| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yochai Wolf, Simon Yona, Ki-Wook Kim, Steffen Jun. Microglia, seen from the CX3CR1 angle. Frontiers in cellular neuroscience. vol 7. 2013-03-20. PMID:23507975. |
here we summarize our current understanding of the physiological role of cx3cr1 for microglia function and the cx3c axis in microglial/neuronal crosstalk in homeostasis and under challenge. |
2013-03-20 |
2023-08-12 |
Not clear |
| Yochai Wolf, Simon Yona, Ki-Wook Kim, Steffen Jun. Microglia, seen from the CX3CR1 angle. Frontiers in cellular neuroscience. vol 7. 2013-03-20. PMID:23507975. |
moreover, we will discuss the efforts of our laboratory and others to exploit cx3cr1 promoter activity for the visualization and genetic manipulation of microglia to probe their functional contributions in the central nerve system (cns) context. |
2013-03-20 |
2023-08-12 |
Not clear |
| Mibel M Pabon, Jennifer N Jernberg, Josh Morganti, Jessika Contreras, Charles E Hudson, Ronald L Klein, Paula C Bickfor. A spirulina-enhanced diet provides neuroprotection in an α-synuclein model of Parkinson's disease. PloS one. vol 7. issue 9. 2013-02-28. PMID:23028885. |
this decrease in microglia activation may have been due, in part, to the effect of spirulina to increase expression of the fractalkine receptor (cx3cr1) on microglia. |
2013-02-28 |
2023-08-12 |
rat |
| Jayne Abraham, Patrick D Fox, Carlo Condello, Alyssa Bartolini, Sookyong Ko. Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures. Neurobiology of disease. vol 46. issue 2. 2013-01-24. PMID:22366182. |
to address the role of activated microglia in the pathogenesis of childhood epilepsy, we first examined the time course of microglia activation following kainic acid-induced status epilepticus (ka-se) in cx3cr1(gfp/+) transgenic mice whose microglia are fluorescently labeled. |
2013-01-24 |
2023-08-12 |
mouse |
| Kallirhoe Kalinderi, Sevasti Bostantjopoulou, Zoe Katsarou, Jordi Clarimón, Liana Fidan. Lack of association between CX3CR1 V249I and T280M polymorphisms and risk of Parkinson's disease in a Greek population. Genetic testing and molecular biomarkers. vol 16. issue 8. 2013-01-14. PMID:22747084. |
in the brain, the chemokine receptor cx3cr1 is exclusively expressed in microglia, selectively mediating microglia-neuron interaction in response to its ligand, the chemokine fractalkine. |
2013-01-14 |
2023-08-12 |
Not clear |
| Maki Hoshiko, Isabelle Arnoux, Elena Avignone, Nobuhiko Yamamoto, Etienne Audina. Deficiency of the microglial receptor CX3CR1 impairs postnatal functional development of thalamocortical synapses in the barrel cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 43. 2013-01-07. PMID:23100431. |
indeed, at this developmental stage fractalkine is overexpressed within the barrels and cx3cr1 deficiency delays microglial cell recruitment into the barrel centers. |
2013-01-07 |
2023-08-12 |
mouse |
| Samar Etemad, Rasheeda Mohd Zamin, Marc J Ruitenberg, Luis Filgueir. A novel in vitro human microglia model: characterization of human monocyte-derived microglia. Journal of neuroscience methods. vol 209. issue 1. 2012-11-23. PMID:22659341. |
m-mg displayed a comparable phenotype to the human microglia cell line hmc3, expressing very low levels of cd45, cd14 and hla-dr, cd11b and cd11c; and undetectable levels of cd40, cd80 and cd83, and a distinct pattern of chemokine receptors (positive for ccr1, ccr2, ccr4, ccr5, cxcr1, cxcr3, cx3cr1; negative for ccr6 and ccr7). |
2012-11-23 |
2023-08-12 |
human |
