| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Milica Jankovic, Natasa Spasojevic, Harisa Ferizovic, Bojana Stefanovic, Sladjana Dronja. Sex specific effects of the fatty acid amide hydrolase inhibitor URB597 on memory and brain β Neuroscience letters. vol 768. 2021-12-07. PMID:34843876. |
sex specific effects of the fatty acid amide hydrolase inhibitor urb597 on memory and brain β an increasing body of evidence shows significant sex differences in the mammalian brain in multiple behaviours and psychiatric and neurological diseases and as well as that the endocannabinoid system may differ between males and females. |
2021-12-07 |
2023-08-13 |
Not clear |
| Duncan G J Green, Jinhee Kim, Stephen J Kish, Rachel F Tyndale, Matthew N Hill, Antonio P Strafella, Junchao Tong, Tina McCluskey, Duncan J Westwood, Sylvain Houle, Nancy J Lobaugh, Isabelle Boilea. Fatty acid amide hydrolase binding is inversely correlated with amygdalar functional connectivity: a combined positron emission tomography and magnetic resonance imaging study in healthy individuals. Journal of psychiatry & neuroscience : JPN. vol 46. issue 2. 2021-12-05. PMID:33729738. |
upregulation of the endocannabinoid enzyme fatty acid amide hydrolase (faah) has been linked to abnormal activity in frontoamygdalar circuits, a hallmark of posttraumatic stress disorder. |
2021-12-05 |
2023-08-13 |
Not clear |
| Sarah Rieck, Sofia Kilgus, Johanna H Meyer, Hao Huang, Lan Zhao, Michaela Matthey, Xin Wang, Steffen Schmitz-Valckenberg, Bernd K Fleischmann, Daniela Wenze. Inhibition of Vascular Growth by Modulation of the Anandamide/Fatty Acid Amide Hydrolase Axis. Arteriosclerosis, thrombosis, and vascular biology. vol 41. issue 12. 2021-12-01. PMID:34615374. |
approach and results: here, we show that inactivation of faah (fatty acid amide hydrolase), the enzyme responsible for degradation of the endocannabinoid anandamide, strongly impairs angiogenesis in vitro and in vivo. |
2021-12-01 |
2023-08-13 |
Not clear |
| Nicole L Zabik, Allesandra S Iadipaolo, Hilary A Marusak, Craig Peters, Kyle Burghardt, Christine A Rabina. A common genetic variant in fatty acid amide hydrolase is linked to alterations in fear extinction neural circuitry in a racially diverse, nonclinical sample of adults. Journal of neuroscience research. 2021-11-30. PMID:34051704. |
emerging data indicate that genetic variation in fatty acid amide hydrolase (faah c385a; rs324420) is associated with increased peripheral endocannabinoid (ecb) levels and lesser threat-related amygdala reactivity. |
2021-11-30 |
2023-08-13 |
Not clear |
| Joseph Bouskila, Maxime Bleau, Catarina Micaelo-Fernandes, Jean-François Bouchard, Maurice Ptit. The Inhibition of the Degrading Enzyme Fatty Acid Amide Hydrolase Alters the Activity of the Cone System in the Vervet Monkey Retina. Brain sciences. vol 11. issue 11. 2021-11-29. PMID:34827417. |
specific cone-mediated responses evoked through the photopic flicker erg appear to be a better way to validate the assumption that endogenous cannabinoids modulate the cone pathway, since faah is mainly expressed in the vervet monkey cone photoreceptors. |
2021-11-29 |
2023-08-13 |
monkey |
| Joseph Bouskila, Maxime Bleau, Catarina Micaelo-Fernandes, Jean-François Bouchard, Maurice Ptit. The Inhibition of the Degrading Enzyme Fatty Acid Amide Hydrolase Alters the Activity of the Cone System in the Vervet Monkey Retina. Brain sciences. vol 11. issue 11. 2021-11-29. PMID:34827417. |
the aim of this study is two-fold: (1) to use the photopic flicker erg to target the cone pathway specifically, and (2) use urb597 as a selective inhibitor of the endocannabinoid degrading enzyme fatty acid amide hydrolase (faah) to enhance the levels of fatty acid amides, particularly anandamide. |
