| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Prerna Jha, Lotten Ragnarsson, Richard J Lewi. Structure-Function of the High Affinity Substrate Binding Site (S1) of Human Norepinephrine Transporter. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32210813. |
the human norepinephrine transporter (hnet) is a member of the neurotransmitter/sodium symporter family, which also includes the neuronal monoamine transporters for serotonin (sert) and dopamine (dat). |
2020-09-28 |
2023-08-13 |
human |
| Ya-Qiu Tang, Zhuo-Ran Li, Shao-Zhi Zhang, Ping Mi, Dong-Yan Chen, Xi-Zeng Fen. Venlafaxine plus melatonin ameliorate reserpine-induced depression-like behavior in zebrafish. Neurotoxicology and teratology. vol 76. 2020-05-04. PMID:31518687. |
we tested the depressive behavior of adult zebrafish through a novel tank test, and evaluated the levels of serotonin (5-ht), dopamine (da) and noradrenaline (na) in zebrafish brain using enzyme-linked immunosorbent assay (elisa), besides that the gene expression of serotonin transporters a (serta), dopamine transporters (dat) and norepinephrine transporters (net), vesicular monoamine transporter2 (vmat2) and monoamine oxidase (mao) were evaluated by qrt-pcr. |
2020-05-04 |
2023-08-13 |
zebrafish |
| Donna Walther, Abdelrahman R Shalabi, Michael H Baumann, Richard A Glenno. Systematic Structure-Activity Studies on Selected 2-, 3-, and 4-Monosubstituted Synthetic Methcathinone Analogs as Monoamine Transporter Releasing Agents. ACS chemical neuroscience. vol 10. issue 1. 2020-02-18. PMID:30354055. |
to formulate structure-activity relationship (sar) generalities, we examined the releasing ability of several simple methcathinone analogs at the three monoamine transporters (i.e., the dopamine, norepinephrine, and serotonin transporters, dat, net, and sert, respectively) using in vitro assay methods. |
2020-02-18 |
2023-08-13 |
Not clear |
| Anna Rickli, Marius C Hoener, Matthias E Liecht. Pharmacological profiles of compounds in preworkout supplements ("boosters"). European journal of pharmacology. vol 859. 2020-01-28. PMID:31265842. |
we investigated whether substances that are contained in commercially available athletic multiple-ingredient preworkout supplements exert amphetamine-type activity at norepinephrine, dopamine, and serotonin transporters (net, dat, and sert, respectively). |
2020-01-28 |
2023-08-13 |
human |
| Felix P Mayer, Daniela Cintulova, Dorothea A Pittrich, Laurin Wimmer, Dino Luethi, Marion Holy, Kathrin Jaentsch, Sonja Tischberger, Guenter Gmeiner, Marius C Hoener, Matthias E Liechti, Marko D Mihovilovic, Harald H Sitt. Stereochemistry of phase-1 metabolites of mephedrone determines their effectiveness as releasers at the serotonin transporter. Neuropharmacology. vol 148. 2019-12-27. PMID:30610839. |
mephedrone (4-methyl-n-methylcathinone) is a psychostimulant that promotes release of monoamines via the high affinity transporters for dopamine (dat), norepinephrine (net) and serotonin (sert). |
2019-12-27 |
2023-08-13 |
human |
| Felix P Mayer, Diethart Schmid, Marion Holy, Lynette C Daws, Harald H Sitt. "Polytox" synthetic cathinone abuse: A potential role for organic cation transporter 3 in combined cathinone-induced efflux. Neurochemistry international. vol 123. 2019-12-26. PMID:30248432. |
mdpv and mephedrone interfere with the function of the high affinity transporters for dopamine (dat), norepinephrine (net) and serotonin (sert), resulting in increased extracellular levels of these monoamines, though their mechanism of action differs. |
2019-12-26 |
2023-08-13 |
Not clear |
| Alan Frazer, Greg A. Gerhardt, Lynette C. Daw. New views of biogenic amine transporter function: implications for neuropsychopharmacology. The international journal of neuropsychopharmacology. vol 2. issue 4. 2019-11-20. PMID:11285147. |
