| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stefan Zahov, David Garzinsky, Walburga Hanekamp, Matthias Leh. 1-Heteroarylpropan-2-ones as inhibitors of fatty acid amide hydrolase: Studies on structure-activity relationships and metabolic stability. Bioorganic & medicinal chemistry. vol 25. issue 3. 2017-08-03. PMID:27989417. |
the serine hydrolase fatty acid amide hydrolase (faah) catalyzes the degradation of the endocannabinoid anandamide, which possesses analgesic and anti-inflammatory effects. |
2017-08-03 |
2023-08-13 |
Not clear |
| Stephen O Pember, Galo L Mejia, Theodore J Price, Robert J Pasteri. Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties. Bioorganic & medicinal chemistry letters. vol 26. issue 12. 2017-07-20. PMID:27130358. |
fatty acid amide hydrolase (faah) is a membrane anchored serine hydrolase that has a principle role in the metabolism of the endogenous cannabinoid anandamide. |
2017-07-20 |
2023-08-13 |
human |
| Jenny L Wilkerson, Sudeshna Ghosh, Mohammed Mustafa, Rehab A Abdullah, Micah J Niphakis, Roberto Cabrera, Rafael L Maldonado, Benjamin F Cravatt, Aron H Lichtma. The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice. Neuropharmacology. vol 114. 2017-07-11. PMID:27890602. |
inhibitors of the primary endocannabinoid catabolic enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) show opioid-sparing effects in preclinical models of pain. |
2017-07-11 |
2023-08-13 |
mouse |
| Agnieszka Zakrzeska, Tomasz Grędziński, Wioleta Kisiel, Ewa Chabielsk. Cannabinoids and haemostasis. Postepy higieny i medycyny doswiadczalnej (Online). vol 70. issue 0. 2017-07-10. PMID:27383573. |
the range of biological functions of endo- and plant cannabinoids, expanded to include the process of hemostasis, may constitute a condition for their recognition as a new factor responsible for thromboembolism in smokers of marijuana, in pathological disorders with increased levels of endocannabinoids and in individuals with polymorphisms of faah c385a and a385a. |
2017-07-10 |
2023-08-13 |
Not clear |
| Serena Montanari, Laura Scalvini, Manuela Bartolini, Federica Belluti, Silvia Gobbi, Vincenza Andrisano, Alessia Ligresti, Vincenzo Di Marzo, Silvia Rivara, Marco Mor, Alessandra Bisi, Angela Ramp. Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents. Journal of medicinal chemistry. vol 59. issue 13. 2017-05-29. PMID:27309570. |
in particular, indirectly enhancing endocannabinoid signaling to therapeutic levels through faah inhibition might be beneficial for neurodegenerative disorders such as alzheimer's disease, effectively preventing or slowing the progression of the disease. |
2017-05-29 |
2023-08-13 |
Not clear |
| Michał Biernacki, Wojciech Łuczaj, Agnieszka Gęgotek, Marek Toczek, Katarzyna Bielawska, Elżbieta Skrzydlewsk. Crosstalk between liver antioxidant and the endocannabinoid systems after chronic administration of the FAAH inhibitor, URB597, to hypertensive rats. Toxicology and applied pharmacology. vol 301. 2017-05-26. PMID:27086176. |
crosstalk between liver antioxidant and the endocannabinoid systems after chronic administration of the faah inhibitor, urb597, to hypertensive rats. |
2017-05-26 |
2023-08-13 |
rat |
| Michał Biernacki, Wojciech Łuczaj, Agnieszka Gęgotek, Marek Toczek, Katarzyna Bielawska, Elżbieta Skrzydlewsk. Crosstalk between liver antioxidant and the endocannabinoid systems after chronic administration of the FAAH inhibitor, URB597, to hypertensive rats. Toxicology and applied pharmacology. vol 301. 2017-05-26. PMID:27086176. |
