| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nathan J Kolla, Isabelle Boileau, R Michael Bagb. Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders. Scientific reports. vol 12. issue 1. 2022-01-22. PMID:35064143. |
fatty acid amide hydrolase (faah), an enzyme of the endocannabinoid system (ecs), has been linked to regulation of mood through modulation of anandamide, an endocannabinoid. |
2022-01-22 |
2023-08-13 |
human |
| Szymon Hryhorowicz, Marta Kaczmarek-Ryś, Aleksandra Zielińska, Rodney J Scott, Ryszard Słomski, Andrzej Pławsk. Endocannabinoid System as a Promising Therapeutic Target in Inflammatory Bowel Disease - A Systematic Review. Frontiers in immunology. vol 12. 2022-01-10. PMID:35003109. |
it consists of cannabinoid receptors (cb1 and cb2), transporters for cellular uptake of endocannabinoid ligands, endogenous bioactive lipids (anandamide and 2-arachidonoylglycerol), and the enzymes responsible for their synthesis and degradation (fatty acid amide hydrolase and monoacylglycerol lipase), the manipulation of which through agonists and antagonists of the system, shows a potential therapeutic role for ecs in inflammatory bowel disease. |
2022-01-10 |
2023-08-13 |
Not clear |
| Shrouq I Farah, Samantha Hilston, Ngan Tran, Nikolai Zvonok, Alexandros Makriyanni. 1-, 2- and 3-AG as substrates of the endocannabinoid enzymes and endogenous ligands of the cannabinoid receptor 1. Biochemical and biophysical research communications. vol 591. 2022-01-07. PMID:34995983. |
here, we present the interaction profiles of 2-ag and its isomerization products, 1- and 3-ag, with the endocannabinoid mgl, abhd6 and faah enzymes as well as the cb1 receptor. |
2022-01-07 |
2023-08-13 |
Not clear |
| Subramaniam Jayanthi, Ritvik Peesapati, Michael T McCoy, Bruce Ladenheim, Jean Lud Cade. Footshock-Induced Abstinence from Compulsive Methamphetamine Self-administration in Rat Model Is Accompanied by Increased Hippocampal Expression of Cannabinoid Receptors (CB1 and CB2). Molecular neurobiology. 2022-01-03. PMID:34978045. |
animals were euthanized 2 h after the last meth sa session and their hippocampi were used to measure mrna levels of cannabinoid receptors (cb/cnr), as well as those of synthesizing (dagl-a, dagl-b, napepld) and metabolizing (mgll, faah, ptgs2) enzymes of the endocannabinoid cascade. |
2022-01-03 |
2023-08-13 |
rat |
| Smita Jain, Akansha Bisht, Kanika Verma, Swarnima Negi, Sarvesh Paliwal, Swapnil Sharm. The role of fatty acid amide hydrolase enzyme inhibitors in Alzheimer's disease. Cell biochemistry and function. 2021-12-21. PMID:34931308. |
fatty acid amide hydrolase (faah) is a prominent enzyme of the endocannabinoid system that degrades endogenous cannabinoid anandamide and oleamide. |
2021-12-21 |
2023-08-13 |
Not clear |
| Shivanshu Bajaj, Shreshta Jain, Preeti Vyas, Sandhya Bawa, Divya Vohor. The role of endocannabinoid pathway in the neuropathology of Alzheimer's disease: Can the inhibitors of MAGL and FAAH prove to be potential therapeutic targets against the cognitive impairment associated with Alzheimer's disease? Brain research bulletin. vol 174. 2021-12-10. PMID:34217798. |
the role of endocannabinoid pathway in the neuropathology of alzheimer's disease: can the inhibitors of magl and faah prove to be potential therapeutic targets against the cognitive impairment associated with alzheimer's disease? |
2021-12-10 |
2023-08-13 |
Not clear |
| Shivanshu Bajaj, Shreshta Jain, Preeti Vyas, Sandhya Bawa, Divya Vohor. The role of endocannabinoid pathway in the neuropathology of Alzheimer's disease: Can the inhibitors of MAGL and FAAH prove to be potential therapeutic targets against the cognitive impairment associated with Alzheimer's disease? Brain research bulletin. vol 174. 2021-12-10. PMID:34217798. |
in order to modulate endocannabinoid system, number of agents have been reported amongst which are inhibitors of the monoacylglycerol (magl) and fatty acid amide hydrolase (faah), the enzymes that hydrolyses 2-ag and aea respectively. |
