| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Saskia J Rietjens, Laura Hondebrink, Remco H S Westerink, Jan Meulenbel. Pharmacokinetics and pharmacodynamics of 3,4-methylenedioxymethamphetamine (MDMA): interindividual differences due to polymorphisms and drug-drug interactions. Critical reviews in toxicology. vol 42. issue 10. 2013-03-20. PMID:23030234. |
pretreatment with inhibitors of the dopamine or norepinephrine reuptake transporter (dat or net), 5-ht(2a) or α-β adrenergic receptor antagonists or antipsychotics prior to mdma exposure can also decrease one or more mdma-induced physiological and/or subjective effects. |
2013-03-20 |
2023-08-12 |
Not clear |
| Yosefu Arime, Yoshiyuki Kasahara, F Scott Hall, George R Uhl, Ichiro Sor. Cortico-subcortical neuromodulation involved in the amelioration of prepulse inhibition deficits in dopamine transporter knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 11. 2013-02-26. PMID:22781838. |
we recently reported that nisoxetine, a selective norepinephrine transporter (net) inhibitor, reversed the ppi deficits that have been identified in dopamine transporter (dat) knockout (ko) mice. |
2013-02-26 |
2023-08-12 |
mouse |
| Rachel W S Li, Cui Yang, Y W Kwan, S W Chan, Simon M Y Lee, George P H Leun. Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells. Frontiers in pharmacology. vol 4. 2013-02-15. PMID:23407616. |
the specific serotonin re-uptake transporter (sert) inhibitor citalopram, the specific norepinephrine transporter (net) inhibitor desipramine, and the dopamine transporter (dat) inhibitor gbr12935 inhibited 5-ht uptake in hbvsmcs with ic(50) values of 97.03 ± 40.10, 10.49 ± 5.98, and 2.80 ± 1.04 μm, respectively. |
2013-02-15 |
2023-08-12 |
human |
| Stephen J Kohut, Kathleen L Decicco-Skinner, Shirin Johari, Zachary E Hurwitz, Michael H Baumann, Anthony L Rile. Differential modulation of cocaine's discriminative cue by repeated and variable stress exposure: relation to monoamine transporter levels. Neuropharmacology. vol 63. issue 2. 2012-11-19. PMID:22516586. |
dopamine (dat), serotonin (sert) and norepinephrine (net) transporter levels in mesocorticolimbic areas were also measured using western blotting after stress exposure to determine if the relative ratio of these proteins may explain differences in behavior. |
2012-11-19 |
2023-08-12 |
rat |
| Joel G Anderson, Paula T Cooney, Keith M Erikso. Inhibition of DAT function attenuates manganese accumulation in the globus pallidus. Environmental toxicology and pharmacology. vol 23. issue 2. 2012-10-02. PMID:17387379. |
our primary goal of this study was to examine the potential roles of the monoamine transporters, dopamine transporter (dat), serotonin transporter (sert) and norepinephrine transporter (net), in neuronal mn transport. |
2012-10-02 |
2023-08-12 |
rat |
| Xue Y Zhu, Jagan R Etukala, Suresh V K Eyunni, Vincent Setola, Bryan L Roth, Seth Y Ablordeppe. Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants. European journal of medicinal chemistry. vol 53. 2012-09-25. PMID:22520153. |
in addition, compound 20 binds with low affinity to the dopamine transporter (dat), the norepinephrine transporter (net) and 5ht(2c) receptor, which are desirable properties as selectivity for sert (and not dat or net) is associated with an absence of cardiovascular side effects. |
2012-09-25 |
2023-08-12 |
Not clear |
| Shankar Sadasivan, Brooks B Pond, Amar K Pani, Chunxu Qu, Yun Jiao, Richard J Smeyn. Methylphenidate exposure induces dopamine neuron loss and activation of microglia in the basal ganglia of mice. PloS one. vol 7. issue 3. 2012-08-03. PMID:22470460. |
methylphenidate (mph) is a psychostimulant that exerts its pharmacological effects via preferential blockade of the dopamine transporter (dat) and the norepinephrine transporter (net), resulting in increased monoamine levels in the synapse. |
2012-08-03 |
2023-08-12 |
mouse |
