| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rudy Schreiber, Una Campbell, Maria S Quinton, Larry W Hardy, Q Kevin Fang, Robert Le. In vitro and in vivo pharmacological characterization of dasotraline, a dual dopamine and norepinephrine transporter inhibitor in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-07-05. PMID:35785702. |
inhibitors of dopamine transporters (dat), norepinephrine transporters (net) and serotonin transporters (sert) are effective treatments for neuropsychiatric diseases. |
2022-07-05 |
2023-08-14 |
Not clear |
| Jesús E Yepez, Jorge Juáre. Modafinil acquires reinforcing effects when combined with citalopram. Pharmacology, biochemistry, and behavior. 2022-05-23. PMID:35605783. |
its action mechanism consists in inhibiting dopamine (dat) and norepinephrine (net) transporters, but it has no affinity for the serotonin transporter (sert). |
2022-05-23 |
2023-08-13 |
rat |
| Nikki J Clauss, W A Owens, Melissa Vitela, Melodi A Bowman, Felix P Mayer, Diethart Schmid, Marion Holy, Harrold H Sitte, Geogianna G Gould, Wouter Koek, Lynette C Daw. Ethanol Inhibits Dopamine Uptake and Augments Rewarding Effects of Cocaine via Organic Cation Transporter 3. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554677. |
both cocaine (blocker of dopamine (da), norepinephrine and serotonin transporters, dat, net and sert, respectively) and ethanol (etoh) increase extracellular levels of these monoamines. |
2022-05-13 |
2023-08-13 |
Not clear |
| Suzanne Underhill, Susan Amar. 3,4-methylenedioxymethamphetamine (MDMA) stimulates activation of TAAR1 and subsequent neurotransmitter transporter internalization in serotonin neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556756. |
in previous studies, we have shown that a closely-related compound, amphetamine (amph), enters neurons through the dopamine and norepinephrine transporters (dat and net) and activates taar1. |
2022-05-13 |
2023-08-13 |
mouse |
| Hongsong Feng, Kaifu Gao, Dong Chen, Li Shen, Alfred J Robison, Edmund Ellsworth, Guo-Wei We. Machine Learning Analysis of Cocaine Addiction Informed by DAT, SERT, and NET-Based Interactome Networks. Journal of chemical theory and computation. 2022-03-16. PMID:35294204. |
among them, the dopamine (dat), serotonin (sert), and norepinephrine (net) transporters are three major targets. |
2022-03-16 |
2023-08-13 |
Not clear |
| Phillip M Mackie, Adithya Gopinath, Dominic M Montas, Alyssa Nielsen, Aidan Smith, Rachel A Nolan, Kaitlyn Runner, Stephanie M Matt, John McNamee, Joshua E Riklan, Kengo Adachi, Andria Doty, Adolfo Ramirez-Zamora, Long Yan, Peter J Gaskill, Wolfgang J Streit, Michael S Okun, Habibeh Khoshboue. Functional characterization of the biogenic amine transporters on human macrophages. JCI insight. 2022-01-11. PMID:35015729. |
to address these knowledge gaps, we investigated the function of norepinephrine (net) and dopamine (dat) transporters on human monocyte-derived macrophages. |
2022-01-11 |
2023-08-13 |
human |
| Thomas J F Angenoorth, Stevan Stankovic, Marco Niello, Marion Holy, Simon D Brandt, Harald H Sitte, Julian Maie. Interaction Profiles of Central Nervous System Active Drugs at Human Organic Cation Transporters 1-3 and Human Plasma Membrane Monoamine Transporter. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884800. |
many psychoactive compounds have been shown to primarily interact with high-affinity and low-capacity solute carrier 6 (slc6) monoamine transporters for norepinephrine (net; norepinephrine transporter), dopamine (dat; dopamine transporter) and serotonin (sert; serotonin transporter). |
2021-12-10 |
2023-08-13 |
human |
| Padmanabhan Mannangatti, Durairaj Ragu Varman, Sammanda Ramamoorthy, Lankupalle D Jayanth. Neurokinin-1 Antagonism Distinguishes the Role of Norepinephrine Transporter from Dopamine Transporter in Mediating Amphetamine Behaviors. Pharmacology. vol 106. issue 11-12. 2021-11-11. PMID:34515205. |
amphetamine (amph) and other psychostimulants act on the norepinephrine (ne) transporter (net) and the dopamine (da) transporter (dat) and enhance ne and da signaling. |
2021-11-11 |
2023-08-13 |
Not clear |
| Paul J Gasse. Organic Cation Transporters in Brain Catecholamine Homeostasis. Handbook of experimental pharmacology. vol 266. 2021-10-28. PMID:33987762. |
most studies of catecholamine clearance have focused on the presynaptic high-affinity, low-capacity dopamine (dat), and norepinephrine (net) transporters, which are members of the uptake |
2021-10-28 |
2023-08-13 |
Not clear |
| Anna Marie Buchanan, Brenna Parke, Parastoo Hashem. Experimental Methods for Investigating Uptake 2 Processes In Vivo. Handbook of experimental pharmacology. vol 266. 2021-10-28. PMID:34196807. |
uptake 1 describes uptake of the monoamine via its designated transporter (sert for serotonin, net for norepinephrine, and dat for dopamine), whereas uptake 2 details multiple transporter types on neurons and glia taking up different types of modulators, not necessarily specific to the monoamine. |
2021-10-28 |
2023-08-13 |
human |