| Meng Zhang, Gezhi Xu, Wei Liu, Yingqin Ni, Wenting Zho. Role of fractalkine/CX3CR1 interaction in light-induced photoreceptor degeneration through regulating retinal microglial activation and migration. PloS one. vol 7. issue 4. 2012-08-31. PMID:22536384. |
the present study was performed to investigate the cross-talk between injured photoreceptors and activated retinal microglia, focusing on the role of fractalkine and its receptor cx3cr1 in light-induced photoreceptor degeneration. |
2012-08-31 |
2023-08-12 |
human |
| Nicolas Boivin, Rafik Menasria, David Gosselin, Serge Rivest, Guy Boivi. Impact of deficiency in CCR2 and CX3CR1 receptors on monocytes trafficking in herpes simplex virus encephalitis. The Journal of general virology. vol 93. issue Pt 6. 2012-07-16. PMID:22377584. |
the role played by resident microglia and by the infiltration of peripheral monocytes/macrophages in the innate immune response during herpes simplex virus type 1 (hsv-1) encephalitis was evaluated in mice deficient for the ccr2 and cx3cr1 receptors. |
2012-07-16 |
2023-08-12 |
mouse |
| Makiko Mizutani, Paula A Pino, Noah Saederup, Israel F Charo, Richard M Ransohoff, Astrid E Cardon. The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood. Journal of immunology (Baltimore, Md. : 1950). vol 188. issue 1. 2012-02-16. PMID:22079990. |
the principal findings include: 1) cx3cr1(+) cells localized to the aorta-gonad-mesonephros region, and visualized at embryonic day (e)9.0 in the yolk sac and neuroectoderm; 2) at e10.5, cx3cr1 single-positive microglial cells were visualized penetrating the neuroepithelium; and 3) cx3cr1 and ccr2 distinguished infiltrating macrophages from resident surveillant or activated microglia within tissue sections and by flow cytometric analyses. |
2012-02-16 |
2023-08-12 |
mouse |
| Yongdong Zhou, Kristopher G Sheets, Eric J Knott, Cornelius E Regan, Jingsheng Tuo, Chi-Chao Chan, William C Gordon, Nicolas G Baza. Cellular and 3D optical coherence tomography assessment during the initiation and progression of retinal degeneration in the Ccl2/Cx3cr1-deficient mouse. Experimental eye research. vol 93. issue 5. 2012-02-03. PMID:21854772. |
the cx3cr1 gene encodes the fractalkine receptor, cx3cr1, and is required for accumulation of monocytes and microglia recruited via ccl2. |
2012-02-03 |
2023-08-12 |
mouse |
| Tomasz Jaworski, Benoit Lechat, David Demedts, Lies Gielis, Herman Devijver, Peter Borghgraef, Hans Duimel, Fons Verheyen, Sebastian Kügler, Fred Van Leuve. Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration. The American journal of pathology. vol 179. issue 4. 2012-01-23. PMID:21839061. |
in cx3cr1(egfp/egfp)-deficient mice, microglia were recruited early to neurons expressing human tau. |
2012-01-23 |
2023-08-12 |
mouse |
| Jeong-Eun Lim, Jinghong Kou, Min Song, Abhinandan Pattanayak, Jingji Jin, Robert Lalonde, Ken-ichiro Fukuch. MyD88 deficiency ameliorates β-amyloidosis in an animal model of Alzheimer's disease. The American journal of pathology. vol 179. issue 3. 2011-12-09. PMID:21763676. |
these results suggest that myd88 deficiency may reduce aβ load by enhancing the phagocytic capability of microglia through fractalkine (the ligand of cx3cr1) signaling and by promoting apoe-mediated clearance of aβ from the brain. |
2011-12-09 |
2023-08-12 |
mouse |
| Seo-Hyun Cho, Binggui Sun, Yungui Zhou, Tiina M Kauppinen, Brian Halabisky, Paul Wes, Richard M Ransohoff, Li Ga. CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease. The Journal of biological chemistry. vol 286. issue 37. 2011-11-22. PMID:21771791. |
