| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrea C Rossetti, Mariusz Papp, Piotr Gruca, Maria Serena Paladini, Giorgio Racagni, Marco A Riva, Raffaella Molten. Stress-induced anhedonia is associated with the activation of the inflammatory system in the rat brain: Restorative effect of pharmacological intervention. Pharmacological research. vol 103. 2016-12-13. PMID:26535964. |
our results demonstrate that only the stressed animals that were characterized by a deficit in sucrose intake showed increased expression of the pro-inflammatory cytokines il-1β, il-6 and up-regulation of markers and mediators of microglia activation such as cd11b, cx3cl1 and its receptor cx3cr1 in comparison with stress-resilient animals. |
2016-12-13 |
2023-08-13 |
human |
| Takashi D Y Kozai, Andrea S Jaquins-Gerstl, Alberto L Vazquez, Adrian C Michael, X Tracy Cu. Dexamethasone retrodialysis attenuates microglial response to implanted probes in vivo. Biomaterials. vol 87. 2016-12-13. PMID:26923363. |
microdialysis probes under artificial cerebrospinal fluid (acsf) perfusion with or without dex were implanted into the cortex of transgenic mice that express gfp in microglia under the cx3cr1 promoter and imaged for 6 h. |
2016-12-13 |
2023-08-13 |
mouse |
| Iris Kim, Lauren M Mlsna, Stella Yoon, Brandy Le, Songtao Yu, Dan Xu, Sookyong Ko. A postnatal peak in microglial development in the mouse hippocampus is correlated with heightened sensitivity to seizure triggers. Brain and behavior. vol 5. issue 12. 2016-10-20. PMID:26807334. |
to determine the temporal correlation between microglial development and age-dependent susceptibility and response to seizures, we quantified developmental changes in basal microglia levels and seizure-induced microglial activation in the hippocampus of cx3cr1(gfp /+) transgenic mice. |
2016-10-20 |
2023-08-13 |
mouse |
| Richard M Ransohoff, Joseph El Khour. Microglia in Health and Disease. Cold Spring Harbor perspectives in biology. vol 8. issue 1. 2016-10-13. PMID:26354893. |
because of the prominent roles cx3cr1 and its ligand fractalkine played in bringing about these advances, we discuss the physiological and pathological roles of microglia as viewed from the cx3cr1-fractalkine perspective, providing a unique viewpoint. |
2016-10-13 |
2023-08-13 |
Not clear |
| David Fernández-López, Joel Faustino, Alexander L Klibanov, Nikita Derugin, Elodie Blanchard, Franziska Simon, Stephen L Leib, Zinaida S Vexle. Microglial Cells Prevent Hemorrhage in Neonatal Focal Arterial Stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 10. 2016-07-19. PMID:26961944. |
consistent with observations in neonatal rats, depletion of microglia before tmcao in p9 cx3cr1(gfp/+)/ccr2(rfp/+) mice exacerbated injury and induced hemorrhages at 24 h. the effects were independent of infiltration of ccr2(rfp/+) monocytes into injured regions. |
2016-07-19 |
2023-08-13 |
mouse |
| Hideo Kohno, Hideto Koso, Kiichiro Okano, Thomas R Sundermeier, Saburo Saito, Sumiko Watanabe, Hiroshi Tsuneoka, Tsutomu Saka. Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration. Journal of neuroinflammation. vol 12. 2016-06-21. PMID:26458944. |
as cx3cr1 is expressed in microglia and ccr2 is reportedly expressed in activated macrophages, these mice have the potential to distinguish microglia and macrophages, yielding novel information about the activation of these inflammatory cells and their individual roles in retinal inflammation. |
2016-06-21 |
2023-08-13 |
