| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carmen Mecca, Ileana Giambanco, Rosario Donato, Cataldo Arcur. Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes. International journal of molecular sciences. vol 19. issue 1. 2018-08-03. PMID:29361745. |
the expression of cx3cl1 in neurons and of its receptor cx3cr1 in microglia determines a specific interaction, playing fundamental roles in the regulation of the maturation and function of these cells. |
2018-08-03 |
2023-08-13 |
human |
| Ronen Reshef, Elena Kudryavitskaya, Haran Shani-Narkiss, Batya Isaacson, Neta Rimmerman, Adi Mizrahi, Raz Yirmiy. The role of microglia and their CX3CR1 signaling in adult neurogenesis in the olfactory bulb. eLife. vol 6. 2018-07-13. PMID:29251592. |
the role of microglia and their cx3cr1 signaling in adult neurogenesis in the olfactory bulb. |
2018-07-13 |
2023-08-13 |
mouse |
| Yawen Peng, Genhua Guo, Bin Shu, Daiqiang Liu, Peng Su, Xuming Zhang, Feng Ga. Spinal CX3CL1/CX3CR1 May Not Directly Participate in the Development of Morphine Tolerance in Rats. Neurochemical research. vol 42. issue 11. 2018-06-26. PMID:28776289. |
the cellular localizations of spinal cx3cl1 and cx3cr1 changed from neuron and microglia, respectively, to all the neural cells during the development of morphine tolerance. |
2018-06-26 |
2023-08-13 |
rat |
| Marta Bolós, María Llorens-Martín, Juan Ramón Perea, Jerónimo Jurado-Arjona, Alberto Rábano, Félix Hernández, Jesús Avil. Absence of CX3CR1 impairs the internalization of Tau by microglia. Molecular neurodegeneration. vol 12. issue 1. 2018-06-12. PMID:28810892. |
absence of cx3cr1 impairs the internalization of tau by microglia. |
2018-06-12 |
2023-08-13 |
Not clear |
| K Ishizuka, Y Fujita, T Kawabata, H Kimura, Y Iwayama, T Inada, Y Okahisa, J Egawa, M Usami, I Kushima, Y Uno, T Okada, M Ikeda, B Aleksic, D Mori, To Someya, T Yoshikawa, N Iwata, H Nakamura, T Yamashita, N Ozak. Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders. Translational psychiatry. vol 7. issue 8. 2018-05-03. PMID:28763059. |
cx3cr1, a g protein-coupled receptor solely expressed by microglia in the brain, has been repeatedly reported to be associated with neurodevelopmental disorders including schizophrenia (scz) and autism spectrum disorders (asd) in transcriptomic and animal studies but not in genetic studies. |
2018-05-03 |
2023-08-13 |
Not clear |
| Matthew K Zabel, Lian Zhao, Yikui Zhang, Shaimar R Gonzalez, Wenxin Ma, Xu Wang, Robert N Fariss, Wai T Won. Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa. Glia. vol 64. issue 9. 2018-01-31. PMID:27314452. |
cx3cr1-deficient microglia demonstrated increased phagocytosis as evidenced by (1) having increased numbers of phagosomes in vivo, (2) an increased rate of phagocytosis of fluorescent beads and photoreceptor cellular debris in vitro, and (3) increased photoreceptor phagocytosis dynamics on live cell imaging in retinal explants, indicating that cx3cr1 signaling in microglia regulates the phagocytic clearance of at-risk photoreceptors. |
2018-01-31 |
2023-08-13 |
mouse |
| Matthew K Zabel, Lian Zhao, Yikui Zhang, Shaimar R Gonzalez, Wenxin Ma, Xu Wang, Robert N Fariss, Wai T Won. Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa. Glia. vol 64. issue 9. 2018-01-31. PMID:27314452. |
we also found that cx3cr1 deficiency in retinal microglia was associated with increased expression of inflammatory cytokines and microglial activation markers. |
2018-01-31 |
2023-08-13 |
mouse |
