| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aitao Wang, Muer Tie, Dongmei Guo, Na Wu, Shanglong Yao, Limei Yan, Xingsheng Zha. A Novel Mechanism of BAM8-22 Inhibiting Microglia Activation: Represses CX3CR1 Expression via Upregulating miR-184. Journal of molecular neuroscience : MN. vol 70. issue 4. 2020-10-08. PMID:31833017. |
what's more, the suppression of cx3cr1 expression eliminated the reversal effect of the mir-184 inhibitor on bam8-22-induced microglia activation and decreased iba-1 expression and pro-inflammatory cytokine secretion. |
2020-10-08 |
2023-08-13 |
mouse |
| Aitao Wang, Muer Tie, Dongmei Guo, Na Wu, Shanglong Yao, Limei Yan, Xingsheng Zha. A Novel Mechanism of BAM8-22 Inhibiting Microglia Activation: Represses CX3CR1 Expression via Upregulating miR-184. Journal of molecular neuroscience : MN. vol 70. issue 4. 2020-10-08. PMID:31833017. |
in bcp models, mir-184 was upregulated by bam8-22 and the elevated level of mir-184 bound to the 3'utr region of cx3cr1 and repressed cx3cr1 expression, thus inhibiting the microglia activation, suggesting the potential application of mir-184/cx3cr1 for bcp treatment. |
2020-10-08 |
2023-08-13 |
mouse |
| Hao Zhou, Jiesi Wang, Yu Zhang, Feng Shao, Weiwen Wan. The Role of Microglial CX3CR1 in Schizophrenia-Related Behaviors Induced by Social Isolation. Frontiers in integrative neuroscience. vol 14. 2020-10-06. PMID:33013335. |
recent studies have demonstrated that fractalkine (cx3cl1) and its receptor cx3cr1 modulate the function of microglia. |
2020-10-06 |
2023-08-13 |
Not clear |
| Namiko Kawamura, Goro Katsuura, Nobuko Yamada-Goto, Ela Novianti, Akio Inui, Akihiro Asakaw. Reduced brain fractalkine-CX3CR1 signaling is involved in the impaired cognition of streptozotocin-treated mice. IBRO reports. vol 9. 2020-10-02. PMID:32995659. |
dexamethasone (dex) application significantly decreased the mrna expression of fractalkine in primary neuron and astrocyte cultures, and of cx3cr1 in primary microglia cultures. |
2020-10-02 |
2023-08-13 |
mouse |
| Namiko Kawamura, Goro Katsuura, Nobuko Yamada-Goto, Ela Novianti, Akio Inui, Akihiro Asakaw. Reduced brain fractalkine-CX3CR1 signaling is involved in the impaired cognition of streptozotocin-treated mice. IBRO reports. vol 9. 2020-10-02. PMID:32995659. |
on the other hand, igf-1 application significantly increased the mrna expression of fractalkine in primary neuron cultures and cx3cr1 in primary microglia cultures. |
2020-10-02 |
2023-08-13 |
mouse |
| Andrew S Mendiola, Rolando Garza, Sandra M Cardona, Shannon A Mythen, Sergio A Lira, Katerina Akassoglou, Astrid E Cardon. Fractalkine Signaling Attenuates Perivascular Clustering of Microglia and Fibrinogen Leakage during Systemic Inflammation in Mouse Models of Diabetic Retinopathy. Frontiers in cellular neuroscience. vol 10. 2020-10-01. PMID:28119571. |
fractalkine (fkn) is a chemokine expressed constitutively by healthy neurons and signals to microglia upon interaction with the fkn receptor, cx3cr1. |
2020-10-01 |
2023-08-13 |
mouse |
| Sandra M Cardona, Sangwon V Kim, Kaira A Church, Vanessa O Torres, Ian A Cleary, Andrew S Mendiola, Stephen P Saville, Stephanie S Watowich, Jan Parker-Thornburg, Alejandro Soto-Ospina, Pedronel Araque, Richard M Ransohoff, Astrid E Cardon. Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1 Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30386211. |
fractalkine (fkn) is a transmembrane chemokine expressed in the cns by neurons and signals through its unique receptor cx3cr1 present in microglia. |
2020-10-01 |
2023-08-13 |
mouse |
| Sandra M Cardona, Sangwon V Kim, Kaira A Church, Vanessa O Torres, Ian A Cleary, Andrew S Mendiola, Stephen P Saville, Stephanie S Watowich, Jan Parker-Thornburg, Alejandro Soto-Ospina, Pedronel Araque, Richard M Ransohoff, Astrid E Cardon. Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1 Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30386211. |
the cx3cr1 human polymorphism i249/m280 present in ∼20% of the population exhibits reduced adhesion for fkn conferring defective signaling whose role in microglia function and influence on neurons during ms remains unsolved. |
2020-10-01 |
2023-08-13 |
mouse |
| Hong-Yun He, Lu Ren, Tao Guo, Yi-Hao Den. Neuronal autophagy aggravates microglial inflammatory injury by downregulating CX3CL1/fractalkine after ischemic stroke. Neural regeneration research. vol 14. issue 2. 2020-09-30. PMID:30531011. |
cx3cl1/fractalkine, a membrane-bound chemokine expressed on neurons, can suppress microglial inflammation by binding to its receptor cx3cr1 on microglia. |
2020-09-30 |
2023-08-13 |
rat |
| Clotilde Lauro, Giuseppina Chece, Lucia Monaco, Fabrizio Antonangeli, Giovanna Peruzzi, Serena Rinaldo, Alessio Paone, Francesca Cutruzzolà, Cristina Limatol. Fractalkine Modulates Microglia Metabolism in Brain Ischemia. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31607865. |
