All Relations between fatty acid amide hydrolase and cannabinoids

Publication Sentence Publish Date Extraction Date Species
Vikram Thakur, Mohammad Bashashati, Josue Enriquez, Munmun Chattopadhya. Inhibiting Fatty Acid Amide Hydrolase Ameliorates Enteropathy in Diabetic Mice: A Cannabinoid 1 Receptor Mediated Mechanism. Veterinary sciences. vol 9. issue 7. 2022-07-25. PMID:35878381. cannabinoid 1 receptor antagonist, am251 blocked the effects of urb597, which may demonstrate that faah inhibitor is a potential remedial strategy for gi dysmotility. 2022-07-25 2023-08-14 mouse
Chaoling Chen, Weili Wang, Justin L Poklis, Aron H Lichtman, Joseph K Ritter, Gaizun Hu, Dengpiao Xie, Ningjun L. Inactivation of fatty acid amide hydrolase protects against ischemic reperfusion injury-induced renal fibrogenesis. Biochimica et biophysica acta. Molecular basis of disease. 2022-06-16. PMID:35710061. although cannabinoid receptors (cb) are recognized as targets for renal fibrosis, the role of endogenous cannabinoid anandamide (aea) and its primary hydrolytic enzyme, fatty acid amide hydrolase (faah), in renal fibrogenesis remains unclear. 2022-06-16 2023-08-14 mouse
Farinaz Ghaderi, Fattah Sotoodehnejadnematalahi, Zahra Hajebrahimi, Abolfazl Fateh, Seyed Davar Siada. Effects of active, inactive, and derivatives of Akkermansia muciniphila on the expression of the endocannabinoid system and PPARs genes. Scientific reports. vol 12. issue 1. 2022-06-15. PMID:35705595. this study aimed to investigate the effects of active and heat-inactivated forms of akkermansia muciniphila, bacterium-derived outer membrane vesicles (omvs), and cell-free supernatant on the transcription of endocannabinoid system (ecs) members, including cannabinoid receptors 1 and 2 (cb1 and cb2), fatty acid amide hydrolase (faah), and peroxisome proliferator-activated receptors (ppars) genes (i.e., α, β/δ, and δ) in caco-2 and hepg-2 cell lines. 2022-06-15 2023-08-14 Not clear
Veronica Lunerti, Hongwu Li, Federica Benvenuti, Qianwei Shen, Ana Domi, Laura Soverchia, Rita Maria Concetta Di Martino, Giovanni Bottegoni, Carolina L Haass-Koffler, Nazzareno Cannell. The multitarget FAAH inhibitor/D3 partial agonist ARN15381 decreases nicotine self-administration in male rats. European journal of pharmacology. 2022-06-11. PMID:35690082. inhibition of the fatty acid amide hydrolase (faah), the enzyme responsible for the degradation of the endocannabinoid anandamide (aea), palmitoylethanolamide (pea) and oleoylethanolamide (oea), reduces nicotine-enhanced dopamine transmission and acquisition of nicotine self-administration in rats. 2022-06-11 2023-08-14 rat
Marek Zubrzycki, Maria Zubrzycka, Grzegorz Wysiadecki, Janusz Szemraj, Hanna Jerczynska, Mariusz Stasiole. Release of Endocannabinoids into the Cerebrospinal Fluid during the Induction of the Trigemino-Hypoglossal Reflex in Rats. Current issues in molecular biology. vol 44. issue 5. 2022-06-09. PMID:35678693. since the specific effects of endocannabinoids within the orofacial area are largely unknown, we aimed to determine whether an increase in the endocannabinoid concentration in the cerebrospinal fluid (csf) caused by the peripheral administration of the faah inhibitor urb597 and tooth pulp stimulation would affect the transmission of impulses between the sensory and motor centers localized in the vicinity of the third and fourth cerebral ventricles. 2022-06-09 2023-08-14 rat
Marek Zubrzycki, Maria Zubrzycka, Grzegorz Wysiadecki, Janusz Szemraj, Hanna Jerczynska, Mariusz Stasiole. Effect of Fatty Acid Amide Hydrolase Inhibitor URB597 on Orofacial Pain Perception in Rats. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563056. the levels of the investigated mediators anandamide (aea), 2-arachidonyl glycerol (2-ag), substance p (sp), calcitonin-gene-related peptide (cgrp), endomorphin-2 (em-2) and fatty acid amide hydrolase (faah) inhibitor by urb597 and receptors cannabinoid type-1 receptors (cb1r), cannabinoid type-2 receptors (cb2r) and µ-opioid receptors (mor) were determined in the mesencephalon, thalamus and hypothalamus tissues. 2022-05-14 2023-08-13 rat
