| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Petrise Runnels Miles, Michelle L Mundorf, R Mark Wightma. Release and uptake of catecholamines in the bed nucleus of the stria terminalis measured in the mouse brain slice. Synapse (New York, N.Y.). vol 44. issue 3. 2002-06-20. PMID:11954051. |
clearance rates were reduced in the bstv in both norepinephrine transporter knockout (net ko) and dopamine transporter knockout (dat ko) mice when compared to results in wild-type (wt) mice. |
2002-06-20 |
2023-08-12 |
mouse |
| H H Gu, X Wu, B Giros, M G Caron, M J Caplan, G Rudnic. The NH(2)-terminus of norepinephrine transporter contains a basolateral localization signal for epithelial cells. Molecular biology of the cell. vol 12. issue 12. 2002-05-29. PMID:11739781. |
when expressed in epithelial cells, dopamine transporter (dat) was detected predominantly in the apical plasma membrane, whereas norepinephrine transporter (net) was found in the basolateral membrane, despite 67% overall amino acid sequence identity. |
2002-05-29 |
2023-08-12 |
Not clear |
| Evgeny A Budygin, Carrie E John, Yolanda Mateo, Sara R Jone. Lack of cocaine effect on dopamine clearance in the core and shell of the nucleus accumbens of dopamine transporter knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 10. 2002-05-29. PMID:12006604. |
here, we tested the recently proposed hypothesis that in the absence of the dat, the norepinephrine transporter (net) could provide an alternative uptake site for da clearance. |
2002-05-29 |
2023-08-12 |
mouse |
| C D Cook, I F Carroll, P M Beardsle. Cocaine-like discriminative stimulus effects of novel cocaine and 3-phenyltropane analogs in the rat. Psychopharmacology. vol 159. issue 1. 2002-03-13. PMID:11797070. |
although cocaine is an indirect da agonist that binds to all three monoamine transporters, there is much evidence implicating a greater role for the dopamine (dat) than norepinephrine (net) and serotonin (sert) transporters in the behavioral effects of cocaine. |
2002-03-13 |
2023-08-12 |
rat |
| X H Gu, R Zong, N S Kula, R J Baldessarini, J L Neumeye. Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter. Bioorganic & medicinal chemistry letters. vol 11. issue 23. 2002-03-05. PMID:11714608. |
a series of novel fluoroalkyl-containing tropane derivatives was synthesized, and their binding affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) were determined via competitive binding assays. |
2002-03-05 |
2023-08-12 |
Not clear |
| G Eisenhofe. The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines. Pharmacology & therapeutics. vol 91. issue 1. 2001-12-19. PMID:11707293. |
in mammals, neuronal uptake of catecholamines involves the dopamine transporter (dat) at dopaminergic neurons and the norepinephrine transporter (net) at noradrenergic neurons. |
2001-12-19 |
2023-08-12 |
Not clear |
| M L Mundorf, J D Joseph, C M Austin, M G Caron, R M Wightma. Catecholamine release and uptake in the mouse prefrontal cortex. Journal of neurochemistry. vol 79. issue 1. 2001-10-25. PMID:11595765. |
in the prefrontal cortex (pfc), immunohistochemical fluorescence of the plap along with staining for dopamine transporter (dat) and norepinephrine transporter (net) revealed that all three exhibit remarkable spatial overlap. |
2001-10-25 |
2023-08-12 |
mouse |
| C Roubert, C Sagné, M Kapsimali, P Vernier, F Bourrat, B Giro. A Na(+)/Cl(-)-dependent transporter for catecholamines, identified as a norepinephrine transporter, is expressed in the brain of the teleost fish medaka (Oryzias latipes). Molecular pharmacology. vol 60. issue 3. 2001-09-06. PMID:11502876. |
this carrier is very similar to the human neuronal norepinephrine transporter (net) and the human neuronal dopamine transporter (dat), showing 70 and 64% amino acid identity, respectively. |
2001-09-06 |
2023-08-12 |
human |
| G M Miller, S M Yatin, R De La Garza, M Goulet, B K Madra. Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. Brain research. Molecular brain research. vol 87. issue 1. 2001-08-09. PMID:11223167. |
we used rt-pcr to clone monoamine transporters from macaca mulatta, macaca fasicularis and saimiri sciureus (dopamine transporter; dat) and macaca mulatta (norepinephrine transporter; net and serotonin transporter; sert). |
2001-08-09 |
2023-08-12 |
human |
| N Kubota, Y Kiuchi, M Nemoto, H Oyamada, M Ohno, H Funahashi, S Shioda, K Oguch. Regulation of serotonin transporter gene expression in human glial cells by growth factors. European journal of pharmacology. vol 417. issue 1-2. 2001-07-19. PMID:11301061. |
the expression of serotonin transporter mrna was detected by reverse transcriptase-polymerase chain reaction in normal human astrocytes, whereas the dopamine transporter (dat) and the norepinephrine transporter (net) were not detected. |
2001-07-19 |
2023-08-12 |
human |
