| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas M Vigil, Ryan A Frieler, KiAundra L Kilpatrick, Michael M Wang, Richard M Mortense. Aconitate decarboxylase 1 suppresses cerebral ischemia-reperfusion injury in mice. Experimental neurology. vol 347. 2021-12-06. PMID:34699789. |
cell specific knockout of acod1 in myeloid cells (lysm-cre), microglia cells (cx3cr1, cre-ert2) and endothelial cells (cdh5(pac), cre-ert2) did not reproduce lesion volume changes seen in global acod1ko, indicating that circulating myeloid cells, resident microglia and endothelial cell populations are not the primary contributors to the observed phenotype. |
2021-12-06 |
2023-08-13 |
mouse |
| Wenlong Zhang, Philipp Karschnia, Iven-Alex von Mücke-Heim, Matthias Mulazzani, Xiaolan Zhou, Jens Blobner, Niklas Mueller, Nico Teske, Sertac Dede, Tao Xu, Niklas Thon, Hellen Ishikawa-Ankerhold, Andreas Straube, Joerg-Christian Tonn, Louisa von Baumgarte. In vivo two-photon characterization of tumor-associated macrophages and microglia (TAM/M) and CX3CR1 during different steps of brain metastasis formation from lung cancer. Neoplasia (New York, N.Y.). vol 23. issue 11. 2021-11-24. PMID:34587566. |
in vivo two-photon characterization of tumor-associated macrophages and microglia (tam/m) and cx3cr1 during different steps of brain metastasis formation from lung cancer. |
2021-11-24 |
2023-08-13 |
mouse |
| Wenlong Zhang, Philipp Karschnia, Iven-Alex von Mücke-Heim, Matthias Mulazzani, Xiaolan Zhou, Jens Blobner, Niklas Mueller, Nico Teske, Sertac Dede, Tao Xu, Niklas Thon, Hellen Ishikawa-Ankerhold, Andreas Straube, Joerg-Christian Tonn, Louisa von Baumgarte. In vivo two-photon characterization of tumor-associated macrophages and microglia (TAM/M) and CX3CR1 during different steps of brain metastasis formation from lung cancer. Neoplasia (New York, N.Y.). vol 23. issue 11. 2021-11-24. PMID:34587566. |
the influence of tumor-associated macrophages and microglia (tam/m) and their receptor cx3cr1 on different steps of brain metastasis formation from lung cancer is poorly characterized. |
2021-11-24 |
2023-08-13 |
mouse |
| Yan Gao, Kaichao Hu, Juxiang Yang, Shasha Wang, Juntong Li, Qinglin Wu, Zhenzhen Wang, Naihong Chen, Lin Li, Lan Zhan. Tetrahydroxy stilbene glycoside regulates TGF-β/fractalkine/CX3CR1 based on network pharmacology in APP/PS1 mouse model. Neuropeptides. vol 90. 2021-11-22. PMID:34509715. |
together, our work has detailed the whole and major genes in app/ps1 model mouse regulated by tsg, and highlighted the anti-inflammatory function of tsg in mediating cx3cr1 and tgf-β as the tgf-β/fractalkine/cx3xr1 signaling pathway, especially in microglia. |
2021-11-22 |
2023-08-13 |
mouse |
| Fulton T Crews, Jian Zou, Leon G Colema. Extracellular microvesicles promote microglia-mediated pro-inflammatory responses to ethanol. Journal of neuroscience research. vol 99. issue 8. 2021-11-18. PMID:33611821. |
ethanol caused a unique immune gene signature that featured: temporal induction of pro-inflammatory tnf-α and il-1β, reduction of homeostatic microglia state gene tmem119, progressive increases in purinergic receptor p2ry12 and the microglial inhibitory fractalkine receptor cx3cr1, an increase in the microglial presynaptic gene c1q, and a reduction in the phagocytic gene trem2. |
2021-11-18 |
2023-08-13 |
Not clear |
| Gen-Lin He, Ze-Ze Wang, Xue-Ting Yu, Ting-Ting Shen, Zhen Luo, Ping Li, Xue Luo, Yu-Long Tan, Peng Gao, Xue-Sen Yan. The involvement of microglial CX3CR1 in heat acclimation-induced amelioration of adult hippocampal neurogenesis impairment in EMF-exposed mice. Brain research bulletin. vol 177. 2021-11-18. PMID:34555433. |
moreover, alterations in the phenotypes of activated microglia and decreased expression levels of cx3cr1, but not sirtuin 1 (sirt1), were observed in the brains of emf-exposed mice. |
