| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Klára Gyires, Zoltán S Zádor. Role of Cannabinoids in Gastrointestinal Mucosal Defense and Inflammation. Current neuropharmacology. vol 14. issue 8. 2017-01-17. PMID:26935536. |
similarly, indirect activation of cannabinoid receptors through elevation of endocannabinoid levels by globally acting or peripherally restricted inhibitors of their metabolizing enzymes (faah, magl) or by inhibitors of their cellular uptake reduces the gastric mucosal lesions induced by nsaids in a cb1 receptor-dependent fashion. |
2017-01-17 |
2023-08-13 |
Not clear |
| Claudius Füllhase, Andrea Schreiber, Armin Giese, Michael Schmidt, Francesco Montorsi, Christian Gratzke, Giovanni La Croce, Fabio Castiglione, Christian Stief, Petter Hedlun. Spinal neuronal cannabinoid receptors mediate urodynamic effects of systemic fatty acid amide hydrolase (FAAH) inhibition in rats. Neurourology and urodynamics. vol 35. issue 4. 2017-01-09. PMID:25788026. |
spinal neuronal cannabinoid receptors mediate urodynamic effects of systemic fatty acid amide hydrolase (faah) inhibition in rats. |
2017-01-09 |
2023-08-13 |
rat |
| Claudius Füllhase, Andrea Schreiber, Armin Giese, Michael Schmidt, Francesco Montorsi, Christian Gratzke, Giovanni La Croce, Fabio Castiglione, Christian Stief, Petter Hedlun. Spinal neuronal cannabinoid receptors mediate urodynamic effects of systemic fatty acid amide hydrolase (FAAH) inhibition in rats. Neurourology and urodynamics. vol 35. issue 4. 2017-01-09. PMID:25788026. |
to test if urodynamic effects from systemic fatty acid amide hydrolase (faah) inhibition involve sacral spinal cannabinoid type 1 (cb1) or type 2 (cb2) receptors. |
2017-01-09 |
2023-08-13 |
rat |
| Julien Matricon, Alexandre Seillier, Andrea Giuffrid. Distinct neuronal activation patterns are associated with PCP-induced social withdrawal and its reversal by the endocannabinoid-enhancing drug URB597. Neuroscience research. vol 110. 2017-01-03. PMID:27091613. |
the fatty acid amide hydrolase inhibitor, urb597, an endocannabinoid enhancing drug, reverses social withdrawal in the sub-chronic pcp rat model of schizophrenia, but reduces social interaction (si) in controls. |
2017-01-03 |
2023-08-13 |
rat |
| Lawrence M Carey, Richard A Slivicki, Emma Leishman, Ben Cornett, Ken Mackie, Heather Bradshaw, Andrea G Hohman. A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase. Molecular pain. vol 12. 2016-12-26. PMID:27178246. |
fatty-acid amide hydrolase (faah) is the major enzyme responsible for degradation of anandamide, an endocannabinoid. |
2016-12-26 |
2023-08-13 |
mouse |
| Lawrence M Carey, Richard A Slivicki, Emma Leishman, Ben Cornett, Ken Mackie, Heather Bradshaw, Andrea G Hohman. A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase. Molecular pain. vol 12. 2016-12-26. PMID:27178246. |
pharmacological inhibition or genetic deletion of faah (faah ko) produces antinociception in preclinical pain models that is largely attributed to anandamide-induced activation of cannabinoid receptors. |
2016-12-26 |
2023-08-13 |
mouse |
| Anne Kerbrat, Jean-Christophe Ferré, Pierre Fillatre, Thomas Ronzière, Stéphane Vannier, Béatrice Carsin-Nicol, Sylvain Lavoué, Marc Vérin, Jean-Yves Gauvrit, Yves Le Tulzo, Gilles Eda. Acute Neurologic Disorder from an Inhibitor of Fatty Acid Amide Hydrolase. The New England journal of medicine. vol 375. issue 18. 2016-12-13. PMID:27806235. |
a decrease in fatty acid amide hydrolase (faah) activity increases the levels of endogenous analogues of cannabinoids, or endocannabinoids. |
2016-12-13 |
2023-08-13 |
human |