2021-12-10 |
2023-08-13 |
Not clear |
| A Ronchi, F Grauso, F Zito Marino, V Quagliariello, N Maurea, G Facchini, M Montopoli, R Franco, M Berretta, E M Messall. Endocannabinoid system expression in ovarian epithelial tumors according to the dualistic model of ovarian carcinogenesis. European review for medical and pharmacological sciences. vol 25. issue 14. 2021-12-10. PMID:34337715. |
our study aimed to confirm the expression of the endocannabinoid system in the human epithelial ovarian tumors, assessing the immunohistochemical expression of cannabinoid receptor type 1 and fatty acid amide hydrolase in benign, borderline and malignant tumors. |
2021-12-10 |
2023-08-13 |
human |
| Stacey Herriage, Guangping Chen, Carey Pop. Concentration-dependent effects of chlorpyrifos oxon on peroxisome proliferator-activated receptor signaling in MCF-7 cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 78. 2021-12-10. PMID:34756920. |
ache is critical in regulating cholinergic signaling while faah catalyzes the inactivation of fatty acid signaling lipids including the endocannabinoid (ecb) n-arachidonylethanolamine (anandamide, aea) and ecb-like metabolites (e.g., oleoylethanolamide, oea). |
2021-12-10 |
2023-08-13 |
human |
| Milica Jankovic, Natasa Spasojevic, Harisa Ferizovic, Bojana Stefanovic, Sladjana Dronja. Sex specific effects of the fatty acid amide hydrolase inhibitor URB597 on memory and brain β Neuroscience letters. vol 768. 2021-12-07. PMID:34843876. |
sex specific effects of the fatty acid amide hydrolase inhibitor urb597 on memory and brain β an increasing body of evidence shows significant sex differences in the mammalian brain in multiple behaviours and psychiatric and neurological diseases and as well as that the endocannabinoid system may differ between males and females. |
2021-12-07 |
2023-08-13 |
Not clear |
| Duncan G J Green, Jinhee Kim, Stephen J Kish, Rachel F Tyndale, Matthew N Hill, Antonio P Strafella, Junchao Tong, Tina McCluskey, Duncan J Westwood, Sylvain Houle, Nancy J Lobaugh, Isabelle Boilea. Fatty acid amide hydrolase binding is inversely correlated with amygdalar functional connectivity: a combined positron emission tomography and magnetic resonance imaging study in healthy individuals. Journal of psychiatry & neuroscience : JPN. vol 46. issue 2. 2021-12-05. PMID:33729738. |
upregulation of the endocannabinoid enzyme fatty acid amide hydrolase (faah) has been linked to abnormal activity in frontoamygdalar circuits, a hallmark of posttraumatic stress disorder. |
2021-12-05 |
2023-08-13 |
Not clear |
| Sarah Rieck, Sofia Kilgus, Johanna H Meyer, Hao Huang, Lan Zhao, Michaela Matthey, Xin Wang, Steffen Schmitz-Valckenberg, Bernd K Fleischmann, Daniela Wenze. Inhibition of Vascular Growth by Modulation of the Anandamide/Fatty Acid Amide Hydrolase Axis. Arteriosclerosis, thrombosis, and vascular biology. vol 41. issue 12. 2021-12-01. PMID:34615374. |
approach and results: here, we show that inactivation of faah (fatty acid amide hydrolase), the enzyme responsible for degradation of the endocannabinoid anandamide, strongly impairs angiogenesis in vitro and in vivo. |
2021-12-01 |
2023-08-13 |
Not clear |
| Nicole L Zabik, Allesandra S Iadipaolo, Hilary A Marusak, Craig Peters, Kyle Burghardt, Christine A Rabina. A common genetic variant in fatty acid amide hydrolase is linked to alterations in fear extinction neural circuitry in a racially diverse, nonclinical sample of adults. Journal of neuroscience research. 2021-11-30. PMID:34051704. |
emerging data indicate that genetic variation in fatty acid amide hydrolase (faah c385a; rs324420) is associated with increased peripheral endocannabinoid (ecb) levels and lesser threat-related amygdala reactivity. |
2021-11-30 |
2023-08-13 |
Not clear |
| Joseph Bouskila, Maxime Bleau, Catarina Micaelo-Fernandes, Jean-François Bouchard, Maurice Ptit. The Inhibition of the Degrading Enzyme Fatty Acid Amide Hydrolase Alters the Activity of the Cone System in the Vervet Monkey Retina. Brain sciences. vol 11. issue 11. 2021-11-29. PMID:34827417. |
