| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anne C Solga, Winnie W Pong, Jason Walker, Todd Wylie, Vincent Magrini, Anthony J Apicelli, Malachi Griffith, Obi L Griffith, Shinichi Kohsaka, Gregory F Wu, David L Brody, Elaine R Mardis, David H Gutman. RNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease. Glia. vol 63. issue 4. 2015-10-29. PMID:25258010. |
in the current study, we performed rna-sequencing using cx3cr1(+/gfp) labeled microglia isolated from the brainstem of 6-week-old mice to compare the transcriptomes of facs-sorted versus laser capture microdissection (lcm). |
2015-10-29 |
2023-08-13 |
mouse |
| Xi Wang, Kai Cao, Xin Sun, Yongxiong Chen, Zhaoxia Duan, Li Sun, Lei Guo, Paul Bai, Dongming Sun, Jianqing Fan, Xijing He, Wise Young, Yi Re. Macrophages in spinal cord injury: phenotypic and functional change from exposure to myelin debris. Glia. vol 63. issue 4. 2015-10-29. PMID:25452166. |
infiltrating bmdms expressing higher mac-2 and lower cx3cr1 migrate to the epicenter of injury, while microglia expressing lower mac-2 but higher cx3cr1 distribute to the edges of lesion. |
2015-10-29 |
2023-08-13 |
Not clear |
| Valérie Jolivel, Frank Bicker, Fabien Binamé, Robert Ploen, Stefanie Keller, René Gollan, Betty Jurek, Jérôme Birkenstock, Laura Poisa-Beiro, Julia Bruttger, Verena Opitz, Serge C Thal, Ari Waisman, Tobias Bäuerle, Michael K Schäfer, Frauke Zipp, Mirko H H Schmid. Perivascular microglia promote blood vessel disintegration in the ischemic penumbra. Acta neuropathologica. vol 129. issue 2. 2015-09-21. PMID:25500713. |
to study the role of microglia in cortical stroke and blood vessel stability, cx3cr1(+/gfp) mice were subjected to transient middle cerebral artery occlusion and then microglia were investigated using time-lapse two-photon microscopy in vivo. |
2015-09-21 |
2023-08-13 |
mouse |
| Feng Xiao, Jun-Mei Xu, Xing-Hua Jian. CX3 chemokine receptor 1 deficiency leads to reduced dendritic complexity and delayed maturation of newborn neurons in the adult mouse hippocampus. Neural regeneration research. vol 10. issue 5. 2015-06-25. PMID:26109952. |
previous studies have shown that microglia impact the proliferation and differentiation of neurons during hippocampal neurogenesis via the fractalkine/cx3 chemokine receptor 1 (cx3cr1) signaling pathway. |
2015-06-25 |
2023-08-13 |
mouse |
| Ke Wang, Bo Peng, Bin Li. Fractalkine receptor regulates microglial neurotoxicity in an experimental mouse glaucoma model. Glia. vol 62. issue 12. 2015-06-19. PMID:24989686. |
in the present study, we investigated the role of the chemokine receptor cx3cr1 in microglia activation and retinal ganglion cell (rgc) death in an experimental mouse glaucoma model with transient elevation of intraocular pressure (iop). |
2015-06-19 |
2023-08-13 |
mouse |
| Ke Wang, Bo Peng, Bin Li. Fractalkine receptor regulates microglial neurotoxicity in an experimental mouse glaucoma model. Glia. vol 62. issue 12. 2015-06-19. PMID:24989686. |
overall, these findings provided novel insight into the mechanisms by which cx3cr1 modulated microglia activation under elevated iop. |
2015-06-19 |
2023-08-13 |
mouse |
| Nicole Maphis, Guixiang Xu, Olga N Kokiko-Cochran, Astrid E Cardona, Richard M Ransohoff, Bruce T Lamb, Kiran Bhaska. Loss of tau rescues inflammation-mediated neurodegeneration. Frontiers in neuroscience. vol 9. 2015-06-19. PMID:26089772. |
first, mapt (+/+) neurons displayed elevated levels of annexin v (a5) and tunel (markers of neurodegeneration) when co-cultured with lps-treated cx3cr1 (-/-)microglia, which is rescued in mapt (-/-) neurons. |
2015-06-19 |
