| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Keying Zhu, Melanie Pieber, Jinming Han, Klas Blomgren, Xing-Mei Zhang, Robert A Harris, Harald Lun. Absence of microglia or presence of peripherally-derived macrophages does not affect tau pathology in young or old hTau mice. Glia. vol 68. issue 7. 2021-08-18. PMID:32039516. |
to assess the direct impact of microglia on tau pathology we developed a protocol for long-term microglial depletion in cx3cr1 |
2021-08-18 |
2023-08-13 |
mouse |
| Sami Piirainen, Keerthana Chithanathan, Kanchan Bisht, Maria Piirsalu, Julie Conner Savage, Marie-Eve Tremblay, Li Tia. Microglia contribute to social behavioral adaptation to chronic stress. Glia. vol 69. issue 10. 2021-08-18. PMID:34145941. |
this study aimed to determine whether microglia contribute to adaptive response of the brain and behavior toward stress using a mild and adaptive stress model - chronic restraint stress (crs) - with wild type (wt) and cx3cr1-gfp (cx3cr1[g]) mice and human schizophrenia patients' data. |
2021-08-18 |
2023-08-13 |
mouse |
| Xilei Li, Zhi Ye, Qulian Guo, E Wang, Yundan Pa. PDTC ameliorates neuropathic pain by inhibiting microglial activation via blockage of the TNFα-CX3CR1 pathway. European journal of histochemistry : EJH. vol 65. issue 1. 2021-08-05. PMID:33728865. |
in vitro bv-2 microglia activation was induced by tnf-a incubation, and the levels of cx3cr1 were assessed by western blot and reverse transcription-polymerase chain reaction. |
2021-08-05 |
2023-08-13 |
rat |
| Xilei Li, Zhi Ye, Qulian Guo, E Wang, Yundan Pa. PDTC ameliorates neuropathic pain by inhibiting microglial activation via blockage of the TNFα-CX3CR1 pathway. European journal of histochemistry : EJH. vol 65. issue 1. 2021-08-05. PMID:33728865. |
the nf-κb activation might be responsible for tnf-a-induced cx3cr1 up-regulation in microglia. |
2021-08-05 |
2023-08-13 |
rat |
| Bingjie Qin, Ni Luo, Yuxing Li, Denghui Gong, Jun Zheng, Xiao Tan, Weihong Zhen. Protective effect of gastrodin on peripheral neuropathy induced by anti-tumor treatment with vincristine in rat models. Drug and chemical toxicology. vol 44. issue 1. 2021-08-03. PMID:30554535. |
gastrodin relieved cipn by inhibiting activation of spinal microglia through fractalkine (cx3cl1) and its receptor cx3cr1, then inhibited p38/mitogen-activated protein kinase (mapk) signaling pathway and reduced the expression of inflammatory factor tnf-α and interleukin-1β (il-1β). |
2021-08-03 |
2023-08-13 |
human |
| Marta González-Prieto, Irene L Gutiérrez, Borja García-Bueno, Javier R Caso, Juan C Leza, Adriana Ortega-Hernández, Dulcenombre Gómez-Garre, José L M Madriga. Microglial CX3CR1 production increases in Alzheimer's disease and is regulated by noradrenaline. Glia. vol 69. issue 1. 2021-07-28. PMID:32662924. |
the activation of microglial cx3cr1, sole receptor for cx3cl1, reduces the activation of microglia, which is known to largely contribute to the neuronal damage characteristic of ad. |
2021-07-28 |
2023-08-13 |
mouse |
| Marta González-Prieto, Irene L Gutiérrez, Borja García-Bueno, Javier R Caso, Juan C Leza, Adriana Ortega-Hernández, Dulcenombre Gómez-Garre, José L M Madriga. Microglial CX3CR1 production increases in Alzheimer's disease and is regulated by noradrenaline. Glia. vol 69. issue 1. 2021-07-28. PMID:32662924. |
