| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Wang, Hanyi Ling, Hui He, Nan Hu, Lin Xiao, Yue Zhang, Lei Xie, Zili Yo. Dysfunctional synaptic pruning by microglia correlates with cognitive impairment in sleep-deprived mice: Involvement of CX3CR1 signaling. Neurobiology of stress. vol 25. 2023-08-07. PMID:37547773. |
dysfunctional synaptic pruning by microglia correlates with cognitive impairment in sleep-deprived mice: involvement of cx3cr1 signaling. |
2023-08-07 |
2023-08-14 |
mouse |
| Shunyi Zhao, Jiaying Zheng, Lingxiao Wang, Anthony D Umpierre, Sebastian Parusel, Manling Xie, Aastha Dheer, Katayoun Ayasoufi, Aaron J Johnson, Jason R Richardson, Long-Jun W. Chemogenetic manipulation of CX3CR1 Molecular psychiatry. 2023-06-26. PMID:37365239. |
chemogenetic manipulation of cx3cr1 chemogenetic approaches using designer receptors exclusively activated by designer drugs (dreadd, a family of engineered gpcrs) were recently employed in microglia. |
2023-06-26 |
2023-08-14 |
Not clear |
| Matilda Iemmolo, Giulio Ghersi, Giulia Bivon. The Cytokine CX3CL1 and ADAMs/MMPs in Concerted Cross-Talk Influencing Neurodegenerative Diseases. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175729. |
cx3cl1, as an adhesion molecule, on the one hand, plays an inhibiting role in the pro-inflammatory response in the central nervous system (cns) and shows neuroprotective effects by binding its membrane receptor (cx3cr1) present into microglia cells and maintaining them in a quiescent state; on the other hand, the scx3cl1 isoform seems to promote neurodegeneration. |
2023-05-14 |
2023-08-14 |
Not clear |
| Giulia Bivona, Matilda Iemmolo, Giulio Ghers. CX3CL1 Pathway as a Molecular Target for Treatment Strategies in Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175935. |
fkn and its microglial receptor cx3cr1 are crucial players in the interplay between neurons and microglia, modulating the operation of some neural circuits and the efficacy and persistence of immune response against injury. |
2023-05-14 |
2023-08-14 |
Not clear |
| Michela Perrone, Martina Pagano, Carmela Belardo, Flavia Ricciardi, Federica Ricciardi, Antimo Fusco, Maria Consiglia Trotta, Rosmara Infantino, Francesca Gargano, Andrea Parente, Rosa Giacca, Gorizio Pieretti, Livio Luongo, Sabatino Maione, Serena Boccella, Francesca Guid. Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology: A possible cross-talk with C-X-C chemokine receptor 1 (CXCR1). Neuropharmacology. 2023-02-16. PMID:36796675. |
likewise, hcar2 stimulation reduced the proinflammatory mediators mrna expression induced by neuronal chemokine fractalkine (fkn), a neuronal derived chemokine activating its unique receptor, chemokine receptor 1 (cx3cr1) on microglia surface. |
2023-02-16 |
2023-08-14 |
rat |
| Yong Chen, Dan Li, Ningcen Li, PeiYong Loh, Yi Guo, Xiyou Hu, Jingyu Zhang, Baomin Dou, Lifen Wang, Chaobo Yang, Tao Guo, Shuangli Chen, Zhen Liu, Bo Chen, Zelin Che. Role of nerve signal transduction and neuroimmune crosstalk in mediating the analgesic effects of acupuncture for neuropathic pain. Frontiers in neurology. vol 14. 2023-02-09. PMID:36756246. |
moreover, neuroinflammation in pain can be inhibited by acupuncture through inhibiting jak2/stat3, pi3k/mtor pathways, down regulating chemokine receptor cx3cr1 on microglia and up regulating adenosine receptor a1rs on astrocytes, inhibiting the activation of glia and reducing tnf-α and other inflammatory substances. |
2023-02-09 |
2023-08-14 |
Not clear |
| N P Camacho-Hernández, F Peña-Orteg. Fractalkine/CX3CR1-Dependent Modulation of Synaptic and Network Plasticity in Health and Disease. Neural plasticity. vol 2023. 2023-01-16. PMID:36644710. |
