| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zheng Zhou, Juan Zhen, Nathan K Karpowich, Regina M Goetz, Christopher J Law, Maarten E A Reith, Da-Neng Wan. LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science (New York, N.Y.). vol 317. issue 5843. 2007-09-21. PMID:17690258. |
tricyclic antidepressants exert their pharmacological effect-inhibiting the reuptake of serotonin, norepinephrine, and dopamine-by directly blocking neurotransmitter transporters (sert, net, and dat, respectively) in the presynaptic membrane. |
2007-09-21 |
2023-08-12 |
human |
| Vishakantha Murthy, Huw M L Davies, Simon J Hedley, Steven R Childer. Irreversible binding of a novel phenylisothiocyanate tropane analog to monoamine transporters in rat brain. Biochemical pharmacology. vol 74. issue 2. 2007-08-16. PMID:17540345. |
irreversible tropane analogs have been useful in identifying binding sites of cocaine on biogenic amine transporters, including transporters for dopamine (dat), serotonin (sert) and norepinephrine (net). |
2007-08-16 |
2023-08-12 |
rat |
| Michael Decker, Jochen Lehman. Agonistic and antagonistic bivalent ligands for serotonin and dopamine receptors including their transporters. Current topics in medicinal chemistry. vol 7. issue 4. 2007-06-07. PMID:17305576. |
selectivity profiles and affinities depend strongly on the length of the alkylene-spacer: for some dimeric inhibitors the norepinephrine transporter (net) and the dopamine transporter (dat) affinities changed gradually, but for the serotonin transporter (sert) a pentamethylene spacer showed the highest potency. |
2007-06-07 |
2023-08-12 |
Not clear |
| Nianhang Chen, Maarten E A Reit. Substrates and inhibitors display different sensitivity to expression level of the dopamine transporter in heterologously expressing cells. Journal of neurochemistry. vol 101. issue 2. 2007-06-01. PMID:17250655. |
transiently expressing intact hek293 cells, transfected with increasing amounts of dat cdna, displayed increasing levels of surface dat, binding of the cocaine analog [(3)h]2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane ([(3)h]cft), and uptake of [(3)h]da, [(3)h]n-methyl-4-phenylpyridinium ([(3)h]mpp(+)), [(3)h]norepinephrine, and [(3)h]serotonin. |
2007-06-01 |
2023-08-12 |
human |
| C Sogawa, N Sogawa, J Tagawa, A Fujino, K Ohyama, M Asanuma, M Funada, S Kitayam. 5-Methoxy-N,N-diisopropyltryptamine (Foxy), a selective and high affinity inhibitor of serotonin transporter. Toxicology letters. vol 170. issue 1. 2007-06-01. PMID:17382495. |
in the present study, we investigated the actions of 5-meo-dipt against monoamine neurotransmitter transporters, including the transporters for dopamine (dat), norepinephrine (net), and serotonin (sert), using cos-7 cells heterologously expressing these transporters and rat brain synaptosomes. |
2007-06-01 |
2023-08-12 |
rat |
| J W Schwartz, D Piston, L J DeFelic. Molecular microfluorometry: converting arbitrary fluorescence units into absolute molecular concentrations to study binding kinetics and stoichiometry in transporters. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722229. |
cotransport in norepinephrine (net), epinephrine (epit), dopamine (dat), and serotonin (sert) transporters couples downhill na+ flux to uphill transmitter flux. |
2007-05-23 |
2023-08-12 |
Not clear |
| Xiang Liu, Samuel D Banister, MacDonald J Christie, Richard Banati, Steve Meikle, Mark J Coster, Michael Kassio. Trishomocubanes: novel sigma ligands modulate cocaine-induced behavioural effects. European journal of pharmacology. vol 555. issue 1. 2007-04-26. PMID:17113074. |
