| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dorothy P Schafer, Christopher T Heller, Georgia Gunner, Molly Heller, Christopher Gordon, Timothy Hammond, Yochai Wolf, Steffen Jung, Beth Steven. Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression. eLife. vol 5. 2017-11-16. PMID:27458802. |
furthermore, loss or gain of mecp2 expression specifically in microglia (cx3cr1(creer);mecp2(fl/y)or cx3cr1(cr)(eer); mecp2(lsl/y)) had little effect on excessive engulfment, synapse loss, or phenotypic abnormalities. |
2017-11-16 |
2023-08-13 |
mouse |
| Jijun Xu, Yuying Tang, Mian Xie, Bihua Bie, Jiang Wu, Hui Yang, Joseph F Foss, Bin Yang, Richard W Rosenquist, Mohamed Nagui. Activation of cannabinoid receptor 2 attenuates mechanical allodynia and neuroinflammatory responses in a chronic post-ischemic pain model of complex regional pain syndrome type I in rats. The European journal of neuroscience. vol 44. issue 12. 2017-11-13. PMID:27717112. |
mda7 treatment was found to interfere with early events in the crps-i neuroinflammatory response by suppressing peripheral edema, spinal microglial activation and expression of cx3cr1 and cb2 receptors on the microglia in the spinal cord. |
2017-11-13 |
2023-08-13 |
rat |
| Sabine Sellner, Ricardo Paricio-Montesinos, Alena Spieß, Annette Masuch, Daniel Erny, Laura A Harsan, Dominik V Elverfeldt, Marius Schwabenland, Knut Biber, Ori Staszewski, Sergio Lira, Steffen Jung, Marco Prinz, Thomas Blan. Microglial CX3CR1 promotes adult neurogenesis by inhibiting Sirt 1/p65 signaling independent of CX3CL1. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27639555. |
homo and heterozygote cx3cr1 mutant mice, which harbor a green fluorescent protein (egfp) in their cx3cr1 loci, represent a widely used animal model to study microglia and peripheral myeloid cells. |
2017-10-25 |
2023-08-13 |
mouse |
| Sabine Sellner, Ricardo Paricio-Montesinos, Alena Spieß, Annette Masuch, Daniel Erny, Laura A Harsan, Dominik V Elverfeldt, Marius Schwabenland, Knut Biber, Ori Staszewski, Sergio Lira, Steffen Jung, Marco Prinz, Thomas Blan. Microglial CX3CR1 promotes adult neurogenesis by inhibiting Sirt 1/p65 signaling independent of CX3CL1. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27639555. |
here we report that microglia in the dentate gyrus (dg) of cx3cr1 (-/-) mice displayed elevated microglial sirtuin 1 (sirt1) expression levels and nuclear factor kappa-light-chain-enhancer of activated b cells (nf-kb) p65 activation, despite unaltered morphology when compared to cx3cr1 (+/-) or cx3cr1 (+/+) controls. |
2017-10-25 |
2023-08-13 |
mouse |
| Sabine Sellner, Ricardo Paricio-Montesinos, Alena Spieß, Annette Masuch, Daniel Erny, Laura A Harsan, Dominik V Elverfeldt, Marius Schwabenland, Knut Biber, Ori Staszewski, Sergio Lira, Steffen Jung, Marco Prinz, Thomas Blan. Microglial CX3CR1 promotes adult neurogenesis by inhibiting Sirt 1/p65 signaling independent of CX3CL1. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27639555. |
in conclusion, our data indicate that deletion of cx3cr1 from microglia under resting conditions modifies brain areas with elevated cellular turnover independent of cx3cl1. |
2017-10-25 |
2023-08-13 |
mouse |
| Vincent R Parillaud, Guillaume Lornet, Yann Monnet, Anne-Laure Privat, Andrei T Haddad, Vanessa Brochard, Amaury Bekaert, Camille Baudesson de Chanville, Etienne C Hirsch, Christophe Combadière, Stéphane Hunot, Christian S Lobsige. Analysis of monocyte infiltration in MPTP mice reveals that microglial CX3CR1 protects against neurotoxic over-induction of monocyte-attracting CCL2 by astrocytes. Journal of neuroinflammation. vol 14. issue 1. 2017-10-11. PMID:28320442. |
