| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rosaria Greco, Chiara Demartini, Annamaria Zanaboni, Ilenia Casini, Roberto De Icco, Angelo Reggiani, Alessandra Misto, Daniele Piomelli, Cristina Tassorell. Characterization of the peripheral FAAH inhibitor, URB937, in animal models of acute and chronic migraine. Neurobiology of disease. vol 147. 2021-11-01. PMID:33129939. |
inhibiting the activity of fatty-acid amide hydrolase (faah), the enzyme that deactivates the endocannabinoid anandamide, enhances anandamide-mediated signaling and holds promise as a molecular target for the treatment of human pathologies such as anxiety and pain. |
2021-11-01 |
2023-08-13 |
human |
| Alex J Berry, Olga Zubko, Suzanne J Reeves, Robert J Howar. Endocannabinoid system alterations in Alzheimer's disease: A systematic review of human studies. Brain research. vol 1749. 2021-10-27. PMID:32980333. |
we attempted to identify reported changes in the expression and activity of: cannabinoid receptors 1 and 2; anandamide (aea); 2-arachidonoylglycerol (2-ag); monoacylglycerol lipase (magl); fatty acid amide hydrolase (faah); and transient receptor potential cation channel v1 (trpv1). |
2021-10-27 |
2023-08-13 |
human |
| M Shah Sufian, M Ruhul Amin, Declan W Al. Early suppression of the endocannabinoid degrading enzymes FAAH and MAGL alters locomotor development in zebrafish. The Journal of experimental biology. vol 224. issue 16. 2021-10-27. PMID:34435626. |
early suppression of the endocannabinoid degrading enzymes faah and magl alters locomotor development in zebrafish. |
2021-10-27 |
2023-08-13 |
zebrafish |
| Susanna M Saario, Michele K McKinney, Anna E Speers, Chu Wang, Benjamin F Cravat. Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase(). Chemical science. vol 3. issue 1. 2021-10-21. PMID:22737400. |
fatty acid amide hydrolase (faah) is an integral membrane enzyme that degrades the endocannabinoid anandamide (aea) and several other bioactive lipid amides. |
2021-10-21 |
2023-08-12 |
Not clear |
| Jianqin Zhuang, De-Ping Yang, Xiaoyu Tian, Spyros P Nikas, Rishi Sharma, Jason Jianxin Guo, Alexandros Makriyanni. Targeting the Endocannabinoid System for Neuroprotection: A Journal of pharmaceutics & pharmacology. vol 1. issue 1. 2021-10-21. PMID:24533425. |
targeting the endocannabinoid system for neuroprotection: a fatty acid amide hydrolase (faah), the enzyme involved in the inactivation of the endocannabinoid anandamide (aea), is being considered as a therapeutic target for analgesia and neuroprotection. |
2021-10-21 |
2023-08-12 |
human |
| Kay Ahn, Douglas S Johnson, Benjamin F Cravat. Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders. Expert opinion on drug discovery. vol 4. issue 7. 2021-10-20. PMID:20544003. |
background: fatty acid amide hydrolase (faah) is an integral membrane enzyme that hydrolyzes the endocannabinoid anandamide and related amidated signaling lipids. |
2021-10-20 |
2023-08-12 |
human |
| Douglas S Johnson, Cory Stiff, Scott E Lazerwith, Suzanne R Kesten, Lorraine K Fay, Mark Morris, David Beidler, Marya B Liimatta, Sarah E Smith, David T Dudley, Nalini Sadagopan, Shobha N Bhattachar, Stephen J Kesten, Tyzoon K Nomanbhoy, Benjamin F Cravatt, Kay Ah. Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor. ACS medicinal chemistry letters. vol 2. issue 2. 2021-10-20. PMID:21666860. |
fatty acid amide hydrolase (faah) is an integral membrane serine hydrolase that degrades the fatty acid amide family of signaling lipids, including the endocannabinoid anandamide. |
2021-10-20 |
2023-08-12 |
human |