2021-11-29 |
2023-08-13 |
monkey |
| Robert Ramer, Felix Wittig, Burkhard Hin. The Endocannabinoid System as a Pharmacological Target for New Cancer Therapies. Cancers. vol 13. issue 22. 2021-11-29. PMID:34830856. |
this review summarises the relevant preclinical studies with faah and magl inhibitors compared to studies with cannabinoids and provides an overview of the regulation of the endocannabinoid system in cancer. |
2021-11-29 |
2023-08-13 |
Not clear |
| Tina K Thethi, Aster Sigel, Shanker Japa, Bonnie Katalenich, Shuqian Liu, Tuyen Nguyen, Joshua Larrazolo, Stephanie Syu, Esther Carefoot, Roberta McDuffie, Vivian Fonsec. Racial and sex differences in the polymorphisms of the endocannabinoid receptor genes in obesity. Journal of diabetes and its complications. vol 34. issue 11. 2021-11-24. PMID:32732136. |
the endocannabinoid system (ec) and polymorphism in the endocannabinoid receptor type 1 (cnr1) gene 3813a/g and 4895a/g and in the fatty acid amide hydrolase (faah) are associated with obesity. |
2021-11-24 |
2023-08-13 |
Not clear |
| Jenny L Wilkerson, Joshua A Bilbrey, Jasmine S Felix, Alexandros Makriyannis, Lance R McMaho. Untapped endocannabinoid pharmacological targets: Pipe dream or pipeline? Pharmacology, biochemistry, and behavior. vol 206. 2021-11-24. PMID:33932409. |
the endocannabinoid system comprises both cannabinoid receptors, their endogenous ligands including 2-arachidonoylglycerol (2-ag), n-arachidonylethanolamine (anandamide, aea), and enzymes that regulate the synthesis and degradation of endogenous ligands which include diacylglycerol lipase alpha (dagl-α), diacylglycerol lipase beta (dagl-β), fatty acid amide hydrolase (faah), monoacylglycerol lipase (magl), α/β hydrolase domain 6 (abhd6). |
2021-11-24 |
2023-08-13 |
Not clear |
| Mohaddeseh Ebrahimi-Ghiri, Faezeh Shahini, Mohammad-Reza Zarrindas. The effect of URB597, exercise or their combination on the performance of 6-OHDA mouse model of Parkinson disease in the elevated plus maze, tail suspension test and step-down task. Metabolic brain disease. vol 36. issue 8. 2021-11-11. PMID:34599739. |
here, we investigated the effect of a low dose of fatty acid amide hydrolase inhibitor urb597 (as an enhancer of endocannabinoid anandamide levels), exercise or their combination on some behavior alterations in pd mice lesioned by 6-hydroxydopamine (6-ohda). |
2021-11-11 |
2023-08-13 |
mouse |
| Laura M Best, Jeffrey D Wardell, Rachel F Tyndale, Matthew D McPhee, Bernard Le Foll, Stephen J Kish, Isabelle Boileau, Christian S Hendersho. Association of the Fatty Acid Amide Hydrolase C385A Polymorphism With Alcohol Use Severity and Coping Motives in Heavy-Drinking Youth. Alcoholism, clinical and experimental research. vol 45. issue 3. 2021-11-02. PMID:33460184. |
reduced function of fatty acid amide hydrolase, the catabolic enzyme for the endocannabinoid anandamide, can be inherited through a functional genetic polymorphism (faah rs324420, c385a, p129t). |
2021-11-02 |
2023-08-13 |
Not clear |
| Rosaria Greco, Chiara Demartini, Annamaria Zanaboni, Ilenia Casini, Roberto De Icco, Angelo Reggiani, Alessandra Misto, Daniele Piomelli, Cristina Tassorell. Characterization of the peripheral FAAH inhibitor, URB937, in animal models of acute and chronic migraine. Neurobiology of disease. vol 147. 2021-11-01. PMID:33129939. |
inhibiting the activity of fatty-acid amide hydrolase (faah), the enzyme that deactivates the endocannabinoid anandamide, enhances anandamide-mediated signaling and holds promise as a molecular target for the treatment of human pathologies such as anxiety and pain. |
2021-11-01 |
2023-08-13 |
human |
| Alex J Berry, Olga Zubko, Suzanne J Reeves, Robert J Howar. Endocannabinoid system alterations in Alzheimer's disease: A systematic review of human studies. Brain research. vol 1749. 2021-10-27. PMID:32980333. |
