| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Catya Jiménez-Torres, Katherine D Porter, Jamison A Hastie, Charles Adeniran, Omar Moukha-Chafiq, Theresa H Nguyen, Subramaniam Ananthan, Corinne E Augelli-Szafran, Chang-Guo Zhan, Jun Zh. Effects of SRI-32743, a Novel Quinazoline Structure-Based Compound, on HIV-1 Tat and Cocaine Interaction with Norepinephrine Transporter. International journal of molecular sciences. vol 25. issue 14. 2024-07-27. PMID:39063123. |
we have demonstrated that in vivo expression of tat in tat transgenic mice decreases dopamine uptake through both dopamine transporter (dat) and norepinephrine transporter (net) in the prefrontal cortex. |
2024-07-27 |
2024-07-29 |
mouse |
| Arnav Paul, Diwakar Shukl. Oligomerization of Monoamine Transporters. Sub-cellular biochemistry. vol 104. 2024-07-04. PMID:38963486. |
the mat family functions using the electrochemical gradient of ions across the membrane and comprises three transporters, dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net). |
2024-07-04 |
2024-07-10 |
Not clear |
| Sixiang Chen, Xingyu Huang, Xintong Zhang, Chan Li, Yuan-Wei Zhan. A Conserved Intramolecular Ion-Pair Plays a Critical but Divergent Role in Regulation of Dimerization and Transport Function among the Monoamine Transporters. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612840. |
the monoamine transporters, including the serotonin transporter (sert), dopamine transporter (dat), and norepinephrine transporter (net), are the therapeutic targets for the treatment of many neuropsychiatric disorders. |
2024-04-13 |
2024-04-15 |
Not clear |
| Zhiwei Huang, Junhao Wu, Yihui Guan, Yumei Wei, Fang Xie, Yifeng She. PET/CT study of dopamine transporter (DAT) binding with the triple reuptake inhibitor toludesvenlafaxine in rats and humans. European journal of nuclear medicine and molecular imaging. 2024-04-08. PMID:38587645. |
despite the in vitro evidence that toludesvenlafaxine inhibits the reuptake of serotonin (5-ht), norepinephrine (ne) and dopamine (da), there is no in vivo evidence that toludesvenlafaxine binds to dat and increases da level, a mechanism thought to contribute to its favorable clinical performance. |
2024-04-08 |
2024-04-10 |
rat |
| Lauren R Fitzgerald, Brenda M Gannon, Donna Walther, Antonio Landavazo, Takato Hiranita, Bruce E Blough, Michael H Baumann, William E Fantegross. Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones. Neuropharmacology. 2023-12-28. PMID:38154512. |
automated photobeam analysis was used to evaluate effects of drugs on ambulatory activity in mice, whereas in vitro assays were used to determine activities at transporters for dopamine (dat), norepinephrine (net), and 5-ht (sert) in rat brain synaptosomes. |
2023-12-28 |
2023-12-31 |
mouse |
| Hyomin Ahn, Kichul Park, Dongyoung Kim, Sung-Gil Chi, Kee-Hyun Choi, Seo-Jung Han, Chiman Son. Implications for Combination Therapy of Selective Monoamine Reuptake Inhibitors on Dopamine Transporters. Biomedicines. vol 11. issue 10. 2023-10-30. PMID:37893219. |
monoamine transporters, including dopamine, norepinephrine, and serotonin transporters (dat, net, and sert, respectively), are important therapeutic targets due to their essential roles in the brain. |
2023-10-30 |
2023-11-08 |
Not clear |
| Felix P Mayer, Marco Niello, Simon Bulling, Yuan-Wei Zhang, Yang Li, Oliver Kudlacek, Marion Holy, Fatemeh Kooti, Walter Sandtner, Gary Rudnick, Diethart Schmid, Harald H Sitt. Mephedrone induces partial release at human dopamine transporters but full release at human serotonin transporters. Neuropharmacology. 2023-09-13. PMID:37703919. |
the stimulating properties are believed to arise from the ability of mephedrone to interact with the high-affinity transporters for dopamine (da) (dat) and norepinephrine (net), whereas the entactogenic effect presumably relies on its activity at the serotonin (5-ht) transporter (sert). |
2023-09-13 |
2023-10-07 |
human |
| Natalia F Sardi, Ana C Pescador, Evellyn M Azevedo, José A Pochapski, Caroline Kukolj, Katherinne M Spercoski, Anderson J M Andrade, Claudio da Cunha, Luana Fische. Sleep and pain: a role for the anterior cingulate cortex, nucleus accumbens and dopamine in the increased pain sensitivity following sleep restriction. The journal of pain. 2023-09-06. PMID:37673193. |
data on indirect dopaminergic parameters, dat glycosylation and darpp-32 phosphorylation, as well as dopamine, serotonin and norepinephrine levels, suggest that dopaminergic function decreases in the nucleus accumbens and anterior cingulate cortex after sleep restriction. |
2023-09-06 |
2023-10-07 |
rat |
| Florian Koban, Michael Freissmut. The cell cycle protein MAD2 facilitates endocytosis of the serotonin transporter in the neuronal soma. EMBO reports. 2023-08-02. PMID:37530743. |
monoamine transporters retrieve serotonin (sert), dopamine (dat), and norepinephrine (net) from the synaptic cleft. |
2023-08-02 |
2023-08-14 |
Not clear |
| Mattias Persson, Svante Vikingsson, Robert Kronstrand, Henrik Gree. Characterization of neurotransmitter inhibition for seven cathinones by a proprietary fluorescent dye method. Drug testing and analysis. 2023-07-25. PMID:37489044. |
