| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abdelrahman R Shalabi, Donna Walther, Michael H Baumann, Richard A Glenno. Deconstructed Analogues of Bupropion Reveal Structural Requirements for Transporter Inhibition versus Substrate-Induced Neurotransmitter Release. ACS chemical neuroscience. vol 8. issue 6. 2018-05-01. PMID:28220701. |
bupropion (1), an α-aminophenone uptake inhibitor at plasma membrane transporters for dopamine (dat) and norepinephrine (net), is a widely prescribed antidepressant and smoking cessation aid. |
2018-05-01 |
2023-08-13 |
Not clear |
| Ernesto Solis, John S Partilla, Farhana Sakloth, Iwona Ruchala, Kathryn L Schwienteck, Louis J De Felice, Jose M Eltit, Richard A Glennon, S Stevens Negus, Michael H Bauman. N-Alkylated Analogs of 4-Methylamphetamine (4-MA) Differentially Affect Monoamine Transporters and Abuse Liability. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 10. 2018-04-24. PMID:28530234. |
clandestine chemists synthesize novel stimulant drugs by exploiting structural templates known to target monoamine transporters for dopamine, norepinephrine, and serotonin (dat, net, and sert, respectively). |
2018-04-24 |
2023-08-13 |
rat |
| Suraj Adhikary, Daniel J Deredge, Anu Nagarajan, Lucy R Forrest, Patrick L Wintrode, Satinder K Sing. Conformational dynamics of a neurotransmitter:sodium symporter in a lipid bilayer. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 10. 2018-04-10. PMID:28223522. |
the symporters for the biogenic amines serotonin (sert), dopamine (dat), and norepinephrine (net) are targets of multiple psychoactive agents, and their dysfunction has been implicated in numerous neuropsychiatric ailments. |
2018-04-10 |
2023-08-13 |
Not clear |
| Yanhui Chen, Xiaolan Zheng, Linqi Xie, Liang Huang, Zhongling Ke, Jie Zheng, Hongzhu Lu, Jun H. Glucocorticoids/glucocorticoid receptors effect on dopaminergic neurotransmitters in ADHD rats. Brain research bulletin. vol 131. 2018-04-09. PMID:28458039. |
the levels of dopamine, norepinephrine, and dopamine transporter (dat) in the prefrontal cortex and striatum were also tested. |
2018-04-09 |
2023-08-13 |
rat |
| Predrag Kalaba, Nilima Y Aher, Marija Ilić, Vladimir Dragačević, Marcus Wieder, Andras G Miklosi, Martin Zehl, Judith Wackerlig, Alexander Roller, Tetyana Beryozkina, Bojana Radoman, Sivaprakasam R Saroja, Wolfgang Lindner, Eduardo Perez Gonzalez, Vasiliy Bakulev, Johann Jakob Leban, Harald H Sitte, Ernst Urban, Thierry Langer, Gert Lube. Heterocyclic Analogues of Modafinil as Novel, Atypical Dopamine Transporter Inhibitors. Journal of medicinal chemistry. vol 60. issue 22. 2018-01-23. PMID:29091428. |
it was the aim of this study to synthesize and characterize such analogues and, indeed, a series of compounds were showing higher activities on the dat and a higher selectivity toward dat versus serotonin and norepinephrine transporters than modafinil. |
2018-01-23 |
2023-08-13 |
Not clear |
| A Chiavaroli, L Recinella, C Ferrante, S Martinotti, M Vacca, L Brunetti, G Orlando, S Leon. Effects of central fibroblast growth factor 21 and irisin in anxiety-like behavior. Journal of biological regulators and homeostatic agents. vol 31. issue 3. 2017-12-14. PMID:28890831. |
prefrontal cortex levels of norepinephrine (ne), dopamine (da) and serotonin (5-hydroxytryptamine, 5-ht) and the gene expression of catechol-o-methyltransferase (comt), dopamine transport (dat) and tyrosine hydroxylase (th), were measured by high performance liquid chromatography (hplc) analysis and real-time reverse transcription polymerase chain reaction (rt-pcr). |
2017-12-14 |
2023-08-13 |
rat |