| Min-Xuan Xu, Rong Yu, Li-Fei Shao, Yan-Xiu Zhang, Chen-Xu Ge, Xin-Meng Liu, Wen-Yuan Wu, Jian-Mei Li, Ling-Dong Kon. Up-regulated fractalkine (FKN) and its receptor CX3CR1 are involved in fructose-induced neuroinflammation: Suppression by curcumin. Brain, behavior, and immunity. vol 58. 2018-01-17. PMID:26765996. |
serum fkn levels, as well as hypothalamic fkn and cx3cr1 gene expression, were significantly increased in fructose-fed mice with hypothalamic microglia activation. |
2018-01-17 |
2023-08-13 |
mouse |
| Xiao-Mei Wu, Yong Liu, Zhong-Ming Qian, Qian-Qian Luo, Ya K. CX3CL1/CX3CR1 Axis Plays a Key Role in Ischemia-Induced Oligodendrocyte Injury via p38MAPK Signaling Pathway. Molecular neurobiology. vol 53. issue 6. 2018-01-15. PMID:26189830. |
we investigated the effects of cx3cl1, cx3cr1 shrna, and p38mapk inhibitor on the apoptosis, proliferation, and myelin proteolipid protein (plp) expression in oligodendrocytes in co-cultures with bv2 microglia under ischemia. |
2018-01-15 |
2023-08-13 |
Not clear |
| Xiao-Mei Wu, Yong Liu, Zhong-Ming Qian, Qian-Qian Luo, Ya K. CX3CL1/CX3CR1 Axis Plays a Key Role in Ischemia-Induced Oligodendrocyte Injury via p38MAPK Signaling Pathway. Molecular neurobiology. vol 53. issue 6. 2018-01-15. PMID:26189830. |
all these effects of cx3cl1 were suppressed by pre-treatment of bv2 microglia with cx3cr1 shrna to silence cx3cr1 expression or sb203580 to inhibit p38mapk pathway. |
2018-01-15 |
2023-08-13 |
Not clear |
| Sung Hoon Baik, Seokjo Kang, Sung Min Son, Inhee Mook-Jun. Microglia contributes to plaque growth by cell death due to uptake of amyloid β in the brain of Alzheimer's disease mouse model. Glia. vol 64. issue 12. 2018-01-05. PMID:27658617. |
in the present study, we confirmed how microglia are involved in aβ plaque formation and their growth in the brain of 5xfad mice, the aβ-overexpressing ad transgenic mouse model, and performed serial intravital two-photon microscopy (tpm) imaging of the brains of 5xfad mice crossed with macrophage/microglia-specific gfp-expressing cx3cr1 |
2018-01-05 |
2023-08-13 |
mouse |
| Yoojin Seo, Hyung-Sik Kim, Insung Kang, Soon Won Choi, Tae-Hoon Shin, Ji-Hee Shin, Byung-Chul Lee, Jin Young Lee, Jae-Jun Kim, Myung Geun Kook, Kyung-Sun Kan. Cathepsin S contributes to microglia-mediated olfactory dysfunction through the regulation of Cx3cl1-Cx3cr1 axis in a Niemann-Pick disease type C1 model. Glia. vol 64. issue 12. 2018-01-05. PMID:27687148. |
microglia in the ob of npc1 mice strongly expressed cx3c chemokine receptor 1 (cx3cr1), a specific receptor for the neural chemokine c-x3-c motif ligand 1 (cx3cl1). |
2018-01-05 |
2023-08-13 |
mouse |
| Annette Masuch, Rianne van der Pijl, Lisa Füner, Yochai Wolf, Bart Eggen, Erik Boddeke, Knut Bibe. Microglia replenished OHSC: A culture system to study in vivo like adult microglia. Glia. vol 64. issue 8. 2018-01-04. PMID:27145902. |
moreover, wild-type slices replenished with microglia from tnfα-deficient animals provide similar results as ohsc prepared from microglia-specific tnfα-knockout mice (cx3cr1(cre) /tnfα(fl/fl) ). |
2018-01-04 |
2023-08-13 |
mouse |
| Giampaolo Milior, Cynthia Lecours, Louis Samson, Kanchan Bisht, Silvia Poggini, Francesca Pagani, Cristina Deflorio, Clotilde Lauro, Silvia Alboni, Cristina Limatola, Igor Branchi, Marie-Eve Tremblay, Laura Magg. Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress. Brain, behavior, and immunity. vol 55. 2017-12-29. PMID:26231972. |