the aim of this study was to evaluate the effects of chronic administration of the fatty acid amide hydrolase (faah) inhibitor [3-(3-carbamoylphenyl)phenyl]n-cyclohexylcarbamate (urb597) on the endocannabinoid system and on the redox balance in the livers of doca-salt hypertensive rats. |
2017-05-26 |
2023-08-13 |
rat |
| Vyvyca J Walker, Alisha P Griffin, Dagan K Hammar, Paul F Hollenber. Metabolism of Anandamide by Human Cytochrome P450 2J2 in the Reconstituted System and Human Intestinal Microsomes. The Journal of pharmacology and experimental therapeutics. vol 357. issue 3. 2017-05-23. PMID:27000802. |
faah hydrolyzes and, as a consequence, inactivates anandamide (aea), a prominent endocannabinoid. |
2017-05-23 |
2023-08-13 |
human |
| Irene M Wohlman, Gabriella M Composto, Diane E Heck, Ned D Heindel, C Jeffrey Lacey, Christophe D Guillon, Robert P Casillas, Claire R Croutch, Donald R Gerecke, Debra L Laskin, Laurie B Joseph, Jeffrey D Laski. Mustard vesicants alter expression of the endocannabinoid system in mouse skin. Toxicology and applied pharmacology. vol 303. 2017-05-23. PMID:27125198. |
taken together, these data indicate that the endocannabinoid system is important in regulating skin homeostasis and that inhibitors of faah may be useful as medical countermeasures against vesicants. |
2017-05-23 |
2023-08-13 |
mouse |
| Manuel Luis Wolfson, Julieta Aisemberg, Fernando Correa, Ana María Franch. Peripheral Blood Mononuclear Cells Infiltration Downregulates Decidual FAAH Activity in an LPS-Induced Embryo Resorption Model. Journal of cellular physiology. vol 232. issue 6. 2017-05-15. PMID:27731508. |
inactivation of faah, the main degrading enzyme of anandamide and similar endocannabinoids, could lead to an increased decidual endocannabinoid tone with embryotoxic effects. |
2017-05-15 |
2023-08-13 |
mouse |
| Stephen Pawsey, Mike Wood, Helen Browne, Kirsteen Donaldson, Mark Christie, Steven Warringto. Safety, Tolerability and Pharmacokinetics of FAAH Inhibitor V158866: A Double-Blind, Randomised, Placebo-Controlled Phase I Study in Healthy Volunteers. Drugs in R&D. vol 16. issue 2. 2017-05-01. PMID:26987975. |
the inhibition of fatty acid amide hydrolase 1 (faah) has been proposed as a novel mechanism for treating pain syndromes by increasing the levels of endogenous cannabinoids (ecs). |
2017-05-01 |
2023-08-13 |
human |
| A Abolghasemi, E Dirandeh, Z Ansari Pirsaraei, B Shohre. Dietary conjugated linoleic acid supplementation alters the expression of genes involved in the endocannabinoid system in the bovine endometrium and increases plasma progesterone concentrations. Theriogenology. vol 86. issue 6. 2017-04-17. PMID:27262886. |
the abundance of mrna encoding endocannabinoid receptor (cnr2), n-acyl phosphatidylethanolamine phospholipase d (napepld), fatty acid amide hydrolase (faah), n-acylethanolamine acid amidase (naaa), and monoglyceride lipase (mgll) was measured by real-time pcr. |
2017-04-17 |
2023-08-13 |
cattle |
| Rita Scarpelli, Oscar Sasso, Daniele Piomell. A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation. ChemMedChem. vol 11. issue 12. 2017-03-27. PMID:26486424. |
the endogenous levels of anandamide, an endocannabinoid mediator with analgesic and tissue-protective functions, are regulated by fatty acid amide hydrolase (faah). |
2017-03-27 |
2023-08-13 |
Not clear |
| Giorgia Macedonio, Azzurra Stefanucci, Cristina Maccallini, Sako Mirzaie, Ettore Novellino, Adriano Mollic. Hemopressin Peptides as Modulators of the Endocannabinoid System and their Potential Applications as Therapeutic Tools. Protein and peptide letters. vol 23. issue 12. 2017-03-27. PMID:27748182. |