| Ahmed M Hussein, Yogesh D Aher, Predrag Kalaba, Nilima Y Aher, Vladimir Dragačević, Bojana Radoman, Marija Ilić, Johann Leban, Tetyana Beryozkina, Abdel Baset M A Ahmed, Ernst Urban, Thierry Langer, Gert Lube. A novel heterocyclic compound improves working memory in the radial arm maze and modulates the dopamine receptor D1R in frontal cortex of the Sprague-Dawley rat. Behavioural brain research. vol 332. 2017-12-12. PMID:28629964. |
ce-125 (4-((benzhydrylsulfinyl)methyl)-2-cyclopropylthiazole), was tested for dopamine (dat), serotonin and norepinephrine re-uptake inhibition by a well-established system. |
2017-12-12 |
2023-08-13 |
rat |
| Gavin McLaughlin, Noreen Morris, Pierce V Kavanagh, John D Power, Geraldine Dowling, Brendan Twamley, John O'Brien, Brian Talbot, Donna Walther, John S Partilla, Michael H Baumann, Simon D Brand. Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone. Drug testing and analysis. vol 9. issue 3. 2017-07-18. PMID:27524685. |
all three substances were also studied for their uptake and releasing properties at dopamine transporters (dat), norepinephrine transporters (net) and serotonin transporters (sert) using in vitro monoamine transporter assays in rat brain synaptosomes and compared to mephedrone. |
2017-07-18 |
2023-08-13 |
rat |
| S Stevens Negus, Matthew L Bank. Decoding the Structure of Abuse Potential for New Psychoactive Substances: Structure-Activity Relationships for Abuse-Related Effects of 4-Substituted Methcathinone Analogs. Current topics in behavioral neurosciences. vol 32. 2017-07-11. PMID:27696217. |
many cathinone analogs act as substrates or inhibitors at dopamine, norepinephrine, and serotonin transporters (dat, net, sert, respectively). |
2017-07-11 |
2023-08-13 |
rat |
| Michael H Baumann, Mohammad O Bukhari, Kurt R Lehner, Sebastien Anizan, Kenner C Rice, Marta Concheiro, Marilyn A Huesti. Neuropharmacology of 3,4-Methylenedioxypyrovalerone (MDPV), Its Metabolites, and Related Analogs. Current topics in behavioral neurosciences. vol 32. 2017-07-11. PMID:27830575. |
mdpv acts as a potent uptake inhibitor at plasma membrane transporters for dopamine (dat) and norepinephrine (net) in nervous tissue. |
2017-07-11 |
2023-08-13 |
rat |
| Melissa M Conti, Samantha M Meadows, Mitchell Melikhov-Sosin, David Lindenbach, Joy Hallmark, David F Werner, Christopher Bisho. Monoamine transporter contributions to l-DOPA effects in hemi-parkinsonian rats. Neuropharmacology. vol 110. issue Pt A. 2017-07-10. PMID:27452719. |
serotonin and norepinephrine transporters (sert and net, respectively) have affinity for dopamine uptake especially when dopamine transporters (dat) are scant. |
2017-07-10 |
2023-08-13 |
rat |
| Samantha E Yohn, Emily E Errante, Aaron Rosenbloom-Snow, Matthew Somerville, Margaret Rowland, Kristin Tokarski, Nadia Zafar, Merce Correa, John D Salamon. Blockade of uptake for dopamine, but not norepinephrine or 5-HT, increases selection of high effort instrumental activity: Implications for treatment of effort-related motivational symptoms in psychopathology. Neuropharmacology. vol 109. 2017-06-19. PMID:27329556. |
the present studies investigated the ability of drugs that block dopamine transport (dat), norepinephrine transport (net), and serotonin transport (sert) to modulate work output in rats responding on a test of effort-related decision making (i.e., a progressive ratio (prog)/chow feeding choice task). |
2017-06-19 |
2023-08-13 |
rat |
| Sarah E Bradshaw, Kara L Agster, Barry D Waterhouse, Jill A McGaugh. Age-related changes in prefrontal norepinephrine transporter density: The basis for improved cognitive flexibility after low doses of atomoxetine in adolescent rats. Brain research. vol 1641. issue Pt B. 2017-05-02. PMID:26774596. |
while both of these drugs act as norepinephrine reuptake inhibitors, higher doses of atomoxetine and all doses of methylphenidate also block dopamine transporters (dat). |
