| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yunsung Nam, Eun-Joo Shin, Seung Woo Shin, Yong Kwang Lim, Jong Ho Jung, Jeong Hyun Lee, Jong Ryul Ha, Jong Seok Chae, Sung Kwon Ko, Ji Hoon Jeong, Choon-Gon Jang, Hyoung-Chun Ki. YY162 prevents ADHD-like behavioral side effects and cytotoxicity induced by Aroclor1254 via interactive signaling between antioxidant potential, BDNF/TrkB, DAT and NET. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 65. 2014-10-28. PMID:24394491. |
furthermore, yy162 attenuated reductions in p-trkb, bdnf, dopamine transporter (dat) and norepinephrine transporter (net) expression. |
2014-10-28 |
2023-08-12 |
mouse |
| Floor van Heesch, Jolanda Prins, Jan Pieter Konsman, Gerdien A H Korte-Bouws, Koen G C Westphal, Joanna Rybka, Berend Olivier, Aletta D Kraneveld, S Mechiel Kort. Lipopolysaccharide increases degradation of central monoamines: an in vivo microdialysis study in the nucleus accumbens and medial prefrontal cortex of mice. European journal of pharmacology. vol 725. 2014-10-28. PMID:24444442. |
less is known about the effect of lps on the biological activity of dopamine transporters (dat) and norepinephrine transporters (net). |
2014-10-28 |
2023-08-12 |
mouse |
| John S Markowitz, Hao-Jie Zhu, Kennerly S Patric. Isopropylphenidate: an ester homolog of methylphenidate with sustained and selective dopaminergic activity and reduced drug interaction liability. Journal of child and adolescent psychopharmacology. vol 23. issue 10. 2014-10-06. PMID:24261661. |
a wide range of mph analogues (dl-α-[2-piperidyl]-phenylacetic acid esters) have been synthesized with the dopamine transporter (dat) and norepinephrine transporter (net) as principle neuropharmacological targets. |
2014-10-06 |
2023-08-12 |
Not clear |
| Yoshiyuki Kasahara, Yumiko Kubo, Ichiro Sor. [Analysis of dopamine transporter knockout mice as an animal model of AD/HD]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 33. issue 5-6. 2014-09-25. PMID:25069256. |
it is likely that methylphenidate and nisoxetine activate the prefrontal catecholamine systems by blocking the norepinephrine transporter (net) function, thereby helping to improve ad/hd-like behavior in dat ko mice. |
2014-09-25 |
2023-08-13 |
mouse |
| Kirsty Danielson, Fraser Putt, Penelope Truman, Bronwyn M Kivel. The effects of nicotine and tobacco particulate matter on dopamine uptake in the rat brain. Synapse (New York, N.Y.). vol 68. issue 2. 2014-08-11. PMID:23999947. |
this study has examined the acute and chronic effects of nicotine and a tobacco extract (tpm) on dopamine uptake by the dopamine and norepinephrine transporters (dat and net) ex vivo using rotating disk electrode voltammetry, and quantified dat and net protein and mrna expression in key brain regions. |
2014-08-11 |
2023-08-12 |
rat |
| Shuang Liu, Congxiang Zha, Kassoum Nacro, Min Hu, Wenge Cui, Yuh-Lin Yang, Ulhas Bhatt, Aruna Sambandam, Matthew Isherwood, Larry Yet, Michael T Herr, Sarah Ebeltoft, Carla Hassler, Linda Fleming, Anthony D Pechulis, Anne Payen-Fornicola, Nicholas Holman, Dennis Milanowski, Ian Cotterill, Vadim Mozhaev, Yuri Khmelnitsky, Peter R Guzzo, Bruce J Sargent, Bruce F Molino, Richard Olson, Dalton King, Snjezana Lelas, Yu-Wen Li, Kim Johnson, Thaddeus Molski, Anitra Orie, Alicia Ng, Roy Haskell, Wendy Clarke, Robert Bertekap, Jonathan O'Connell, Nicholas Lodge, Michael Sinz, Stephen Adams, Robert Zaczek, John E Maco. Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors. ACS medicinal chemistry letters. vol 5. issue 7. 2014-07-22. PMID:25050161. |
a series of 4-bicyclic heteroaryl 1,2,3,4-tetrahydroisoquinoline inhibitors of the serotonin transporter (sert), norepinephrine transporter (net), and dopamine transporter (dat) was discovered. |
2014-07-22 |
2023-08-13 |
mouse |
| Sucharita S Somkuwar, Chloe J Jordan, Kathleen M Kantak, Linda P Dwoski. Adolescent atomoxetine treatment in a rodent model of ADHD: effects on cocaine self-administration and dopamine transporters in frontostriatal regions. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 13. 2014-07-01. PMID:23822950. |