these hydrolases, such as fatty acid amide hydrolase (faah) and monoacylglyceride lipase (magl), are possible therapeutic targets for the development of new drugs as indirect cannabinoid agonists. |
2017-03-27 |
2023-08-13 |
rat |
| Marisol Maya-López, Hipolito A Ruiz-Contreras, María de Jesús Negrete-Ruíz, Julián Elías Martínez-Sánchez, Juan Benítez-Valenzuela, Ana Laura Colín-González, Juana Villeda-Hernández, Laura Sánchez-Chapul, Carmen Parra-Cid, Edgar Rangel-López, Abel Santamarí. URB597 reduces biochemical, behavioral and morphological alterations in two neurotoxic models in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 88. 2017-03-13. PMID:28157650. |
urb597 is a compound largely linked to the inhibition of fatty acid amide hydrolase (faah), an enzyme responsible for the metabolic degradation of the endocannabinoid anandamide (aea). |
2017-03-13 |
2023-08-13 |
rat |
| Ludovica Monti, Azzurra Stefanucci, Stefano Pieretti, Francesca Marzoli, Lorenzo Fidanza, Adriano Mollica, Sako Mirzaie, Simone Carradori, Luciano De Petrocellis, Aniello Schiano Moriello, Sándor Benyhe, Ferenc Zádor, Edina Szűcs, Ferenc Ötvös, Anna I Erdei, Reza Samavati, Szabolcs Dvorácskó, Csaba Tömböly, Ettore Novellin. Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates. Journal of enzyme inhibition and medicinal chemistry. vol 31. issue 6. 2017-03-06. PMID:27063555. |
fatty acid amide hydrolase inhibition was evaluated, together with binding assays of cannabinoid receptors. |
2017-03-06 |
2023-08-13 |
Not clear |
| Benoit Forget, Mihail Guranda, Islam Gamaleddin, Steven R Goldberg, Bernard Le Fol. Attenuation of cue-induced reinstatement of nicotine seeking by URB597 through cannabinoid CB1 receptor in rats. Psychopharmacology. vol 233. issue 10. 2017-02-22. PMID:26864774. |
the endocannabinoid system is composed of endocannabinoids (such as anandamide), their target receptors (cb1 and cb2 receptors, cb1rs and cb2rs), the enzymes that degrade them (fatty-acid-amide-hydrolase (faah) for anandamide), and an endocannabinoid transporter. |
2017-02-22 |
2023-08-13 |
rat |
| Ozgur Yesilyurt, Mutlu Cayirli, Yusuf Serdar Sakin, Melik Seyrek, Ahmet Akar, Ahmet Dogru. Systemic and spinal administration of FAAH, MAGL inhibitors and dual FAAH/MAGL inhibitors produce antipruritic effect in mice. Archives of dermatological research. vol 308. issue 5. 2017-02-17. PMID:27126057. |
the increase of endocannabinoid tonus by inhibiting fatty acid amide hydrolase (faah) or monoacylglycerol lipase (magl) represents a promising therapeutic approach in a variety of disease to overcome serious central side effects of exocannabinoids. |
2017-02-17 |
2023-08-13 |
mouse |
| Sean D Kodani, Haley B Overby, Christophe Morisseau, Jiangang Chen, Ling Zhao, Bruce D Hammoc. Parabens inhibit fatty acid amide hydrolase: A potential role in paraben-enhanced 3T3-L1 adipocyte differentiation. Toxicology letters. vol 262. 2017-02-06. PMID:27659731. |
we hypothesized these biological effects could be due to interference with the endocannabinoid system and identified fatty acid amide hydrolase (faah) as the direct molecular target of parabens. |
2017-02-06 |
2023-08-13 |
Not clear |
| Marta Baranowska-Kuczko, Hanna Kozłowska, Monika Kloza, Olga Karpińska, Marek Toczek, Ewa Harasim, Irena Kasacka, Barbara Malinowsk. Protective role of cannabinoid CB1 receptors and vascular effects of chronic administration of FAAH inhibitor URB597 in DOCA-salt hypertensive rats. Life sciences. vol 151. 2017-02-02. PMID:26969765. |
protective role of cannabinoid cb1 receptors and vascular effects of chronic administration of faah inhibitor urb597 in doca-salt hypertensive rats. |
2017-02-02 |
2023-08-13 |
rat |