Marek Zubrzycki, Maria Zubrzycka, Grzegorz Wysiadecki, Janusz Szemraj, Hanna Jerczynska, Mariusz Stasiole. Effect of Fatty Acid Amide Hydrolase Inhibitor URB597 on Orofacial Pain Perception in Rats. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563056. we have shown that increasing endocannabinoid aea levels by both central and peripheral inhibition of faah inhibitor by urb597 has an antinociceptive effect on the trigemino-hypoglossal reflex mediated by cb1r and influences the activation of the brain areas studied. 2022-05-14 2023-08-13 rat
Pritha Shah, Aqsa Siddique, Ami Thakkar, Sankalp Gharat, Angel Godad, Pravin Kale, Gaurav Dosh. An update on novel therapeutic intervention in Rheumatoid arthritis. International immunopharmacology. vol 109. 2022-05-03. PMID:35504203. prostaglandins, leukotrienes, platelet-activating factor, cannabinoids, and specific fatty acid amide hydrolase are all examples of small molecular metabolites. 2022-05-03 2023-08-13 Not clear
Adriana Della Pietra, Juha Savinainen, Rashid Giniatulli. Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457225. we describe here: (i) migraine pain signaling pathways, which could serve as specific targets for antinociception; (ii) a divergent distribution of magl and faah activities in the key regions of the pns and cns implicated in migraine pain signaling; (iii) a complexity of anti-nociceptive effects of endocbs mediated by cannabinoid receptors and through a direct modulation of ion channels in nociceptive neurons; and (iv) the spectrum of emerging potent magl and faah inhibitors which efficiently increase endocbs levels. 2022-04-23 2023-08-13 Not clear
Lakhan S Khara, Md Ruhul Amin, Declan W Al. Inhibiting the endocannabinoid degrading enzymes FAAH and MAGL during zebrafish embryogenesis alters sensorimotor function. The Journal of experimental biology. 2022-04-19. PMID:35438163. inhibiting the endocannabinoid degrading enzymes faah and magl during zebrafish embryogenesis alters sensorimotor function. 2022-04-19 2023-08-13 zebrafish
Shivanshu Bajaj, Saima Zameer, Shreshta Jain, Vaishali Yadav, Divya Vohor. Effect of the MAGL/FAAH Dual Inhibitor JZL-195 on Streptozotocin-Induced Alzheimer's Disease-like Sporadic Dementia in Mice with an Emphasis on Aβ, HSP-70, Neuroinflammation, and Oxidative Stress. ACS chemical neuroscience. 2022-03-22. PMID:35316021. recently, pharmacological inhibition of endocannabinoid (ecb)-degrading enzymes, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), is being investigated to modulate the pathology of alzheimer's disease. 2022-03-22 2023-08-13 mouse
Erin Jordan, Gia-Nam Nguyen, Alexander Piechot, Oliver Kayse. Cannabinoids as New Drug Candidates for the Treatment of Glaucoma. Planta medica. 2022-03-17. PMID:35299275. especially the role of the endocannabinoid system (fatty acid amide hydrolase, monoacylglycerol lipase) impacting the prostaglandin network (cyclooxygenase, pge, pgf) and neuroprotection by inhibition of nitric oxide radical formation is in the focus of this review. 2022-03-17 2023-08-13 Not clear
Changqing Xu, Barkha J Yadav-Samudrala, Callie Xu, Bhupendra Nath, Twisha Mistry, Wei Jiang, Micah J Niphakis, Benjamin F Cravatt, Somnath Mukhopadhyay, Aron H Lichtman, Bogna M Ignatowska-Jankowska, Sylvia Fittin. Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms. Cells. vol 11. issue 5. 2022-03-10. PMID:35269478. inhibitory neurotransmission is sex-dependently affected by tat expression in transgenic mice and suppressed by the fatty acid amide hydrolase enzyme inhibitor pf3845 via cannabinoid type-1 receptor mechanisms. 2022-03-10 2023-08-13 mouse
