| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z Zhuang, S Choi, C Hou, M Mu, M Kung, P D Acton, H F Kun. A novel serotonin transporter ligand: (5-iodo-2-(2-dimethylaminomethylphenoxy)-benzyl alcohol. Nuclear medicine and biology. vol 27. issue 2. 2000-07-27. PMID:10773546. |
dopamine [dat], norepinephrine [net], and sert, respectively), odam showed a strong inhibition on sert (k(i) = 0.12 +/- 0.02 nm). |
2000-07-27 |
2023-08-12 |
rat |
| M M Goodman, C D Kilts, R Keil, B Shi, L Martarello, D Xing, J Votaw, T D Ely, P Lambert, M J Owens, V M Camp, E Malveaux, J M Hoffma. 18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters. Nuclear medicine and biology. vol 27. issue 1. 2000-07-07. PMID:10755640. |
competition binding in cells stably expressing the transfected human dat serotonin transporter (sert) and norepinephrine transporter (net) labeled by [3h]win 35428, [3h]citalopram, and [3h]nisoxetine, respectively, indicated the following order of dat affinity: gbr 12909 > cit >> 2beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(3-fluoropropyl) nortropane (fpct) > fecnt. |
2000-07-07 |
2023-08-12 |
human |
| A Hoepping, K M Johnson, C George, J Flippen-Anderson, A P Kozikowsk. Novel conformationally constrained tropane analogues by 6-endo-trig radical cyclization and stille coupling - switch of activity toward the serotonin and/or norepinephrine transporter. Journal of medicinal chemistry. vol 43. issue 10. 2000-06-29. PMID:10821718. |
(1s,3r, 6s)-(z)-9-(thienylmethylene)-7-azatricyclo[4.3.1.0(3, 7)]decane-2beta-carboxylic acid methyl ester (5h) exhibits reasonable activity at the dopamine transporter (dat) (k(i) = 268 nm) and good activity at the norepinephrine transporter (net) (k(i) = 26 nm). |
2000-06-29 |
2023-08-12 |
rat |
| H Umegaki, H Ikari, H Nakahata, J Yoshimura, H Endo, T Yamamoto, A Iguch. Low plasma epinephrine in elderly female subjects of dementia of Alzheimer type. Brain research. vol 858. issue 1. 2000-04-25. PMID:10700598. |
in the present study, we measured the plasma level of epinephrine, norepinephrine, dopamine, glucose, and insulin during a fasting state in the morning in hospitalized dat (n=66), vascular dementia (vd) (n=28), or non-demented (nd) (n=21) females (mean age dat=82. |
2000-04-25 |
2023-08-12 |
human |
| S Wang, S Sakamuri, I J Enyedy, A P Kozikowski, O Deschaux, B C Bandyopadhyay, S R Tella, W A Zaman, K M Johnso. Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies. Journal of medicinal chemistry. vol 43. issue 3. 2000-03-13. PMID:10669562. |
a novel, fairly potent dopamine transporter (dat) inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone (3, k(i) values of 492 and 360 nm in binding affinity and inhibition of dopamine reuptake, respectively), with significant functional antagonism against cocaine and a different in vitro pharmacological profile from cocaine at the three transporter sites (dopamine, serotonin, and norepinephrine) was discovered through 3d-database pharmacophore searching. |
2000-03-13 |
2023-08-12 |
mouse |
| S W Choi, D R Elmaleh, R N Hanson, A J Fischma. Novel 3-aminomethyl- and 4-aminopiperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazines: synthesis and evaluation as dopamine transporter ligands. Journal of medicinal chemistry. vol 43. issue 2. 2000-02-28. PMID:10649976. |
the results indicated that most of the new compounds preferentially inhibited norepinephrine reuptake by its transporter (net) but in some cases retained binding selectivity for the dat. |
2000-02-28 |
2023-08-12 |
Not clear |