| Maya R Jacobson, Jeremy J Watts, Tania Da Silva, Rachel F Tyndale, Pablo M Rusjan, Sylvain Houle, Alan A Wilson, Ruth A Ross, Isabelle Boileau, Romina Mizrah. Fatty acid amide hydrolase is lower in young cannabis users. Addiction biology. vol 26. issue 1. 2021-10-05. PMID:31960544. |
we have recently shown that levels of fatty acid amide hydrolase (faah), the enzyme that metabolizes the endocannabinoid anandamide, are lower in the brains of adult cannabis users (cus) (34 ± 11 years of age), tested during early abstinence. |
2021-10-05 |
2023-08-13 |
human |
| Navatha Alugubelly, Afzaal N Mohammed, Russell L Car. Persistent proteomic changes in glutamatergic and GABAergic signaling in the amygdala of adolescent rats exposed to chlorpyrifos as juveniles. Neurotoxicology. vol 85. 2021-09-22. PMID:34058248. |
exposure to cpf at these levels inhibits the endocannabinoid metabolizing enzyme fatty acid amide hydrolase (faah) but it is not clear what the persistent effects of this inhibition are. |
2021-09-22 |
2023-08-13 |
rat |
| Reshed Abohalaka, Turgut Emrah Bozkurt, Tuba Reçber, Sevgen Celik Onder, Emirhan Nemutlu, Sedef Kır, Inci Sahin-Erdeml. The effects of systemic and local fatty acid amide hydrolase and monoacylglycerol lipase inhibitor treatments on the metabolomic profile of lungs. Biomedical chromatography : BMC. 2021-09-17. PMID:34449902. |
previously, we have shown that increasing the tissue endocannabinoid levels by fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) inhibitors can prevent airway inflammation and hyperreactivity. |
2021-09-17 |
2023-08-13 |
mouse |
| Xiaoru Dong, Dingang Zhang, Rongzhe Zhu, Xiaochen Liu, Yonghong Ye, Yan Jian. Spatio-temporal effects of acute alcohol intoxication on endocannabinoid system in rat brain and blood. Alcohol (Fayetteville, N.Y.). vol 88. 2021-09-15. PMID:32738384. |
we have closely monitored the critical indicators reflecting changes of the ecs during the entire process from alcohol absorption to its metabolization, after acute alcohol (4.5 g/kg) intake by intragastric administration, including two key endocannabinoids (arachidonoylethanolamide and 2-arachidonoylglycerol) and their hydrolytic enzymes (fatty acid amide hydrolase and monoacylglycerol lipase) in blood and three brain regions, as well as a crucial and abundant receptor (cannabinoid 1 receptor) of the ecs in the three brain regions. |
2021-09-15 |
2023-08-13 |
human |
| Noëlle van Egmond, Verena M Straub, Mario van der Stel. Targeting Endocannabinoid Signaling: FAAH and MAG Lipase Inhibitors. Annual review of pharmacology and toxicology. vol 61. 2021-09-09. PMID:32867595. |
targeting endocannabinoid signaling: faah and mag lipase inhibitors. |
2021-09-09 |
2023-08-13 |
Not clear |
| Lucinda M Sisk, Kristina M Rapuano, May I Conley, Abigail S Greene, Corey Horien, Monica D Rosenberg, Dustin Scheinost, R Todd Constable, Charles E Glatt, B J Casey, Dylan G Ge. Genetic variation in endocannabinoid signaling is associated with differential network-level functional connectivity in youth. Journal of neuroscience research. 2021-09-08. PMID:34496065. |
the fatty acid amide hydrolase (faah) c385a polymorphism, which is associated with enhanced endocannabinoid signaling in the brain, has been identified across species as a potential protective factor from anxiety. |
2021-09-08 |
2023-08-13 |
human |
| Dorsa Rafiei, Nathan J Koll. Elevated Brain Fatty Acid Amide Hydrolase Induces Depressive-Like Phenotypes in Rodent Models: A Review. International journal of molecular sciences. vol 22. issue 3. 2021-09-06. PMID:33494322. |
altered activity of fatty acid amide hydrolase (faah), an enzyme of the endocannabinoid system, has been implicated in several neuropsychiatric disorders, including major depressive disorder (mdd). |