2023-08-13 |
mouse |
| Anna K Clark, Doris Gruber-Schoffnegger, Ruth Drdla-Schutting, Katharina J Gerhold, Marzia Malcangio, Jürgen Sandkühle. Selective activation of microglia facilitates synaptic strength. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 11. 2015-06-15. PMID:25788673. |
specifically, the activation of the cx3cr1 receptor by fractalkine induces the release of interleukin-1β from microglia, which modulates nmda signaling in postsynaptic neurons, leading to the release of an eicosanoid messenger, which ultimately enhances presynaptic neurotransmitter release. |
2015-06-15 |
2023-08-13 |
rat |
| Antoine Lampron, Antoine Larochelle, Nathalie Laflamme, Paul Préfontaine, Marie-Michèle Plante, Maria Gabriela Sánchez, V Wee Yong, Peter K Stys, Marie-Ève Tremblay, Serge Rives. Inefficient clearance of myelin debris by microglia impairs remyelinating processes. The Journal of experimental medicine. vol 212. issue 4. 2015-06-11. PMID:25779633. |
these results highlight the crucial role played by cx3cr1 in myelin removal and show that there can be no efficient remyelination after a primary demyelinating insult if myelin clearance by microglia is impaired. |
2015-06-11 |
2023-08-13 |
mouse |
| Ronen Reshef, Tirzah Kreisel, Dorsa Beroukhim Kay, Raz Yirmiy. Microglia and their CX3CR1 signaling are involved in hippocampal- but not olfactory bulb-related memory and neurogenesis. Brain, behavior, and immunity. vol 41. 2015-06-09. PMID:24933434. |
microglia and their cx3cr1 signaling are involved in hippocampal- but not olfactory bulb-related memory and neurogenesis. |
2015-06-09 |
2023-08-13 |
mouse |
| Ronen Reshef, Tirzah Kreisel, Dorsa Beroukhim Kay, Raz Yirmiy. Microglia and their CX3CR1 signaling are involved in hippocampal- but not olfactory bulb-related memory and neurogenesis. Brain, behavior, and immunity. vol 41. 2015-06-09. PMID:24933434. |
recent studies demonstrate that microglia play an important role in cognitive and neuroplasticity processes, at least partly via microglial cx3c receptor 1 (cx3cr1) signaling. |
2015-06-09 |
2023-08-13 |
mouse |
| Ronen Reshef, Tirzah Kreisel, Dorsa Beroukhim Kay, Raz Yirmiy. Microglia and their CX3CR1 signaling are involved in hippocampal- but not olfactory bulb-related memory and neurogenesis. Brain, behavior, and immunity. vol 41. 2015-06-09. PMID:24933434. |
a similar increase in hippocampal-dependent memory functioning and microglia number was also induced by pharmacological inhibition of cx3cr1 signaling, using chronic (2weeks) i.c.v. |
2015-06-09 |
2023-08-13 |
mouse |
| Ronen Reshef, Tirzah Kreisel, Dorsa Beroukhim Kay, Raz Yirmiy. Microglia and their CX3CR1 signaling are involved in hippocampal- but not olfactory bulb-related memory and neurogenesis. Brain, behavior, and immunity. vol 41. 2015-06-09. PMID:24933434. |
these results support the notion that in the hippocampus microglia and their interactions with neurons via the cx3cr1 play an important role in memory functioning and neurogenesis, whereas in the ob microglia do not seem to be involved in these processes. |
2015-06-09 |
2023-08-13 |
mouse |
| Nadine Richter, Stefan Wendt, Petya B Georgieva, Dolores Hambardzumyan, Christiane Nolte, Helmut Kettenman. Glioma-associated microglia and macrophages/monocytes display distinct electrophysiological properties and do not communicate via gap junctions. Neuroscience letters. vol 583. 2015-06-05. PMID:25261595. |
using the cx3cr1(gfp/wt)ccr2(rfp/wt) knock-in mouse line, we distinguished membrane currents of glioma-associated microglia and macrophages/monocytes in acute brain slices prepared 14-16 days after inoculation of gl261 glioma cells. |
