| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susan M Learned-Coughlin, Mats Bergström, Irina Savitcheva, John Ascher, Virginia D Schmith, Bengt Långstro. In vivo activity of bupropion at the human dopamine transporter as measured by positron emission tomography. Biological psychiatry. vol 54. issue 8. 2004-01-12. PMID:14550679. |
converging lines of evidence are consistent with an inhibitory effect of the antidepressant and smoking-cessation aid bupropion on dopamine and norepinephrine reuptake, but the in vivo effects of the drug at the human dopamine transporter (dat) have not been studied to date. |
2004-01-12 |
2023-08-12 |
human |
| Raul R Gainetdinov, Marc G Caro. Monoamine transporters: from genes to behavior. Annual review of pharmacology and toxicology. vol 43. 2003-09-09. PMID:12359863. |
these transporters for dopamine (dat), serotonin (sert), and norepinephrine (net), which are expressed selectively on the corresponding neurons, are established targets of many psychostimulants, antidepressants, and neurotoxins. |
2003-09-09 |
2023-08-12 |
mouse |
| Jianjing Cao, Santosh S Kulkarni, Stephen M Husbands, Wayne D Bowen, Wanda Williams, Theresa Kopajtic, Jonathan L Katz, Clifford George, Amy Hauck Newma. Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents. Journal of medicinal chemistry. vol 46. issue 13. 2003-07-15. PMID:12801223. |
a second series of bis(4'-fluorophenyl)amine analogues have now been prepared in which the most potent dat compound, 19 (k(i) = 8.5 nm), was selective over serotonin transporter (sert/dat = 94), norepinephrine transporter (net/dat = 63), and sigma(1) receptor binding (sigma(1)/dat = 44). |
2003-07-15 |
2023-08-12 |
Not clear |
| Rohit B Kolhatkar, Sujit K Ghorai, Clifford George, Maarten E A Reith, Aloke K Dutt. Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine. Journal of medicinal chemistry. vol 46. issue 11. 2003-06-23. PMID:12747792. |
all novel compounds were tested for their affinity at the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in competing for the binding of [3h]win 35 428, [3h]citalopram, and [3h]nisoxetine, respectively. |
2003-06-23 |
2023-08-12 |
Not clear |
| Hiroshi Takeda, Masato Inazu, Teruhiko Matsumiy. Astroglial dopamine transport is mediated by norepinephrine transporter. Naunyn-Schmiedeberg's archives of pharmacology. vol 366. issue 6. 2003-06-04. PMID:12444505. |
reverse transcription-polymerase chain reaction (rt-pcr) with da transporter (dat)-, norepinephrine (ne) transporter (net)- and organic cation transporter 3 (oct3)-specific primers demonstrated that rat cortical astrocytes and frontal cortex expressed dat, net and oct3 mrna. |
2003-06-04 |
2023-08-12 |
rat |
| Elisabeth Greiner, Thomas Prisinzano, Edward M Johnson, Christina M Dersch, Jamila Marcus, John S Partilla, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine. Journal of medicinal chemistry. vol 46. issue 8. 2003-05-08. PMID:12672246. |
a series of 4-[2-[bis(4-fluorophenyl)methoxy]ethyl-1-benzylpiperidines were examined for their ability to bind to the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net). |
2003-05-08 |
2023-08-12 |
Not clear |
| Mark M Goodman, Ping Chen, Christophe Plisson, Laurent Martarello, James Galt, John R Votaw, Clinton D Kilts, Gene Malveaux, Vernon M Camp, Bing Shi, Timothy D Ely, Leonard Howell, Jon McConathy, Charles B Nemerof. Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography. Journal of medicinal chemistry. vol 46. issue 6. 2003-04-07. PMID:12620070. |