2021-09-06 |
2023-08-13 |
Not clear |
| Zubeyir Elmazoglu, Edgar Rangel-López, Omar Noel Medina-Campos, José Pedraza-Chaverri, Isaac Túnez, Michael Aschner, Abel Santamaría, Çimen Karas. Cannabinoid-profiled agents improve cell survival via reduction of oxidative stress and inflammation, and Nrf2 activation in a toxic model combining hyperglycemia+Aβ Neurochemistry international. vol 140. 2021-09-02. PMID:32781098. |
here we characterized the protective properties of the endocannabinoids arachidonylethanolamide (aea) and 2-arachidonoylglycerol (2-ag), the synthetic cannabinoids cp 55-940 and win 55,212-2, and the fatty acid amide hydrolase (faah) inhibitor urb597, on a combined hyperglycemia + oligomeric amyloid β peptide (aβ |
2021-09-02 |
2023-08-13 |
Not clear |
| Adrián Bartoll, Ana Toledano-Zaragoza, Josefina Casas, Manuel Guzmán, Edward H Schuchman, María Dolores Ledesm. Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling. EMBO molecular medicine. vol 12. issue 11. 2021-08-18. PMID:33016621. |
inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling. |
2021-08-18 |
2023-08-13 |
mouse |
| A R Tejeda-Martínez, J M Viveros-Paredes, G V Hidalgo-Franco, E Pardo-González, V Chaparro-Huerta, R E González-Castañeda, M E Flores-Sot. Chronic Inhibition of FAAH Reduces Depressive-Like Behavior and Improves Dentate Gyrus Proliferation after Chronic Unpredictable Stress Exposure. Behavioural neurology. vol 2021. 2021-08-18. PMID:33833828. |
levels of the endocannabinoid anandamide (aea) seem to affect these depression-by-stress-related features and could be modulated by fatty acid amide hydrolase (faah). |
2021-08-18 |
2023-08-13 |
mouse |
| Juan Suárez, Sophia Khom, Francisco Alén, Luis A Natividad, Florence P Varodayan, Reesha R Patel, Dean Kirson, Rocío Arco, Antonio Ballesta, Michal Bajo, Leticia Rubio, Rémi Martin-Fardon, Fernando Rodríguez de Fonseca, Marisa Robert. Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala. Addiction biology. vol 25. issue 5. 2021-08-11. PMID:31339221. |
the increase in ethanol self-administration was associated with (a) reductions in levels of the endocannabinoids n-arachidonoylethanolomine and 2-arachidonoylglycerol in the cea, (b) increased amygdalar gene expression of cannabinoid type-1 receptor (cb1), n-acyl phosphatidylethanolamine phospholipase d (nape-pld), fatty acid amid hydrolase (faah), (c) decreased amygdalar gene expression of ionotropic ampa (glua2 and glua4) and metabotropic (mglu3) glutamate receptors, and (d) increased glutamatergic receptor function. |
2021-08-11 |
2023-08-13 |
Not clear |
| Luca Carnevali, Rosario Statello, Federica Vacondio, Francesca Ferlenghi, Gilberto Spadoni, Silvia Rivara, Marco Mor, Andrea Sgoif. Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 32. 2021-08-10. PMID:31948828. |
pharmacological inhibition of the enzyme fatty acid amide hydrolase (faah), which terminates signaling of the endocannabinoid n-arachidonoylethanolamine (or anandamide, aea), exerts favourable effects in rodent models of stress-related depression. |
2021-08-10 |
2023-08-13 |
rat |
| Lisa E Flannery, Daniel M Kerr, Edel M Hughes, Colm Kelly, Jonathan Costello, Aoife M Thornton, Rachel M Humphrey, David P Finn, Michelle Roch. N-acylethanolamine regulation of TLR3-induced hyperthermia and neuroinflammatory gene expression: A role for PPARα. Journal of neuroimmunology. vol 358. 2021-08-09. PMID:34265624. |
synthetic cannabinoids and enhancing cannabinoid tone via inhibition of fatty acid amide hydrolase (faah) has been demonstrated to modulate tlr3-induced neuroimmune responses and associated sickness behaviour. |
2021-08-09 |
2023-08-13 |
Not clear |