| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fabio Del Bello, Farhana Sakloth, John S Partilla, Michael H Baumann, Richard A Glenno. Ethylenedioxy homologs of N-methyl-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) and its corresponding cathinone analog methylenedioxymethcathinone: Interactions with transporters for serotonin, dopamine, and norepinephrine. Bioorganic & medicinal chemistry. vol 23. issue 17. 2016-06-20. PMID:26233799. |
here, we prepared n-methyl-(3,4-ethylenedioxyphenyl)-2-aminopropane (edma; 3), both of its optical isomers, and β-keto edma (i.e., edmc; 4) to examine their effects at transporters for serotonin (sert), dopamine (dat), and norepinephrine (net). |
2016-06-20 |
2023-08-13 |
Not clear |
| Jeffrey S Stehouwer, Mark M Goodma. Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine. PET clinics. vol 4. issue 1. 2016-05-10. PMID:20216936. |
this review focuses on the development of fluorine-18 radiolabeled pet tracers for imaging the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net). |
2016-05-10 |
2023-08-12 |
Not clear |
| Gavin McLaughlin, Noreen Morris, Pierce V Kavanagh, John D Power, Brendan Twamley, John O'Brien, Brian Talbot, Geraldine Dowling, Olivia Mahony, Simon D Brandt, Julian Patrick, Roland P Archer, John S Partilla, Michael H Bauman. Synthesis, characterization, and monoamine transporter activity of the new psychoactive substance 3',4'-methylenedioxy-4-methylaminorex (MDMAR). Drug testing and analysis. vol 7. issue 7. 2016-05-04. PMID:25331619. |
cis-mdmar, trans-mdmar, cis-4,4'-dmar and trans-4,4'-dmar were more potent than mdma in their ability to function as efficacious substrate-type releasers at the dopamine (dat) and norepinephrine (net) transporters in rat brain tissue. |
2016-05-04 |
2023-08-13 |
rat |
| Barbara Bottalico, Radovan Pilka, Irene Larsson, Bertil Casslen, Karel Marsal, Stefan R Hansso. Plasma membrane and vesicular monoamine transporters in normal endometrium and early pregnancy decidua. Molecular human reproduction. vol 9. issue 7. 2016-04-23. PMID:12802045. |
extracellular monoamine levels are regulated primarily through re-uptake by specific membrane-bound transporter proteins dopamine transporter (dat), norepinephrine transporter (net) and serotonin transporter (sert). |
2016-04-23 |
2023-08-12 |
Not clear |
| R Kolanos, J S Partilla, M H Baumann, B A Hutsell, M L Banks, S S Negus, R A Glenno. Stereoselective Actions of Methylenedioxypyrovalerone (MDPV) To Inhibit Dopamine and Norepinephrine Transporters and Facilitate Intracranial Self-Stimulation in Rats. ACS chemical neuroscience. vol 6. issue 5. 2016-03-07. PMID:25688761. |
the designer stimulant methylenedioxypyrovalerone (mdpv) is a potent reuptake inhibitor at transporters for dopamine (dat) and norepinephrine (net) that produces a constellation of abuse-related behavioral effects. |
2016-03-07 |
2023-08-13 |
rat |
| Yogesh D Aher, Saraswathi Subramaniyan, Bharanidharan Shanmugasundaram, Ajinkya Sase, Sivaprakasam R Saroja, Marion Holy, Harald Höger, Tetyana Beryozkina, Harald H Sitte, Johann J Leban, Gert Lube. A Novel Heterocyclic Compound CE-104 Enhances Spatial Working Memory in the Radial Arm Maze in Rats and Modulates the Dopaminergic System. Frontiers in behavioral neuroscience. vol 10. 2016-03-04. PMID:26941626. |
the efficacy of ce-104 in blocking mat [dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter] was determined using in vitro neurotransmitter uptake assay. |
2016-03-04 |
2023-08-13 |
human |
| Anna Rickli, Marius C Hoener, Matthias E Liecht. Monoamine transporter and receptor interaction profiles of novel psychoactive substances: para-halogenated amphetamines and pyrovalerone cathinones. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 3. 2015-12-15. PMID:25624004. |
we tested the potency of these compounds to inhibit the norepinephrine (ne), dopamine (da), and serotonin (5-ht) transporters (net, dat, and sert, respectively) using human embryonic kidney 293 cells that express the respective human transporters. |