2015-06-05 |
2023-08-13 |
mouse |
| Francesca Pagani, Rosa C Paolicelli, Emanuele Murana, Barbara Cortese, Silvia Di Angelantonio, Emanuele Zurolo, Eva Guiducci, Tiago A Ferreira, Stefano Garofalo, Myriam Catalano, Giuseppina D'Alessandro, Alessandra Porzia, Giovanna Peruzzi, Fabrizio Mainiero, Cristina Limatola, Cornelius T Gross, Davide Ragozzin. Defective microglial development in the hippocampus of Cx3cr1 deficient mice. Frontiers in cellular neuroscience. vol 9. 2015-04-15. PMID:25873863. |
fractalkine is an important neuronal chemokine whose expression increases during development and that can influence microglia function via the fractalkine receptor, cx3cr1. |
2015-04-15 |
2023-08-13 |
mouse |
| Francesca Pagani, Rosa C Paolicelli, Emanuele Murana, Barbara Cortese, Silvia Di Angelantonio, Emanuele Zurolo, Eva Guiducci, Tiago A Ferreira, Stefano Garofalo, Myriam Catalano, Giuseppina D'Alessandro, Alessandra Porzia, Giovanna Peruzzi, Fabrizio Mainiero, Cristina Limatola, Cornelius T Gross, Davide Ragozzin. Defective microglial development in the hippocampus of Cx3cr1 deficient mice. Frontiers in cellular neuroscience. vol 9. 2015-04-15. PMID:25873863. |
mice lacking cx3cr1 show a variety of neuronal defects thought to be the result of deficient microglia function. |
2015-04-15 |
2023-08-13 |
mouse |
| Francesca Pagani, Rosa C Paolicelli, Emanuele Murana, Barbara Cortese, Silvia Di Angelantonio, Emanuele Zurolo, Eva Guiducci, Tiago A Ferreira, Stefano Garofalo, Myriam Catalano, Giuseppina D'Alessandro, Alessandra Porzia, Giovanna Peruzzi, Fabrizio Mainiero, Cristina Limatola, Cornelius T Gross, Davide Ragozzin. Defective microglial development in the hippocampus of Cx3cr1 deficient mice. Frontiers in cellular neuroscience. vol 9. 2015-04-15. PMID:25873863. |
activation of cx3cr1 is important for the proper migration of microglia to sites of injury and into the brain during development. |
2015-04-15 |
2023-08-13 |
mouse |
| Francesca Pagani, Rosa C Paolicelli, Emanuele Murana, Barbara Cortese, Silvia Di Angelantonio, Emanuele Zurolo, Eva Guiducci, Tiago A Ferreira, Stefano Garofalo, Myriam Catalano, Giuseppina D'Alessandro, Alessandra Porzia, Giovanna Peruzzi, Fabrizio Mainiero, Cristina Limatola, Cornelius T Gross, Davide Ragozzin. Defective microglial development in the hippocampus of Cx3cr1 deficient mice. Frontiers in cellular neuroscience. vol 9. 2015-04-15. PMID:25873863. |
specifically, we found that the occurrence of an outward rectifying k(+) current, typical of activated microglia, that peaked during the second and third postnatal week, was reduced in cx3cr1 knockout mice. |
2015-04-15 |
2023-08-13 |
mouse |
| Ming Duan, Honghong Yao, Yu Cai, Ke Liao, Pankaj Seth, Shilpa Buc. HIV-1 Tat disrupts CX3CL1-CX3CR1 axis in microglia via the NF-κBYY1 pathway. Current HIV research. vol 12. issue 3. 2015-04-01. PMID:24862326. |
interaction between cx3cl1 (fractalkine) and fkn receptor (cx3cr1) is highly functional in the brain, and is known to regulate a complex network of paracrine and autocrine interactions between neurons and microglia. |
2015-04-01 |
2023-08-13 |
mouse |
| Ming Duan, Honghong Yao, Yu Cai, Ke Liao, Pankaj Seth, Shilpa Buc. HIV-1 Tat disrupts CX3CL1-CX3CR1 axis in microglia via the NF-κBYY1 pathway. Current HIV research. vol 12. issue 3. 2015-04-01. PMID:24862326. |
here we showed that exposure of primary microglia and bv2 cells to exogenous tat protein resulted in down-regulation of cx3cr1 mrna and protein expression, with a concomitant induction of proinflammatory responses. |
2015-04-01 |
2023-08-13 |
mouse |