| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrea Pirone, Carlo Cantile, Vincenzo Miragliotta, Carla Lenzi, Elisabetta Giannessi, Bruno Cozz. Immunohistochemical distribution of the cannabinoid receptor 1 and fatty acid amide hydrolase in the dog claustrum. Journal of chemical neuroanatomy. vol 74. 2018-01-10. PMID:26907575. |
cannabinoid receptor 1 (cb1r) and fatty acid amide hydrolase (faah) are part of the endocannabinoid system (ecb) which exerts a neuromodulatory activity on different brain functions and plays a key role in neurogenesis. |
2018-01-10 |
2023-08-13 |
dog |
| Na Cui, Yang Yang, Yueming Xu, Jie Zhang, Lei Jiang, Guimin Ha. Decreased expression of fatty acid amide hydrolase in women with polycystic ovary syndrome. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 33. issue 5. 2018-01-04. PMID:28132572. |
the expression of cannabinoid receptors (cb1) and fatty acid amide hydrolase (faah) in the endometrium were immunohistochemically stained and compared between women with pcos and the control group. |
2018-01-04 |
2023-08-13 |
Not clear |
| Douglas R Smith, Christine M Stanley, Theodore Foss, Richard G Boles, Kevin McKerna. Rare genetic variants in the endocannabinoid system genes CNR1 and DAGLA are associated with neurological phenotypes in humans. PloS one. vol 12. issue 11. 2017-12-26. PMID:29145497. |
rare genetic variants in the core endocannabinoid system genes cnr1, cnr2, dagla, mgll and faah were identified in molecular testing data from 6,032 patients with a broad spectrum of neurological disorders. |
2017-12-26 |
2023-08-13 |
mouse |
| Iram P Rodriguez-Sanchez, Josee Guindon, Marco Ruiz, M Elizabeth Tejero, Gene Hubbard, Laura E Martinez-de-Villarreal, Hugo A Barrera-Saldaña, Edward J Dick, Anthony G Comuzzie, Natalia E Schlabritz-Loutsevitc. The endocannabinoid system in the baboon (Papio spp.) as a complex framework for developmental pharmacology. Neurotoxicology and teratology. vol 58. 2017-12-22. PMID:27327781. |
consumption of exogenous cannabinoids interferes with the endogenous cannabinoid (or "endocannabinoid" (ecb)) system (ecs), which comprises n-arachidonylethanolamide (anandamide, aea), 2-arachidonoyl glycerol (2-ag), endocannabinoid receptors (cannabinoid receptors 1 and 2 (cb1r and cb2r), encoded by cnr1 and cnr2, respectively), and synthesizing/degrading enzymes (faah, fatty-acid amide hydrolase; magl, monoacylglycerol lipase; dagl-α, diacylglycerol lipase-alpha). |
2017-12-22 |
2023-08-13 |
Not clear |
| Emma Leishman, Ben Cornett, Karl Spork, Alex Straiker, Ken Mackie, Heather B Bradsha. Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain. Pharmacological research. vol 110. 2017-12-21. PMID:27109320. |
the enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) hydrolyze endogenous cannabinoids (ecbs), n-arachidonoyl ethanolamine (aea) and 2-arachidonoyl glycerol (2-ag), respectively. |
2017-12-21 |
2023-08-13 |
mouse |
| Wei Li, Cong-Li Zhang, Zheng-Guo Qi. Differential expression of endocannabinoid system-related genes in the dorsal hippocampus following expression and reinstatement of morphine conditioned place preference in mice. Neuroscience letters. vol 643. 2017-12-19. PMID:28192193. |
we found that expression of morphine cpp was associated with significant increases in mrna expression for the primary clearance routes for anandamide (aea) and 2-ag (fatty acid amide hydrolase [faah] and monoacylglycerol lipase [magl], respectively), but with reductions in cannabinoid 1 receptors (cb1r) and cb2r in dorsal hippocampus following the expression of cpp. |
2017-12-19 |
2023-08-13 |
mouse |
| Ying Wang, Xia Zhan. FAAH inhibition produces antidepressant-like efforts of mice to acute stress via synaptic long-term depression. Behavioural brain research. vol 324. 2017-12-13. PMID:28193523. |
recent studies have shown that inhibition of fatty acid amide hydrolase (faah), the major degradative enzyme of the endocannabinoid n-arachidonoylethanolamine (aea), produced antidepressant behavioral responses, but its underlying mechanism is not clear. |