fractalkine signaling - which comprises the chemokine cx3cl1, mainly expressed by neurons, and its receptor cx3cr1, almost exclusively present on microglia in the healthy brain - has been reported to critically regulate microglial activity. |
2017-12-29 |
2023-08-13 |
mouse |
| Sabine Hellwig, Simone Brioschi, Sandra Dieni, Lars Frings, Annette Masuch, Thomas Blank, Knut Bibe. Altered microglia morphology and higher resilience to stress-induced depression-like behavior in CX3CR1-deficient mice. Brain, behavior, and immunity. vol 55. 2017-12-29. PMID:26576722. |
thus, we aimed to clarify the role of microglia and cx3cr1 in depressive behavior by subjecting cx3cr1-deficient mice to a particular chronic despair model (cdm) paradigm known to exhibit face validity to major depressive disorder. |
2017-12-29 |
2023-08-13 |
mouse |
| Sabine Hellwig, Simone Brioschi, Sandra Dieni, Lars Frings, Annette Masuch, Thomas Blank, Knut Bibe. Altered microglia morphology and higher resilience to stress-induced depression-like behavior in CX3CR1-deficient mice. Brain, behavior, and immunity. vol 55. 2017-12-29. PMID:26576722. |
in contrast, cx3cr1 deficient mice showed a clear resistance to either (i) stress-induced depressive-like behavior, (ii) changes in microglia morphology and (iii) antidepressant treatment. |
2017-12-29 |
2023-08-13 |
mouse |
| Sabine Hellwig, Simone Brioschi, Sandra Dieni, Lars Frings, Annette Masuch, Thomas Blank, Knut Bibe. Altered microglia morphology and higher resilience to stress-induced depression-like behavior in CX3CR1-deficient mice. Brain, behavior, and immunity. vol 55. 2017-12-29. PMID:26576722. |
the lack of effects in cx3cr1 deficient mice suggests that microglia hyper-ramification is controlled by neuron-microglia signaling via the cx3c axis. |
2017-12-29 |
2023-08-13 |
mouse |
| Peter J Amos, Susan Fung, Amanda Case, Jerusalem Kifelew, Leah Osnis, Carole L Smith, Kevin Green, Alipi Naydenov, Macarena Aloi, Jesse J Hubbard, Aravind Ramakrishnan, Gwenn A Garden, Suman Jayade. Modulation of Hematopoietic Lineage Specification Impacts TREM2 Expression in Microglia-Like Cells Derived From Human Stem Cells. ASN neuro. vol 9. issue 4. 2017-12-08. PMID:28683563. |
using immunofluorescence microscopy, flow cytometry, and reverse transcription polymerase chain reaction, we observed cells with microglia morphology expressing a repertoire of markers associated with microglia: iba1, cx3cr1, cd11b, trem2, hexb, and p2ry12. |
2017-12-08 |
2023-08-13 |
human |
| Q Q Zhou, S S Chen, Q Q Zhang, P F Liu, H Z Fang, Y Yang, L C Zhan. Cerebrospinal fluid-contacting nucleus mediates nociception via release of fractalkine. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 50. issue 9. 2017-11-27. PMID:28793053. |
the results show that fkn is expressed by neurons, via expression of its only receptor cx3cr1 in the microglia. |
2017-11-27 |
2023-08-13 |
rat |
| Nan Gu, Jiyun Peng, Madhuvika Murugan, Xi Wang, Ukpong B Eyo, Dongming Sun, Yi Ren, Emanuel DiCicco-Bloom, Wise Young, Hailong Dong, Long-Jun W. Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury. Cell reports. vol 16. issue 3. 2017-11-20. PMID:27373153. |
here, we found that spinal microgliosis predominantly results from local proliferation of resident microglia but not from infiltrating monocytes after spinal nerve transection (snt) by using two genetic mouse models (ccr2(rfp/+):cx3cr1(gfp/+) and cx3cr1(creer/+):r26(tdtomato/+) mice) as well as specific staining of microglia and macrophages. |
2017-11-20 |
2023-08-13 |
mouse |