we attempted to identify reported changes in the expression and activity of: cannabinoid receptors 1 and 2; anandamide (aea); 2-arachidonoylglycerol (2-ag); monoacylglycerol lipase (magl); fatty acid amide hydrolase (faah); and transient receptor potential cation channel v1 (trpv1). |
2021-10-27 |
2023-08-13 |
human |
| M Shah Sufian, M Ruhul Amin, Declan W Al. Early suppression of the endocannabinoid degrading enzymes FAAH and MAGL alters locomotor development in zebrafish. The Journal of experimental biology. vol 224. issue 16. 2021-10-27. PMID:34435626. |
early suppression of the endocannabinoid degrading enzymes faah and magl alters locomotor development in zebrafish. |
2021-10-27 |
2023-08-13 |
zebrafish |
| Susanna M Saario, Michele K McKinney, Anna E Speers, Chu Wang, Benjamin F Cravat. Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase(). Chemical science. vol 3. issue 1. 2021-10-21. PMID:22737400. |
fatty acid amide hydrolase (faah) is an integral membrane enzyme that degrades the endocannabinoid anandamide (aea) and several other bioactive lipid amides. |
2021-10-21 |
2023-08-12 |
Not clear |
| Jianqin Zhuang, De-Ping Yang, Xiaoyu Tian, Spyros P Nikas, Rishi Sharma, Jason Jianxin Guo, Alexandros Makriyanni. Targeting the Endocannabinoid System for Neuroprotection: A Journal of pharmaceutics & pharmacology. vol 1. issue 1. 2021-10-21. PMID:24533425. |
targeting the endocannabinoid system for neuroprotection: a fatty acid amide hydrolase (faah), the enzyme involved in the inactivation of the endocannabinoid anandamide (aea), is being considered as a therapeutic target for analgesia and neuroprotection. |
2021-10-21 |
2023-08-12 |
human |
| Kay Ahn, Douglas S Johnson, Benjamin F Cravat. Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders. Expert opinion on drug discovery. vol 4. issue 7. 2021-10-20. PMID:20544003. |
background: fatty acid amide hydrolase (faah) is an integral membrane enzyme that hydrolyzes the endocannabinoid anandamide and related amidated signaling lipids. |
2021-10-20 |
2023-08-12 |
human |
| Douglas S Johnson, Cory Stiff, Scott E Lazerwith, Suzanne R Kesten, Lorraine K Fay, Mark Morris, David Beidler, Marya B Liimatta, Sarah E Smith, David T Dudley, Nalini Sadagopan, Shobha N Bhattachar, Stephen J Kesten, Tyzoon K Nomanbhoy, Benjamin F Cravatt, Kay Ah. Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor. ACS medicinal chemistry letters. vol 2. issue 2. 2021-10-20. PMID:21666860. |
fatty acid amide hydrolase (faah) is an integral membrane serine hydrolase that degrades the fatty acid amide family of signaling lipids, including the endocannabinoid anandamide. |
2021-10-20 |
2023-08-12 |
human |
| Maya R Jacobson, Jeremy J Watts, Tania Da Silva, Rachel F Tyndale, Pablo M Rusjan, Sylvain Houle, Alan A Wilson, Ruth A Ross, Isabelle Boileau, Romina Mizrah. Fatty acid amide hydrolase is lower in young cannabis users. Addiction biology. vol 26. issue 1. 2021-10-05. PMID:31960544. |
we have recently shown that levels of fatty acid amide hydrolase (faah), the enzyme that metabolizes the endocannabinoid anandamide, are lower in the brains of adult cannabis users (cus) (34 ± 11 years of age), tested during early abstinence. |
2021-10-05 |
2023-08-13 |
human |
| Navatha Alugubelly, Afzaal N Mohammed, Russell L Car. Persistent proteomic changes in glutamatergic and GABAergic signaling in the amygdala of adolescent rats exposed to chlorpyrifos as juveniles. Neurotoxicology. vol 85. 2021-09-22. PMID:34058248. |
exposure to cpf at these levels inhibits the endocannabinoid metabolizing enzyme fatty acid amide hydrolase (faah) but it is not clear what the persistent effects of this inhibition are. |
2021-09-22 |
2023-08-13 |
rat |