both compounds have negligible affinity for the dopamine (dat), serotonin (sert), and norepinephrine (net) transporters. |
2007-04-26 |
2023-08-12 |
Not clear |
| Piotr Popik, Martyna Krawczyk, Krystyna Golembiowska, Gabriel Nowak, Aaron Janowsky, Phil Skolnick, Arnold Lippa, Anthony S Basil. Pharmacological profile of the "triple" monoamine neurotransmitter uptake inhibitor, DOV 102,677. Cellular and molecular neurobiology. vol 26. issue 4-6. 2007-04-24. PMID:16636898. |
radioligand binding to the dopamine (dat), norepinephrine (net), and serotonin (sert) transporters is inhibited with k (i) values of 222, 1030, and 740 nm, respectively. |
2007-04-24 |
2023-08-12 |
mouse |
| Linda P Dwoskin, Anthony S Rauhut, Kelley A King-Pospisil, Michael T Bard. Review of the pharmacology and clinical profile of bupropion, an antidepressant and tobacco use cessation agent. CNS drug reviews. vol 12. issue 3-4. 2007-03-02. PMID:17227286. |
bupropion hydrochloride ((+/-)-2-tert-butylamino)-3'-chloropropiophenone x hcl) is a nonselective inhibitor of the dopamine transporter (dat) and the norepinephrine transporter (net) and is also an antagonist at neuronal nicotinic acetylcholine receptors (nachrs). |
2007-03-02 |
2023-08-12 |
human |
| John S Markowitz, C Lindsay DeVane, Linda K Pestreich, Kennerly S Patrick, Rafael Muni. A comprehensive in vitro screening of d-, l-, and dl-threo-methylphenidate: an exploratory study. Journal of child and adolescent psychopharmacology. vol 16. issue 6. 2007-03-01. PMID:17201613. |
d-mph exhibited prominent affinity at the norepinephrine transporter (net) site, even exceeding such affinity at the dopamine transporter (dat). |
2007-03-01 |
2023-08-12 |
Not clear |
| Stanley Caveney, Wendy Cladman, LouAnn Verellen, Cam Donl. Ancestry of neuronal monoamine transporters in the Metazoa. The Journal of experimental biology. vol 209. issue Pt 24. 2007-02-28. PMID:17142674. |
furthermore, the genes for dopamine and norepinephrine transporters of vertebrates are paralogous, apparently having arisen through duplication of an invertebrate mat gene after the loss of an invertebrate-type dat gene in a basal protochordate. |
2007-02-28 |
2023-08-12 |
Not clear |
| Jeffrey S Stehouwer, Nachwa Jarkas, Fanxing Zeng, Ronald J Voll, Larry Williams, Michael J Owens, John R Votaw, Mark M Goodma. Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. Journal of medicinal chemistry. vol 49. issue 23. 2007-01-19. PMID:17154506. |
2beta-carbomethoxy-3beta-(3'-((z)-2-iodoethenyl)phenyl)nortropane (mzient, 1) and 2beta-carbomethoxy-3beta-(3'-((z)-2-bromoethenyl)phenyl)nortropane (mzbrent, 2) were synthesized and evaluated for binding to the human serotonin, dopamine, and norepinephrine transporters (sert, dat, and net, respectively) using transfected cells. |
2007-01-19 |
2023-08-12 |
human |
| Yu-Shin Ding, Kuo-Shyan Lin, Jean Loga. PET imaging of norepinephrine transporters. Current pharmaceutical design. vol 12. issue 30. 2007-01-03. PMID:17073682. |
the fact that all three monoamine (dopamine, norepinephrine, and serotonin) transporters (dat, net and sert) are involved in various neurological and psychiatric diseases further emphasizes the need to develop suitable net ligands so that researchers will be able to probe the contributions of each monoamine transporter system to specific cns disorders. |
2007-01-03 |
2023-08-12 |
Not clear |
| Bertha K Madras, Zhihua Xie, Zhicheng Lin, Amy Jassen, Helen Panas, Laurie Lynch, Ryan Johnson, Eli Livni, Thomas J Spencer, Ali A Bonab, Gregory M Miller, Alan J Fischma. Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16885432. |