| F Markus Leweke, Juliane K Mueller, Bettina Lange, Cathrin Rohlede. Therapeutic Potential of Cannabinoids in Psychosis. Biological psychiatry. vol 79. issue 7. 2016-10-28. PMID:26852073. |
second, the modulation of endocannabinoid levels by use of the phytocannabinoid cannabidiol and selective fatty acid amide hydrolase inhibitors has been proposed, and the antipsychotic properties of cannabidiol are currently being investigated in humans. |
2016-10-28 |
2023-08-13 |
Not clear |
| Marco Migliore, Damien Habrant, Oscar Sasso, Clara Albani, Sine Mandrup Bertozzi, Andrea Armirotti, Daniele Piomelli, Rita Scarpell. Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies. European journal of medicinal chemistry. vol 109. 2016-10-21. PMID:26774927. |
this favorable interaction is attributed to the accumulation of protective faah substrates, such as the endocannabinoid anandamide, and suggests that agents simultaneously targeting cox and faah might provide an innovative strategy to combat pain and inflammation with reduced side effects. |
2016-10-21 |
2023-08-13 |
Not clear |
| Nicholas S Adamson Barnes, Vanessa A Mitchell, Nicholas P Kazantzis, Christopher W Vaugha. Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model. British journal of pharmacology. vol 173. issue 1. 2016-10-13. PMID:26398331. |
conversely, selective fatty acid amide hydrolase (faah) inhibitors that enhance the endocannabinoid system have a better therapeutic window, but lesser efficacy. |
2016-10-13 |
2023-08-13 |
Not clear |
| Lu Wang, Joji Yui, Qifan Wang, Yiding Zhang, Wakana Mori, Yoko Shimoda, Masayuki Fujinaga, Katsushi Kumata, Tomoteru Yamasaki, Akiko Hatori, Benjamin H Rotstein, Thomas Lee Collier, Chongzhao Ran, Neil Vasdev, Ming-Rong Zhang, Steven H Lian. Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([¹¹C]MPPO) Based on α-Ketoheterocyclic Scaffold. ACS chemical neuroscience. vol 7. issue 1. 2016-10-13. PMID:26505525. |
fatty acid amide hydrolase (faah) is one of the principle enzymes for metabolizing endogenous cannabinoid neurotransmitters such as anandamide, and thus regulates endocannabinoid (ecb) signaling. |
2016-10-13 |
2023-08-13 |
Not clear |
| Lu Wang, Joji Yui, Qifan Wang, Yiding Zhang, Wakana Mori, Yoko Shimoda, Masayuki Fujinaga, Katsushi Kumata, Tomoteru Yamasaki, Akiko Hatori, Benjamin H Rotstein, Thomas Lee Collier, Chongzhao Ran, Neil Vasdev, Ming-Rong Zhang, Steven H Lian. Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([¹¹C]MPPO) Based on α-Ketoheterocyclic Scaffold. ACS chemical neuroscience. vol 7. issue 1. 2016-10-13. PMID:26505525. |
quantification of faah in the living brain by positron emission tomography (pet) would help our understanding of the endocannabinoid system in these conditions. |
2016-10-13 |
2023-08-13 |
Not clear |
| Kristiina Cajanus, Emil J Holmström, Maija Wessman, Verneri Anttila, Mari A Kaunisto, Eija Kals. Effect of endocannabinoid degradation on pain: role of FAAH polymorphisms in experimental and postoperative pain in women treated for breast cancer. Pain. vol 157. issue 2. 2016-10-13. PMID:26808012. |
effect of endocannabinoid degradation on pain: role of faah polymorphisms in experimental and postoperative pain in women treated for breast cancer. |
2016-10-13 |
2023-08-13 |
Not clear |
| Kristiina Cajanus, Emil J Holmström, Maija Wessman, Verneri Anttila, Mari A Kaunisto, Eija Kals. Effect of endocannabinoid degradation on pain: role of FAAH polymorphisms in experimental and postoperative pain in women treated for breast cancer. Pain. vol 157. issue 2. 2016-10-13. PMID:26808012. |
fatty acid amide hydrolase (faah) metabolizes the endocannabinoid anandamide, which has an important role in nociception. |
