| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nelly Maritza Vega-Rivera, Leonardo Ortiz-López, Andrea Granados-Juárez, Erika Monserrat Estrada-Camarena, Gerardo Bernabé Ramírez-Rodrígue. Melatonin Reverses the Depression-associated Behaviour and Regulates Microglia, Fractalkine Expression and Neurogenesis in Adult Mice Exposed to Chronic Mild Stress. Neuroscience. vol 440. 2021-05-14. PMID:32417342. |
melatonin and citalopram induced similar antidepressant-like activities that occurred with some of the the following findings: (1) reversal of the morphological alterations in microglia; (2) reversal of the decreased immunoreactivity to cx3cl1 and cx3cr1 in the dentate gyrus; (3) positive regulation of cell proliferation, survival and complexity of the dendritic trees of doublecortin-cells; and (4) modifications of peripheral cx3cl1 expression. |
2021-05-14 |
2023-08-13 |
mouse |
| Alita Soch, Sarah J Spence. Consequences of early life overfeeding for microglia - Perspectives from rodent models. Brain, behavior, and immunity. vol 88. 2021-04-27. PMID:32088312. |
to specifically investigate the role of microglia in these programming effects our group has developed a novel transgenic rat with a diphtheria toxin receptor insertion in the promoter region for the cx3cr1 gene, expressed on microglia and monocytes; allowing us to conditionally ablate microglia throughout the brain. |
2021-04-27 |
2023-08-13 |
rat |
| Michael J Butler, Rachel M Cole, Nicholas P Deems, Martha A Belury, Ruth M Barriento. Fatty food, fatty acids, and microglial priming in the adult and aged hippocampus and amygdala. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32544595. |
our results indicate that hfd increased gene expression of microglial markers of activation indicative of microglial priming, including cd11b, mhcii, cx3cr1, and nlrp3, as well as the pro-inflammatory marker il-1β in both hippocampus and amygdala-derived microglia. |
2021-04-27 |
2023-08-13 |
rat |
| Alexandra Grubman, Teresa H Vandekolk, Jan Schröder, Guizhi Sun, Jessica Hatwell-Humble, Jonathan Chan, Minna Oksanen, Sarka Lehtonen, Cameron Hunt, Jari E Koistinaho, Susan K Nilsson, John M Haynes, Colin W Pouton, Jose M Pol. A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture. Stem cell reports. vol 14. issue 6. 2021-04-19. PMID:32442534. |
a cx3cr1 reporter hesc line facilitates integrative analysis of in-vitro-derived microglia and improved microglia identity upon neuron-glia co-culture. |
2021-04-19 |
2023-08-13 |
human |
| Xilei Li, Qulian Guo, Zhi Ye, E Wang, Wangyuan Zou, Zhihua Sun, Zhenghua He, Tao Zhong, Yingqi Weng, Yundan Pa. PPAR γ Prevents Neuropathic Pain by Down-Regulating CX3CR1 and Attenuating M1 Activation of Microglia in the Spinal Cord of Rats Using a Sciatic Chronic Constriction Injury Model. Frontiers in neuroscience. vol 15. 2021-04-13. PMID:33841075. |
ppar γ prevents neuropathic pain by down-regulating cx3cr1 and attenuating m1 activation of microglia in the spinal cord of rats using a sciatic chronic constriction injury model. |
2021-04-13 |
2023-08-13 |
rat |
| Paulina Pawelec, Malgorzata Ziemka-Nalecz, Joanna Sypecka, Teresa Zalewsk. The Impact of the CX3CL1/CX3CR1 Axis in Neurological Disorders. Cells. vol 9. issue 10. 2021-04-02. PMID:33065974. |
cx3cl1 signals through its unique receptor, cx3cr1, that is expressed in microglia. |
2021-04-02 |
2023-08-13 |
Not clear |