| Erik R Hill, Xiaoqin Huang, Chang-Guo Zhan, F Ivy Carroll, Howard H G. Interaction of tyrosine 151 in norepinephrine transporter with the 2β group of cocaine analog RTI-113. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21420984. |
cocaine binds and inhibits dopamine transporter (dat), norepinephrine transporter (net) and serotonin transporter. |
2012-04-17 |
2023-08-12 |
Not clear |
| Shaine A Cararas, Sari Izenwasser, Dean Wade, Amy Housman, Abha Verma, Stacey A Lomenzo, Mark L Trudel. Further structure-activity relationship studies on 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives at monoamine transporters. Bioorganic & medicinal chemistry. vol 19. issue 24. 2012-03-19. PMID:22055716. |
the synthesis and structure-activity relationships of 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives were investigated at the dopamine transporter (dat), the serotonin transporter (sert) and norepinephrine transporter (net). |
2012-03-19 |
2023-08-12 |
Not clear |
| J-W Tian, W-L Jiang, Y Zhong, Q Meng, Y Gai, H-B Zhu, J Hou, Y Xing, Y-X L. Preclinical pharmacology of TP1, a novel potent triple reuptake inhibitor with antidepressant properties. Neuroscience. vol 196. 2012-02-23. PMID:21925241. |
triple reuptake inhibitors (tris) that block the dopamine transporter (dat), norepinephrine transporter (net), and serotonin transporter (sert) are being developed as a new class of antidepressant that may have better efficacy and fewer side effects compared with traditional antidepressants. |
2012-02-23 |
2023-08-12 |
human |
| Chiharu Sogawa, Norio Sogawa, Kazumi Ohyama, Ruri Kikura-Hanajiri, Yukihiro Goda, Ichiro Sora, Shigeo Kitayam. Methylone and monoamine transporters: correlation with toxicity. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886563. |
we examined here the effects of methylone on the transporters for dopamine (dat), norepinephrine (net), and serotonin (sert), using a heterologous expression system in cho cells, in association with its cytotoxicity. |
2011-11-10 |
2023-08-12 |
Not clear |
| Karen Miguita, Quirino Cordeiro, Roseli Gedanke Shavitt, Eurípedes Constantino Miguel, Homero Vallad. Association study between genetic monoaminergic polymorphisms and OCD response to clomipramine treatment. Arquivos de neuro-psiquiatria. vol 69. issue 2B. 2011-11-08. PMID:21625751. |
in the present paper, we investigated the 5httlpr and stin2 polymorphisms in the promoter region of the serotonin transporter gene (slc6a4), the g861c polymorphism (rs6296) of the serotonin receptor 1d beta (htr1b), the t102c (rs6113) and c516t (rs6305) polymorphisms of the serotonin receptor gene subtype 2a (htr2a), the dat utr, dat intron 8 and dat intron 14 of the dopamine transporter gene (slc6a3), the val-158-met (rs4680) polymorphism of the comt and the silent mutation g1287a (rs5569) in the norepinephrine transporter gene (slc6a2). |
2011-11-08 |
2023-08-12 |
Not clear |
| Liming Shao, Michael C Hewitt, Scott C Malcolm, Fengjiang Wang, Jianguo Ma, Una C Campbell, Nancy A Spicer, Sharon R Engel, Larry W Hardy, Zhi-Dong Jiang, Rudy Schreiber, Kerry L Spear, Mark A Varne. Synthesis and pharmacological characterization of bicyclic triple reuptake inhibitor 3-aryl octahydrocyclopenta[c]pyrrole analogues. Journal of medicinal chemistry. vol 54. issue 15. 2011-10-07. PMID:21739935. |
the present work expands the chemical space known to offer potent inhibition of the serotonin transporter (sert), norepinephrine transporter (net), and dopamine transporter (dat) and discloses novel bicyclic octahydrocyclopenta[c]pyrrole and octahydro-1h-isoindole scaffolds as potent triple reuptake inhibitors (tris) for the potential treatment of depression. |
2011-10-07 |
2023-08-12 |
mouse |
| Stacey J Sukoff Rizzo, Sarah K Leonard, Adam Gilbert, Paul Dollings, Deborah L Smith, Mei-Yi Zhang, Li Di, Brian J Platt, Sarah Neal, Jason M Dwyer, Corey N Bender, Jean Zhang, Tim Lock, Dianne Kowal, Angela Kramer, Andrew Randall, Christine Huselton, Karthick Vishwanathan, Susanna Y Tse, John Butera, Robert H Ring, Sharon Rosenzweig-Lipson, Zoë A Hughes, John Dunlo. The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise? The Journal of pharmacology and experimental therapeutics. vol 338. issue 1. 2011-08-30. PMID:21508084. |