in the cns, the chemokine cx3cl1 (fractalkine) is expressed on neurons while its specific receptor cx3cr1 is expressed on microglia and macrophages. |
2020-09-30 |
2023-08-13 |
Not clear |
| Kevin T Breen, Sarah R Anderson, Michael R Steele, David J Calkins, Alejandra Bosco, Monica L Vette. Loss of Fractalkine Signaling Exacerbates Axon Transport Dysfunction in a Chronic Model of Glaucoma. Frontiers in neuroscience. vol 10. 2020-09-29. PMID:27932942. |
our findings suggest that distinct mechanisms may contribute to different aspects of rgc decline in glaucoma, with axonal transport selectively altered after loss of cx3cr1 in microglia and/or macrophages. |
2020-09-29 |
2023-08-13 |
mouse |
| Le Wang, Yang Liu, Shuxin Yan, Tianshu Du, Xia Fu, Xiaoli Gong, Xinyu Zhou, Ting Zhang, Xiaomin Wan. Disease Progression-Dependent Expression of CD200R1 and CX3CR1 in Mouse Models of Parkinson's Disease. Aging and disease. vol 11. issue 2. 2020-09-28. PMID:32257540. |
in primary cultured microglia, cd200r1 and cx3cr1 expressions are both directly regulated by lps or α-synuclein, and cd200r1 expression is more sensitively regulated than cx3cr1. |
2020-09-28 |
2023-08-13 |
mouse |
| Danka A Kozareva, Gerard M Moloney, Alan E Hoban, Valerio Rossini, Ken Nally, John F Cryan, Yvonne M Nola. A role for the orphan nuclear receptor TLX in the interaction between neural precursor cells and microglia. Neuronal signaling. vol 3. issue 1. 2020-09-28. PMID:32269832. |
microglial and neuronal cross-talk is mediated in part by the chemokine fractalkine/chemokine (c-x3-c motif) ligand 1 (cx3cl1) released from neurons, and its receptor cx3c chemokine receptor 1 (cx3cr1) which is expressed on microglia. |
2020-09-28 |
2023-08-13 |
mouse |
| Hariharakrishnan Chidambaram, Rashmi Das, Subashchandrabose Chinnathamb. Interaction of Tau with the chemokine receptor, CX3CR1 and its effect on microglial activation, migration and proliferation. Cell & bioscience. vol 10. 2020-09-28. PMID:32944223. |
chemokine receptor, cx3cr1 is mostly expressed on microglia and is involved in maintaining the microglia in a quiescent state by binding to its ligand, fractalkine (cx3cl1), which is expressed in neurons as both soluble or membrane-bound state. |
2020-09-28 |
2023-08-13 |
Not clear |
| Hariharakrishnan Chidambaram, Rashmi Das, Subashchandrabose Chinnathamb. Interaction of Tau with the chemokine receptor, CX3CR1 and its effect on microglial activation, migration and proliferation. Cell & bioscience. vol 10. 2020-09-28. PMID:32944223. |
in microglia, phagocytosis and internalization of extracellular tau species occurs in the presence of a chemokine receptor, cx3cr1 which binds directly to tau and promotes its internalization. |
2020-09-28 |
2023-08-13 |
Not clear |
| T C Peixoto, E G Moura, E Oliveira, V Younes-Rapozo, P N Soares, V S T Rodrigues, M A Torsoni, A S Torsoni, A C Manhães, P C Lisbo. Hypothalamic Neuropeptides Expression and Hypothalamic Inflammation in Adult Rats that Were Exposed to Tobacco Smoke during Breastfeeding: Sex-Related Differences. Neuroscience. vol 418. 2020-09-24. PMID:31487543. |
the protein contents of cx3cr1 (marker of activated microglia) and α7nachr (anti-inflammatory marker) were not altered in both se males and females. |
2020-09-24 |
2023-08-13 |
rat |
| Anne Wolf, Marc Herb, Michael Schramm, Thomas Langman. The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye. Nature communications. vol 11. issue 1. 2020-08-17. PMID:32483169. |
here, we report that tamoxifen-induced conditional deletion of tspo in resident microglia using cx3cr1 |
2020-08-17 |
2023-08-13 |
Not clear |
| Stefka Gyoneva, Raghavendra Hosur, David Gosselin, Baohong Zhang, Zhengyu Ouyang, Anne C Cotleur, Michael Peterson, Norm Allaire, Ravi Challa, Patrick Cullen, Chris Roberts, Kelly Miao, Taylor L Reynolds, Christopher K Glass, Linda Burkly, Richard M Ransohof. Life science alliance. vol 2. issue 6. 2020-07-22. PMID:31792059. |
cx3cr1, one of the highest expressed genes in microglia in mice and humans, is implicated in numerous microglial functions. |
2020-07-22 |
2023-08-13 |
mouse |
| Runjing Cao, Shiping Li, Junxiang Yin, Li Guo, Jiong Sh. Sirtuin 3 promotes microglia migration by upregulating CX3CR1. Cell adhesion & migration. vol 13. issue 1. 2020-06-15. PMID:31208274. |
sirtuin 3 promotes microglia migration by upregulating cx3cr1. |
2020-06-15 |
2023-08-13 |
Not clear |
| Runjing Cao, Shiping Li, Junxiang Yin, Li Guo, Jiong Sh. Sirtuin 3 promotes microglia migration by upregulating CX3CR1. Cell adhesion & migration. vol 13. issue 1. 2020-06-15. PMID:31208274. |
our study for the first time shows that sirt3 promotes microglia migration by upregulating cx3cr1. |
2020-06-15 |
2023-08-13 |
Not clear |