our aim was to reassess this open question, by taking advantage of the recent recognition that chemokine receptors ccr2 and cx3cr1 can differentiate between inflammatory monocytes and microglia, enabling to test whether ccr2 |
2017-10-11 |
2023-08-13 |
mouse |
| Matthew McMillin, Stephanie Grant, Gabriel Frampton, Sarah Andry, Adam Brown, Sharon DeMorro. Fractalkine suppression during hepatic encephalopathy promotes neuroinflammation in mice. Journal of neuroinflammation. vol 13. issue 1. 2017-10-04. PMID:27561705. |
fractalkine is a chemokine that is expressed primarily in neurons and through signaling with its receptor cx3cr1 on microglia, leads to microglia remaining in a quiescent state. |
2017-10-04 |
2023-08-13 |
mouse |
| Sinead A O'Sullivan, Fabrizio Gasparini, Anis K Mir, Kumlesh K De. Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes. Journal of neuroinflammation. vol 13. issue 1. 2017-10-02. PMID:27549131. |
although somewhat controversial, cx3cr1 is reported to be expressed in neurons and microglia. |
2017-10-02 |
2023-08-13 |
human |
| Thais F Galatro, Inge R Holtman, Antonio M Lerario, Ilia D Vainchtein, Nieske Brouwer, Paula R Sola, Mariana M Veras, Tulio F Pereira, Renata E P Leite, Thomas Möller, Paul D Wes, Mari C Sogayar, Jon D Laman, Wilfred den Dunnen, Carlos A Pasqualucci, Sueli M Oba-Shinjo, Erik W G M Boddeke, Suely K N Marie, Bart J L Egge. Transcriptomic analysis of purified human cortical microglia reveals age-associated changes. Nature neuroscience. vol 20. issue 8. 2017-09-05. PMID:28671693. |
overall, genes expressed by human microglia were similar to those in mouse, including established microglial genes cx3cr1, p2ry12 and itgam (cd11b). |
2017-09-05 |
2023-08-13 |
mouse |
| Jun Tang, Hongping Miao, Bing Jiang, Qianwei Chen, Liang Tan, Yihao Tao, Jianbo Zhang, Fabao Gao, Hua Feng, Gang Zhu, Zhi Che. A selective CB2R agonist (JWH133) restores neuronal circuit after Germinal Matrix Hemorrhage in the preterm via CX3CR1 Neuropharmacology. vol 119. 2017-08-31. PMID:28153531. |
a selective cb2r agonist (jwh133) restores neuronal circuit after germinal matrix hemorrhage in the preterm via cx3cr1 microglia play dual roles after germinal matrix hemorrhage, and the neurotrophic phenotype maybe neuroprotective. |
2017-08-31 |
2023-08-13 |
Not clear |
| Irena Balzekas, Jose Hernandez, Jacob White, Sookyong Ko. Confounding effect of EEG implantation surgery: Inadequacy of surgical control in a two hit model of temporal lobe epilepsy. Neuroscience letters. vol 622. 2017-07-19. PMID:27095588. |
we then directly compared electrode-implantation and ka-sz in seizure naive cx3cr1(gfp/+) transgenic c57bl/6 mice, wherein microglia express green fluorescent protein (gfp), to determine if microglia activation related to surgery was associated with the increased seizure susceptibility in electrode-implanted mice from the two-hit model. |
2017-07-19 |
2023-08-13 |
mouse |
| Bo Ma, Leyan Xu, Xiaodong Pan, Lixin Sun, Jinhui Ding, Chengsong Xie, Vassilis E Koliatsos, Huaibin Ca. LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways. Human molecular genetics. vol 25. issue 16. 2017-07-13. PMID:27378696. |
chemokine (c-x3-c) receptor 1 (cx3cr1), predominantly expressed by microglia, suppresses microglial inflammation while promotes migration. |
2017-07-13 |
2023-08-13 |
Not clear |
| Bo Ma, Leyan Xu, Xiaodong Pan, Lixin Sun, Jinhui Ding, Chengsong Xie, Vassilis E Koliatsos, Huaibin Ca. LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways. Human molecular genetics. vol 25. issue 16. 2017-07-13. PMID:27378696. |