mouse |
| Sandra M Cardona, Andrew S Mendiola, Ya-Chin Yang, Sarina L Adkins, Vanessa Torres, Astrid E Cardon. Disruption of Fractalkine Signaling Leads to Microglial Activation and Neuronal Damage in the Diabetic Retina. ASN neuro. vol 7. issue 5. 2016-06-07. PMID:26514658. |
fkn signals via its unique receptor cx3cr1 expressed on microglia and other peripheral leukocytes. |
2016-06-07 |
2023-08-13 |
mouse |
| Xi Feng, Frank Szulzewsky, Alexan Yerevanian, Zhihong Chen, David Heinzmann, Rikke Darling Rasmussen, Virginia Alvarez-Garcia, Yeonghwan Kim, Bingcheng Wang, Ilaria Tamagno, Hao Zhou, Xiaoxia Li, Helmut Kettenmann, Richard M Ransohoff, Dolores Hambardzumya. Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis. Oncotarget. vol 6. issue 17. 2016-04-26. PMID:25987130. |
here we tested the hypothesis that loss of the fractalkine receptor cx3cr1 in microglia and monocytes would affect gliomagenesis. |
2016-04-26 |
2023-08-13 |
mouse |
| Xi Feng, Frank Szulzewsky, Alexan Yerevanian, Zhihong Chen, David Heinzmann, Rikke Darling Rasmussen, Virginia Alvarez-Garcia, Yeonghwan Kim, Bingcheng Wang, Ilaria Tamagno, Hao Zhou, Xiaoxia Li, Helmut Kettenmann, Richard M Ransohoff, Dolores Hambardzumya. Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis. Oncotarget. vol 6. issue 17. 2016-04-26. PMID:25987130. |
loss of cx3cr1 in microglia in a monocyte-free environment had no impact on tumor growth and did not alter microglial migration. |
2016-04-26 |
2023-08-13 |
mouse |
| Jenny Dworzak, Benoît Renvoisé, Johnny Habchi, Emma V Yates, Christophe Combadière, Tuomas P Knowles, Christopher M Dobson, Craig Blackstone, Ole Paulsen, Philip M Murph. Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity. PloS one. vol 10. issue 6. 2016-02-22. PMID:26038823. |
a complicating factor is that cx3cr1 has been demonstrated in both neurons and microglia. |
2016-02-22 |
2023-08-13 |
mouse |
| Carlo Condello, Peng Yuan, Aaron Schain, Jaime Grutzendle. Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques. Nature communications. vol 6. 2016-02-02. PMID:25630253. |
cx3cr1 gene deletion or anti-aβ immunotherapy causes expansion of microglia coverage and reduced neuritic dystrophy. |
2016-02-02 |
2023-08-13 |
mouse |
| Marc-André Bellavance, David Gosselin, V Wee Yong, Peter K Stys, Serge Rives. Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity. Brain structure & function. vol 220. issue 3. 2016-01-27. PMID:24706067. |
in murine models of these diseases, disruption of cx3cr1 signaling has thus far generated data either in favor or against a neuroprotective role of this crucial regulator of microglia and monocyte functions. |
2016-01-27 |
2023-08-13 |
mouse |
| Marc-André Bellavance, David Gosselin, V Wee Yong, Peter K Stys, Serge Rives. Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity. Brain structure & function. vol 220. issue 3. 2016-01-27. PMID:24706067. |
furthermore, cx3cr1 deletion significantly exacerbated neuronal death, behavioral deficits and activation of microglia cells following sterile excitotoxicity. |
2016-01-27 |
2023-08-13 |
mouse |
| Clotilde Lauro, Myriam Catalano, Flavia Trettel, Cristina Limatol. Fractalkine in the nervous system: neuroprotective or neurotoxic molecule? Annals of the New York Academy of Sciences. vol 1351. 2016-01-26. PMID:26084002. |
the expression of cx3cl1 on neurons and of its receptor cx3cr1 on microglia facilitates a privileged interaction, playing important roles in regulating the function and maturation of these cells. |
