| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tetsuya Mizuno, Jun Kawanokuchi, Kenji Numata, Akio Suzumur. Production and neuroprotective functions of fractalkine in the central nervous system. Brain research. vol 979. issue 1-2. 2003-09-25. PMID:12850572. |
both fractalkine and cx3cr1 were expressed constitutively in neurons, microglia, and astrocytes. |
2003-09-25 |
2023-08-12 |
Not clear |
| R Cotter, C Williams, L Ryan, David Erichsen, A Lopez, H Peng, J Zhen. Fractalkine (CX3CL1) and brain inflammation: Implications for HIV-1-associated dementia. Journal of neurovirology. vol 8. issue 6. 2003-03-03. PMID:12476352. |
upon binding to the cx3c receptor one (cx3cr1), fkn induces adhesion, chemoattraction, and activation of leukocytes, including brain macrophages and microglia (mp). |
2003-03-03 |
2023-08-12 |
human |
| Shuzhen Chen, Defang Luo, Wolfgang J Streit, Jeffrey K Harriso. TGF-beta1 upregulates CX3CR1 expression and inhibits fractalkine-stimulated signaling in rat microglia. Journal of neuroimmunology. vol 133. issue 1-2. 2003-01-14. PMID:12446007. |
tgf-beta1 upregulates cx3cr1 expression and inhibits fractalkine-stimulated signaling in rat microglia. |
2003-01-14 |
2023-08-12 |
rat |
| Shuzhen Chen, Defang Luo, Wolfgang J Streit, Jeffrey K Harriso. TGF-beta1 upregulates CX3CR1 expression and inhibits fractalkine-stimulated signaling in rat microglia. Journal of neuroimmunology. vol 133. issue 1-2. 2003-01-14. PMID:12446007. |
to explore the relationship between tgf-beta1 and cx3cr1 in the cns, the effects of tgf-beta1 on cx3cr1 mrna, protein and fractalkine-dependent stimulation of signal transduction cascades in primary cultures of rat microglia were examined. |
2003-01-14 |
2023-08-12 |
rat |
| Kozo Hatori, Atsushi Nagai, Rochelle Heisel, Jae K Ryu, Seung U Ki. Fractalkine and fractalkine receptors in human neurons and glial cells. Journal of neuroscience research. vol 69. issue 3. 2002-09-09. PMID:12125082. |
human neurons and microglia expressed cx3cr1 mrna, but astrocytes did not. |
2002-09-09 |
2023-08-12 |
human |
| Glauco Tarozzo, Marilena Campanella, Michela Ghiani, Alessandro Bulfone, Massimiliano Beltram. Expression of fractalkine and its receptor, CX3CR1, in response to ischaemia-reperfusion brain injury in the rat. The European journal of neuroscience. vol 15. issue 10. 2002-08-06. PMID:12059974. |
cx3cr1 expression was detected in the activated microglial cells of the ischaemic tissue 24 and 48 h after ischaemia, and became strongly up-regulated in macrophages/phagocytic microglia inside the infarcted tissue 7 days after ischaemia. |
2002-08-06 |
2023-08-12 |
rat |
| Paula Marie Hughes, Michelle Sandra Botham, Stefan Frentzel, Anis Mir, Victor Hugh Perr. Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS. Glia. vol 37. issue 4. 2002-05-10. PMID:11870871. |
resident microglia associated with the parenchyma and macrophages in the meninges and choroid plexus constituitively express cx3cr1. |
2002-05-10 |
2023-08-12 |
mouse |
| Paula Marie Hughes, Michelle Sandra Botham, Stefan Frentzel, Anis Mir, Victor Hugh Perr. Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS. Glia. vol 37. issue 4. 2002-05-10. PMID:11870871. |
in a prion model of chronic neurodegeneration and inflammation, cx3cl1 immunoreactivity is upregulated in astrocytes and cx3cr1 expression is elevated on microglia. |
2002-05-10 |
2023-08-12 |
mouse |
| Paula Marie Hughes, Michelle Sandra Botham, Stefan Frentzel, Anis Mir, Victor Hugh Perr. Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS. Glia. vol 37. issue 4. 2002-05-10. PMID:11870871. |
acute inflammatory responses in the cns, induced by stereotaxic injections of lipopolysaccharide or kainic acid, results in activation of microglia and astrocytes but no detectable changes in the glial expression of cx3cl1 or cx3cr1. |
2002-05-10 |
2023-08-12 |
mouse |
| E W Boddeke, I Meigel, S Frentzel, K Biber, L Q Renn, P Gebicke-Härte. Functional expression of the fractalkine (CX3C) receptor and its regulation by lipopolysaccharide in rat microglia. European journal of pharmacology. vol 374. issue 2. 1999-09-28. PMID:10422773. |
functional expression of cx3cr1, a recently discovered receptor for the chemokine fractalkine, was investigated in cultured rat microglia. |
1999-09-28 |
2023-08-12 |
rat |
| J K Harrison, Y Jiang, S Chen, Y Xia, D Maciejewski, R K McNamara, W J Streit, M N Salafranca, S Adhikari, D A Thompson, P Botti, K B Bacon, L Fen. Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 18. 1998-09-28. PMID:9724801. |
these data describe mechanisms of cellular communication between neurons and microglia, involving fractalkine and cx3cr1, which occur in both normal and pathological states of the central nervous system. |
1998-09-28 |
2023-08-12 |
rat |
| A Nishiyori, M Minami, Y Ohtani, S Takami, J Yamamoto, N Kawaguchi, T Kume, A Akaike, M Sato. Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia? FEBS letters. vol 429. issue 2. 1998-07-27. PMID:9650583. |
localization of fractalkine and cx3cr1 mrnas in rat brain: does fractalkine play a role in signaling from neuron to microglia? |
1998-07-27 |
2023-08-12 |
rat |
| A Nishiyori, M Minami, Y Ohtani, S Takami, J Yamamoto, N Kawaguchi, T Kume, A Akaike, M Sato. Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia? FEBS letters. vol 429. issue 2. 1998-07-27. PMID:9650583. |
the in vitro study suggested the cells expressing cx3cr1 mrna are microglia, not astrocytes or neurons. |
1998-07-27 |
2023-08-12 |
rat |
| Y Jiang, M N Salafranca, S Adhikari, Y Xia, L Feng, M K Sonntag, C M deFiebre, N A Pennell, W J Streit, J K Harriso. Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis. Journal of neuroimmunology. vol 86. issue 1. 1998-07-16. PMID:9655467. |
primary cultures of rat microglia expressed ccr5 mrna that was regulated by ifn-gamma, while both cultured astrocytes and microglia were found to contain mrna for cxcr4 and cx3cr1. |
1998-07-16 |
2023-08-12 |
rat |