to start addressing this need, a method measuring the inhibition of the dopamine, serotonin, and norepinephrine transporters (dat, sert, and net) by stimulant drugs was developed. |
2023-07-25 |
2023-08-14 |
Not clear |
| Cecilia E Villanueva, Bruno Hagenbuc. Palmitoylation of Solute Carriers. Biochemical pharmacology. 2023-07-22. PMID:37481134. |
among the best-characterized transporters are the glucose transporters glut1 (slc2a1) and glut4 (slc2a4), the three monoamine transporters norepinephrine transporter (net; slc6a2), dopamine transporter (dat; slc6a3), and serotonin transporter (sert; slc6a4), and the sodium-calcium exchanger ncx1 (slc8a1). |
2023-07-22 |
2023-08-14 |
Not clear |
| N J Clauss, F P Mayer, W A Owens, M Vitela, K M Clarke, M A Bowman, R E Horton, D Gründemann, D Schmid, M Holy, G G Gould, W Koek, H H Sitte, L C Daw. Ethanol inhibits dopamine uptake via organic cation transporter 3: Implications for ethanol and cocaine co-abuse. Molecular psychiatry. 2023-06-12. PMID:37308680. |
cocaine increases extracellular monoamines by blocking dopamine (da), norepinephrine (ne) and serotonin (5-ht) transporters (dat, net and sert, respectively). |
2023-06-12 |
2023-08-14 |
mouse |
| Shaili Aggarwal, Ole Valente Mortense. Discovery and Development of Monoamine Transporter Ligands. Advances in neurobiology. vol 30. 2023-03-17. PMID:36928847. |
the mat family is comprised of three main members - the dopamine transporter (dat), the norepinephrine transporter (net), and the serotonin transporter (sert). |
2023-03-17 |
2023-08-14 |
Not clear |
| Sara Soufsaf, Philippe Robaey, Fahima Nekk. An exploratory analysis of the performance of methylphenidate regimens based on a PKPD model of dopamine and norepinephrine transporter occupancy. Journal of pharmacokinetics and pharmacodynamics. 2023-03-17. PMID:36930337. |
methylphenidate (mph) is a psychostimulant which inhibits the uptake of dopamine and norepinephrine transporters, dat and net, and is mostly used to treat attention deficit/hyperactivity disorder. |
2023-03-17 |
2023-08-14 |
Not clear |
| X Zhang, M S Berridge, S M Apana, W Slikker, M G Paule, John Talpo. Discontinuation of methylphenidate after long-term exposure in nonhuman primates. Neurotoxicology and teratology. 2023-03-09. PMID:36893929. |
the blockage of the dopamine transporter (dat) and the norepinephrine transporter (net) by mph may help with adhd symptoms by boosting monoamine levels in the synapse. |
2023-03-09 |
2023-08-14 |
human |
| Michael R Chojnacki, Eric B Thorndike, John S Partilla, Kenner C Rice, Charles W Schindler, Michael H Bauman. The Journal of pharmacology and experimental therapeutics. 2023-01-20. PMID:36669877. |
synaptosomes were prepared from rat caudate for dopamine transporter (dat) assays, or from whole brain minus caudate and cerebellum for norepinephrine transporter (net) and serotonin transporter (sert) assays. |
2023-01-20 |
2023-08-14 |
rat |
| Gustavo Henrique Marques Sousa, Renan Augusto Gomes, Eliseu Ortega de Oliveira, Gustavo Henrique Goulart Trossin. Machine learning methods applied for the prediction of biological activities of triple reuptake inhibitors. Journal of biomolecular structure & dynamics. 2022-12-22. PMID:36546689. |
thus, major efforts have been made to develop drugs that inhibit serotonin (sert), norepinephrine (net) and dopamine (dat) transporters and increase the availability of these monoamines. |
2022-12-22 |
2023-08-14 |
Not clear |
| David Matuskey, Jean-Dominique Gallezot, Nabeel Nabulsi, Shannan Henry, Kristen Torres, Mark Dias, Gustavo A Angarita, Yiyun Huang, Susan E Shoaf, Richard E Carson, Shailly Mehrotr. Neurotransmitter transporter occupancy following administration of centanafadine sustained-release tablets: A phase 1 study in healthy male adults. Journal of psychopharmacology (Oxford, England). 2022-12-14. PMID:36515395. |
centanafadine is an inhibitor of reuptake transporters for norepinephrine (net), dopamine (dat) and serotonin (sert). |
2022-12-14 |
2023-08-14 |
Not clear |
| Mehmet Evren Öztürk, Anıl Yirün, Selinay Başak Erdemli-Köse, Aylin Balcı-Özyurt, Deniz Arca Çakır, Didem Oral, Pınar Erkekoğl. Evaluation of the toxic effects of thimerosal and/or aluminum hydroxide in SH-SY5Y cell line. Human & experimental toxicology. vol 41. 2022-11-21. PMID:36411272. |
nuclear factor erythroid 2-associated factor 2 (nrf2), norepinephrine (ne), dopamine transporter (dat) and dopamine beta β-hydroxylase (dbh) levels were measured by sandwich elisa kits while 8-hydroxy deoxyguanosine (8-ohdg) and dopamine levels were determined by competitive elisa kits. |
2022-11-21 |
2023-08-14 |
Not clear |
| Mathieu Di Miceli, Asma Derf, Benjamin Gronie. Consequences of Acute or Chronic Methylphenidate Exposure Using Ex Vivo Neurochemistry and In Vivo Electrophysiology in the Prefrontal Cortex and Striatum of Rats. International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955717. |
mph blocks both the norepinephrine and dopamine reuptake transporters (net and dat, respectively). |
2022-08-12 |
2023-08-14 |
rat |