we postulated that modafinil enhances wakefulness by modulating dopamine (dat), norepinephrine (net), or serotonin (sert) transporter activities. |
2006-12-04 |
2023-08-12 |
human |
| Bertha K Madras, Zhihua Xie, Zhicheng Lin, Amy Jassen, Helen Panas, Laurie Lynch, Ryan Johnson, Eli Livni, Thomas J Spencer, Ali A Bonab, Gregory M Miller, Alan J Fischma. Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16885432. |
in vitro, modafinil inhibited [(3)h]dopamine (ic(50) = 6.4 microm), [(3)h]norepinephrine (ic(50) = 35.6 microm), and [(3)h]serotonin (ic(50) > 500 microm) transport via the human dat, net, and sert. |
2006-12-04 |
2023-08-12 |
human |
| Bertha K Madras, Michele A Fahey, Martin Goulet, Zhicheng Lin, Jacob Bendor, Claudia Goodrich, Peter C Meltzer, David R Elmaleh, Eli Livni, Ali A Bonab, Alan J Fischma. Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16885433. |
four potent dat inhibitors, with relatively high norepinephrine transporter, but low sert affinities, that occupied the dat improved activity in parkinsonian monkeys, whereas three high-affinity dat inhibitors with low dat occupancy did not. |
2006-12-04 |
2023-08-12 |
monkey |
| Mu-Fa Zou, Jianjing Cao, Theresa Kopajtic, Rajeev I Desai, Jonathan L Katz, Amy Hauck Newma. Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation. Journal of medicinal chemistry. vol 49. issue 21. 2006-12-04. PMID:17034144. |
when the (s)-2-carboalkoxy substituent was replaced with (s)-2-ethenyl, the resulting analogue 11 demonstrated the highest dat binding affinity in the series (k(i) = 1.81 nm) with dat selectivity over serotonin transporters (sert; 989-fold), norepinephrine transporters (net; 261-fold) and muscarinic receptors (90-fold). |
2006-12-04 |
2023-08-12 |
human |
| Janusz K Rybakowski, Alina Borkowska, Piotr M Czerski, Monika Dmitrzak-Weglarz, Maria Skibinska, Pawel Kapelski, Joanna Hause. Performance on the Wisconsin Card Sorting Test in schizophrenia and genes of dopaminergic inactivation (COMT, DAT, NET). Psychiatry research. vol 143. issue 1. 2006-11-09. PMID:16712949. |
the aim of the study was to test an association between polymorphisms of genes connected with dopaminergic inactivation in prefrontal cortex [catechol-o-methyltransferase (comt), dopamine transporter (dat), norepinephrine transporter (net)], and performance on the wisconsin card sorting test (wcst), in schizophrenic patients. |
2006-11-09 |
2023-08-12 |
cat |
| Motoyasu Yamashita, Setsu Fukushima, Hao-wei Shen, F Scott Hall, George R Uhl, Yohtaro Numachi, Hideaki Kobayashi, Ichiro Sor. Norepinephrine transporter blockade can normalize the prepulse inhibition deficits found in dopamine transporter knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 10. 2006-11-01. PMID:16407898. |
treatments with high dose psychostimulants that block dat as well as the norepinephrine (net) and serotonin (sert) transporters (60 mg/kg cocaine or methylphenidate) significantly impaired ppi in wild-type mice. |
2006-11-01 |
2023-08-12 |
mouse |
| Fanxing Zeng, Nachwa Jarkas, Michael J Owens, Clinton D Kilts, Charles B Nemeroff, Mark M Goodma. Synthesis and monoamine transporter affinity of front bridged tricyclic 3beta-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2beta-position. Bioorganic & medicinal chemistry letters. vol 16. issue 17. 2006-10-16. PMID:16784855. |
a series of front bridged tricyclic 3beta-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2beta-position was synthesized, and their binding affinities were determined in cells transfected to express human norepinephrine transporter (net), serotonin transporter (sert), and dopamine transporter (dat) via competition binding assays. |
2006-10-16 |
2023-08-12 |
human |