2015-12-15 |
2023-08-13 |
human |
| Ole V Mortensen, Sandhya Kortager. Designing modulators of monoamine transporters using virtual screening techniques. Frontiers in pharmacology. vol 6. 2015-10-20. PMID:26483692. |
the plasma-membrane monoamine transporters (mats), including the serotonin (sert), norepinephrine (net) and dopamine (dat) transporters, serve a pivotal role in limiting monoamine-mediated neurotransmission through the reuptake of their respective monoamine neurotransmitters. |
2015-10-20 |
2023-08-13 |
drosophila_melanogaster |
| Laurence L Miller, Michael D Leitl, Matthew L Banks, Bruce E Blough, S Stevens Negu. Effects of the triple monoamine uptake inhibitor amitifadine on pain-related depression of behavior and mesolimbic dopamine release in rats. Pain. vol 156. issue 1. 2015-09-30. PMID:25599313. |
amitifadine is a "triple uptake inhibitor" that inhibits dat with approximately 5- to 10-fold weaker potency than it inhibits serotonin and norepinephrine transporters. |
2015-09-30 |
2023-08-13 |
rat |
| Stefanie H Grimm, Georg Höfner, Klaus T Wanne. Development and validation of an LC-ESI-MS/MS method for the triple reuptake inhibitor indatraline enabling its quantification in MS Binding Assays. Analytical and bioanalytical chemistry. vol 407. issue 2. 2015-09-28. PMID:25450050. |
we herein present the first lc-ms/ms quantification method for indatraline, a highly potent nonselective inhibitor of the three monoamine transporters (for dopamine, dat; norepinephrine, net; serotonin, sert), and its application to ms binding assays. |
2015-09-28 |
2023-08-13 |
Not clear |
| Daniel Jenson, Kechun Yang, Alexandra Acevedo-Rodriguez, Amber Levine, John I Broussard, Jianrong Tang, John A Dan. Dopamine and norepinephrine receptors participate in methylphenidate enhancement of in vivo hippocampal synaptic plasticity. Neuropharmacology. vol 90. 2015-08-20. PMID:25445492. |
our hypothesis was that mph affects hippocampal synaptic plasticity underlying learning because mph boosts catecholamine signaling by blocking the dopamine and norepinephrine transporters (dat and net respectively). |
2015-08-20 |
2023-08-13 |
mouse |
| Bronwyn Kivell, Zeljko Uzelac, Santhanalakshmi Sundaramurthy, Jeyaganesh Rajamanickam, Amy Ewald, Vladimir Chefer, Vanaja Jaligam, Elizabeth Bolan, Bridget Simonson, Balasubramaniam Annamalai, Padmanabhan Mannangatti, Thomas E Prisinzano, Ivone Gomes, Lakshmi A Devi, Lankupalle D Jayanthi, Harald H Sitte, Sammanda Ramamoorthy, Toni S Shippenber. Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism. Neuropharmacology. vol 86. 2015-07-14. PMID:25107591. |
while sala increased dat activity, sala treatment decreased serotonin transporter (sert) activity and had no effect on norepinephrine transporter (net) activity. |
2015-07-14 |
2023-08-13 |
Not clear |
| Mariane Cristovão Bagatin, Camila Santos Suniga Tozatti, Layara Akemi Abiko, Diego Alberto dos Santos Yamazaki, Priscila Rebeca Alves Silva, Leonardo Martins Perego, Elisabeth Aparecida Audi, Flavio Augusto Vicente Seixas, Ernani Abicht Basso, Gisele de Freitas Gauz. Molecular docking and panicolytic effect of 8-prenylnaringenin in the elevated T-maze. Chemical & pharmaceutical bulletin. vol 62. issue 12. 2015-07-14. PMID:25450631. |
to evaluate the interactions of 8-pn with monoamine transporters, a docking study was performed for both the r and s configurations of 8-pn towards sert, norepinephrine (net) and dopamine transporters (dat). |
2015-07-14 |
2023-08-13 |
rat |
| Javier A Urra, Franz Villaroel-Espíndola, Alejandra A Covarrubias, Joan Enric Rodríguez-Gil, Alfredo Ramírez-Reveco, Ilona I Conch. Presence and function of dopamine transporter (DAT) in stallion sperm: dopamine modulates sperm motility and acrosomal integrity. PloS one. vol 9. issue 11. 2015-07-08. PMID:25402186. |