| Lynette C Daw. Organic Cation Transporters in Psychiatric Disorders. Handbook of experimental pharmacology. vol 266. 2021-10-28. PMID:34282486. |
other classes of antidepressant work by blocking the norepinephrine or dopamine transporters (net and dat), the high-affinity, low-capacity uptake-1 transporters for norepinephrine and dopamine, or by blocking combinations of sert, net, and dat. |
2021-10-28 |
2023-08-13 |
Not clear |
| Shreyas Bhat, Marco Niello, Klaus Schicker, Christian Pifl, Harald H Sitte, Michael Freissmuth, Walter Sandtne. Handling of intracellular K eLife. vol 10. 2021-10-19. PMID:34061030. |
handling of intracellular k the concentrative power of the transporters for dopamine (dat), norepinephrine (net), and serotonin (sert) is thought to be fueled by the transmembrane na |
2021-10-19 |
2023-08-13 |
Not clear |
| X Zhang, J Talpos, M S Berridge, S M Apana, W Slikker, C Wang, M G Paul. MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates. Neurotoxicology and teratology. vol 87. 2021-09-21. PMID:34265415. |
mph is believed to exert its pharmacological effects via preferential blockade of the dopamine transporter (dat) and the norepinephrine transporter (net), resulting in increased monoamine levels in the synapse. |
2021-09-21 |
2023-08-13 |
monkey |
| Renee A Rotolo, Rose E Presby, Olivia Tracy, Sokaina Asar, Jen-Hau Yang, Merce Correa, Fraser Murray, John D Salamon. The novel atypical dopamine transport inhibitor CT-005404 has pro-motivational effects in neurochemical and inflammatory models of effort-based dysfunctions related to psychopathology. Neuropharmacology. vol 183. 2021-09-13. PMID:32956676. |
the present studies focused on the initial characterization of a novel atypical dat inhibitor, ct-005404, which binds to dat with high selectivity relative to serotonin and norepinephrine transport, and produces long-term elevations of extracellular da. |
2021-09-13 |
2023-08-13 |
rat |
| Karolina E Kolaczynska, Jan Thomann, Marius C Hoener, Matthias E Liecht. The Pharmacological Profile of Second Generation Pyrovalerone Cathinones and Related Cathinone Derivative. International journal of molecular sciences. vol 22. issue 15. 2021-09-08. PMID:34361040. |
we assessed several pyrovalerone and related cathinone derivatives at the human norepinephrine (net), dopamine (dat), and serotonin (sert) uptake transporters using hek293 cells overexpressing each respective transporter. |
2021-09-08 |
2023-08-13 |
human |
| Ottavia Dipasquale, Daniel Martins, Arjun Sethi, Mattia Veronese, Swen Hesse, Michael Rullmann, Osama Sabri, Federico Turkheimer, Neil A Harrison, Mitul A Mehta, Mara Cercignan. Unravelling the effects of methylphenidate on the dopaminergic and noradrenergic functional circuits. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 9. 2021-06-23. PMID:32473593. |
here, we focus on methylphenidate (mph), which binds to the dopamine transporter (dat) and the norepinephrine transporter (net), to unravel its effects on dopaminergic and noradrenergic functional circuits in the healthy brain at rest. |
2021-06-23 |
2023-08-13 |
Not clear |
| Charles Adeniran, Yaxia Yuan, Sarah E Davis, Ciai Lin, Jiahui Xu, Jun Zhu, Chang-Guo Zha. Binding Mode of Human Norepinephrine Transporter Interacting with HIV-1 Tat. ACS chemical neuroscience. vol 12. issue 9. 2021-06-18. PMID:33886267. |
hiv-infected patients have displayed increased synaptic levels of dopamine (da) due to reduced binding and function of monoamine transporters such as the norepinephrine transporter (net) and the dopamine transporter (dat). |
2021-06-18 |
2023-08-13 |
human |
| Madeline M Pantoni, Stephanie A Carmack, Leen Hammam, Stephan G Anagnostara. Dopamine and norepinephrine transporter inhibition for long-term fear memory enhancement. Behavioural brain research. vol 378. 2021-04-29. PMID:31580915. |
by one prevalent view, psychostimulants exert their procognitive effects exclusively through norepinephrine transporter (net) inhibition, however increasing evidence suggests that dat also plays a critical role in their cognitive-enhancing properties, including long-term memory enhancement. |
2021-04-29 |
2023-08-13 |
mouse |
| Marco Niello, Daniela Cintulová, Philip Raithmayr, Marion Holy, Kathrin Jäntsch, Claire Colas, Gerhard F Ecker, Harald H Sitte, Marko D Mihovilovi. Effects of Hydroxylated Mephedrone Metabolites on Monoamine Transporter Activity Frontiers in pharmacology. vol 12. 2021-04-28. PMID:33897439. |
it elicits the release of monoamines via the high affinity transporters for dopamine (dat), norepinephrine (net) and serotonin (sert). |
2021-04-28 |
2023-08-13 |
Not clear |
| Suzanne M Underhill, Mark S Colt, Susan G Amar. Amphetamine Stimulates Endocytosis of the Norepinephrine and Neuronal Glutamate Transporters in Cultured Locus Coeruleus Neurons. Neurochemical research. vol 45. issue 6. 2021-03-22. PMID:31912366. |
since amph is a transported inhibitor of both dat and the norepinephrine transporter (net), and eaat3 is also expressed in norepinephrine (ne) neurons, we explored the possibility that this signaling cascade occurs in ne neurons. |
2021-03-22 |
2023-08-13 |
Not clear |