cx3cr1 is a g protein-coupled receptor that is expressed exclusively by microglia within the brain parenchyma. |
2023-01-16 |
2023-08-14 |
Not clear |
| Monique M A de Almeida, Adrianne E S Watson, Sana Bibi, Nicole L Dittmann, Kara Goodkey, Pedram Sharafodinzadeh, Danny Galleguillos, Maryam Nakhaei-Nejad, Jayasankar Kosaraju, Noam Steinberg, Beatrix S Wang, Tim Footz, Fabrizio Giuliani, Jing Wang, Simonetta Sipione, Julia M Edgar, Anastassia Voronov. Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model. Stem cell reports. 2023-01-07. PMID:36608690. |
finally, we show that activated opcs and microglia/macrophages express fractalkine receptor cx3cr1 in vivo, and that in opc-microglia co-cultures fractalkine increases in vitro oligodendrocyte differentiation by modulating both opc and microglia biology. |
2023-01-07 |
2023-08-14 |
mouse |
| E De Felice, E Gonçalves de Andrade, M T Golia, F González Ibáñez, M Khakpour, M A Di Castro, S Garofalo, E Di Pietro, C Benatti, N Brunello, F Tascedda, B Kaminska, C Limatola, D Ragozzino, M E Tremblay, S Alboni, L Magg. Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions. Journal of neuroinflammation. vol 19. issue 1. 2022-12-09. PMID:36482444. |
this was recapitulated in cx3cr1 knockout mice, indicating that microglia have a key role in setting the conditions for plasticity processes in a region-specific manner, and that the cx3cl1-cx3cr1 pathway is a key element in determining the basal level of ca1 ltp in the two regions. |
2022-12-09 |
2023-08-14 |
mouse |
| Qiong Wu, Hua Wang, Xueyan Liu, Yajuan Zhao, Peng S. Microglial activation and over pruning involved in developmental epilepsy. Journal of neuropathology and experimental neurology. 2022-12-01. PMID:36453895. |
to understand the potential role of microglia in synaptic pruning following status epilepticus (se), we examined the time course of expression of iba-1, and immune and neuroinflammatory regulators, including cd86, cd206, and cx3cr1, and tlr4/nf-κb after se induced by pilocarpine in rats. |
2022-12-01 |
2023-08-14 |
rat |
| Qiong Wu, Hua Wang, Xueyan Liu, Yajuan Zhao, Peng S. Microglial activation and over pruning involved in developmental epilepsy. Journal of neuropathology and experimental neurology. 2022-12-01. PMID:36453895. |
the expression of the chemokine receptor cx3cr1 in microglia increased to varying degrees after se, and expression of the presynaptic protein synapsin decreased. |
2022-12-01 |
2023-08-14 |
rat |
| Maeve Boyce, Ying Xin, Olivia Chowdhury, Peng Shang, Haitao Liu, Victoria Koontz, Anastasia Strizhakova, Mihir Nemani, Stacey Hose, J Samuel Zigler, Matthew Campbell, Debasish Sinha, James T Handa, Kai Kaarniranta, Jiang Qian, Sayan Ghos. Microglia-Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model. Cells. vol 11. issue 22. 2022-11-26. PMID:36428965. |
using well-characterized genetically engineered mouse models as tools, we show that in the diseased state, retinal pigmented epithelial (rpe) cells trigger pro-inflammatory (m1) transition in microglia with diminished expression of the homeostatic marker, cx3cr1. |
2022-11-26 |
2023-08-14 |
mouse |
| Namiko Kawamura, Goro Katsuura, Nobuko Yamada-Goto, Riho Nakama, Yuki Kambe, Atsuro Miyata, Tomoyuki Furuyashiki, Shuh Narumiya, Yoshihiro Ogawa, Akio Inu. Brain fractalkine-CX3CR1 signalling is anti-obesity system as anorexigenic and anti-inflammatory actions in diet-induced obese mice. Scientific reports. vol 12. issue 1. 2022-07-23. PMID:35871167. |
in the brain, fractalkine is expressed in neurons and binds to a cx3c chemokine receptor 1 (cx3cr1) in microglia. |
2022-07-23 |
2023-08-14 |
mouse |