biogenic amine transporters, namely the dopamine (da), norepinephrine (ne) and 5-hydroxytryptamine (serotonin, 5-ht) transporters (dat, net and 5-htt, respectively) appear to be the key elements in regulating biogenic amine neurotransmission. |
2019-11-20 |
2023-08-12 |
Not clear |
| Umberto M Battisti, Ramsey Sitta, Alan Harris, Farhana Sakloth, Donna Walther, Iwona Ruchala, S Stevens Negus, Michael H Baumann, Richard A Glennon, Jose M Elti. Effects of N-Alkyl-4-Methylamphetamine Optical Isomers on Plasma Membrane Monoamine Transporters and Abuse-Related Behavior. ACS chemical neuroscience. vol 9. issue 7. 2019-09-30. PMID:29697951. |
4-methylamphetamine (4-ma) is an emerging drug of abuse that acts as a substrate at plasma membrane transporters for dopamine (dat), norepinephrine (net), and serotonin (sert), thereby causing nonexocytotic release of monoamine transmitters via reverse transport. |
2019-09-30 |
2023-08-13 |
rat |
| Jose Luiz Costa, Kelly Francisco Cunha, Rafael Lanaro, Ricardo Leal Cunha, Donna Walther, Michael H Bauman. Analytical quantification, intoxication case series, and pharmacological mechanism of action for N-ethylnorpentylone (N-ethylpentylone or ephylone). Drug testing and analysis. vol 11. issue 3. 2019-08-27. PMID:30207090. |
the activity of n-ethylnorpentylone at plasma membrane transporters for dopamine (dat), norepinephrine (net) and 5-ht (sert) was assessed using in vitro assays measuring uptake inhibition and evoked release of [ |
2019-08-27 |
2023-08-13 |
human |
| J A Suyama, M L Banks, S S Negu. Effects of repeated treatment with methcathinone, mephedrone, and fenfluramine on intracranial self-stimulation in rats. Psychopharmacology. vol 236. issue 3. 2019-08-27. PMID:30232529. |
synthetic cathinones constitute a class of abused drugs that can act at dopamine, norepinephrine, and serotonin transporters (dat, net, and sert, respectively). |
2019-08-27 |
2023-08-13 |
rat |
| Tatiana Sorkina, Shiqi Ma, Mads Breum Larsen, Simon C Watkins, Alexander Sorki. Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter. eLife. vol 7. 2019-07-22. PMID:29630493. |
we found that the cell-permeable furopyrimidine aim-100 promotes dramatic oligomerization, clustering and cie of human and mouse dopamine transporters (dat), but not of their close homologues, norepinephrine and serotonin transporters. |
2019-07-22 |
2023-08-13 |
mouse |
| Linda D Simmler, Matthias E Liecht. Pharmacology of MDMA- and Amphetamine-Like New Psychoactive Substances. Handbook of experimental pharmacology. vol 252. 2019-06-13. PMID:29633178. |
amphetamine-like nps induce psychostimulation and euphoria mediated predominantly by norepinephrine (ne) and dopamine (da) transporter (net and dat) inhibition and transporter-mediated release of ne and da, thus showing a more catecholamine-selective profile. |
2019-06-13 |
2023-08-13 |
Not clear |
| Brenda M Gannon, Michael H Baumann, Donna Walther, Cristian Jimenez-Morigosa, Agnieszka Sulima, Kenner C Rice, Gregory T Collin. The abuse-related effects of pyrrolidine-containing cathinones are related to their potency and selectivity to inhibit the dopamine transporter. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 12. 2019-03-11. PMID:30305739. |
synthetic cathinones are common constituents of abused "bath salts" preparations and represent a large family of structurally related compounds that function as cocaine-like inhibitors or amphetamine-like substrates of dopamine (dat), norepinephrine (net), and serotonin (sert) transporters. |
2019-03-11 |
2023-08-13 |
rat |
| Julian Maier, Felix P Mayer, Dino Luethi, Marion Holy, Kathrin Jäntsch, Harald Reither, Lena Hirtler, Marius C Hoener, Matthias E Liechti, Christian Pifl, Simon D Brandt, Harald H Sitt. The psychostimulant (±)-cis-4,4'-dimethylaminorex (4,4'-DMAR) interacts with human plasmalemmal and vesicular monoamine transporters. Neuropharmacology. vol 138. 2019-02-13. PMID:29908239. |
we used in vitro uptake inhibition and transporter release assays to determine the effects of 4,4'-dmar on human high-affinity transporters for dopamine (dat), norepinephrine (net) and serotonin (sert). |