therefore, alterations of cx3cr1 production in microglia could translate into the enhancement or inhibition of cx3cl1 anti-inflammatory effects. |
2021-07-28 |
2023-08-13 |
mouse |
| Marta González-Prieto, Irene L Gutiérrez, Borja García-Bueno, Javier R Caso, Juan C Leza, Adriana Ortega-Hernández, Dulcenombre Gómez-Garre, José L M Madriga. Microglial CX3CR1 production increases in Alzheimer's disease and is regulated by noradrenaline. Glia. vol 69. issue 1. 2021-07-28. PMID:32662924. |
however, direct administration of na to primary rat microglia or human hmc3 cells inhibits cx3cr1 production, suggesting that microglia responses to na may be altered in the absence of cx3cl1-producing neurons or other nonmicroglial external factors. |
2021-07-28 |
2023-08-13 |
mouse |
| Younghwan Lee, Ji-Won Lee, Hyeri Nam, Seong-Woon Y. Cx3cr1 Molecular brain. vol 13. issue 1. 2021-07-08. PMID:32513210. |
cx3cr1 microglia are macrophages resident in the central nervous system. |
2021-07-08 |
2023-08-13 |
Not clear |
| Namiko Kawamura, Goro Katsuura, Nobuko Yamada-Goto, Ela Novianti, Akio Inui, Akihiro Asakaw. Impaired brain fractalkine-CX3CR1 signaling is implicated in cognitive dysfunction in diet-induced obese mice. BMJ open diabetes research & care. vol 9. issue 1. 2021-06-30. PMID:33568358. |
fractalkine released from neurons acts on its receptor, cx3c chemokine receptor 1 (cx3cr1), in the microglia to regulate several brain functions. |
2021-06-30 |
2023-08-13 |
mouse |
| Nobuhito Murai, Maisam Mitalipova, Rudolf Jaenisc. Functional analysis of CX3CR1 in human induced pluripotent stem (iPS) cell-derived microglia-like cells. The European journal of neuroscience. vol 52. issue 7. 2021-06-21. PMID:32579729. |
cx3c chemokine receptor 1 (cx3cr1), which is specifically expressed in microglia, regulates microglia homeostatic functions such as microglial activation and is downregulated in aged brain and disease-associated microglia in rodents, yet its role in human microglia is not fully understood. |
2021-06-21 |
2023-08-13 |
human |
| Nobuhito Murai, Maisam Mitalipova, Rudolf Jaenisc. Functional analysis of CX3CR1 in human induced pluripotent stem (iPS) cell-derived microglia-like cells. The European journal of neuroscience. vol 52. issue 7. 2021-06-21. PMID:32579729. |
in this study, we investigated the function of cx3cr1 in human microglia using human induced pluripotent stem (ips) cell-derived microglia-like cells. |
2021-06-21 |
2023-08-13 |
human |
| Nobuhito Murai, Maisam Mitalipova, Rudolf Jaenisc. Functional analysis of CX3CR1 in human induced pluripotent stem (iPS) cell-derived microglia-like cells. The European journal of neuroscience. vol 52. issue 7. 2021-06-21. PMID:32579729. |
these results suggest that cx3cr1 in human microglia may contribute to microglial homeostasis by regulating inflammatory response and phagocytosis. |
2021-06-21 |
2023-08-13 |
human |
| Efthalia Angelopoulou, Yam Nath Paudel, Mohd Farooq Shaikh, Christina Piper. Fractalkine (CX3CL1) signaling and neuroinflammation in Parkinson's disease: Potential clinical and therapeutic implications. Pharmacological research. vol 158. 2021-06-03. PMID:32445958. |
fractalkine (cx3cl1), a chemokine mainly expressed by neurons, can modulate microglial activity through binding to its sole g-protein-coupled receptor (cx3cr1), expressed by microglia. |
2021-06-03 |
2023-08-13 |
mouse |