| N S Kula, R J Baldessarini, F I Tarazi, R Fisser, S Wang, J Trometer, J L Neumeye. [3H]beta-CIT: a radioligand for dopamine transporters in rat brain tissue. European journal of pharmacology. vol 385. issue 2-3. 2000-02-17. PMID:10607889. |
with rat forebrain tissue, [3h]beta-cit showed high affinity for dopamine transporters (dat), with selectivity for dat over norepinephrine transporters, but not serotonin transporters, as well as dat-stereoselectivity with beta-cit, amphetamine and methylphenidate. |
2000-02-17 |
2023-08-12 |
rat |
| C Pifl, E A Singe. Ion dependence of carrier-mediated release in dopamine or norepinephrine transporter-transfected cells questions the hypothesis of facilitated exchange diffusion. Molecular pharmacology. vol 56. issue 5. 1999-11-24. PMID:10531412. |
the mechanism of release mediated by the human dopamine and norepinephrine transporter (dat and net, respectively) was studied by a superfusion technique in human embryonic kidney 293 cells stably transfected with the respective transporter cdna and loaded with the metabolically inert substrate [(3)h]1-methyl-4-phenylpyridinium. |
1999-11-24 |
2023-08-12 |
human |
| M J Kuhar, K M McGirr, R G Hunter, P D Lambert, B E Garrett, F I Carrol. Studies of selected phenyltropanes at monoamine transporters. Drug and alcohol dependence. vol 56. issue 1. 1999-10-12. PMID:10462087. |
in this study, 18 3-phenyltropane analogues were characterized in uptake and binding studies at dopamine (dat), norepinephrine (net) and serotonin (sert) transporters from the rat, and in binding at dat in rat, rhesus monkey, and human brain tissue. |
1999-10-12 |
2023-08-12 |
human |
| P D Acton, M P Kung, M Mu, K Plössl, C Hou, M Siciliano, S Oya, H F Kun. Single-photon emission tomography imaging of serotonin transporters in the non-human primate brain with the selective radioligand [(123)I]IDAM. European journal of nuclear medicine. vol 26. issue 8. 1999-10-07. PMID:10436198. |
in vitro binding studies suggest a high selectivity of idam for sert (k(i)=0.097 nm), with considerably lower affinities for norepinephrine and dopamine transporters (net k(i)= 234 nm and dat k(i)>10 microm, respectively). |
1999-10-07 |
2023-08-12 |
Not clear |
| K S Danek Burgess, J B Justic. Effects of serine mutations in transmembrane domain 7 of the human norepinephrine transporter on substrate binding and transport. Journal of neurochemistry. vol 73. issue 2. 1999-08-13. PMID:10428062. |
these conserved serine residues in the dopamine (da) and norepinephrine transporters (dat and net, respectively) have also been shown to affect substrate transport in the rat dat. |
1999-08-13 |
2023-08-12 |
human |
| M Nishimura, K Sato, S Shimada, M Tohyam. Expression of norepinephrine and serotonin transporter mRNAs in the rat superior cervical ganglion. Brain research. Molecular brain research. vol 67. issue 1. 1999-05-21. PMID:10101235. |
we investigated the gene expression of three monoamine transporters (norepinephrine transporter, net; serotonin transporter, sert; and dopamine transporter, dat) in the rat superior cervical ganglion (scg). |
1999-05-21 |
2023-08-12 |
rat |
| E C Petrie, R C Veith, P Szo. Bupropion and desipramine increase dopamine transporter mRNA expression in the ventral tegmental area/substantia nigra of rat brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 22. issue 5. 1998-11-18. PMID:9723124. |
regulation of dopamine transporter (dat) mrna was studied in rats treated with the dat blocker bupropion (bup; 15 or 30 mg/kg tid x 2d), the norepinephrine transporter blocker desipramine (dmi; 10 mg/kg/d x 2d), or saline. |
1998-11-18 |
2023-08-12 |
rat |