in vitro selectivity profiling of met-1 demonstrated physiologically relevant transporter binding affinity at serotonin transporter (sert), dopamine transporter (dat), and norepinephrine transporter (net) (323, 3020, and 3410 nm, respectively); whereas the parent compound amn082 had appreciable affinity at net (1385 nm). |
2011-08-30 |
2023-08-12 |
rat |
| Jingying Liu, Lin Zhu, Karl Plössl, Brian P Lieberman, Hank F Kun. Synthesis and evaluation of novel N-fluoropyridyl derivatives of tropane as potential PET imaging agents for the dopamine transporter. Bioorganic & medicinal chemistry letters. vol 21. issue 10. 2011-08-23. PMID:21458259. |
a series of novel n-fluoropyridyl-containing tropane derivatives were synthesized and their binding affinities for the dopamine transporter (dat), serotonin transporter (sert) and norepinephrine (net) were determined via competitive radioligand binding assays. |
2011-08-23 |
2023-08-12 |
Not clear |
| Bhaskar Gopishetty, Stuart Hazeldine, Soumava Santra, Mark Johnson, Gyan Modi, Solav Ali, Juan Zhen, Maarten Reith, Aloke Dutt. Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents. Journal of medicinal chemistry. vol 54. issue 8. 2011-07-04. PMID:21446715. |
the novel compounds were tested for their affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2011-07-04 |
2023-08-12 |
rat |
| John A Gruner, Joanne R Mathiasen, Dorothy G Flood, Maciej Gasio. Characterization of pharmacological and wake-promoting properties of the dopaminergic stimulant sydnocarb in rats. The Journal of pharmacology and experimental therapeutics. vol 337. issue 2. 2011-06-21. PMID:21300706. |
sydnocarb potently (k(i) = 8.3 ± 0.7 nm) blocked recombinant human dat expressed in chinese hamster ovary-k1 cells and less potently blocked the norepinephrine transporter (k(i) = 10.1 ± 1.5 μm). |
2011-06-21 |
2023-08-12 |
human |
| Teodora-Adriana Perles-Barbacaru, Daniel Procissi, Andrey V Demyanenko, F Scott Hall, George R Uhl, Russell E Jacob. Quantitative pharmacologic MRI: mapping the cerebral blood volume response to cocaine in dopamine transporter knockout mice. NeuroImage. vol 55. issue 2. 2011-06-10. PMID:21185387. |
cocaine acts to block the dopamine, norepinephrine, and serotonin transporters (dat, net, and sert) that clear their respective neurotransmitters from the synapses, helping to terminate cognate neurotransmission. |
2011-06-10 |
2023-08-12 |
mouse |
| Susanna Nencetti, Maria R Mazzoni, Gabriella Ortore, Annalina Lapucci, Janette Giuntini, Elisabetta Orlandini, Irene Banti, Elisa Nuti, Antonio Lucacchini, Gino Giannaccini, Armando Rossell. Synthesis, molecular docking and binding studies of selective serotonin transporter inhibitors. European journal of medicinal chemistry. vol 46. issue 3. 2011-06-02. PMID:21272963. |
with the aim of obtaining compounds possessing high sert selectivity, in the present work we synthesized and studied the inhibition of serotonin (sert), dopamine (dat) and norepinephrine (net) transporters by docking studies and experimental binding measurements of a series of 4-(aryl)piperidin-3-one o-4-benzyl oxime hydrochlorides (1-10) of both e and z configuration. |
2011-06-02 |
2023-08-12 |
Not clear |
| Anja W Fjorback, Heidi K Müller, Jana Haase, Merete K Raarup, Ove Wibor. Modulation of the dopamine transporter by interaction with Secretory Carrier Membrane Protein 2. Biochemical and biophysical research communications. vol 406. issue 2. 2011-05-05. PMID:21295544. |
the monoamine transporters for dopamine (dat), norepinephrine (net) and serotonin (sert) facilitate the homeostatic balance of neurotransmitters in the synaptic cleft and thus, play a fundamental role in regulating neuronal activity. |
2011-05-05 |
2023-08-12 |
Not clear |