| Deanna Doughty, Surendra K Rajpurohit, Amy Trang, Ahmet Alptekin, Ahmet K Korkaya, Bhagelu R Achyut, Ali S Arbab, Jennifer W Bradfor. Development of a novel purification protocol to isolate and identify brain microglia. Experimental biology and medicine (Maywood, N.J.). 2022-06-06. PMID:35666093. |
we also describe flow cytometry methods using novel cell surface markers, including cx3cr1 and siglec-h, to specifically label microglia while avoiding other bone marrow and/or non-cns derived macrophages and monocytes, which has been historically difficult to achieve. |
2022-06-06 |
2023-08-14 |
mouse |
| Yan Chen, Hengrui Zhang, Yu Zhao, Ye Zhang, Saige Yin, Yan Hu, Guolan Ma, Di Lu, Jun Su. Microglial integrin, chemokine receptors, and inflammatory response vary with development. Biochemical and biophysical research communications. vol 615. 2022-05-24. PMID:35609421. |
results showed that implantation of microglia into the cns until adulthood resulted in dynamic changes in the expression levels of cd11b (α chain of complement receptor 3) and cx3cr1 (a chemokine receptor), which were consistent and correlated. |
2022-05-24 |
2023-08-13 |
Not clear |
| Andrew S Mendiola, Kaira A Church, Sandra M Cardona, Difernando Vanegas, Shannon A Garcia, Wendy Macklin, Sergio A Lira, Richard M Ransohoff, Erzsebet Kokovay, Chin-Hsing Annie Lin, Astrid E Cardon. Defective fractalkine-CX3CR1 signaling aggravates neuroinflammation and affects recovery from cuprizone-induced demyelination. Journal of neurochemistry. 2022-05-13. PMID:35560167. |
the fractalkine receptor cx3cr1 limits the activation of pathogenic microglia and the human polymorphic cx3cr1 |
2022-05-13 |
2023-08-13 |
human |
| Lu Zheng, Yi Wang, Bin Shao, Huijuan Zhou, Xing Li, Cai Zhang, Ning Sun, Jing Sh. Multiple Mild Stimulations Reduce Membrane Distribution of CX3CR1 Promoted by Annexin a1 in Microglia to Attenuate Excessive Dendritic Spine Pruning and Cognitive Deficits Caused by a Transient Ischemic Attack in Mice. Neuroscience bulletin. 2022-03-30. PMID:35352285. |
multiple mild stimulations reduce membrane distribution of cx3cr1 promoted by annexin a1 in microglia to attenuate excessive dendritic spine pruning and cognitive deficits caused by a transient ischemic attack in mice. |
2022-03-30 |
2023-08-13 |
mouse |
| Lu Zheng, Yi Wang, Bin Shao, Huijuan Zhou, Xing Li, Cai Zhang, Ning Sun, Jing Sh. Multiple Mild Stimulations Reduce Membrane Distribution of CX3CR1 Promoted by Annexin a1 in Microglia to Attenuate Excessive Dendritic Spine Pruning and Cognitive Deficits Caused by a Transient Ischemic Attack in Mice. Neuroscience bulletin. 2022-03-30. PMID:35352285. |
tia promoted the interaction of anxa1 and cx3cr1, increased the membrane distribution of cx3cr1 in microglia, and thus enhanced the cx3cr1 and cx3cl1 interaction. |
2022-03-30 |
2023-08-13 |
mouse |
| Lu Zheng, Yi Wang, Bin Shao, Huijuan Zhou, Xing Li, Cai Zhang, Ning Sun, Jing Sh. Multiple Mild Stimulations Reduce Membrane Distribution of CX3CR1 Promoted by Annexin a1 in Microglia to Attenuate Excessive Dendritic Spine Pruning and Cognitive Deficits Caused by a Transient Ischemic Attack in Mice. Neuroscience bulletin. 2022-03-30. PMID:35352285. |
meanwhile, the cx3cr1 membrane distribution and cx3cr1-cx3cl1 interaction were upregulated in primary cultured microglia overexpressing anxa1, and the spine density was significantly reduced in co-cultured microglia overexpressing anxa1 and neurons. |
2022-03-30 |
2023-08-13 |
mouse |
| Koichi Inou. Potential significance of CX3CR1 dynamics in stress resilience against neuronal disorders. Neural regeneration research. vol 17. issue 10. 2022-03-09. PMID:35259822. |
the receptor for fkn, cx3cr1, is usually expressed in microglia in the brain, and therefore the inflammatory response of microglia is modified by fkn. |
2022-03-09 |
2023-08-13 |
human |