| Chan Noh, Hyo Jung Shin, Seounghun Lee, Song I Kim, Yoon-Hee Kim, Won Hyung Lee, Dong Woon Kim, Sun Yeul Lee, Young Kwon K. CX3CR1-Targeted PLGA Nanoparticles Reduce Microglia Activation and Pain Behavior in Rats with Spinal Nerve Ligation. International journal of molecular sciences. vol 21. issue 10. 2021-02-11. PMID:32423102. |
activation of cx3cr1 in microglia plays an important role in the development of neuropathic pain. |
2021-02-11 |
2023-08-13 |
rat |
| Chan Noh, Hyo Jung Shin, Seounghun Lee, Song I Kim, Yoon-Hee Kim, Won Hyung Lee, Dong Woon Kim, Sun Yeul Lee, Young Kwon K. CX3CR1-Targeted PLGA Nanoparticles Reduce Microglia Activation and Pain Behavior in Rats with Spinal Nerve Ligation. International journal of molecular sciences. vol 21. issue 10. 2021-02-11. PMID:32423102. |
cx3cr1 sirna-treated rats exhibited significant reductions in the activation of microglia in the spinal dorsal horn and a downregulation of proinflammatory mediators, as well as a significant attenuation of mechanical allodynia. |
2021-02-11 |
2023-08-13 |
rat |
| Guozhao Chen, Zhiping Zhou, Weiping Sha, Liming Wang, Fei Yan, Xiaomei Yang, Xia Qin, Muyao Wu, Di Li, Shoujin Tian, Gang Che. A novel CX3CR1 inhibitor AZD8797 facilitates early recovery of rat acute spinal cord injury by inhibiting inflammation and apoptosis. International journal of molecular medicine. vol 45. issue 5. 2021-02-04. PMID:32323731. |
the enhanced expression of cx3cr1 was detected in astrocytes and microglia of the injured spinal cord. |
2021-02-04 |
2023-08-13 |
rat |
| b' Ivan Pilipovi\\xc4\\x87, Zorica Stoji\\xc4\\x87-Vukani\\xc4\\x87, Ivana Priji\\xc4\\x87, Neboj\\xc5\\xa1a Jasni\\xc4\\x87, Gordana Leposavi\\xc4\\x8. Propranolol diminished severity of rat EAE by enhancing immunoregulatory/protective properties of spinal cord microglia. Neurobiology of disease. vol 134. 2021-01-13. PMID:31689515.' |
this was associated with the increased proportion of microglia expressing cx3cr1, the key molecule in their immunomodulatory/neuroprotective action, and upregulation of cx3cr1 downstream nrf2 gene. |
2021-01-13 |
2023-08-13 |
rat |
| Erica Mondo, Shannon C Becker, Amanda G Kautzman, Martina Schifferer, Christina E Baer, Jiapei Chen, Eric J Huang, Mikael Simons, Dorothy P Schafe. A Developmental Analysis of Juxtavascular Microglia Dynamics and Interactions with the Vasculature. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 34. 2021-01-04. PMID:32661024. |
here, we use the male and female mouse cerebral cortex to show that a higher percentage of microglia associate with the vasculature during the first week of postnatal development compared with older ages and that the timing of these associations is dependent on the fractalkine receptor (cx3cr1). |
2021-01-04 |
2023-08-13 |
mouse |
| Katarzyna Chamera, Ewa Trojan, Magdalena Szuster-Głuszczak, Agnieszka Basta-Kai. The Potential Role of Dysfunctions in Neuron-Microglia Communication in the Pathogenesis of Brain Disorders. Current neuropharmacology. vol 18. issue 5. 2020-11-25. PMID:31729301. |
they are principally expressed by neurons when their receptors, cx3cr1 and cd200r, respectively, are predominantly present on the microglia, resulting in the specific axis which maintains the cns homeostasis. |
2020-11-25 |
2023-08-13 |
Not clear |
| Jing Li, Runtian Zhao, Yuhan Jiang, Yi Xu, Huan Zhao, Xiaoling Lyu, Tao W. Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia. Food & function. vol 11. issue 2. 2020-11-23. PMID:32003387. |