2017-12-13 |
2023-08-13 |
mouse |
| Russell L Carr, Nathan H Armstrong, Alenda T Buchanan, Jeffrey B Eells, Afzaal N Mohammed, Matthew K Ross, Carole A Nai. Decreased anxiety in juvenile rats following exposure to low levels of chlorpyrifos during development. Neurotoxicology. vol 59. 2017-11-22. PMID:26642910. |
exposure to chlorpyrifos (cpf) during the late preweanling period in rats inhibits the endocannabinoid metabolizing enzymes fatty acid hydrolase (faah) and monoacylglycerol lipase (magl), resulting in accumulation of their respective substrates anandamide (aea) and 2-arachidonylglycerol (2-ag). |
2017-11-22 |
2023-08-13 |
rat |
| Elif Bilgic, Elif Guzel, Sevil Kose, Makbule Cisel Aydin, Eda Karaismailoglu, Irem Akar, Alp Usubutun, Petek Korkusu. Endocannabinoids modulate apoptosis in endometriosis and adenomyosis. Acta histochemica. vol 119. issue 5. 2017-11-16. PMID:28549792. |
endocannabinoid receptors cb1 and cb2, their synthesizing and catabolizing enzymes (faah, nape-pld, dagl, magl) and the apoptotic indexes were immunohistochemically assessed in endometriotic and adenomyotic tissues. |
2017-11-16 |
2023-08-13 |
Not clear |
| Jenny L Wiley, Timothy W Lefever, Nikita S Pulley, Julie A Marusich, Benjamin F Cravatt, Aron H Lichtma. Just add water: cannabinoid discrimination in a water T-maze with FAAH(-/-) and FAAH(+/+) mice. Behavioural pharmacology. vol 27. issue 5. 2017-11-08. PMID:27385208. |
just add water: cannabinoid discrimination in a water t-maze with faah(-/-) and faah(+/+) mice. |
2017-11-08 |
2023-08-13 |
mouse |
| Josée Guindo. A novel inhibitor of endocannabinoid catabolic enzymes sheds light on behind the scene interplay between chronic pain, analgesic tolerance, and heroin dependence. Neuropharmacology. vol 114. 2017-10-26. PMID:27890603. |
wilkerson and colleagues, in this issue, examine sa-57, an inhibitor of two different endocannabinoid catabolic enzymes faah and magl, demonstrating its analgesic effectiveness and morphine-sparing properties in a chronic pain model, as well as its ability to reduce heroin seeking behavior in a self-administration paradigm in mice. |
2017-10-26 |
2023-08-13 |
mouse |
| Whitney E Melroy-Greif, Kirk C Wilhelmsen, Cindy L Ehler. Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans. Drug and alcohol dependence. vol 166. 2017-10-23. PMID:27394933. |
five genes known to play a role in the endocannabinoid system and cuds were examined in a community sample of young adult mexican americans (mas): cnr1, mgll, faah, dagla, and daglb. |
2017-10-23 |
2023-08-13 |
Not clear |
| Lu Wang, Wakana Mori, Ran Cheng, Joji Yui, Akiko Hatori, Longle Ma, Yiding Zhang, Benjamin H Rotstein, Masayuki Fujinaga, Yoko Shimoda, Tomoteru Yamasaki, Lin Xie, Yuji Nagai, Takafumi Minamimoto, Makoto Higuchi, Neil Vasdev, Ming-Rong Zhang, Steven H Lian. Synthesis and Preclinical Evaluation of Sulfonamido-based [(11)C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase. Theranostics. vol 6. issue 8. 2017-10-16. PMID:27279908. |
the most potent compounds were a novel magl inhibitor, n-((1-(1h-1,2,4-triazole-1-carbonyl)piperidin-4-yl) methyl)-4-chlorobenzenesulfonamide (tzpu; ic50 = 35.9 nm), and the known inhibitor 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(((4-chlorophenyl)sulfonamido) methyl)piperidine-1-carboxylate (sar127303; ic50 = 39.3 nm), which were also shown to be selective for magl over fatty acid amide hydrolase (faah), and cannabinoid receptors (cb1 & cb2). |
2017-10-16 |
2023-08-13 |
rat |
| Angel Escamilla-Ramírez, Esperanza García, Guadalupe Palencia-Hernández, Ana Laura Colín-González, Sonia Galván-Arzate, Isaac Túnez, Julio Sotelo, Abel Santamarí. URB597 and the Cannabinoid WIN55,212-2 Reduce Behavioral and Neurochemical Deficits Induced by MPTP in Mice: Possible Role of Redox Modulation and NMDA Receptors. Neurotoxicity research. vol 31. issue 4. 2017-10-02. PMID:28092019. |