| E G Jönsson, M M Nöthen, J P Gustavsson, H Neidt, R Bunzel, P Propping, G C Sedval. Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationships to monoamine metabolite concentrations in CSF of healthy volunteers. Psychiatry research. vol 79. issue 1. 1998-10-06. PMID:9676821. |
we investigated the possible relationships between dna polymorphisms in the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) genes and csf concentrations of homovanillic acid (hva), 5-hydroxyindoleacetic acid (5-hiaa), and 3-methoxy-4-hydroxyphenylglycol (mhpg) in healthy volunteers (n = 66). |
1998-10-06 |
2023-08-12 |
human |
| K S Avor, S Singh, T W Seale, B Pouw, G P Basmadjia. 2beta-Substituted analogues of 4'-iodococaine: synthesis and dopamine transporter binding potencies. Journal of medicinal chemistry. vol 41. issue 13. 1998-07-09. PMID:9632371. |
hydroxylation of 8 at the 2'-position gave 14 which enhanced not only the binding potency at the dat by another 2-fold but also the selectivity at the dat over the norepinephrine and serotonin transporters. |
1998-07-09 |
2023-08-12 |
mouse |
| S A Burchett, M J Banno. Serotonin, dopamine and norepinephrine transporter mRNAs: heterogeneity of distribution and response to 'binge' cocaine administration. Brain research. Molecular brain research. vol 49. issue 1-2. 1998-02-11. PMID:9387868. |
quantitative in situ hybridization was utilized to map the distribution and abundance of the serotonin, dopamine and norepinephrine transporter (sert, dat and net, respectively) mrnas. |
1998-02-11 |
2023-08-12 |
rat |
| A F Hoffman, G A Gerhard. In vivo electrochemical studies of dopamine clearance in the rat substantia nigra: effects of locally applied uptake inhibitors and unilateral 6-hydroxydopamine lesions. Journal of neurochemistry. vol 70. issue 1. 1998-02-02. PMID:9422361. |
to establish that da clearance within the sn was mediated primarily by the da transporter (dat) rather than the norepinephrine transporter (net) or the serotonin transporter (sert), we locally applied uptake inhibitors with different selectivity profiles for the various amine transporters. |
1998-02-02 |
2023-08-12 |
rat |
| D P Figlewicz, M D Brot, A L McCall, P Szo. Diabetes causes differential changes in CNS noradrenergic and dopaminergic neurons in the rat: a molecular study. Brain research. vol 736. issue 1-2. 1997-02-26. PMID:8930308. |
we have previously reported that chronic elevation of insulin in the cns of rats results in opposing changes of the mrna expression for the norepinephrine transporter (net; decreased) and the dopamine transporter (dat; increased). |
1997-02-26 |
2023-08-12 |
rat |
| T Kadota, T Yamaai, Y Saito, Y Akita, S Kawashima, K Moroi, N Inagaki, K Kadot. Expression of dopamine transporter at the tips of growing neurites of PC12 cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 44. issue 9. 1996-11-06. PMID:8773564. |
gbr12909, a specific inhibitor of dat, blocked the [3h]-dopamine at a concentration of 10(-7) m. the expression of dat and norepinephrine transporter (net) mrna in the pc12 cells was examined by reverse transcriptase-polymerase chain reaction (rt-pcr). |
1996-11-06 |
2023-08-12 |
rat |
| S J Gatley, D Pan, R Chen, G Chaturvedi, Y S Din. Affinities of methylphenidate derivatives for dopamine, norepinephrine and serotonin transporters. Life sciences. vol 58. issue 12. 1996-09-20. PMID:8786705. |
ic50 values for binding these compounds to rat brain monoamine transporters were assessed using [3h]win 35,428 (striatal membranes, dopamine transporters, dat), [3h]nisoxetine (frontal cortex membranes, norepinephrine transporters, net) and [3h]paroxetine (brain stem membranes, 5ht transporters, 5htt). |
1996-09-20 |
2023-08-12 |
rat |