| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming Duan, Honghong Yao, Yu Cai, Ke Liao, Pankaj Seth, Shilpa Buc. HIV-1 Tat disrupts CX3CL1-CX3CR1 axis in microglia via the NF-κBYY1 pathway. Current HIV research. vol 12. issue 3. 2015-04-01. PMID:24862326. |
taken together, these results demonstrate that hiv-1 tat protein suppresses cx3cr1 expression in microglia via nf-κb-yy1 pathway and attenuates cx3cl1-induced functional response of microglia. |
2015-04-01 |
2023-08-13 |
mouse |
| Anna L Xavier, Flavia R S Lima, Maiken Nedergaard, João R L Meneze. Ontogeny of CX3CR1-EGFP expressing cells unveil microglia as an integral component of the postnatal subventricular zone. Frontiers in cellular neuroscience. vol 9. 2015-03-05. PMID:25741237. |
analysis of the transgenic mice strain that has one locus of the constitutively expressed fractalkine cx3cr1 receptor replaced by the gene encoding the enhanced green fluorescent protein (egfp) circumvented the antigenic plasticity of the microglia, thus allowing us to depict microglia within the svz/rms pathway during early development. |
2015-03-05 |
2023-08-13 |
mouse |
| Elisa Ferretti, Vito Pistoia, Anna Corcion. Role of fractalkine/CX3CL1 and its receptor in the pathogenesis of inflammatory and malignant diseases with emphasis on B cell malignancies. Mediators of inflammation. vol 2014. 2014-12-18. PMID:24799766. |
the biological activities of cx3cl1 are mediated by cx3cr1, that is expressed on different cell types such as nk cells, cd14(+) monocytes, cytotoxic effector t cells, b cells, neurons, microglia, smooth muscle cells, and tumor cells. |
2014-12-18 |
2023-08-13 |
human |
| Chao Bian, Zhe-Chen Wang, Jia-Le Yang, Ning Lu, Zhi-Qi Zhao, Yu-Qiu Zhan. Up-regulation of interleukin-23 induces persistent allodynia via CX3CL1 and interleukin-18 signaling in the rat spinal cord after tetanic sciatic stimulation. Brain, behavior, and immunity. vol 37. 2014-11-04. PMID:24362237. |
interestingly, il-18 and cx3cr1 were exclusively expressed in microglia, while il-18r was mainly localized in astrocytes. |
2014-11-04 |
2023-08-12 |
rat |
| Teresita L Briones, Julie Woods, Magdalena Wadowsk. Chronic neuroinflammation and cognitive impairment following transient global cerebral ischemia: role of fractalkine/CX3CR1 signaling. Journal of neuroinflammation. vol 11. 2014-09-16. PMID:24447880. |
a major participant in neuroinflammation is microglia and microglial activation usually regulated by the chemokine cx3cl1 (fractalkine) and its receptor, cx3cr1. |
2014-09-16 |
2023-08-12 |
human |
| Julia Grizenkova, Shaheen Akhtar, Sebastian Brandner, John Collinge, Sarah E Lloy. Microglial Cx3cr1 knockout reduces prion disease incubation time in mice. BMC neuroscience. vol 15. 2014-08-27. PMID:24655482. |
in the central nervous system the chemokine cx3cl1 (fractalkine) is expressed by neurons and its exclusive receptor cx3cr1 is expressed solely on microglia. |
2014-08-27 |
2023-08-12 |
mouse |
| Cristina Limatola, Richard M Ransohof. Modulating neurotoxicity through CX3CL1/CX3CR1 signaling. Frontiers in cellular neuroscience. vol 8. 2014-08-25. PMID:25152714. |
the pivotal description of the localization of the unique cx3cl1 receptor, cx3cr1, on microglial cells, firmed up by the generation of cx3cr1(gfp/gfp) mice, opened the road to the hypothesis of some specific key interactions between microglia and neurons mediated by this pair. |
2014-08-25 |
2023-08-13 |
mouse |
| Ukpong B Eyo, Sam A Miner, Katelin E Ahlers, Long-Jun Wu, Michael E Daile. P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation. Neuropharmacology. vol 73. 2014-08-13. PMID:23770338. |
to validate and extend these in vitro findings, we assessed parenchymal microglia in freshly isolated hippocampal tissue slices from gfp-reporter mice (cx3cr1(gfp/+)). |
2014-08-13 |
2023-08-12 |
mouse |
| Bo Peng, Jia Xiao, Ke Wang, Kwok-Fai So, George L Tipoe, Bin Li. Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 24. 2014-08-04. PMID:24920619. |
third, we found that cx3cr1 deficiency dysregulated microglia activation and subsequently resulted in increased photoreceptor vulnerability in rd10 mice, suggesting that the cx3cl1/cx3cr1 signaling pathway might protect against microglia neurotoxicity. |