2021-11-18 |
2023-08-13 |
mouse |
| Jessica Cornell, Shelbi Salinas, Hou-Yuan Huang, Miou Zho. Microglia regulation of synaptic plasticity and learning and memory. Neural regeneration research. vol 17. issue 4. 2021-11-10. PMID:34472455. |
through the c1q, c3 and cr3 "eat me" and cd47 and sirpα "don't eat me" complement pathways, as well as other pathways such as cx3cr1 signaling, resting microglia regulate synaptic pruning, a process crucial for the promotion of synapse formation and the regulation of neuronal activity and synaptic plasticity. |
2021-11-10 |
2023-08-13 |
Not clear |
| Shui-Sheng Yu, Zi-Yu Li, Xin-Zhong Xu, Fei Yao, Yang Luo, Yan-Chang Liu, Li Cheng, Mei-Ge Zheng, Jue-Hua Jin. M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury. Neural regeneration research. vol 17. issue 5. 2021-11-10. PMID:34558535. |
here, we found that both microglia (cx3cr1 |
2021-11-10 |
2023-08-13 |
Not clear |
| Giedre Milinkeviciute, Sima M Chokr, Emily M Castro, Karina S Crame. CX3CR1 mutation alters synaptic and astrocytic protein expression, topographic gradients, and response latencies in the auditory brainstem. The Journal of comparative neurology. vol 529. issue 11. 2021-10-29. PMID:33797066. |
here, we investigated the role of signaling through the fractalkine receptor (cx3cr1), which is expressed by microglia and mediates communication with neurons. |
2021-10-29 |
2023-08-13 |
Not clear |
| Ming-Lei Guo, Ernest T Chivero, Shannon E Callen, Shilpa Buc. NLRP3 Inflammasome Is Involved in Cocaine-Mediated Potentiation on Behavioral Changes in CX3CR1-Deficient Mice. Journal of personalized medicine. vol 11. issue 10. 2021-10-26. PMID:34683104. |
here, we employed cx3cr1-gfp mice (cx3cr1 functional deficiency, cx3cr1-/-) to explore whether primed microglia could potentiate cocaine-mediated behavioral changes and the possible underlying mechanisms. |
2021-10-26 |
2023-08-13 |
mouse |
| Kara Lopez-Lengowski, Annie Kathuria, Kaia Gerlovin, Rakesh Karmachary. Co-Culturing Microglia and Cortical Neurons Differentiated from Human Induced Pluripotent Stem Cells. Journal of visualized experiments : JoVE. issue 175. 2021-10-21. PMID:34633366. |
human microglia generated using this protocol were positive for the markers cd11c, iba1, p2ry12, and tmem119, and expressed the microglial-related genes aif1, cx3cr1, itgam, itgax, p2ry12, and tmem119. |
2021-10-21 |
2023-08-13 |
human |
| Fumihiro Saika, Shinsuke Matsuzaki, Shiroh Kishioka, Norikazu Kiguch. Chemogenetic Activation of CX3CR1-Expressing Spinal Microglia Using Gq-DREADD Elicits Mechanical Allodynia in Male Mice. Cells. vol 10. issue 4. 2021-10-20. PMID:33921365. |
here, we aimed at determining the role of sex differences in the behavioral and functional outcomes of the chemogenetic activation of spinal microglia using gq-designer receptors exclusively activated by designer drugs (gq-dreadd) driven by the microglia-specific cx3cr1 promoter. |
2021-10-20 |
2023-08-13 |
mouse |
| Jiaojiao Wang, Huijiao Pan, Zhenyu Lin, Chunjin Xiong, Chunhua Wei, Huanhuan Li, Fan Tong, Xiaorong Don. Neuroprotective Effect of Fractalkine on Radiation-induced Brain Injury Through Promoting the M2 Polarization of Microglia. Molecular neurobiology. vol 58. issue 3. 2021-10-13. PMID:33089423. |
furthermore, while inhibiting the expression of cx3cr1, which exclusively expressed on microglia in the brain, the regulatory effect of fkn on microglia and cognitive ability of mice disappeared after radiation. |
2021-10-13 |
2023-08-13 |
mouse |
| Jiaojiao Wang, Huijiao Pan, Zhenyu Lin, Chunjin Xiong, Chunhua Wei, Huanhuan Li, Fan Tong, Xiaorong Don. Neuroprotective Effect of Fractalkine on Radiation-induced Brain Injury Through Promoting the M2 Polarization of Microglia. Molecular neurobiology. vol 58. issue 3. 2021-10-13. PMID:33089423. |