while synthetic cannabinoid receptor (cbr) agonists such as win55,212-2 act directly on cbr, agents like urb597, a fatty acid amide hydrolase (faah) inhibitor, induce a more "physiological" activation of cbr by increasing the endogenous levels of the endocannabinoid anandamide (aea). |
2017-10-02 |
2023-08-13 |
mouse |
| Alessandro Deplano, Carmine Marco Morgillo, Monica Demurtas, Emmelie Björklund, Mariateresa Cipriano, Mona Svensson, Sanaz Hashemian, Giovanni Smaldone, Emilia Pedone, F Javier Luque, Maria G Cabiddu, Ettore Novellino, Christopher J Fowler, Bruno Catalanotti, Valentina Onni. Novel propanamides as fatty acid amide hydrolase inhibitors. European journal of medicinal chemistry. vol 136. 2017-09-26. PMID:28535469. |
fatty acid amide hydrolase (faah) has a key role in the control of the cannabinoid signaling, through the hydrolysis of the endocannabinoids anandamide and in some tissues 2-arachidonoylglycerol. |
2017-09-26 |
2023-08-13 |
mouse |
| Alessandro Deplano, Carmine Marco Morgillo, Monica Demurtas, Emmelie Björklund, Mariateresa Cipriano, Mona Svensson, Sanaz Hashemian, Giovanni Smaldone, Emilia Pedone, F Javier Luque, Maria G Cabiddu, Ettore Novellino, Christopher J Fowler, Bruno Catalanotti, Valentina Onni. Novel propanamides as fatty acid amide hydrolase inhibitors. European journal of medicinal chemistry. vol 136. 2017-09-26. PMID:28535469. |
faah inhibition represents a promising strategy to activate the cannabinoid system, since it does not result in the psychotropic and peripheral side effects characterizing the agonists of the cannabinoid receptors. |
2017-09-26 |
2023-08-13 |
mouse |
| Carmen Rodríguez-Cueto, Mariluz Hernández-Gálvez, Cecilia J Hillard, Patricia Maciel, Sara Valdeolivas, José A Ramos, María Gómez-Ruiz, Javier Fernández-Rui. Altered striatal endocannabinoid signaling in a transgenic mouse model of spinocerebellar ataxia type-3. PloS one. vol 12. issue 4. 2017-09-07. PMID:28448548. |
we also measured the endocannabinoid lipids in the striatum and despite a marked increase in the faah enzyme in this area, no overall changes in these lipids were found. |
2017-09-07 |
2023-08-13 |
mouse |
| Liubov Shubina, Rubin Aliev, Valentina Kitchigin. Endocannabinoid-dependent protection against kainic acid-induced long-term alteration of brain oscillations in guinea pigs. Brain research. vol 1661. 2017-08-16. PMID:28192082. |
to clarify whether the activation of endocannabinoid (ecb) system can influence toxic ka action, am404, an ecb reuptake inhibitor, and urb597, an inhibitor of fatty acid amide hydrolase, were applied. |
2017-08-16 |
2023-08-13 |
Not clear |
| Isabelle Boileau, Esmaeil Mansouri, Belinda Williams, Bernard Le Foll, Pablo Rusjan, Romina Mizrahi, Rachel F Tyndale, Marilyn A Huestis, Doris E Payer, Alan A Wilson, Sylvain Houle, Stephen J Kish, Junchao Ton. Fatty Acid Amide Hydrolase Binding in Brain of Cannabis Users: Imaging With the Novel Radiotracer [ Biological psychiatry. vol 80. issue 9. 2017-08-09. PMID:27345297. |
fatty acid amide hydrolase binding in brain of cannabis users: imaging with the novel radiotracer [ one of the major mechanisms for terminating the actions of the endocannabinoid anandamide is hydrolysis by fatty acid amide hydrolase (faah), and inhibitors of the enzyme were suggested as potential treatment for human cannabis dependence. |
2017-08-09 |
2023-08-13 |
human |
| Vidya Chidambaran, Valentina Pilipenko, Kristie Spruance, Raja Venkatasubramanian, Jing Niu, Tsuyoshi Fukuda, Tomoyuki Mizuno, Kejian Zhang, Kenneth Kaufman, Alexander A Vinks, Lisa J Martin, Senthilkumar Sadhasiva. Fatty acid amide hydrolase-morphine interaction influences ventilatory response to hypercapnia and postoperative opioid outcomes in children. Pharmacogenomics. vol 18. issue 2. 2017-08-03. PMID:27977335. |
fatty acid amide hydrolase (faah) degrades anandamide, an endogenous cannabinoid. |
2017-08-03 |
2023-08-13 |
Not clear |