specific cone-mediated responses evoked through the photopic flicker erg appear to be a better way to validate the assumption that endogenous cannabinoids modulate the cone pathway, since faah is mainly expressed in the vervet monkey cone photoreceptors. |
2021-11-29 |
2023-08-13 |
monkey |
| Joseph Bouskila, Maxime Bleau, Catarina Micaelo-Fernandes, Jean-François Bouchard, Maurice Ptit. The Inhibition of the Degrading Enzyme Fatty Acid Amide Hydrolase Alters the Activity of the Cone System in the Vervet Monkey Retina. Brain sciences. vol 11. issue 11. 2021-11-29. PMID:34827417. |
the aim of this study is two-fold: (1) to use the photopic flicker erg to target the cone pathway specifically, and (2) use urb597 as a selective inhibitor of the endocannabinoid degrading enzyme fatty acid amide hydrolase (faah) to enhance the levels of fatty acid amides, particularly anandamide. |
2021-11-29 |
2023-08-13 |
monkey |
| Robert Ramer, Felix Wittig, Burkhard Hin. The Endocannabinoid System as a Pharmacological Target for New Cancer Therapies. Cancers. vol 13. issue 22. 2021-11-29. PMID:34830856. |
this review summarises the relevant preclinical studies with faah and magl inhibitors compared to studies with cannabinoids and provides an overview of the regulation of the endocannabinoid system in cancer. |
2021-11-29 |
2023-08-13 |
Not clear |
| Tina K Thethi, Aster Sigel, Shanker Japa, Bonnie Katalenich, Shuqian Liu, Tuyen Nguyen, Joshua Larrazolo, Stephanie Syu, Esther Carefoot, Roberta McDuffie, Vivian Fonsec. Racial and sex differences in the polymorphisms of the endocannabinoid receptor genes in obesity. Journal of diabetes and its complications. vol 34. issue 11. 2021-11-24. PMID:32732136. |
the endocannabinoid system (ec) and polymorphism in the endocannabinoid receptor type 1 (cnr1) gene 3813a/g and 4895a/g and in the fatty acid amide hydrolase (faah) are associated with obesity. |
2021-11-24 |
2023-08-13 |
Not clear |
| Jenny L Wilkerson, Joshua A Bilbrey, Jasmine S Felix, Alexandros Makriyannis, Lance R McMaho. Untapped endocannabinoid pharmacological targets: Pipe dream or pipeline? Pharmacology, biochemistry, and behavior. vol 206. 2021-11-24. PMID:33932409. |
the endocannabinoid system comprises both cannabinoid receptors, their endogenous ligands including 2-arachidonoylglycerol (2-ag), n-arachidonylethanolamine (anandamide, aea), and enzymes that regulate the synthesis and degradation of endogenous ligands which include diacylglycerol lipase alpha (dagl-α), diacylglycerol lipase beta (dagl-β), fatty acid amide hydrolase (faah), monoacylglycerol lipase (magl), α/β hydrolase domain 6 (abhd6). |
2021-11-24 |
2023-08-13 |
Not clear |
| Mohaddeseh Ebrahimi-Ghiri, Faezeh Shahini, Mohammad-Reza Zarrindas. The effect of URB597, exercise or their combination on the performance of 6-OHDA mouse model of Parkinson disease in the elevated plus maze, tail suspension test and step-down task. Metabolic brain disease. vol 36. issue 8. 2021-11-11. PMID:34599739. |
here, we investigated the effect of a low dose of fatty acid amide hydrolase inhibitor urb597 (as an enhancer of endocannabinoid anandamide levels), exercise or their combination on some behavior alterations in pd mice lesioned by 6-hydroxydopamine (6-ohda). |
2021-11-11 |
2023-08-13 |
mouse |
| Laura M Best, Jeffrey D Wardell, Rachel F Tyndale, Matthew D McPhee, Bernard Le Foll, Stephen J Kish, Isabelle Boileau, Christian S Hendersho. Association of the Fatty Acid Amide Hydrolase C385A Polymorphism With Alcohol Use Severity and Coping Motives in Heavy-Drinking Youth. Alcoholism, clinical and experimental research. vol 45. issue 3. 2021-11-02. PMID:33460184. |
reduced function of fatty acid amide hydrolase, the catabolic enzyme for the endocannabinoid anandamide, can be inherited through a functional genetic polymorphism (faah rs324420, c385a, p129t). |
2021-11-02 |
2023-08-13 |
Not clear |