2019-02-13 |
2023-08-13 |
human |
| Rheaclare Fraser-Spears, Anwen M Krause-Heuer, Mohamed Basiouny, Felix P Mayer, Retrouvailles Manishimwe, Naomi A Wyatt, Jeremy C Dobrowolski, Maxine P Roberts, Ivan Greguric, Naresh Kumar, Wouter Koek, Harald H Sitte, Paul D Callaghan, Benjamin H Fraser, Lynette C Daw. Comparative analysis of novel decynium-22 analogs to inhibit transport by the low-affinity, high-capacity monoamine transporters, organic cation transporters 2 and 3, and plasma membrane monoamine transporter. European journal of pharmacology. vol 842. 2019-02-04. PMID:30473490. |
here, we extend these findings to determine the affinity of these analogs for oct2, oct3 and pmat, as well as serotonin, norepinephrine and dopamine transporters (sert, net and dat) using a combination of uptake competition with [ |
2019-02-04 |
2023-08-13 |
mouse |
| Felix P Mayer, Nadine V Burchardt, Ann M Decker, John S Partilla, Yang Li, Gavin McLaughlin, Pierce V Kavanagh, Walter Sandtner, Bruce E Blough, Simon D Brandt, Michael H Baumann, Harald H Sitt. Fluorinated phenmetrazine "legal highs" act as substrates for high-affinity monoamine transporters of the SLC6 family. Neuropharmacology. vol 134. issue Pt A. 2018-11-07. PMID:28988906. |
here we tested 3-fpm and its positional isomers, 2-fpm and 4-fpm, for their abilities to interact with plasma membrane monoamine transporters for dopamine (dat), norepinephrine (net) and serotonin (sert). |
2018-11-07 |
2023-08-13 |
Not clear |
| Shaili Aggarwal, Ole V Mortense. Overview of Monoamine Transporters. Current protocols in pharmacology. vol 79. 2018-07-26. PMID:29261228. |
the dopamine (dat), serotonin (sert), and norepinephrine (net) transporters, which are collectively referred to as monoamine transporters (mats), play significant roles in regulating the neuronal response to these neurotransmitters. |
2018-07-26 |
2023-08-13 |
Not clear |
| Patrick Neiens, Angela De Simone, Anna Ramershoven, Georg Höfner, Lars Allmendinger, Klaus T Wanne. Development and validation of an LC-ESI-MS/MS method for the quantification of D-84, reboxetine and citalopram for their use in MS Binding Assays addressing the monoamine transporters hDAT, hSERT and hNET. Biomedical chromatography : BMC. vol 32. issue 7. 2018-06-25. PMID:29500932. |
in this study, we present an lc-esi-ms/ms method for the quantification of (r,r)-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol [(r,r)-d-84, (r,r)-1], (s,s)-reboxetine [(s,s)-2], and (s)-citalopram [(s)-3] employed as highly selective nonlabeled reporter ligands in ms binding assays addressing the dopamine [dat, (r,r)-d-84], norepinephrine [net, (s,s)-reboxetine] and serotonin transporter [sert, (s)-citalopram], respectively. |
2018-06-25 |
2023-08-13 |
Not clear |
| Talia Zeppelin, Lucy Kate Ladefoged, Steffen Sinning, Xavier Periole, Birgit Schiøt. A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition. PLoS computational biology. vol 14. issue 1. 2018-06-18. PMID:29329285. |
we also provide evidence, from coarse grain md simulations that the chol sites observed in the dat crystal structures are preserved in all human monoamine transporters (dopamine, serotonin and norepinephrine), suggesting that our findings might extend to the entire family. |
2018-06-18 |
2023-08-13 |
human |
| Liga Zvejniece, Baiba Svalbe, Edijs Vavers, Marina Makrecka-Kuka, Elina Makarova, Vilnis Liepins, Ivars Kalvinsh, Edgars Liepinsh, Maija Dambrov. S-phenylpiracetam, a selective DAT inhibitor, reduces body weight gain without influencing locomotor activity. Pharmacology, biochemistry, and behavior. vol 160. 2018-05-09. PMID:28743458. |
recently, it was shown that s-phenylpiracetam is a selective dopamine transporter (dat) inhibitor that does not influence norepinephrine (ne) or serotonin (5-ht) receptors. |
2018-05-09 |
2023-08-13 |
mouse |