using the spontaneously hypertensive rat (shr) model of adhd, we reported that adolescent treatment with the stimulant methylphenidate, a dopamine (dat) and norepinephrine (net) transporter inhibitor, enhanced cocaine self-administration during adulthood, and was associated with increased dat function in mpfc. |
2014-07-01 |
2023-08-12 |
rat |
| Dean G Brown, Peter R Bernstein, Ye Wu, Rebecca A Urbanek, Christopher W Becker, Scott R Throner, Bruce T Dembofsky, Gary B Steelman, Lois A Lazor, Clay W Scott, Michael W Wood, Steven S Wesolowski, David A Nugiel, Stephanie Koch, Jian Yu, Donald E Pivonka, Shuang Li, Carol Thompson, Anna Zacco, Charles S Elmore, Patricia Schroeder, JianWei Liu, Christopher A Hurley, Stuart Ward, Hazel J Hunt, Karen Williams, Joseph McLaughlin, Valerie Hoesch, Simon Sydserff, Donna Maier, David Aharon. Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity. ACS medicinal chemistry letters. vol 4. issue 1. 2014-06-05. PMID:24900562. |
herein, we describe the discovery of inhibitors of norepinephrine (net) and dopamine (dat) transporters with reduced activity relative to serotonin transporters (sert). |
2014-06-05 |
2023-08-13 |
rat |
| Linda D Simmler, Anna Rickli, York Schramm, Marius C Hoener, Matthias E Liecht. Pharmacological profiles of aminoindanes, piperazines, and pipradrol derivatives. Biochemical pharmacology. vol 88. issue 2. 2014-04-22. PMID:24486525. |
we investigated norepinephrine (ne), dopamine (da), and serotonin (5-hydroxytryptamine [5-ht]) uptake inhibition using human embryonic kidney 293 (hek 293) cells that express the respective human monoamine transporters (net, dat, and sert). |
2014-04-22 |
2023-08-12 |
human |
| Henry A Spiller, Hannah L Hays, Alfred Alegua. Overdose of drugs for attention-deficit hyperactivity disorder: clinical presentation, mechanisms of toxicity, and management. CNS drugs. vol 27. issue 7. 2014-02-03. PMID:23757186. |
amphetamine, dextroamphetamine, and methylphenidate act as substrates for the cellular monoamine transporter, especially the dopamine transporter (dat) and less so the norepinephrine (net) and serotonin transporter. |
2014-02-03 |
2023-08-12 |
human |
| Seyed Khosrow Tayebati, Daniele Tomassoni, Innocent Ejike Nwankwo, Antonio Di Stefano, Piera Sozio, Laura Serafina Cerasa, Francesco Ament. Modulation of monoaminergic transporters by choline-containing phospholipids in rat brain. CNS & neurological disorders drug targets. vol 12. issue 1. 2013-12-23. PMID:23244432. |
the present study was designed to assess the influence of treatment for 7 days with choline-equivalent doses (cdp-choline: 325 mg/kg/day; gpc: 150 mg/kg/day) of these compounds on brain dopamine (da), and serotonin (5-ht) levels and on da plasma membrane transporter (dat), vesicular monoamine transporters (vmat1 and vmat2), serotonin transporter (sert), and norepinephrine transporter (net) in the rat. |
2013-12-23 |
2023-08-12 |
rat |
| Richard J Karpowicz, Matthew Dunn, David Sulzer, Dalibor Same. APP+, a fluorescent analogue of the neurotoxin MPP+, is a marker of catecholamine neurons in brain tissue, but not a fluorescent false neurotransmitter. ACS chemical neuroscience. vol 4. issue 5. 2013-10-22. PMID:23647019. |
app+ is a substrate for the dopamine transporter (dat), norepinephrine transporter (net), and serotonin transporter (sert), and as such represented a candidate for the development of new ffn probes. |
2013-10-22 |
2023-08-12 |
mouse |
| Inah Choi, Pitna Kim, So Hyun Joo, Min Kyeong Kim, Jin Hee Park, Hee Jin Kim, Jong Hoon Ryu, Jae Hoon Cheong, Chan Young Shi. Effects of Preconceptional Ethanol Consumption on ADHD-Like Symptoms in Sprague-Dawley Rat Offsprings. Biomolecules & therapeutics. vol 20. issue 2. 2013-10-11. PMID:24116300. |
and reduction of striatal dopamine transporter (dat) level was observed by western blot in the etoh group, compared to control (con) group, while the immunohistochemical analysis exhibited increased expression of norepinephrine transporter (net) in the frontal cortex. |