| Eoin O'Neill, Éadaoin W Griffin, Ruairi O'Sullivan, Carol Murray, Lucy Ryan, Justin Yssel, Andrew Harkin, Colm Cunningha. Acute neuroinflammation, sickness behavior and working memory responses to acute systemic LPS challenge following noradrenergic lesion in mice. Brain, behavior, and immunity. vol 94. 2021-05-28. PMID:33307172. |
this did not significantly alter numbers of pu.1-positive microglia, iba1-positive microglial morphology or mrna expression of microglia-associated gene transcripts (tyrobp, sall1, cd68, sra2, clec7a) in the hippocampus or frontal cortex and produced modest reductions in cx3cr1 and p2ry12. |
2021-05-28 |
2023-08-13 |
mouse |
| Anne-Laure Hemonnot-Girard, Audrey J Valverde, Jennifer Hua, Charlene Delaygue, Nathalie Linck, Tangui Maurice, François Rassendren, Helene Hirbe. Analysis of CX3CR1 haplodeficiency in male and female APP Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:33190798. |
analysis of cx3cr1 haplodeficiency in male and female app microglia, the resident immune cells of the brain, have recently emerged as key players in alzheimer disease (ad) pathogenesis, but their roles in ad remain largely elusive and require further investigation. |
2021-05-27 |
2023-08-13 |
mouse |
| Ye Liu, Tianxiang Zhang, Dewang Meng, Li Sun, Guili Yang, Yating He, Chao Zhan. Involvement of CX3CL1/CX3CR1 in depression and cognitive impairment induced by chronic unpredictable stress and relevant underlying mechanism. Behavioural brain research. vol 381. 2021-05-26. PMID:31765724. |
a major participant in neuroinflammation is microglia, and fractalkine signaling (which comprises the chemokine cx3cl1, mainly expressed by neurons, and its receptor cx3cr1, almost exclusively present on microglia in healthy brains) has been reported to critically regulate microglial activity. |
2021-05-26 |
2023-08-13 |
human |
| Qin Wu, Yuping Chen, Wenying Zhang, Siyuan Song, Ziyang Xu, Hong Zhang, Liping Liu, Jihu Su. Upregulation of Chemokines in the Paraventricular Nucleus of the Hypothalamus in Rats with Stress-Induced Hypertension. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-21. PMID:33199674. |
the numbers of cx3cr1 (receptor of cx3cl1)-immunostained cells and oxycocin-42 (ox-42, marker of microglia)-positive cells increased in pvn of the sih rats. |
2021-05-21 |
2023-08-13 |
rat |
| Zi-Rong Li, Yuan-Shan Han, Zhuo Liu, Hong-Qing Zhao, Jian Liu, Hui Yang, Yu-Hong Wan. GR/NF-κB signaling pathway regulates hippocampal inflammatory responses in diabetic rats with chronic unpredictable mild stress. European journal of pharmacology. vol 895. 2021-05-19. PMID:33465356. |
apart from enhanced depressive behavior, diabetes-depressed condition also up-regulated the expression of hippocampus microglia chemokine Ⅰ receptor (cx3cr1) and secretion of several pro-inflammatory factors, in particular, interleukin 1β (il-1β), interleukin-6 (il-6), interleukin-8 (il-8) and tumor necrosis factor - α (tnf-α). |
2021-05-19 |
2023-08-13 |
rat |
| Hariharakrishnan Chidambaram, Subashchandrabose Chinnathamb. G-Protein Coupled Receptors and Tau-different Roles in Alzheimer's Disease. Neuroscience. vol 438. 2021-05-14. PMID:32335218. |
in the microglia, the extra-cellular tau binding to a chemokine gpcr, cx3cr1 triggers its internalization, whereas tau phosphorylation at specific sites decreases its binding affinity to this receptor. |
2021-05-14 |
2023-08-13 |
Not clear |