| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Duan, Aowei Lv, Zhen Guo, Qi Liu, Chen Tian, Ying Yang, Jin Bi, Xintong Yu, Guoping Peng, Benyan Luo, Zhijian Cai, Bin Xu, Ying Fu, Jing Zhan. CX3CR1 Journal of neuroinflammation. vol 21. issue 1. 2024-10-10. PMID:39385200. |
cx3cr1 in neuroinflammation, distinguishing microglia from macrophages and identifying microglial-specific biomarkers in peripheral blood pose significant challenges. |
2024-10-10 |
2024-10-12 |
human |
| Jing Duan, Aowei Lv, Zhen Guo, Qi Liu, Chen Tian, Ying Yang, Jin Bi, Xintong Yu, Guoping Peng, Benyan Luo, Zhijian Cai, Bin Xu, Ying Fu, Jing Zhan. CX3CR1 Journal of neuroinflammation. vol 21. issue 1. 2024-10-10. PMID:39385200. |
this study comprehensively profiled the extracellular vesicles (evs) of microglia and macrophages, respectively, revealing co-expressed evs with uchl1 and cx3cr1 as evs derived specifically from microglia in human blood. |
2024-10-10 |
2024-10-12 |
human |
| Idris Akinlusi, Brian Kan, Ted Shi, Jose Barragan, Carlos Bouchot, Jorge L Cervante. EXPRESS: Human microglia polarization following infection with the Lyme disease spirochete. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 2024-09-26. PMID:39324305. |
increased inos and simultaneously decreased expression of cx3cr1 at 24 hours, may suggest initiation of neuroprotective regulation of microglia recruitment to neuroinflammation. |
2024-09-26 |
2024-09-28 |
human |
| Haojie Ding, Xuan Shi, Junwei Ma, Chang Cao, Yangyang Liu, Jinxin Lu, Lei Bai, Xiang Li, Haiying L. Integrative transcriptomic analysis reveals Cd72 as a novel pro-inflammatory factor in microglia following experimental ischemic stroke. Experimental neurology. 2024-09-26. PMID:39326825. |
we observed significant upregulation of cd72 in microglia following mcao/r, and selective knockdown of cd72 using cx3cr1 |
2024-09-26 |
2024-09-29 |
Not clear |
| Shevon N Alexander, Olivia A Reed, Michael D Burto. Spinal cord microglia drive sex differences in ethanol-mediated PGE2-induced allodynia. Brain, behavior, and immunity. 2024-08-15. PMID:39147173. |
our study used a novel genetic model where tlr4 expression is removed from the entire body by introducing a floxed transcriptional blocker (tlr4-null background (tlr4loxtb)), then restricted to microglia by breeding tlr4loxtb animals with cx3cr1:creert2 animals. |
2024-08-15 |
2024-08-18 |
mouse |
| Shashwat Tripathi, Hinda Najem, Corey Dussold, Sebastian Pacheco, Ruochen Du, Moloud Sooreshjani, Lisa A Hurley, James P Chandler, Roger Stupp, Adam M Sonabend, Craig M Horbinski, Rimas V Lukas, Joanne Xiu, Giselle Y López, Theodore P Nicolaides, Valerie Brown, Nitin R Wadhwani, Sandi K Lam, Charles David James, Ganesh Rao, Maria G Castro, Amy B Heimberger, Michael DeCuyper. Pediatric glioma immune profiling identifies TIM3 as a therapeutic target in BRAF-Fusion pilocytic astrocytoma. The Journal of clinical investigation. 2024-08-13. PMID:39137048. |
the therapeutic activity of anti-tim3 is abrogated in the cx3cr1 microglia knockout background. |
2024-08-13 |
2024-08-16 |
mouse |
| Mateusz Wątroba, Anna D Grabowska, Dariusz Szukiewic. Chemokine CX3CL1 (Fractalkine) Signaling and Diabetic Encephalopathy. International journal of molecular sciences. vol 25. issue 14. 2024-07-27. PMID:39062768. |
fractalkine (cx3cl1) has unique properties as an adhesion molecule and chemoattractant, and by acting on its only receptor, cx3cr1, it regulates the activity of microglia in physiological states and neuroinflammation. |
2024-07-27 |
2024-07-29 |
Not clear |