competition binding in cells stably expressing the transfected human sert, dopamine transporter (dat), and norepinephrine transporter (net) using [(3)h]citalopram, [(3)h]win 35,428, and [(3)h]nisoxetine, respectively, demonstrated the following order of sert affinity (k(i) in nm): zient (0.05) > nor-cit (0.12) >> eient (1.15) > fluvoxamine (1.46). |
2003-04-07 |
2023-08-12 |
human |
| Toshihiro Dohi, Shigeo Kitayama, Key Kumagai, Wataru Hashimoto, Katsuya Morit. [Pharmacology of monoamine neurotransmitter transporters]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 120. issue 5. 2003-03-12. PMID:12491807. |
following exocytotic release, the biogenic amine neurotransmitters, norepinephrine, dopamine, and serotonin are removed from the synaptic cleft by the respective transporter, net, dat, and sert, located on the plasma membrane and then re-stored into synaptic vesicles by vesicular monoamine transporter, vmat. |
2003-03-12 |
2023-08-12 |
Not clear |
| Päivi Marjamäki, Jörg Zessin, Olli Eskola, Tove Grönroos, Merja Haaparanta, Jörgen Bergman, Pertti Lehikoinen, Sarita Forsback, Peter Brust, Jörg Steinbach, Olof Soli. S-[18F]fluoromethyl-(+)-McN5652, a PET tracer for the serotonin transporter: evaluation in rats. Synapse (New York, N.Y.). vol 47. issue 1. 2003-03-07. PMID:12422372. |
gbr12909 and nisoxetine, selective inhibitors for dopamine transporter (dat) and norepinephrine transporter (net), respectively, showed no significant effects on the uptake of [(18)f]fme-mcn. |
2003-03-07 |
2023-08-12 |
rat |
| M K Hahn, R D Blakel. Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders. The pharmacogenomics journal. vol 2. issue 4. 2003-02-10. PMID:12196911. |
the norepinephrine, dopamine and serotonin transporters (net, dat and sert, respectively), limit cellular signaling by recapturing released neurotransmitter, and serve as targets for antidepressants and drugs of abuse, emphasizing the integral role these molecules play in neurotransmission and pathology. |
2003-02-10 |
2023-08-12 |
human |
| Bruce R Stevens, Daniel H Feldman, Zhilin Liu, William R Harve. Conserved tyrosine-147 plays a critical role in the ligand-gated current of the epithelial cation/amino acid transporter/channel CAATCH1. The Journal of experimental biology. vol 205. issue Pt 16. 2003-02-07. PMID:12124378. |
this tyrosine residue is conserved within the third transmembrane domain in members of the na(+):neurotransmitter transporter family (snf), where it plays a role in binding pharmacological ligands such as cocaine to the serotonin (sert), dopamine (dat) and norepinephrine (net) transporters. |
2003-02-07 |
2023-08-12 |
xenopus_laevis |
| Kentaro Wakayama, Sumio Ohtsuki, Hitomi Takanaga, Ken-ichi Hosoya, Tetsuya Terasak. Localization of norepinephrine and serotonin transporter in mouse brain capillary endothelial cells. Neuroscience research. vol 44. issue 2. 2002-12-04. PMID:12354632. |
mrna expression of norepinephrine transporter (net) and serotonin transporter (sert) has been detected in a conditionally immortalized mouse brain capillary endothelial cell line (tm-bbb4) used as an in vitro model of the bbb, whereas no dopamine transporter (dat) was detected. |
2002-12-04 |
2023-08-12 |
mouse |
| Andy N Mead, Beatriz A Rocha, David M Donovan, Jonathan L Kat. Intravenous cocaine induced-activity and behavioural sensitization in norepinephrine-, but not dopamine-transporter knockout mice. The European journal of neuroscience. vol 16. issue 3. 2002-11-08. PMID:12193195. |
previously, it was reported that both norepinephrine transporter (net) and dopamine transporter (dat) knockout (ko) mice were sensitive to the reinforcing effects of cocaine. |
2002-11-08 |
2023-08-12 |
mouse |
