| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Myfanwy Cohen, Suja Mohammed, Mary Kavurma, Polina E Nedoboy, Siân Cartland, Melissa M J Farnham, Paul M Pilowsk. Microglia in the RVLM of SHR have reduced P2Y12R and CX3CR1 expression, shorter processes, and lower cell density. Autonomic neuroscience : basic & clinical. vol 216. 2020-03-10. PMID:30598122. |
microglia in the rvlm of shr have reduced p2y12r and cx3cr1 expression, shorter processes, and lower cell density. |
2020-03-10 |
2023-08-13 |
rat |
| Jingjing Zhang, Yufei Liu, Xinyao Liu, Song Li, Cheng Cheng, Sheng Chen, Weidong L. Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model. Translational neurodegeneration. vol 7. 2020-02-25. PMID:30607245. |
neurons can express chemokine (c-x3-c motif) ligand 1 (cx3cl1), which mediates microglial activation via interacting with its sole receptor cx3cr1 in microglia. |
2020-02-25 |
2023-08-13 |
mouse |
| Zhen Xu, Wei-Hua Shi, Long-Biao Xu, Min-Feng Shao, Zu-Peng Chen, Guo-Chong Zhu, Qun Ho. Resident Microglia Activate before Peripheral Monocyte Infiltration and p75NTR Blockade Reduces Microglial Activation and Early Brain Injury after Subarachnoid Hemorrhage. ACS chemical neuroscience. vol 10. issue 1. 2020-02-18. PMID:30117729. |
therefore, we designed this study to investigate the time course of resident microglia activation and peripheral monocyte infiltration, as well as the microglial expression of p75ntr by using cx3c-chemokine receptor 1 (cx3cr1) and chemokine receptor 2 (ccr2) double transgenic mice (cx3cr1 |
2020-02-18 |
2023-08-13 |
mouse |
| Ji Hyeon Ahn, Dae Won Kim, Joon Ha Park, Tae-Kyeong Lee, Hyang-Ah Lee, Moo-Ho Won, Choong-Hyun Le. Expression changes of CX3CL1 and CX3CR1 proteins in the hippocampal CA1 field of the gerbil following transient global cerebral ischemia. International journal of molecular medicine. vol 44. issue 3. 2020-02-04. PMID:31524247. |
on the other hand, cx3cr1 immunoreactivity was significantly increased in microglia from 5 days after tgci. |
2020-02-04 |
2023-08-13 |
Not clear |
| Ji Hyeon Ahn, Dae Won Kim, Joon Ha Park, Tae-Kyeong Lee, Hyang-Ah Lee, Moo-Ho Won, Choong-Hyun Le. Expression changes of CX3CL1 and CX3CR1 proteins in the hippocampal CA1 field of the gerbil following transient global cerebral ischemia. International journal of molecular medicine. vol 44. issue 3. 2020-02-04. PMID:31524247. |
these results showed that cx3cl1 and cx3cr1 protein expression levels in pyramidal cells and microglia in the hippocampal ca1 field following tgci were changed, indicating that tgci‑induced expression changes of cx3cl1 and cx3cr1 proteins might be closely associated with tgci‑induced delayed neuronal death and microglial activation. |
2020-02-04 |
2023-08-13 |
Not clear |
| Daniel Younger, Madhuvika Murugan, Kakulavarapu V Rama Rao, Long-Jun Wu, Namas Chandr. Microglia Receptors in Animal Models of Traumatic Brain Injury. Molecular neurobiology. vol 56. issue 7. 2020-01-14. PMID:30554385. |
since receptors act as sensors for activation, we highlight certain microglia receptors that have been implicated in tbi pathology, including fractalkine receptor (cx3cr1), purinergic receptor (p2y12r), toll-like receptor (tlr4), scavenger receptors, tumor necrosis factor receptor (tnf-1r), interleukin receptor (il-1r), complement receptors, and peroxisome proliferator-activated receptor (ppar). |
2020-01-14 |
2023-08-13 |
Not clear |
