| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Kotian, S W Mascarella, P Abraham, A H Lewin, J W Boja, M J Kuhar, F I Carrol. Synthesis, ligand binding, and quantitative structure-activity relationship study of 3 beta-(4'-substituted phenyl)-2 beta-heterocyclic tropanes: evidence for an electrostatic interaction at the 2 beta-position. Journal of medicinal chemistry. vol 39. issue 14. 1996-09-10. PMID:8709106. |
several of the compounds showed high affinity and selectivity for the dopamine transporter (dat) relative to the serotonin and norepinephrine transporters. |
1996-09-10 |
2023-08-12 |
Not clear |
| J L Neumeyer, G Tamagnan, S Wang, Y Gao, R A Milius, N S Kula, R J Baldessarin. N-substituted analogs of 2 beta-carbomethoxy-3 beta- (4'-iodophenyl)tropane (beta-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain. Journal of medicinal chemistry. vol 39. issue 2. 1996-02-28. PMID:8558525. |
this report concerns the synthesis and chemical characterization of novel series of n-substituted 2 beta-carbomethoxy-3 beta-(4'-iodophenyl)tropane (beta-cit, 2) analogs and their neuropharmacological evaluation for affinity at dopamine (dat), serotonin (5-htt), and norepinephrine membrane transporters in rat brain tissue. |
1996-02-28 |
2023-08-12 |
rat |
| S C Wall, H Gu, G Rudnic. Biogenic amine flux mediated by cloned transporters stably expressed in cultured cell lines: amphetamine specificity for inhibition and efflux. Molecular pharmacology. vol 47. issue 3. 1995-04-28. PMID:7700252. |
llc-pk1 cells have been stably transfected with cdnas encoding the human norepinephrine transporter (net), rat dopamine transporter (dat), and rat serotonin transporter. |
1995-04-28 |
2023-08-12 |
human |
| D Lorang, S G Amara, R B Simerl. Cell-type-specific expression of catecholamine transporters in the rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 8. 1994-08-30. PMID:8046459. |
the dopamine transporter (dat) and norepinephrine transporter (net) terminate catecholaminergic neurotransmission at synapses by high-affinity sodium-dependent reuptake into presynaptic terminals, and are the initial sites of action for drugs of abuse and antidepressants. |
1994-08-30 |
2023-08-12 |
rat |
| B Vitiello, R C Veith, S E Molchan, R A Martinez, B A Lawlor, J Radcliffe, J L Hill, T Sunderlan. Autonomic dysfunction in patients with dementia of the Alzheimer type. Biological psychiatry. vol 34. issue 7. 1994-02-03. PMID:8268327. |
to evaluate the autonomic sympathetic system in dat, we measured lying and standing blood pressure (bp), pulse, and plasma epinephrine (e) and norepinephrine (ne) in 60 dat patients (mean age +/- sd = 65 +/- 8 years), and 20 normal elderly controls. |
1994-02-03 |
2023-08-12 |
Not clear |
| E Martignoni, G Bono, F Blandini, E Sinforiani, P Merlo, G Napp. Monoamines and related metabolite levels in the cerebrospinal fluid of patients with dementia of Alzheimer type. Influence of treatment with L-deprenyl. Journal of neural transmission. Parkinson's disease and dementia section. vol 3. issue 1. 1991-08-14. PMID:1712206. |
the cerebrospinal fluid (csf) levels of norepinephrine (ne), epinephrine (e), dopamine (da), 3-methoxy-4-hydroxyphenylglycol (mhpg), 5-hydroxyindoleacetic acid (5-hiaa), and homovanillic acid (hva) were studied in 14 patients suffering from dementia of alzheimer type (dat) and in 14 controls. |
1991-08-14 |
2023-08-11 |
Not clear |
| D W Gietzen, D Fregeau, T Goodman, P G Weiler, K Graf, J Magliozz. Lymphocyte beta-adrenoceptor/effector complex in aging and dementia of the Alzheimer type. Alzheimer disease and associated disorders. vol 3. issue 3. 1989-11-02. PMID:2551349. |
we examined density (bmax), affinity (kd), and norepinephrine (ne)-stimulated cyclic adenosine monophosphate (camp) generation of the beta-adrenergic receptor on lymphocytes in patients with dementia of the alzheimer type (dat, n = 13), in normal aged controls (aged, n = 27), and in young controls (young, n = 21). |
1989-11-02 |
2023-08-11 |
Not clear |