| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Su-Min Li, Theresa A Kopajtic, Matthew J O'Callaghan, Gregory E Agoston, Jianjing Cao, Amy Hauck Newman, Jonathan L Kat. N-substituted benztropine analogs: selective dopamine transporter ligands with a fast onset of action and minimal cocaine-like behavioral effects. The Journal of pharmacology and experimental therapeutics. vol 336. issue 2. 2011-03-03. PMID:21088247. |
the compounds had 5.6 to 30 nm affinities at the dopamine transporter (dat), with uniformly lower affinities at norepinephrine and serotonin transporters (from 490-4600 and 1420-7350 nm, respectively). |
2011-03-03 |
2023-08-12 |
rat |
| Jonas Hannestad, Jean-Dominique Gallezot, Beata Planeta-Wilson, Shu-Fei Lin, Wendol A Williams, Christopher H van Dyck, Robert T Malison, Richard E Carson, Yu-Shin Din. Clinically relevant doses of methylphenidate significantly occupy norepinephrine transporters in humans in vivo. Biological psychiatry. vol 68. issue 9. 2011-02-15. PMID:20691429. |
in vitro, the affinity of methylphenidate for the norepinephrine transporter (net) is higher than that for the dopamine transporter (dat). |
2011-02-15 |
2023-08-12 |
Not clear |
| Barbara J Caldarone, Neil E Paterson, Jia Zhou, Daniela Brunner, Alan P Kozikowski, Koen G C Westphal, Gerdien A H Korte-Bouws, Jolanda Prins, S Mechiel Korte, Berend Olivier, Afshin Ghavam. The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties. The Journal of pharmacology and experimental therapeutics. vol 335. issue 3. 2011-02-03. PMID:20864506. |
triple reuptake inhibitors (tris) that block the dopamine transporter (dat), norepinephrine transporter, and serotonin transporter are being developed as a new class of antidepressant that may have better efficacy and fewer side effects compared with traditional antidepressants. |
2011-02-03 |
2023-08-12 |
mouse |
| Chiharu Sogawa, Chieko Mitsuhata, Kei Kumagai-Morioka, Norio Sogawa, Kazumi Ohyama, Katsuya Morita, Katsuyuki Kozai, Toshihiro Dohi, Shigeo Kitayam. Expression and function of variants of human catecholamine transporters lacking the fifth transmembrane region encoded by exon 6. PloS one. vol 5. issue 8. 2010-11-04. PMID:20700532. |
the transporters for dopamine (dat) and norepinephrine (net) are members of the na+- and cl--dependent neurotransmitter transporter family slc6. |
2010-11-04 |
2023-08-12 |
human |
| b' Mikko K\\xc3\\xa4enm\\xc3\\xa4ki, Anne Tammim\\xc3\\xa4ki, Timo My\\xc3\\xb6h\\xc3\\xa4nen, Kaisa Pakarinen, Carolina Amberg, Maria Karayiorgou, Joseph A Gogos, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice. Journal of neurochemistry. vol 114. issue 6. 2010-10-19. PMID:20626558.' |
because of low levels of dopamine transporter (dat), it is proposed that the majority of released da is taken up by either norepinephrine transporter (net) and subsequently metabolized by monoamine oxidize (mao) or by uptake(2) (to glial cells and post-synaptic neurons) and metabolized by comt. |
2010-10-19 |
2023-08-12 |
mouse |
| Peng Zhang, George Cyriac, Theresa Kopajtic, Yongfang Zhao, Jonathan A Javitch, Jonathan L Katz, Amy Hauck Newma. Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters. Journal of medicinal chemistry. vol 53. issue 16. 2010-09-16. PMID:20672825. |
to further explore structure-activity relationships at the serotonin transporter (sert), a series of (+/-)-4- and 5-substituted citalopram analogues were designed, synthesized, and evaluated for binding at the sert, dopamine transporter (dat) and norepinephrine transporter (net) in native rodent tissue. |
2010-09-16 |
2023-08-12 |
Not clear |
| Jeffrey S Stehouwer, Lauryn M Daniel, Ping Chen, Ronald J Voll, Larry Williams, Susan J Plott, John R Votaw, Michael J Owens, Leonard Howell, Mark M Goodma. Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomography. Journal of medicinal chemistry. vol 53. issue 15. 2010-09-08. PMID:20597489. |
