 2023-05-03. PMID:37132109. |
furthermore, naturally occurring cannabinoid metabolic enzymes (faah and magl) inhibit the nlrp3 inflammasome complex, which may offer significant neuroprotection. |
2023-05-03 |
2023-08-14 |
Not clear |
| Georgia Balsevich, Gavin N Petrie, Daniel E Heinz, Arashdeep Singh, Robert J Aukema, Avery C Hunker, Haley A Vecchiarelli, Hiulan Yau, Martin Sticht, Roger J Thompson, Francis S Lee, Larry S Zweifel, Prasanth K Chelikani, Nils C Gassen, Matthew N Hil. A genetic variant of fatty acid amide hydrolase (FAAH) exacerbates hormone-mediated orexigenic feeding in mice. eLife. vol 12. 2023-04-11. PMID:37039453. |
fatty acid amide hydrolase (faah) degrades the endocannabinoid anandamide. |
2023-04-11 |
2023-08-14 |
mouse |
| Adriana Della Pietra, Georgii Krivoshein, Konstantin Ivanov, Raisa Giniatullina, Henna-Kaisa Jyrkkänen, Ville Leinonen, Marko Lehtonen, Arn M J M van den Maagdenberg, Juha Savinainen, Rashid Giniatulli. Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain. The journal of headache and pain. vol 24. issue 1. 2023-04-10. PMID:37038131. |
engaging the endocannabinoid system through inhibition of monoacylglycerol lipase (magl) and fatty acid amide hydrolase (faah), degrading endocannabinoids (endocbs) 2-arachidonoylglycerol (2-ag) and anandamide (aea), was proposed as a promising approach to ameliorate migraine pain. |
2023-04-10 |
2023-08-14 |
human |
| Yannick Fotio, Alex Mabou Tagne, Kwang-Mook Jung, Daniele Piomell. Fatty acid amide hydrolase inhibition alleviates anxiety-like symptoms in a rat model used to study post-traumatic stress disorder. Psychopharmacology. 2023-04-05. PMID:37017699. |
preclinical and clinical evidence shows that inhibitors of the enzyme fatty acid amide hydrolase (faah), which deactivates the endocannabinoid anandamide, exhibit anxiolytic-like properties in animal models. |
2023-04-05 |
2023-08-14 |
rat |
| Leila Hosseinzadeh Anvar, Asghar Alejafar, Seyyed Ebrahim Moosavi, Saeid Charsouei, Narges Zeynalzadeh, Leila Mehdizadeh Fanid, Babak Emamalizadeh, Zahra Hassanpour Aydinlou, Helaleh Vaezi, Adel Kashefi, Carlos Tomaz, Masoud Nikanfar, Ali Ahmadalipou. The study of rs324420 (C385A) polymorphism of the FAAH gene of the endocannabinoid system in patients with epilepsy and ADHD. Epilepsy research. vol 192. 2023-04-05. PMID:37018974. |
the study of rs324420 (c385a) polymorphism of the faah gene of the endocannabinoid system in patients with epilepsy and adhd. |
2023-04-05 |
2023-08-14 |
human |
| b' Bruno M Fonseca, Niloy Bhowmick, Sara Cunha, Jo\\xc3\\xa3o Maia, Georgina Correia-da-Silva, Nat\\xc3\\xa9rcia Teixeira, Susana I S\\xc3\\xa. Long-Term Tamoxifen Effects in the Cyclic Interaction of the Endocannabinoid and Endocrine System in the Rat Central Nervous System. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979699.' |
within the female reproductive tract, estrogen increases the expression of the cannabinoid receptors cb1 and cb2, and modifies the levels of anandamide (aea), the major endocannabinoid, by altering the expression of both aea synthesis (nape-pld) and catabolic enzymes (faah). |
2023-03-29 |
2023-08-14 |
rat |
| Simone Battaglia, Chiara Di Fazio, Carmelo M Vicario, Alessio Avenant. Neuropharmacological Modulation of N-methyl-D-aspartate, Noradrenaline and Endocannabinoid Receptors in Fear Extinction Learning: Synaptic Transmission and Plasticity. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36983000. |
we show that the administration of n-methyl-d-aspartate (nmda) agonists and modulation of the endocannabinoid system by fatty acid amide hydrolase (faah) inhibition can boost extinction learning through the stabilization and regulation of the receptor concentration. |
2023-03-29 |
2023-08-14 |
Not clear |
| Barbara Emons, Larissa Arning, Vera-Estelle Makulla, Maria-Theresia Suchy, Dimitrios Tsikas, Thomas Lücke, Jörg T Epplen, Georg Juckel, Patrik Rose. Endocannabinergic modulation of central serotonergic activity in healthy human volunteers. Annals of general psychiatry. vol 22. issue 1. 2023-03-18. PMID:36932421. |
since the cannabinoid (cb) 1 receptor is activated by endogenous ligands such as aea and 2ag, whose concentration are controlled by the fatty acid amide hydrolase (faah) and monoacylglycerol lipase, respectively, we investigated the effects on serotonergic utilization. |
2023-03-18 |
2023-08-14 |
human |
| Barbara Emons, Larissa Arning, Vera-Estelle Makulla, Maria-Theresia Suchy, Dimitrios Tsikas, Thomas Lücke, Jörg T Epplen, Georg Juckel, Patrik Rose. Endocannabinergic modulation of central serotonergic activity in healthy human volunteers. Annals of general psychiatry. vol 22. issue 1. 2023-03-18. PMID:36932421. |
in this study, we investigated the impact of the rs1049353 single-nucleotide polymorphism (snp) of the cannabinoid receptor 1 (cnr1) gene, which codes the endocannabinoid cb1 receptor, and the rs324420 snp of the faah gene on the serotonergic and endocannabinoid system in 59 healthy volunteers. |
2023-03-18 |
2023-08-14 |
human |
| Arijana Demaili, Anna Portugalov, Michal Dudai, Mouna Maroun, Irit Akirav, Katharina Braun, Jörg Boc. Epigenetic (re)programming of gene expression changes of CB1R and FAAH in the medial prefrontal cortex in response to early life and adolescence stress exposure. Frontiers in cellular neuroscience. vol 17. 2023-03-13. PMID:36909279. |
thus, the present study addressed the hypotheses that els and adolescent stress differentially affect the expression of regulatory elements of the endocannabinoid system, cannabinoid receptor 1 (cb1r) and fatty acid amide hydrolase (faah) in the medial prefrontal cortex (mpfc) of adult female rats. |
2023-03-13 |
2023-08-14 |
rat |