2016-10-13 |
2023-08-13 |
Not clear |
| Imre Farkas, Csaba Vastagh, Erzsébet Farkas, Flóra Bálint, Katalin Skrapits, Erik Hrabovszky, Csaba Fekete, Zsolt Liposit. Glucagon-Like Peptide-1 Excites Firing and Increases GABAergic Miniature Postsynaptic Currents (mPSCs) in Gonadotropin-Releasing Hormone (GnRH) Neurons of the Male Mice via Activation of Nitric Oxide (NO) and Suppression of Endocannabinoid Signaling Pathways. Frontiers in cellular neuroscience. vol 10. 2016-09-27. PMID:27672360. |
intracellular application of the transient receptor potential vanilloid 1 (trpv1)-antagonist 2e-n-(2, 3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1, 1-dimethylethyl)phenyl]-2-propenamide (amg9810; 10 μm) or the fatty acid amide hydrolase (faah)-inhibitor pf3845 (5 μm) impeded the glp-1-triggered endocannabinoid pathway indicating an anandamide-trpv1-sensitive control of 2-arachidonoylglycerol (2-ag) production. |
2016-09-27 |
2023-08-13 |
mouse |
| Sari Yrjölä, Teija Parkkari, Dina Navia-Paldanius, Tuomo Laitinen, Agnieszka A Kaczor, Tarja Kokkola, Frank Adusei-Mensah, Juha R Savinainen, Jarmo T Laitinen, Antti Poso, Amy Alexander, June Penman, Lisa Stott, Marie Anskat, Andrew J Irving, Tapio J Nevalaine. Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists. European journal of medicinal chemistry. vol 107. 2016-09-20. PMID:26575458. |
the designed compounds were not active when tested against various endocannabinoid targets (cb1r, cb2r, faah, mgl, abhd6 and abhd12), indicating compounds' selectivity for the gpr55. |
2016-09-20 |
2023-08-13 |
Not clear |
| Parisa Hasanein, Masumeh Ghafari-Vahe. Fatty acid amide hydrolase inhibitor URB597 prevented tolerance and cognitive deficits induced by chronic morphine administration in rats. Behavioural pharmacology. vol 27. issue 1. 2016-09-19. PMID:26274041. |
inhibitors of the endocannabinoid metabolic enzyme fatty acid amide hydrolase exert therapeutic effects, but might also be associated with some of the adverse effects of cannabis. |
2016-09-19 |
2023-08-13 |
rat |
| Shintaro Ogawa, Hiroshi Kunug. Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future Antidepressants. Current neuropharmacology. vol 13. issue 6. 2016-09-09. PMID:26630956. |
recently, endocannabinoid hydrolytic enzymes such as fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) have become new therapeutic targets in the treatment of mdd. |
2016-09-09 |
2023-08-13 |
Not clear |
| Dylan G Gee, Robert N Fetcho, Deqiang Jing, Anfei Li, Charles E Glatt, Andrew T Drysdale, Alexandra O Cohen, Danielle V Dellarco, Rui R Yang, Anders M Dale, Terry L Jernigan, Francis S Lee, B J Case. Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 16. 2016-09-02. PMID:27001846. |
we tested whether genetic alterations in endocannabinoid signaling related to a common polymorphism in fatty acid amide hydrolase (faah), which alters endocannabinoid anandamide (aea) levels, would impact the development of frontolimbic circuitry implicated in anxiety disorders. |
2016-09-02 |
2023-08-13 |
mouse |
| Xiaofei Sun, Wenbo Deng, Yingju Li, Shuang Tang, Emma Leishman, Heather B Bradshaw, Sudhansu K De. Sustained Endocannabinoid Signaling Compromises Decidual Function and Promotes Inflammation-induced Preterm Birth. The Journal of biological chemistry. vol 291. issue 15. 2016-08-29. PMID:26900150. |
we show here that mice devoid of fatty acid amide hydrolase (faah) with elevated levels ofn-arachidonyl ethanolamide (anandamide), a major endocannabinoid lipid mediator, were more susceptible to ptb upon lipopolysaccharide (lps) challenge. |
2016-08-29 |
2023-08-13 |
mouse |