Sarah E Melford, Anthony H Taylor, Justin C Konj. Nitric oxide positively affects endometrial receptivity via FAAH and NAPE-PLD Reproduction & fertility. vol 2. issue 2. 2022-02-07. PMID:35128447. nitric oxide positively affects endometrial receptivity via faah and nape-pld to determine if models of human 'receptive' and 'non-receptive endometrium' differ in their responses to nitric oxide (no) supplementation by measuring the levels of the enzymes of the endocannabinoid system (ecs) (fatty acid amide hydrolase (faah) and n-acylphosphatidylethanolamine-specific phospholipase d (nape-pld)), which control the 'anandamide tone' essential for successful pregnancy. 2022-02-07 2023-08-13 human
Terri A deRoon-Cassini, Carisa L Bergner, Samantha A Chesney, Nicholas R Schumann, Tara Sander Lee, Karen J Brasel, Cecilia J Hillar. Circulating endocannabinoids and genetic polymorphisms as predictors of posttraumatic stress disorder symptom severity: heterogeneity in a community-based cohort. Translational psychiatry. vol 12. issue 1. 2022-02-02. PMID:35105857. serum concentrations of the endocannabinoids n-arachidonoylethanolamine (aea) and 2-arachidonoylglycerol (2-ag) were determined at both time points and selected genetic polymorphisms in endocannabinoid genes, including rs324420 in fatty acid amide hydrolase, were assessed. 2022-02-02 2023-08-13 human
Maximilian Barth, Stefan Rudolph, Jan Kampschulze, Imke Meyer Zu Vilsendorf, Walburga Hanekamp, Dennis Mulac, Klaus Langer, Matthias Leh. Hexafluoroisopropyl carbamates as selective MAGL and dual MAGL/FAAH inhibitors: biochemical and physicochemical properties. ChemMedChem. 2022-01-24. PMID:35072346. a series of hexafluoroisopropyl carbamates with indolyl-alkyl- and azaindolylalkyl-substituents at the carbamate nitrogen was synthesized and evaluated for inhibition of the endocannabinoid degrading enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl). 2022-01-24 2023-08-13 Not clear
Nathan J Kolla, Isabelle Boileau, R Michael Bagb. Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders. Scientific reports. vol 12. issue 1. 2022-01-22. PMID:35064143. fatty acid amide hydrolase (faah), an enzyme of the endocannabinoid system (ecs), has been linked to regulation of mood through modulation of anandamide, an endocannabinoid. 2022-01-22 2023-08-13 human
Szymon Hryhorowicz, Marta Kaczmarek-Ryś, Aleksandra Zielińska, Rodney J Scott, Ryszard Słomski, Andrzej Pławsk. Endocannabinoid System as a Promising Therapeutic Target in Inflammatory Bowel Disease - A Systematic Review. Frontiers in immunology. vol 12. 2022-01-10. PMID:35003109. it consists of cannabinoid receptors (cb1 and cb2), transporters for cellular uptake of endocannabinoid ligands, endogenous bioactive lipids (anandamide and 2-arachidonoylglycerol), and the enzymes responsible for their synthesis and degradation (fatty acid amide hydrolase and monoacylglycerol lipase), the manipulation of which through agonists and antagonists of the system, shows a potential therapeutic role for ecs in inflammatory bowel disease. 2022-01-10 2023-08-13 Not clear
Shrouq I Farah, Samantha Hilston, Ngan Tran, Nikolai Zvonok, Alexandros Makriyanni. 1-, 2- and 3-AG as substrates of the endocannabinoid enzymes and endogenous ligands of the cannabinoid receptor 1. Biochemical and biophysical research communications. vol 591. 2022-01-07. PMID:34995983. here, we present the interaction profiles of 2-ag and its isomerization products, 1- and 3-ag, with the endocannabinoid mgl, abhd6 and faah enzymes as well as the cb1 receptor. 2022-01-07 2023-08-13 Not clear
Subramaniam Jayanthi, Ritvik Peesapati, Michael T McCoy, Bruce Ladenheim, Jean Lud Cade. Footshock-Induced Abstinence from Compulsive Methamphetamine Self-administration in Rat Model Is Accompanied by Increased Hippocampal Expression of Cannabinoid Receptors (CB1 and CB2). Molecular neurobiology. 2022-01-03. PMID:34978045. animals were euthanized 2 h after the last meth sa session and their hippocampi were used to measure mrna levels of cannabinoid receptors (cb/cnr), as well as those of synthesizing (dagl-a, dagl-b, napepld) and metabolizing (mgll, faah, ptgs2) enzymes of the endocannabinoid cascade. 2022-01-03 2023-08-13 rat