using whole-genome microarray screening, we found that cx3cr1 mrna levels were substantially higher in microglia derived from lrrk2 knockout (lrrk2 |
2017-07-13 |
2023-08-13 |
Not clear |
| Rafik Menasria, Coraline Canivet, Jocelyne Piret, Jean Gosselin, Guy Boivi. Protective role of CX3CR1 signalling in resident cells of the central nervous system during experimental herpes simplex virus encephalitis. The Journal of general virology. vol 98. issue 3. 2017-05-09. PMID:27902351. |
cx3cr1 is an important chemokine receptor expressed on the surface of microglia and blood leukocytes, including monocytes. |
2017-05-09 |
2023-08-13 |
mouse |
| James F Striebel, Brent Race, James A Carroll, Katie Phillips, Bruce Chesebr. Knockout of fractalkine receptor Cx3cr1 does not alter disease or microglial activation in prion-infected mice. The Journal of general virology. vol 97. issue 6. 2017-04-28. PMID:26935332. |
the cx3c chemokine axis consists of fractalkine (cx3cl1) and its receptor (cx3cr1); these are expressed by neurons and microglia respectively, and are known to modulate microglial activation. |
2017-04-28 |
2023-08-13 |
mouse |
| Peiqing Chen, Wenjuan Zhao, Yanjie Guo, Juan Xu, Ming Yi. CX3CL1/CX3CR1 in Alzheimer's Disease: A Target for Neuroprotection. BioMed research international. vol 2016. 2017-02-22. PMID:27429982. |
cx3cl1 is secreted by neurons and plays an important role in modulating glial activation in the central nervous system after binding to its sole receptor cx3cr1 which mainly is expressed on microglia. |
2017-02-22 |
2023-08-13 |
Not clear |
| Joanna Ślusarczyk, Ewa Trojan, Katarzyna Głombik, Katarzyna Chamera, Adam Roman, Bogusława Budziszewska, Agnieszka Basta-Kai. Fractalkine Attenuates Microglial Cell Activation Induced by Prenatal Stress. Neural plasticity. vol 2016. 2016-12-30. PMID:27239349. |
fractalkine (cx3cl1) and its receptor cx3cr1 play a crucial role in the control of the biological activity of the microglia. |
2016-12-30 |
2023-08-13 |
Not clear |
| José Joaquín Merino, Vilma Muñetón-Gómez, María-Isabel Alvárez, Adolfo Toledano-Día. Effects of CX3CR1 and Fractalkine Chemokines in Amyloid Beta Clearance and p-Tau Accumulation in Alzheimer's Disease (AD) Rodent Models: Is Fractalkine a Systemic Biomarker for AD? Current Alzheimer research. vol 13. issue 4. 2016-12-15. PMID:26567742. |
cx3cr1 is a delta chemokine receptor found in microglia and its neuronal ligand, fractalkine, has two isoforms: an anchored-membrane isoform, and a soluble isoform. |
2016-12-15 |
2023-08-13 |
mouse |
| José Joaquín Merino, Vilma Muñetón-Gómez, María-Isabel Alvárez, Adolfo Toledano-Día. Effects of CX3CR1 and Fractalkine Chemokines in Amyloid Beta Clearance and p-Tau Accumulation in Alzheimer's Disease (AD) Rodent Models: Is Fractalkine a Systemic Biomarker for AD? Current Alzheimer research. vol 13. issue 4. 2016-12-15. PMID:26567742. |
this soluble fractalkine maintains microglia in an appropiate state by interacting with cx3cr1. |
2016-12-15 |
2023-08-13 |
mouse |
| Fabrine Sales Massafera Tristão, Márcio Lazzarini, Sabine Martin, Majid Amar, Walter Stühmer, Frank Kirchhoff, Lucas Araújo Caldi Gomes, Laurance Lanfumey, Rui D Prediger, Julia E Sepulveda, Elaine A Del-Bel, Rita Raisman-Vozar. CX3CR1 Disruption Differentially Influences Dopaminergic Neuron Degeneration in Parkinsonian Mice Depending on the Neurotoxin and Route of Administration. Neurotoxicity research. vol 29. issue 3. 2016-12-13. PMID:26403659. |
the neuron-derived chemokine fractalkine (cx3cl1) is an exclusive ligand for the receptor cx3cr1 expressed on microglia. |
2016-12-13 |
2023-08-13 |
mouse |