although fractalkine receptor (cx3cr1) on microglia was found to regulate plaque load, no functional effects have been reported. |
2011-11-22 |
2023-08-12 |
mouse |
| Dustin J Donnelly, Erin E Longbrake, Todd M Shawler, Kristina A Kigerl, Wenmin Lai, C Amy Tovar, Richard M Ransohoff, Phillip G Popovic. Deficient CX3CR1 signaling promotes recovery after mouse spinal cord injury by limiting the recruitment and activation of Ly6Clo/iNOS+ macrophages. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 27. 2011-09-09. PMID:21734283. |
deficient cx3cr1 signaling in intraspinal microglia and monocyte-derived macrophages (mdms) attenuates their ability to synthesize and release inflammatory cytokines and oxidative metabolites. |
2011-09-09 |
2023-08-12 |
mouse |
| Dustin J Donnelly, Erin E Longbrake, Todd M Shawler, Kristina A Kigerl, Wenmin Lai, C Amy Tovar, Richard M Ransohoff, Phillip G Popovic. Deficient CX3CR1 signaling promotes recovery after mouse spinal cord injury by limiting the recruitment and activation of Ly6Clo/iNOS+ macrophages. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 27. 2011-09-09. PMID:21734283. |
thus, blockade of cx3cr1 signaling represents a selective anti-inflammatory therapy that is able to promote neuroprotection, in part by reducing inflammatory signaling in microglia and mdms and recruitment of a novel monocyte subset. |
2011-09-09 |
2023-08-12 |
mouse |
| Sun Shan, Tang Hong-Min, Feng Yi, Gao Jun-Peng, Fan Yue, Tang Yan-Hong, Yang Yun-Ke, Li Wen-Wei, Wang Xiang-Yu, Ma Jun, Wang Guo-Hua, Huang Ya-Ling, Li Hua-Wei, Cai Ding-Fan. New evidences for fractalkine/CX3CL1 involved in substantia nigral microglial activation and behavioral changes in a rat model of Parkinson's disease. Neurobiology of aging. vol 32. issue 3. 2011-07-19. PMID:19368990. |
fractalkine, as an exclusive ligand for cx3cr1 expressed on microglia, has recently been reported to be released out by neurons, and induce microglial activation as a neuron-to-glia signal in the spinal cord. |
2011-07-19 |
2023-08-12 |
rat |
| S-I Yeo, J-E Kim, H J Ryu, C H Seo, B C Lee, I-G Choi, D-S Kim, T-C Kan. The roles of fractalkine/CX3CR1 system in neuronal death following pilocarpine-induced status epilepticus. Journal of neuroimmunology. vol 234. issue 1-2. 2011-07-11. PMID:21481949. |
in non-se induced animals, fractalkine and cx3cr1 immunoreactivity was detected in neurons and microglia, respectively. |
2011-07-11 |
2023-08-12 |
rat |
| Sungho Lee, Nicholas H Varvel, Megan E Konerth, Guixiang Xu, Astrid E Cardona, Richard M Ransohoff, Bruce T Lam. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. The American journal of pathology. vol 177. issue 5. 2011-03-21. PMID:20864679. |
loss of signaling between neurons and microglia via deletion of the microglial receptor, cx3cr1, worsens phenotypes in various models of neurodegenerative diseases. |
2011-03-21 |
2023-08-12 |
mouse |
| Grant W Simmons, Winnie W Pong, Ryan J Emnett, Crystal R White, Scott M Gianino, Fausto J Rodriguez, David H Gutman. Neurofibromatosis-1 heterozygosity increases microglia in a spatially and temporally restricted pattern relevant to mouse optic glioma formation and growth. Journal of neuropathology and experimental neurology. vol 70. issue 1. 2011-03-07. PMID:21157378. |
the increase in microglia in the nf1+/- optic nerve was associated with reduced expression of the chemokine receptor, cx3cr1, such that reduced cx3cr1 expression in cx3cr1-gfp heterozygous knockout mice led to a similar increase in optic nerve microglia. |
2011-03-07 |
2023-08-12 |
mouse |