in vitro competition binding assays demonstrated that compounds 9-12 have a high affinity for the dat and are selective for the dat compared to the serotonin and norepinephrine transporters. |
2010-09-08 |
2023-08-12 |
monkey |
| Gang Zhao, Jie Wang, Guo-Wei Qin, Li-He Gu. Cynomorium songaricum extracts functionally modulate transporters of gamma-aminobutyric acid and monoamine. Neurochemical research. vol 35. issue 4. 2010-08-02. PMID:20084455. |
here, we assessed these potential actions using chinese hamster ovary cells expressing gamma-aminobutyric acid (gaba) transporter (gat-1), dopamine transporter (dat), norepinephrine transporter (net), or serotonin transporter (sert) (i.e. |
2010-08-02 |
2023-08-12 |
Not clear |
| Dianca R Graham, Anita Sidh. Mice expressing the A53T mutant form of human alpha-synuclein exhibit hyperactivity and reduced anxiety-like behavior. Journal of neuroscience research. vol 88. issue 8. 2010-07-12. PMID:20077428. |
in this study, we examined the effect of the ha53t mutation during development by analyzing the protein expression of norepinephrine (net), serotonin (sert), and dopamine (dat) transporters in addition to assessing locomotor and anxiety-like behavior. |
2010-07-12 |
2023-08-12 |
mouse |
| Jermaine D Jones, F Scott Hall, George R Uhl, Anthony L Rile. Dopamine, norepinephrine and serotonin transporter gene deletions differentially alter cocaine-induced taste aversion. Pharmacology, biochemistry, and behavior. vol 94. issue 4. 2010-04-29. PMID:19969013. |
monoamine transporter knockout mice have been useful in the study of many different aspects of cocaine effects relevant to human drug use and addiction, yet an assessment of the effects of deletion of the genes for the dopamine, norepinephrine and serotonin transporters (dat, net, and sert, respectively) on cocaine's aversive properties has yet to be performed (uhl et al., 2002). |
2010-04-29 |
2023-08-12 |
mouse |
| Yusuke Shibui, Xi Jun He, Kazuyuki Uchida, Hiroyuki Nakayam. MPTP-induced neuroblast apoptosis in the subventricular zone is not regulated by dopamine or other monoamine transporters. Neurotoxicology. vol 30. issue 6. 2010-03-09. PMID:19616025. |
the aim of this study is to elucidate the role of dat and other monoamine transporters including vesicular monoamine transporter 2 (vmat2), the serotonin transporter (sert), and the norepinephrine transporter (net) on the neuroblast apoptosis induced by mptp administration. |
2010-03-09 |
2023-08-12 |
mouse |
| Alex Ward, Vyvyca J Walker, Zhaoyang Feng, X Z Shawn X. Cocaine modulates locomotion behavior in C. elegans. PloS one. vol 4. issue 6. 2009-11-17. PMID:19536276. |
cocaine, a potent addictive substance, is an inhibitor of monoamine transporters, including dat (dopamine transporter), sert (serotonin transporter) and net (norepinephrine transporter). |
2009-11-17 |
2023-08-12 |
caenorhabditis_elegans |
| F S Hall, X-F Li, J Randall-Thompson, I Sora, D L Murphy, K-P Lesch, M Caron, G R Uh. Cocaine-conditioned locomotion in dopamine transporter, norepinephrine transporter and 5-HT transporter knockout mice. Neuroscience. vol 162. issue 4. 2009-11-10. PMID:19482066. |
the behavioral effects of cocaine are affected by gene knockout (ko) of the dopamine transporter (dat), the serotonin transporter (sert) and the norepinephrine transporter (net). |
2009-11-10 |
2023-08-12 |
mouse |
| Prashant S Kharkar, Angela M Batman, Juan Zhen, Patrick M Beardsley, Maarten E A Reith, Aloke K Dutt. Synthesis and biological characterization of (3R,4R)-4-(2-(benzhydryloxy)ethyl)-1-((R)-2-hydroxy-2-phenylethyl)-piperidin-3-ol and its stereoisomers for activity toward monoamine transporters. ChemMedChem. vol 4. issue 7. 2009-10-08. PMID:19449323. |
in vitro uptake inhibition data of these molecules indicate high affinity for the dopamine transporter (dat) in addition to moderate to high affinity for the norepinephrine transporter (net). |