2016-01-26 |
2023-08-13 |
human |
| Idrish Ali, Deepti Chugh, Christine T Ekdah. Role of fractalkine-CX3CR1 pathway in seizure-induced microglial activation, neurodegeneration, and neuroblast production in the adult rat brain. Neurobiology of disease. vol 74. 2016-01-06. PMID:25461978. |
fractalkine is a chemokine expressed by both neurons and glia, while its receptor, cx3cr1 is primarily expressed on microglia. |
2016-01-06 |
2023-08-13 |
rat |
| Yong Liu, Xiao-Mei Wu, Qian-Qian Luo, Suna Huang, Qing-Wu Qian Yang, Fa-Xiang Wang, Ya Ke, Zhong-Ming Qia. CX3CL1/CX3CR1-mediated microglia activation plays a detrimental role in ischemic mice brain via p38MAPK/PKC pathway. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 10. 2015-12-30. PMID:25966946. |
the exact roles of activated microglia and fractalkine (cx3cl1)/fractalkine receptor (cx3cr1) signaling are not fully understood in brain ischemic injury and the findings reported are controversial. |
2015-12-30 |
2023-08-13 |
mouse |
| Yong Liu, Xiao-Mei Wu, Qian-Qian Luo, Suna Huang, Qing-Wu Qian Yang, Fa-Xiang Wang, Ya Ke, Zhong-Ming Qia. CX3CL1/CX3CR1-mediated microglia activation plays a detrimental role in ischemic mice brain via p38MAPK/PKC pathway. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 10. 2015-12-30. PMID:25966946. |
here, we investigated the effects of cx3cr1 sirna on the expression of cx3cr1, p38 mitogen-activated protein kinase (p38mapk), protein kinase c (pkc) and inflammatory cytokines, microglia activation, white matter lesions, and cognitive function in mice treated with bilateral common carotid artery stenosis (bcas) in vivo as well as effects of exogenous cx3cl1, cx3cr1 sirna, and sb2035080 on expression of inflammatory cytokines in bv2 microglia treated with oxygen-glucose deprivation (ogd) in vitro. |
2015-12-30 |
2023-08-13 |
mouse |
| Yong Liu, Xiao-Mei Wu, Qian-Qian Luo, Suna Huang, Qing-Wu Qian Yang, Fa-Xiang Wang, Ya Ke, Zhong-Ming Qia. CX3CL1/CX3CR1-mediated microglia activation plays a detrimental role in ischemic mice brain via p38MAPK/PKC pathway. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 10. 2015-12-30. PMID:25966946. |
we showed that cx3cr1 sirna significantly inhibited the increased expression of cx3cr1, p38mapk, pkc as well as tumor necrosis factor-α (tnf-α), interleukin (il)-1β, and il-6, and also attenuated microglia activation, white matter lesions, and cognitive deficits induced by bcas in mice brain. |
2015-12-30 |
2023-08-13 |
mouse |
| Alejandra Bosco, Cesar O Romero, Balamurali K Ambati, Monica L Vette. In vivo dynamics of retinal microglial activation during neurodegeneration: confocal ophthalmoscopic imaging and cell morphometry in mouse glaucoma. Journal of visualized experiments : JoVE. issue 99. 2015-12-15. PMID:25992962. |
this protocol outlines methods for long-term, in vivo imaging of retinal microglia, using confocal ophthalmoscopy (cslo) and cx3cr1(gfp/+) reporter mice, to visualize microglia with cellular resolution. |
2015-12-15 |
2023-08-13 |
mouse |
| Simon Verheijden, Sebastiaan De Schepper, Guy E Boeckxstaen. Neuron-macrophage crosstalk in the intestine: a "microglia" perspective. Frontiers in cellular neuroscience. vol 9. 2015-11-03. PMID:26528133. |
in line, intestinal macrophages, both in the muscularis externa and (sub)mucosa, express high levels of cx3cr1, a feature that was once believed to be unique for microglia. |
2015-11-03 |
2023-08-13 |
Not clear |