in the present study, using immunodetection methods, we revealed the presence of several proteins important for the dopamine uptake and signalling in mammalian sperm, specifically monoamine transporters as dopamine (dat), serotonin (sert) and norepinephrine (net) transporters in equine sperm. |
2015-07-08 |
2023-08-13 |
Not clear |
| Richard B Rothman, Subramaniam Ananthan, John S Partilla, Surendra K Saini, Omar Moukha-Chafiq, Vibha Pathak, Michael H Bauman. Studies of the biogenic amine transporters 15. Identification of novel allosteric dopamine transporter ligands with nanomolar potency. The Journal of pharmacology and experimental therapeutics. vol 353. issue 3. 2015-07-08. PMID:25788711. |
these agents partially inhibited da, serotonin, and norepinephrine uptake, yet were much less potent at inhibiting [(3)h]win35428 binding to the dat. |
2015-07-08 |
2023-08-13 |
rat |
| Thomas Steinkellner, Liudmilla Mus, Birgit Eisenrauch, Andreea Constantinescu, Damiana Leo, Lisa Konrad, Mattias Rickhag, Gunnar Sørensen, Evgenia V Efimova, Eryan Kong, Matthäus Willeit, Tatyana D Sotnikova, Oliver Kudlacek, Ulrik Gether, Michael Freissmuth, Daniela D Pollak, Raul R Gainetdinov, Harald H Sitt. In vivo amphetamine action is contingent on αCaMKII. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 11. 2015-06-15. PMID:24871545. |
cocaine acts as a blocker at the transporters for dopamine (dat), serotonin (sert), and norepinephrine (net), but amphetamines are substrates that do not only block the uptake of monoamines but also induce substrate efflux by promoting reverse transport. |
2015-06-15 |
2023-08-13 |
mouse |
| Simon D Brandt, Michael H Baumann, John S Partilla, Pierce V Kavanagh, John D Power, Brian Talbot, Brendan Twamley, Olivia Mahony, John O'Brien, Simon P Elliott, Roland P Archer, Julian Patrick, Kuldip Singh, Nicola M Dempster, Simon H Cosbe. Characterization of a novel and potentially lethal designer drug (±)-cis-para-methyl-4-methylaminorex (4,4'-DMAR, or 'Serotoni'). Drug testing and analysis. vol 6. issue 7-8. 2015-03-30. PMID:24841869. |
(±)-cis-4,4'-dmar was a potent, efficacious substrate-type releaser at transporters for dopamine, norepinephrine and serotonin with ec50 values of 8.6 ± 1.1 nm (dat), 26.9 ± 5.9 nm (net) and 18.5 ± 2.8 nm (sert), respectively. |
2015-03-30 |
2023-08-13 |
rat |
| John R Lever, Dennis K Miller, Emily A Fergason-Cantrell, Caroline L Green, Lisa D Watkinson, Terry L Carmack, Susan Z Leve. Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418. The Journal of pharmacology and experimental therapeutics. vol 351. issue 1. 2014-11-25. PMID:25100754. |
no appreciable affinity was noted for serotonin and norepinephrine transporters (ki >100 μm), and the dat interaction was weak (ki 9.0 μm). |
2014-11-25 |
2023-08-13 |
mouse |
| Chang Soon Choi, Minha Hong, Ki Chan Kim, Ji-Woon Kim, Sung Min Yang, Hana Seung, Mee Jung Ko, Dong-Hee Choi, Jueng Soo You, Chan Young Shin, Geon Ho Bah. Effects of atomoxetine on hyper-locomotive activity of the prenatally valproate-exposed rat offspring. Biomolecules & therapeutics. vol 22. issue 5. 2014-11-21. PMID:25414770. |
in this study, we examined the effects of two of currently available attention defecit hyperactivity disorder (adhd) medications, methylphenidate (mph) and atomoxetine (atx) targeting dopamine and norepinephrine transporters (dat and net), respectively, on hyperactive behavior of prenatally vpa-exposed rat offspring. |
2014-11-21 |
2023-08-13 |
human |
| Horrick Sharma, Soumava Santra, Joy Debnath, Tamara Antonio, Maarten Reith, Aloke Dutt. Flexible and biomimetic analogs of triple uptake inhibitor 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: Synthesis, biological characterization, and development of a pharmacophore model. Bioorganic & medicinal chemistry. vol 22. issue 1. 2014-11-06. PMID:24315194. |
the model revealed features important for inhibitors to exhibit a balanced activity against dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net). |
2014-11-06 |
2023-08-12 |
Not clear |