immunofluorescence and rt-pcr analysis results showed that ba fully activates the microglia and astrocytes, downregulates the expression of inflammatory factors (tnf-α, nf-kβ, il-1β, il-6, cox-2, inos and cd33) and chemokine receptor cx3cr1, and upregulates the expression of microglia homeostatic factors (trem2 and tyrobp) and toll-like receptors (tlr2 and tlr4). |
2020-11-23 |
2023-08-13 |
mouse |
| Joël Jovanovic, Xuan Liu, Despina Kokona, Martin S Zinkernagel, Andreas Ebnete. Inhibition of inflammatory cells delays retinal degeneration in experimental retinal vein occlusion in mice. Glia. vol 68. issue 3. 2020-11-19. PMID:31652020. |
to test this hypothesis, we depleted microglia by plx5622 (a selective tyrosine kinase inhibitor that targets the colony-stimulating factor-1 receptor) in fractalkine receptor reporter mice (cx3cr1 |
2020-11-19 |
2023-08-13 |
mouse |
| Suzanne E Hickman, Elizabeth K Allison, Uwanda Coleman, Nathan D Kingery-Gallagher, Joseph El Khour. Heterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice. Frontiers in immunology. vol 10. 2020-11-10. PMID:31849963. |
heterozygous cx3cr1 deficiency in microglia restores neuronal β-amyloid clearance pathways and slows progression of alzheimer's like-disease in ps1-app mice. |
2020-11-10 |
2023-08-13 |
mouse |
| Suzanne E Hickman, Elizabeth K Allison, Uwanda Coleman, Nathan D Kingery-Gallagher, Joseph El Khour. Heterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice. Frontiers in immunology. vol 10. 2020-11-10. PMID:31849963. |
cx3cr1 is a chemokine receptor expressed on microglia that binds fractalkine (cx3cl1) and regulates microglial recruitment to sites of neuroinflammation. |
2020-11-10 |
2023-08-13 |
mouse |
| Zsuzsanna Winkler, Dániel Kuti, Ágnes Polyák, Balázs Juhász, Krisztina Gulyás, Nikolett Lénárt, Ádám Dénes, Szilamér Ferenczi, Krisztina J Kovác. Hypoglycemia-activated Hypothalamic Microglia Impairs Glucose Counterregulatory Responses. Scientific reports. vol 9. issue 1. 2020-10-20. PMID:30996341. |
fractalkine-cx3cr1 signaling plays a role in control of microglia during hypoglycemia, because density and solidity of iba1-ir profiles was attenuated in fasted, insulin-treated, cx3cr1 ko mice, which was parallel with exaggerated neuropeptide responses and higher blood glucose levels following insulin administration. |
2020-10-20 |
2023-08-13 |
mouse |
| Aitao Wang, Muer Tie, Dongmei Guo, Na Wu, Shanglong Yao, Limei Yan, Xingsheng Zha. A Novel Mechanism of BAM8-22 Inhibiting Microglia Activation: Represses CX3CR1 Expression via Upregulating miR-184. Journal of molecular neuroscience : MN. vol 70. issue 4. 2020-10-08. PMID:31833017. |
a novel mechanism of bam8-22 inhibiting microglia activation: represses cx3cr1 expression via upregulating mir-184. |
2020-10-08 |
2023-08-13 |
mouse |
| Aitao Wang, Muer Tie, Dongmei Guo, Na Wu, Shanglong Yao, Limei Yan, Xingsheng Zha. A Novel Mechanism of BAM8-22 Inhibiting Microglia Activation: Represses CX3CR1 Expression via Upregulating miR-184. Journal of molecular neuroscience : MN. vol 70. issue 4. 2020-10-08. PMID:31833017. |
the expression of cx3cr1 protein and microglia activation marker, iba-1, was measured by western blot analysis. |
2020-10-08 |
2023-08-13 |
mouse |
| Aitao Wang, Muer Tie, Dongmei Guo, Na Wu, Shanglong Yao, Limei Yan, Xingsheng Zha. A Novel Mechanism of BAM8-22 Inhibiting Microglia Activation: Represses CX3CR1 Expression via Upregulating miR-184. Journal of molecular neuroscience : MN. vol 70. issue 4. 2020-10-08. PMID:31833017. |
further, in vitro studies showed that mir-184 bound to the 3'utr of cx3cr1 and inhibited microglia activation via repressing cx3cr1 expression. |
2020-10-08 |
2023-08-13 |
mouse |