| Josh M Morganti, Danielle S Goulding, Linda J Van Eldi. Deletion of p38α MAPK in microglia blunts trauma-induced inflammatory responses in mice. Journal of neuroinflammation. vol 16. issue 1. 2019-12-24. PMID:31077217. |
we generated conditional cell-specific knockout of p38α in microglia using a cx3cr1 cre-lox system, subjected the p38α knockout and wild-type mice to a controlled cortical impact tbi, and measured inflammatory responses at acute (1-day) and subacute (7-day) post-injury time points. |
2019-12-24 |
2023-08-13 |
mouse |
| Chang Liu, Kun Hong, Huifang Chen, Yanping Niu, Weisong Duan, Yakun Liu, Yingxiao Ji, Binbin Deng, Yuanyuan Li, Zhongyao Li, Di Wen, Chunyan L. Evidence for a protective role of the CX3CL1/CX3CR1 axis in a model of amyotrophic lateral sclerosis. Biological chemistry. vol 400. issue 5. 2019-12-06. PMID:30352020. |
the fractalkine receptor (cx3cr1) is predominantly expressed on microglia. |
2019-12-06 |
2023-08-13 |
mouse |
| Abdullah Al Mamun, Haifu Yu, Sharmeen Romana, Fudong Li. Inflammatory Responses are Sex Specific in Chronic Hypoxic-Ischemic Encephalopathy. Cell transplantation. vol 27. issue 9. 2019-09-23. PMID:29692197. |
female microglia exhibited a more robust anti-inflammatory response that was corresponding to an enhanced expression of cx3c chemokine receptor 1 (cx3cr1) than males. |
2019-09-23 |
2023-08-13 |
Not clear |
| Min-Jung Park, Hyun-Sun Park, Min-Jung You, Jongman Yoo, Seung Hyun Kim, Min-Soo Kwo. Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia. Molecular neurobiology. vol 56. issue 2. 2019-07-11. PMID:29948944. |
five nanomolars of dexamethasone (dex, gc agonist) for 72 h decreased cx3cr1 and cd200r expression and induced ramified form of microglial cells in similar morphology to in vivo resident microglia. |
2019-07-11 |
2023-08-13 |
Not clear |
| Dylan J Finneran, Kevin R Nas. Neuroinflammation and fractalkine signaling in Alzheimer's disease. Journal of neuroinflammation. vol 16. issue 1. 2019-07-01. PMID:30744705. |
fractalkine (cx3cl1; fkn), a unique chemokine with a one-to-one relationship with its receptor, signals through its cognate receptor (cx3cr1) to reduce expression of pro-inflammatory genes in activated microglia. |
2019-07-01 |
2023-08-13 |
Not clear |
| Marcos Galán-Ganga, Ángel J García-Yagüe, Isabel Lastres-Becke. Role of MSK1 in the Induction of NF-κB by the Chemokine CX3CL1 in Microglial Cells. Cellular and molecular neurobiology. vol 39. issue 3. 2019-05-06. PMID:30830503. |
however, the exact roles of cx3cl1, cx3cl1 receptor (cx3cr1) and microglia signalling are not fully understood in neuroinflammation. |
2019-05-06 |
2023-08-13 |
human |
| M Bolós, J R Perea, J Terreros-Roncal, N Pallas-Bazarra, J Jurado-Arjona, J Ávila, M Llorens-Martí. Absence of microglial CX3CR1 impairs the synaptic integration of adult-born hippocampal granule neurons. Brain, behavior, and immunity. vol 68. 2019-03-12. PMID:29017970. |
animals lacking cx3cr1 microglial receptor (cx3cr1-/- mice) exhibit marked alterations not only in microglia but also in neurons located in various regions of the brain. |
2019-03-12 |
2023-08-13 |
mouse |
| Aitao Wang, Tingting Yang, Lingli Zhang, Lizhou Jia, Qingping Wu, Shanglong Yao, Jianjun Xu, Hongxin Yan. IP3-Mediated Calcium Signaling Is Involved in the Mechanism of Fractalkine-Induced Hyperalgesia Response. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-02-13. PMID:30517088. |