| Shunichi Oya, Seok Rye Choi, Heinz Coenen, Hank F Kun. New PET imaging agent for the serotonin transporter: [(18)F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine). Journal of medicinal chemistry. vol 45. issue 21. 2002-11-05. PMID:12361398. |
in vitro binding assays using cell membrane homogenates of llc cells expressing sert, dopamine transporters (dat), or norepinephrine transporters (net) showed excellent binding affinity and selectivity for sert (k(i) = 0.05, 3020, and 650 nm for sert, dat, and net, respectively). |
2002-11-05 |
2023-08-12 |
rat |
| Saira K Shahani, Ratnakumari Lingamaneni, Hugh C Hemming. General anesthetic actions on norepinephrine, dopamine, and gamma-aminobutyric acid transporters in stably transfected cells. Anesthesia and analgesia. vol 95. issue 4. 2002-10-28. PMID:12351264. |
we analyzed the effects of representative volatile and iv general anesthetics on recombinant transporters for norepinephrine (human net), dopamine (rat dat), or gamma-aminobutyric acid (rat gat-1) stably expressed in a porcine kidney cell line (llc-pk(1)). |
2002-10-28 |
2023-08-12 |
human |
| Amy Hauck Newman, Santosh Kulkarn. Probes for the dopamine transporter: new leads toward a cocaine-abuse therapeutic--A focus on analogues of benztropine and rimcazole. Medicinal research reviews. vol 22. issue 5. 2002-10-24. PMID:12210554. |
nevertheless, investigation of the serotonin (sert) and norepinephrine (net) transporters, as well as other receptor systems, with which cocaine either directly or indirectly interacts, has suggested that the dat is not solely responsible for the reinforcing effects of cocaine. |
2002-10-24 |
2023-08-12 |
Not clear |
| W L Woolverton, R Ranaldi, Z Wang, G A Ordway, I A Paul, P Petukhov, A Kozikowsk. Reinforcing strength of a novel dopamine transporter ligand: pharmacodynamic and pharmacokinetic mechanisms. The Journal of pharmacology and experimental therapeutics. vol 303. issue 1. 2002-10-21. PMID:12235253. |
for in vitro binding in monkey brain tissue, (+)-cpca was about one-half as potent as cocaine at the dopamine transporter (dat), and the two compounds had similar affinities at the norepinephrine transporter. |
2002-10-21 |
2023-08-12 |
rat |
| Thomas Prisinzano, Elisabeth Greiner, Edward M Johnson, Christina M Dersch, Jamila Marcus, John S Partilla, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Piperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909): high affinity ligands for the dopamine transporter. Journal of medicinal chemistry. vol 45. issue 19. 2002-10-01. PMID:12213078. |
a series of 4-[2-[bis(4-fluorophenyl)methoxy]ethylpiperidines were examined for their ability to bind to the dopamine transporter (dat), the norepinephrine transporter, and the serotonin transporter (sert). |
2002-10-01 |
2023-08-12 |
Not clear |
| Rajani Maiya, Kari J Buck, R Adron Harris, R Dayne Mayfiel. Ethanol-sensitive sites on the human dopamine transporter. The Journal of biological chemistry. vol 277. issue 34. 2002-09-23. PMID:12070173. |
in the present study, ethanol potentiated the function of dat expressed in hela cells but inhibited the function of the related norepinephrine transporter (net). |
2002-09-23 |
2023-08-12 |
human |
| Dennis K Miller, Sangeetha P Sumithran, Linda P Dwoski. Bupropion inhibits nicotine-evoked [(3)H]overflow from rat striatal slices preloaded with [(3)H]dopamine and from rat hippocampal slices preloaded with [(3)H]norepinephrine. The Journal of pharmacology and experimental therapeutics. vol 302. issue 3. 2002-09-18. PMID:12183670. |
bupropion, an efficacious antidepressant and smoking cessation agent, inhibits dopamine and norepinephrine transporters (dat and net, respectively). |
2002-09-18 |
2023-08-12 |
rat |