2013-10-11 |
2023-08-12 |
rat |
| Robert A Comley, Cristian A Salinas, Mark Slifstein, Marcella Petrone, Carmine Marzano, Idriss Bennacef, Paul Shotbolt, Jasper Van der Aart, Marta Neve, Laura Iavarone, Roberto Gomeni, Marc Laruelle, Frank A Gray, Roger N Gunn, Eugenii A Rabine. Monoamine transporter occupancy of a novel triple reuptake inhibitor in baboons and humans using positron emission tomography. The Journal of pharmacology and experimental therapeutics. vol 346. issue 2. 2013-09-25. PMID:23685546. |
studies were performed in baboons (papio anubis) to determine the relationship between plasma concentration and occupancy of brain serotonin reuptake transporter (sert), dopamine reuptake transporter (dat), and norepinephrine uptake transporter (net) using the radioligands [(11)c]dasb [(n,n-dimethyl-2-(2-amino-4-cyanophenylthio) benzylamine], [(11)c]pe2i [n-(3-iodoprop-2e-enyl)-2β-carbomethoxy-3β-(4-methylphenyl)nortropane], and [(11)c]2-[(2-methoxyphenoxy)phenylmethyl]morpholine (also known as [(11)c]mrb) and in humans using [(11)c]dasb and [(11)c]pe2i. |
2013-09-25 |
2023-08-12 |
Not clear |
| Sucharita S Somkuwar, Mahesh Darna, Kathleen M Kantak, Linda P Dwoski. Adolescence methylphenidate treatment in a rodent model of attention deficit/hyperactivity disorder: dopamine transporter function and cellular distribution in adulthood. Biochemical pharmacology. vol 86. issue 2. 2013-09-03. PMID:23623751. |
methylphenidate, an inhibitor of dopamine and norepinephrine transporters (dat and net, respectively), is a standard treatment for adhd. |
2013-09-03 |
2023-08-12 |
rat |
| Nicholas V Cozzi, Simon D Brandt, Paul F Daley, John S Partilla, Richard B Rothman, Andreas Tulzer, Harald H Sitte, Michael H Bauman. Pharmacological examination of trifluoromethyl ring-substituted methcathinone analogs. European journal of pharmacology. vol 699. issue 1-3. 2013-09-02. PMID:23178523. |
at the norepinephrine and dopamine transporters (net and dat), all tfmap isomers were less potent than methcathinone as uptake inhibitors and releasers. |
2013-09-02 |
2023-08-12 |
rat |
| Les Iversen, Simon Gibbons, Ric Treble, Vincent Setola, Xi-Ping Huang, Bryan L Rot. Neurochemical profiles of some novel psychoactive substances. European journal of pharmacology. vol 700. issue 1-3. 2013-08-05. PMID:23261499. |
thirteen of the test substances acted as inhibitors of monoamine uptake at submicromolar concentrations, including 9 potent inhibitors of the dopamine transporter (dat), 12 potent inhibitors of the norepinephrine transporter (net) and 4 potent inhibitors of the serotonin transporter (sert). |
2013-08-05 |
2023-08-12 |
human |
| David Devos, Caroline Moreau, Arnaud Delval, Kathy Dujardin, Luc Defebvre, Regis Borde. Methylphenidate : a treatment for Parkinson's disease? CNS drugs. vol 27. issue 1. 2013-07-03. PMID:23160937. |
methylphenidate is a cns stimulant that blocks the dat and the noradrenaline (norepinephrine) transporter in the striatum and the prefrontal cortex in particular. |
2013-07-03 |
2023-08-12 |
Not clear |
| Michael H Baumann, John S Partilla, Kurt R Lehne. Psychoactive "bath salts": not so soothing. European journal of pharmacology. vol 698. issue 1-3. 2013-06-10. PMID:23178799. |
similar to other psychomotor stimulants, synthetic cathinones target plasma membrane transporters for dopamine (i.e., dat), norepinephrine (i.e., net) and serotonin (i.e, sert). |
2013-06-10 |
2023-08-12 |
rat |
| Soumava Santra, Sanjib Gogoi, Bhaskar Gopishetty, Tamara Antonio, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Structural exploration of (3S,6S)-6-benzhydryl-N-benzyltetrahydro-2H-pyran-3-amine analogues: identification of potent triple monoamine reuptake inhibitors as potential antidepressants. ChemMedChem. vol 7. issue 12. 2013-04-29. PMID:23060293. |
the new compounds were tested for their affinities for the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net) in rat brain by measuring their capacity to inhibit the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2013-04-29 |
2023-08-12 |
rat |