| J Samochowiec, F Rybakowski, P Czerski, M Zakrzewska, G Stepień, J Pełka-Wysiecka, J Horodnicki, J K Rybakowski, J Hause. Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationship to temperamental dimensions measured by the Temperament and Character Inventory in healthy volunteers. Neuropsychobiology. vol 43. issue 4. 2001-07-05. PMID:11340364. |
we studied the association between temperamental personality dimensions measured with the temperament and character inventory (tci) and polymorphisms of the dopamine (dat), norepinephrine (net) and serotonin (5-htt) transporter genes in 127 healthy polish volunteers. |
2001-07-05 |
2023-08-12 |
human |
| C Roubert, P J Cox, M Bruss, M Hamon, H Bönisch, B Giro. Determination of residues in the norepinephrine transporter that are critical for tricyclic antidepressant affinity. The Journal of biological chemistry. vol 276. issue 11. 2001-06-21. PMID:11092898. |
the norepinephrine (net) and dopamine (dat) transporters are highly homologous proteins, displaying many pharmacological similarities. |
2001-06-21 |
2023-08-12 |
human |
| A L Bauman, S Apparsundaram, S Ramamoorthy, B E Wadzinski, R A Vaughan, R D Blakel. Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 20. 2001-06-07. PMID:11027216. |
recent studies reveal that dopamine (da), norepinephrine (ne), and serotonin (5-ht) transporters (dat, net, and sert, respectively) are rapidly regulated by direct or receptor-mediated activation of cellular kinases, particularly protein kinase c (pkc). |
2001-06-07 |
2023-08-12 |
human |
| I Sora, F S Hall, A M Andrews, M Itokawa, X F Li, H B Wei, C Wichems, K P Lesch, D L Murphy, G R Uh. Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 9. 2001-05-21. PMID:11320258. |
cocaine blocks uptake by neuronal plasma membrane transporters for dopamine (dat), serotonin (sert), and norepinephrine (net). |
2001-05-21 |
2023-08-12 |
mouse |
| A K Dutta, X S Fei, R A Vaughan, J D Gaffaney, N Wang, J R Lever, M E Reit. Design, synthesis, and characterization of a novel, 4-[2-(diphenylmethoxy)ethyl]-1-benzyl piperidine-based, dopamine transporter photoaffinity label. Life sciences. vol 68. issue 16. 2001-04-19. PMID:11292062. |
this photolabeling was antagonized by dat-specific blockers and was unaffected by specific sert and norepinephrine transporter (net) blockers indicating interaction of this novel ligand with the dat. |
2001-04-19 |
2023-08-12 |
Not clear |
| J A Lile, D Morgan, C S Freedland, R S Sinnott, H M Davies, M A Nade. Self-administration of two long-acting monoamine transport blockers in rhesus monkeys. Psychopharmacology. vol 152. issue 4. 2001-02-08. PMID:11140334. |
2beta-propanoyl-3beta-(2-naphthyl)-tropane (hd-23), like cocaine, binds with approximately equal affinity to the dat, the serotonin transporter, and the norepinephrine transporter but has over a 100-fold higher affinity for these monoamine transporters than cocaine. |
2001-02-08 |
2023-08-12 |
monkey |
| H K Wayment, J O Schenk, B A Sor. Characterization of extracellular dopamine clearance in the medial prefrontal cortex: role of monoamine uptake and monoamine oxidase inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 1. 2001-02-08. PMID:11150317. |
rde studies indicate that inhibition by cocaine, specific inhibitors of the dopamine transporter (dat) and norepinephrine transporter (net), and low na(+) produced a 50-70% decrease in the velocity of dopamine clearance. |
2001-02-08 |
2023-08-12 |
rat |
| S Oya, S R Choi, C Hou, M Mu, M P Kung, P D Acton, M Siciliano, H F Kun. 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter ligand. Nuclear medicine and biology. vol 27. issue 3. 2000-09-26. PMID:10832081. |
adam(7) also showed more than 1,000-fold selectivity for sert over norepinephrine transporter (net) and dopamine transporter (dat) ( k(i)=699 and 840 nm, for net and dat, respectively). |
2000-09-26 |
2023-08-12 |
human |
| L Zhao, K M Johnson, M Zhang, J Flippen-Anderson, A P Kozikowsk. Chemical synthesis and pharmacology of 6- and 7-hydroxylated 2-carbomethoxy-3-(p-tolyl)tropanes: antagonism of cocaine's locomotor stimulant effects. Journal of medicinal chemistry. vol 43. issue 17. 2000-09-21. PMID:10966747. |
some of these compounds were found to retain considerable affinity as inhibitors of the dopamine transporter (dat) and the norepinephrine transporter (net), but they were less potent inhibitors of the serotonin transporter (sert). |
2000-09-21 |
2023-08-12 |
rat |
| D H Feldman, W R Harvey, B R Steven. A novel electrogenic amino acid transporter is activated by K+ or Na+, is alkaline pH-dependent, and is Cl--independent. The Journal of biological chemistry. vol 275. issue 32. 2000-09-14. PMID:10829035. |
amino acids such as l-proline, l-threonine, and l-methionine elicited complex current-voltage relationships in alkaline ph-dependent caatch1 that were reminiscent of the behavior of the dopamine, serotonin, and norepinephrine transporters (dat, sert, net) in the presence of their substrates and pharmacological inhibitors such as cocaine or antidepressants. |
2000-09-14 |
2023-08-12 |
xenopus_laevis |