2009-10-08 |
2023-08-12 |
mouse |
| Christian J Fehske, Kristina Leuner, Walter E Mülle. Ginkgo biloba extract (EGb761) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatment. Pharmacological research. vol 60. issue 1. 2009-09-25. PMID:19427589. |
here, we confirm that the norepinephrine (net), the serotonin (sert), the dopamine (dat) uptake transporters and mao activity are inhibited by egb761 in vitro, although rather high concentrations are required for inhibition of mao-a and mao-b activity. |
2009-09-25 |
2023-08-12 |
mouse |
| Gang Zhao, Cheng Bi, Guo-Wei Qin, Li-He Gu. Caulis Sinomenii extracts activate DA/NE transporter and inhibit 5HT transporter. Experimental biology and medicine (Maywood, N.J.). vol 234. issue 8. 2009-09-10. PMID:19491370. |
we assessed whether qft would be biologically active in functionally regulating monoamine transporters using cho cells expressing dopamine transporter (dat), norepinephrine transporter (net), or serotonin transporter (sert) (i.e. |
2009-09-10 |
2023-08-12 |
Not clear |
| Gang Zhao, Xiang-Wei Zheng, Yue Gai, Wen-Jing Chu, Guo-Wei Qin, Li-He Gu. Safflower extracts functionally regulate monoamine transporters. Journal of ethnopharmacology. vol 124. issue 1. 2009-09-09. PMID:19527825. |
our current results showed that all solvent-extracted hh fractions, in different degrees, markedly increased both dopamine uptake by chinese hamster ovary (cho) cells stably expressing dopamine transporter (dat) and norepinephrine uptake by cho cells expressing norepinephrine transporter (net), and also showed that chloroform (hc), ethyl acetate (he), and n-butyl alcohol extract strikingly depressed serotonin uptake by cho cells expressing serotonin transporter (sert); wherein, the potencies of ethanol extract, hc, he, and aqueous extract to up-regulate dopamine/norepinephrine uptake and potency of he to inhibit serotonin uptake were relatively stronger. |
2009-09-09 |
2023-08-12 |
rat |
| B Meyers, M F Kritze. In vitro binding assays using (3)H nisoxetine and (3)H WIN 35,428 reveal selective effects of gonadectomy and hormone replacement in adult male rats on norepinephrine but not dopamine transporter sites in the cerebral cortex. Neuroscience. vol 159. issue 1. 2009-06-25. PMID:19138725. |
specifically, (3)h win 35,428 and (3)h nisoxetine, ligands selective for the dopamine (dat)- and norepinephrine transporter (net) respectively, were used in in vitro binding assays to ask whether gonadectomy altered transporter affinity (kd) and/or binding site number (bmax) in prefrontal cortex, sensorimotor cortex and/or caudate. |
2009-06-25 |
2023-08-12 |
rat |
| Michael Y Aksenov, Marina V Aksenova, Janelle M Silvers, Charles F Mactutus, Rosemarie M Booz. Different effects of selective dopamine uptake inhibitors, GBR 12909 and WIN 35428, on HIV-1 Tat toxicity in rat fetal midbrain neurons. Neurotoxicology. vol 29. issue 6. 2009-03-26. PMID:18606182. |
in this study, we found that the selective inhibitor of dopamine transporter (dat) function, 1-[2-[bis(4-fluorophenyl) methoxy]ethyl]-4-(3-phenylpropyl) piperazine (gbr 12909, vanoxerine), but not the selective inhibitors of serotonin and norepinephrine (sert and net) transporters, sertraline and nizoxetine, emulated cocaine-mediated enhancement of tat neurotoxicity in rat fetal midbrain primary cell cultures. |
2009-03-26 |
2023-08-12 |
rat |
| Lynette C Daw. Unfaithful neurotransmitter transporters: focus on serotonin uptake and implications for antidepressant efficacy. Pharmacology & therapeutics. vol 121. issue 1. 2009-03-18. PMID:19022290. |
biogenic amine transporters for serotonin, norepinephrine and dopamine (sert, net and dat respectively), are the key players terminating transmission of these amines in the central nervous system by their high-affinity uptake. |
2009-03-18 |
2023-08-12 |
Not clear |