background fractalkine is widely expressed throughout the brain and spinal cord, where it can exert effects on pain enhancement and hyperalgesia by activating microglia through cx3c chemokine receptor 1 (cx3cr1), which triggers the release of several pro-inflammatory cytokines in the spinal cord. |
2019-02-13 |
2023-08-13 |
mouse |
| Chao Li, Wei Mao, Yun-Ke Huang, Zhi-Qi Zhao, Ning Ly. [Roles of CX3CR1 in mediation of post-incision induced mechanical pain hypersensitivity: Effects of acupuncture-combined anesthesia]. Sheng li xue bao : [Acta physiologica Sinica]. vol 70. issue 3. 2019-01-04. PMID:29926064. |
cx3cr1 was mainly expressed in microglia in the spinal cord dorsal horn, and its protein level was significantly increased at 3 d after incision compared with that of naïve c57bl/6j mice. |
2019-01-04 |
2023-08-13 |
mouse |
| Chao Li, Wei Mao, Yun-Ke Huang, Zhi-Qi Zhao, Ning Ly. [Roles of CX3CR1 in mediation of post-incision induced mechanical pain hypersensitivity: Effects of acupuncture-combined anesthesia]. Sheng li xue bao : [Acta physiologica Sinica]. vol 70. issue 3. 2019-01-04. PMID:29926064. |
these results suggest that cx3cr1 in microglia is involved in post-incision pain and analgesia of aca. |
2019-01-04 |
2023-08-13 |
mouse |
| Harald Lund, Melanie Pieber, Roham Parsa, Jinming Han, David Grommisch, Ewoud Ewing, Lara Kular, Maria Needhamsen, Alexander Espinosa, Emma Nilsson, Anna K Överby, Oleg Butovsky, Maja Jagodic, Xing-Mei Zhang, Robert A Harri. Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells. Nature communications. vol 9. issue 1. 2018-12-18. PMID:30451869. |
as the factors regulating this process are incompletely understood, we studied niche competition in the brain by depleting microglia with >95% efficiency using cx3cr1 |
2018-12-18 |
2023-08-13 |
Not clear |
| Jinkun Wang, Yan Gan, Pengcheng Han, Junxiang Yin, Qingwei Liu, Soha Ghanian, Feng Gao, Guanghui Gong, Zhiwei Tan. Ischemia-induced Neuronal Cell Death Is Mediated by Chemokine Receptor CX3CR1. Scientific reports. vol 8. issue 1. 2018-11-14. PMID:29323156. |
previous studies have focused on a paracrine interaction between neurons that produce fractalkine and microglia that express cx3cr1 receptors in the central nervous system. |
2018-11-14 |
2023-08-13 |
mouse |
| Christopher Käufer, Chintan Chhatbar, Sonja Bröer, Inken Waltl, Luca Ghita, Ingo Gerhauser, Ulrich Kalinke, Wolfgang Lösche. Chemokine receptors CCR2 and CX3CR1 regulate viral encephalitis-induced hippocampal damage but not seizures. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 38. 2018-10-10. PMID:30181265. |
ccr2 and cx3cr1 are two chemokine receptors that regulate the responses of myeloid cells, such as monocytes and microglia, during inflammation. |
2018-10-10 |
2023-08-13 |
Not clear |
| Ashley S Harms, Aaron D Thome, Zhaoqi Yan, Aubrey M Schonhoff, Gregory P Williams, Xinru Li, Yudong Liu, Hongwei Qin, Etty N Benveniste, David G Standaer. Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease. Experimental neurology. vol 300. 2018-10-03. PMID:29155051. |
here, we used heterozygous reporter knock-in mice in which the first exons of the fractalkine receptor (cx3cr1) and of the c-c chemokine receptor type 2 (ccr2) are replaced with fluorescent reporters to study the role of resident microglia (cx3cr1+) and infiltrating peripheral monocytes (ccr2+), respectively, in the cns. |
2018-10-03 |
2023-08-13 |
mouse |