2017-05-02 |
2023-08-13 |
human |
| Blake A Hutsell, Michael H Baumann, John S Partilla, Matthew L Banks, Rakesh Vekariya, Richard A Glennon, S Stevens Negu. Abuse-related neurochemical and behavioral effects of cathinone and 4-methylcathinone stereoisomers in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 2. 2016-12-13. PMID:26738428. |
for neurochemical studies, drug effects were evaluated on monoamine release through dopamine, norepinephrine, and serotonin transporters (dat, net and sert, respectively) in rat brain synaptosomes. |
2016-12-13 |
2023-08-13 |
rat |
| Louis J De Felic. Chloride requirement for monoamine transporters. Pflugers Archiv : European journal of physiology. vol 468. issue 3. 2016-11-04. PMID:26794730. |
this review focuses on the cl(-) requirement for dopamine, serotonin, and norepinephrine (da, 5-ht, and ne) transport and induced current via the transporters for these transmitters, dat, sert, and net. |
2016-11-04 |
2023-08-13 |
Not clear |
| Ajinkya Sase, Yogesh D Aher, Sivaprakasam R Saroja, Minu Karthika Ganesan, Sunetra Sase, Marion Holy, Harald Höger, Vasiliy Bakulev, Gerhard F Ecker, Thierry Langer, Harald H Sitte, Johann Leban, Gert Lube. A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes. Neuropharmacology. vol 102. 2016-10-07. PMID:26407764. |
binding of ce-103 to the dopamine (dat), serotonin (sert) and norepinephrine (net) transporters and dopamine reuptake inhibition was tested as well as blood brain permeation and a screen for gpcr targets. |
2016-10-07 |
2023-08-13 |
rat |
| Julie A Marusich, Kateland R Antonazzo, Bruce E Blough, Simon D Brandt, Pierce V Kavanagh, John S Partilla, Michael H Bauman. The new psychoactive substances 5-(2-aminopropyl)indole (5-IT) and 6-(2-aminopropyl)indole (6-IT) interact with monoamine transporters in brain tissue. Neuropharmacology. vol 101. 2016-09-22. PMID:26362361. |
here, the monoamine-releasing properties of 5-it, its structural isomer 6-(2-aminopropyl)indole (6-it), and mdma were compared using in vitro release assays at transporters for dopamine (dat), norepinephrine (net), and serotonin (sert) in rat brain synaptosomes. |
2016-09-22 |
2023-08-13 |
mouse |
| Friederike Matthaeus, Patrick Schloss, Thorsten La. Differential Uptake Mechanisms of Fluorescent Substrates into Stem-Cell-Derived Serotonergic Neurons. ACS chemical neuroscience. vol 6. issue 12. 2016-09-21. PMID:26503837. |
the actions of the neurotransmitters serotonin, dopamine, and norepinephrine are partly terminated by diffusion and in part by their uptake into neurons via the selective, high-affinity transporters for serotonin (sert), dopamine (dat), and norepinephrine (net), respectively. |
2016-09-21 |
2023-08-13 |
Not clear |
| Jacob Andersen, Kristoffer B Ringsted, Benny Bang-Andersen, Kristian Strømgaard, Anders S Kristense. Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter. Scientific reports. vol 5. 2016-09-15. PMID:26503701. |
the transporters for norepinephrine and dopamine (net and dat, respectively) constitute the molecular targets for recreational drugs and therapeutics used in the treatment of psychiatric disorders. |
2016-09-15 |
2023-08-13 |
human |
| Thomas Kirmeier, Ranganath Gopalakrishnan, Vanessa Gormanns, Anna M Werner, Serena Cuboni, Georg C Rudolf, Georg Höfner, Klaus T Wanner, Stephan A Sieber, Ulrike Schmidt, Florian Holsboer, Theo Rein, Felix Hausc. Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores. PloS one. vol 11. issue 2. 2016-07-14. PMID:26863431. |
to control for this, we evaluated the binding parameters of azidobupramine to known target sites such as the transporters for serotonin (sert), norepinephrine (net), and dopamine (dat). |
2016-07-14 |
2023-08-13 |
Not clear |