in conclusion, the fkn could attenuate ribi through the microglia polarization toward m2 phenotype by binding to cx3cr1 on microglia. |
2021-10-13 |
2023-08-13 |
mouse |
| Eman Soliman, Jatia Mills, Jing Ju, Alexandra M Kaloss, Erwin Kristobal Gudenschwager Basso, Nathalie Groot, Colin Kelly, Elizabeth A Kowalski, Mohamed Elhassanny, Michael Chen, Xia Wang, Michelle H Theu. Conditional Deletion of EphA4 on Cx3cr1-Expressing Microglia Fails to Influence Histopathological Outcome and Blood Brain Barrier Disruption Following Brain Injury. Frontiers in molecular neuroscience. vol 14. 2021-10-12. PMID:34630039. |
cx3cr1 is a fractalkine receptor expressed on both resident microglia and peripheral-derived macrophages. |
2021-10-12 |
2023-08-13 |
mouse |
| Muhammad Irfan, Kirsten S Evonuk, Tara M DeSilv. Microglia phagocytose oligodendrocyte progenitor cells and synapses during early postnatal development: implications for white versus gray matter maturation. The FEBS journal. 2021-09-29. PMID:34496137. |
our laboratory recently published that microglia with a unique amoeboid morphology invade the corpus callosum and engulf oligodendrocyte progenitor cells (opcs) during early postnatal development before myelination in a fractalkine receptor (cx3cr1)-dependent manner to modulate ensheathment of axons. |
2021-09-29 |
2023-08-13 |
Not clear |
| Zhi-Jie Zhao, Dong-Po Wei, Rui-Zhe Zheng, Tinghua Peng, Xiang Xiao, Fu-Sheng L. The Gene Coexpression Analysis Identifies Functional Modules Dynamically Changed After Traumatic Brain Injury. Computational and mathematical methods in medicine. vol 2021. 2021-09-24. PMID:33953790. |
the green yellow module highlighted genes involved in microglial cell activation such as tyrobp, cx3cr1, grn, trem2, c1qa, and aif1, suggesting that these genes were responsible for the inflammatory response caused by tbi. |
2021-09-24 |
2023-08-13 |
Not clear |
| Lourdes Fernández de Cossío, Chloé Lacabanne, Maude Bordeleau, Garance Castino, Phillip Kyriakakis, Marie-Ève Trembla. Lipopolysaccharide-induced maternal immune activation modulates microglial CX3CR1 protein expression and morphological phenotype in the hippocampus and dentate gyrus, resulting in cognitive inflexibility during late adolescence. Brain, behavior, and immunity. vol 97. 2021-09-22. PMID:34343619. |
the current study sought to evaluate the origin and impact of this reduced hippocampal cx3cr1 mrna expression on microglia and cognition. |
2021-09-22 |
2023-08-13 |
Not clear |
| Marcia G Honig, Conor C Dorian, John D Worthen, Anthony C Micetich, Isabelle A Mulder, Katelyn B Sanchez, William F Pierce, Nobel A Del Mar, Anton Reine. Progressive long-term spatial memory loss following repeat concussive and subconcussive brain injury in mice, associated with dorsal hippocampal neuron loss, microglial phenotype shift, and vascular abnormalities. The European journal of neuroscience. vol 54. issue 5. 2021-09-17. PMID:32090401. |
hierarchical cluster analysis of dorsal hippocampal microglia across the three groups based on morphology and expression of mhcii, cx3cr1, cd68 and iba1 revealed five distinct phenotypes. |
2021-09-17 |
2023-08-13 |
mouse |
| Qingxiu Zhang, Lei He, Mo Chen, Hui Yang, Xiaowei Cao, Xiaomei Liu, Qi Hao, Zhengwei Chen, Tengfei Liu, Xiu-E Wei, Liangqun Ron. PSD-93 mediates the crosstalk between neuron and microglia and facilitates acute ischemic stroke injury by binding to CX3CL1. Journal of neurochemistry. vol 157. issue 6. 2021-08-24. PMID:33599284. |
cx3 chemokine ligand 1 (cx3cl1) is a chemokine specifically expressed in neurons while its receptor cx3cr1 is highly expressed in microglia. |
2021-08-24 |
2023-08-13 |
mouse |