| Bruno Chausse, Nikolai Malorny, Andrea Lewen, Gernot Poschet, Nikolaus Berndt, Oliver Kan. Metabolic flexibility ensures proper neuronal network function in moderate neuroinflammation. Scientific reports. vol 14. issue 1. 2024-06-22. PMID:38909138. |
our results suggest that proinflammatory microglia showing enhanced nitric oxide release and decreased cx3cr1 expression transiently increase the tissue lactate/glucose ratio that depends on transcriptional reprogramming in microglia, not in neurons. |
2024-06-22 |
2024-06-25 |
Not clear |
| Jia-Rui Zhang, Shi-Yu Shen, Meng-Ying Zhai, Zu-Qi Shen, Wei Li, Ling-Feng Liang, Shu-Yuan Yin, Qiu-Qin Han, Bing Li, Yu-Qiu Zhang, Jin Y. Augmented microglial endoplasmic reticulum-mitochondria contacts mediate depression-like behavior in mice induced by chronic social defeat stress. Nature communications. vol 15. issue 1. 2024-06-18. PMID:38890305. |
in addition, reduced grp75 expression in microglia of cx3cr1 |
2024-06-18 |
2024-06-21 |
mouse |
| Huan Yu, Bingqiao Shen, Ruiqi Han, Yang Zhang, Shushu Xu, Yumeng Zhang, Yanzhi Guo, Ping Huang, Shouyue Huang, Yisheng Zhon. CX3CL1-CX3CR1 axis protects retinal ganglion cells by inhibiting microglia activation in a distal optic nerve trauma model. Inflammation and regeneration. vol 44. issue 1. 2024-06-08. PMID:38844990. |
cx3cr1, the only receptor of cx3cl1, is specifically expressed on retinal microglia, whose activation plays a role in the pathological process of optic nerve injury. |
2024-06-08 |
2024-06-10 |
Not clear |
| Huan Yu, Bingqiao Shen, Ruiqi Han, Yang Zhang, Shushu Xu, Yumeng Zhang, Yanzhi Guo, Ping Huang, Shouyue Huang, Yisheng Zhon. CX3CL1-CX3CR1 axis protects retinal ganglion cells by inhibiting microglia activation in a distal optic nerve trauma model. Inflammation and regeneration. vol 44. issue 1. 2024-06-08. PMID:38844990. |
this study aimed to evaluate whether cx3cl1 exerts optic neuroprotection by affecting the activation of microglia by combining with cx3cr1. |
2024-06-08 |
2024-06-10 |
Not clear |
| Janaki Manoja Vinnakota, Francesca Biavasco, Marius Schwabenland, Chintan Chhatbar, Rachael C Adams, Daniel Erny, Sandra Duquesne, Nadia El Khawanky, Dominik Schmidt, Viktor Fetsch, Alexander Zähringer, Henrike Salié, Dimitrios Athanassopoulos, Lukas M Braun, Nora R Javorniczky, Jenny N H G Ho, Katrin Kierdorf, Reinhard Marks, Ralph Wäsch, Federico Simonetta, Geoffroy Andrieux, Dietmar Pfeifer, Gianni Monaco, Christian Capitini, Terry J Fry, Thomas Blank, Bruce R Blazar, Eva Wagner, Matthias Theobald, Clemens Sommer, Matthias Stelljes, Christian Reicherts, Astrid Jeibmann, Jens Schittenhelm, Camelia-Maria Monoranu, Andreas Rosenwald, Martin Kortüm, Leo Rasche, Hermann Einsele, Philipp T Meyer, Joachim Brumberg, Simon Völkl, Andreas Mackensen, Roland Coras, Michael von Bergwelt-Baildon, Nathalie L Albert, Laura M Bartos, Matthias Brendel, Adrien Holzgreve, Matthias Mack, Melanie Boerries, Crystal L Mackall, Justus Duyster, Philipp Henneke, Josef Priller, Natalie Köhler, Felix Strübing, Bertram Bengsch, Marco Ruella, Marion Subklewe, Louisa von Baumgarten, Saar Gill, Marco Prinz, Robert Zeise. Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome. Nature cancer. 2024-05-20. PMID:38741011. |
pharmacological tak1 inhibition or genetic tak1 deletion in microglia using cx3cr1 |
2024-05-20 |
2024-05-27 |
mouse |
| Chunmei Zhang, Yusi Zhang, Ran Zhuang, Kun Yang, Lihua Chen, Boquan Jin, Ying Ma, Yun Zhang, Kang Tan. Alterations in CX3CL1 Levels and Its Role in Viral Pathogenesis. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38674036. |
cx3cl1 signals are transmitted through its unique receptor, cx3cr1, primarily expressed in the microglia of the central nervous system (cns). |
2024-04-27 |
2024-04-29 |
human |
| Jonas Fritze, Chandramouli Muralidharan, Eleanor Stamp, Henrik Ahleniu. Microglia undergo disease-associated transcriptional activation and CX3C motif chemokine receptor 1 expression regulates neurogenesis in the aged brain. Developmental neurobiology. 2024-04-15. PMID:38616340. |
cx3c motif chemokine receptor 1 (cx3cr1) is characteristically expressed by brain microglia where it directs migration to targets for phagocytosis. |
2024-04-15 |
2024-04-17 |
mouse |
| Jonas Fritze, Chandramouli Muralidharan, Eleanor Stamp, Henrik Ahleniu. Microglia undergo disease-associated transcriptional activation and CX3C motif chemokine receptor 1 expression regulates neurogenesis in the aged brain. Developmental neurobiology. 2024-04-15. PMID:38616340. |
we show that cx3cr1 expression, as in dam, is downregulated in old svz microglia and that heterozygous cx3cr1 mice have increased proliferation and neuroblast number in the aged svz but not in the dentate gyrus, identifying cx3cr1 signaling as a novel age and brain region-specific regulator of neurogenesis. |
2024-04-15 |
2024-04-17 |
mouse |
| Elena Di Martino, Anoop Ambikan, Daniel Ramsköld, Takashi Umekawa, Sarantis Giatrellis, Davide Vacondio, Alejandro Lastra Romero, Marta Gómez Galán, Rickard Sandberg, Ulrika Ådén, Volker M Lauschke, Ujjwal Neogi, Klas Blomgren, Julianna Kel. Inflammatory, metabolic, and sex-dependent gene-regulatory dynamics of microglia and macrophages in neonatal hippocampus after hypoxia-ischemia. iScience. vol 27. issue 4. 2024-03-19. PMID:38500830. |
in the present study, we investigated the temporal dynamics of microglia (cx3cr1 |
2024-03-19 |
2024-03-21 |
Not clear |
| Derek Rodriguez, Kaira A Church, Chelsea T Smith, Difernando Vanegas, Sandra M Cardona, Isabel A Muzzio, Kevin R Nash, Astrid E Cardon. Therapeutic Delivery of Soluble Fractalkine Ameliorates Vascular Dysfunction in the Diabetic Retina. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339005. |
microglia exclusively bind to the neuronal-derived chemokine fractalkine (fkn) via the cx3cr1 receptor to ameliorate microglial activation. |
2024-02-10 |
2024-02-12 |
Not clear |
| Genaro E Olveda, Maryanne N Barasa, Robert A Hil. Microglial phagocytosis of single dying oligodendrocytes is mediated by CX3CR1 but not MERTK. bioRxiv : the preprint server for biology. 2024-01-03. PMID:38168326. |
deletion of the fractalkine receptor, cx3cr1, delayed microglia engagement with the cell soma but unexpectedly did not affect the clearance of myelin sheaths. |
2024-01-03 |
2024-01-06 |
mouse |
| Jingchun Pei, Yongwei Zou, Cheng Wan, Shuangshuang Liu, Bin Hu, Zhigao Li, Zhiwei Tan. CX3CR1 mediates Motor Dysfunction in Mice through 5-HTR2a. Behavioural brain research. 2023-12-25. PMID:38145872. |
cx3cr1 knockout could induce motor dysfunction in several neurological disease models mainly through regulating microglia's function. |
2023-12-25 |
2023-12-28 |
mouse |
| Anne-Kathrin Gellner, Janine Reis, Bernd L Fiebich, Brita Fritsc. Cx3cr1 deficiency interferes with learning- and direct current stimulation-mediated neuroplasticity of the motor cortex. The European journal of neuroscience. 2023-12-05. PMID:38049944. |
the role of microglia and their fractalkine receptor cx3cr1 in motor cortical neuroplasticity mediated by dcs or motor learning requires further elucidation. |
2023-12-05 |
2023-12-10 |
Not clear |