2014-08-04 |
2023-08-13 |
mouse |
| Rosa Chiara Paolicelli, Kanchan Bisht, Marie-Ève Trembla. Fractalkine regulation of microglial physiology and consequences on the brain and behavior. Frontiers in cellular neuroscience. vol 8. 2014-06-24. PMID:24860431. |
as part of this special issue on cytokines as players of neuronal plasticity and sensitivity to environment in healthy and pathological brain, our review focuses on the fractalkine signaling pathway, involving the ligand cx3cl1 which is mainly expressed by neurons, and its receptor cx3cr1 that is exclusively found on microglia within the healthy brain. |
2014-06-24 |
2023-08-13 |
mouse |
| Teresa A Evans, Deborah S Barkauskas, Jay T Myers, Elisabeth G Hare, Jing Qiang You, Richard M Ransohoff, Alex Y Huang, Jerry Silve. High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury. Experimental neurology. vol 254. 2014-05-19. PMID:24468477. |
using powerful time-lapse multi-photon imaging, we captured images of interactions between cx3cr1(+/gfp) macrophages and microglia and thy-1(yfp) axons in a mouse dorsal column crush spinal cord injury model. |
2014-05-19 |
2023-08-12 |
mouse |
| Teresa A Evans, Deborah S Barkauskas, Jay T Myers, Elisabeth G Hare, Jing Qiang You, Richard M Ransohoff, Alex Y Huang, Jerry Silve. High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury. Experimental neurology. vol 254. 2014-05-19. PMID:24468477. |
interestingly, cns-resident cx3cr1(+/gfp) microglia did not increasingly accumulate nor participate in neuronal destruction in the lesion during this time period. |
2014-05-19 |
2023-08-12 |
mouse |
| Yang Zhan, Rosa C Paolicelli, Francesco Sforazzini, Laetitia Weinhard, Giulia Bolasco, Francesca Pagani, Alexei L Vyssotski, Angelo Bifone, Alessandro Gozzi, Davide Ragozzino, Cornelius T Gros. Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior. Nature neuroscience. vol 17. issue 3. 2014-05-16. PMID:24487234. |
mice lacking the chemokine receptor cx3cr1 exhibit a transient reduction of microglia during the early postnatal period and a consequent deficit in synaptic pruning. |
2014-05-16 |
2023-08-12 |
mouse |
| Yong Liu, Tianzhi Zhao, Zhao Yang, Qianning L. CX3CR1 RNAi inhibits hypoxia-induced microglia activation via p38MAPK/PKC pathway. International journal of experimental pathology. vol 95. issue 2. 2014-05-14. PMID:24628787. |
cx3cr1 rnai inhibits hypoxia-induced microglia activation via p38mapk/pkc pathway. |
2014-05-14 |
2023-08-12 |
Not clear |
| Yong Liu, Tianzhi Zhao, Zhao Yang, Qianning L. CX3CR1 RNAi inhibits hypoxia-induced microglia activation via p38MAPK/PKC pathway. International journal of experimental pathology. vol 95. issue 2. 2014-05-14. PMID:24628787. |
in addition, hypoxia-induced upregulated expression of fractalkine promotes the activation of microglia and their migration to the lesions through interaction with its receptor cx3cr1. |
2014-05-14 |
2023-08-12 |
Not clear |
| Hui Sun, Karelle Bénardais, Nancy Stanslowsky, Nadine Thau-Habermann, Niko Hensel, Dongya Huang, Peter Claus, Reinhard Dengler, Martin Stangel, Susanne Petr. Therapeutic potential of mesenchymal stromal cells and MSC conditioned medium in Amyotrophic Lateral Sclerosis (ALS)--in vitro evidence from primary motor neuron cultures, NSC-34 cells, astrocytes and microglia. PloS one. vol 8. issue 9. 2014-04-28. PMID:24069165. |
correspondingly, msc cm increased the respective receptor, cx3cr1, in mutant sod1g93a transgenic microglia. |
2014-04-28 |
2023-08-12 |
mouse |
| Hu Huang, Rachel Parlier, Ji-Kui Shen, Gerard A Lutty, Stanley A Vinore. VEGF receptor blockade markedly reduces retinal microglia/macrophage infiltration into laser-induced CNV. PloS one. vol 8. issue 8. 2014-04-08. PMID:23977149. |
in vivo imaging demonstrated accumulation of gfp-expressing microglia into cnv in both cx3cr1(gfp/gfp) and cx3cr1(gfp/+) mice. |
2014-04-08 |
2023-08-12 |
mouse |
| Jiang Wu, Bihua Bie, Hui Yang, Jijun J Xu, David L Brown, Mohamed Nagui. Suppression of central chemokine fractalkine receptor signaling alleviates amyloid-induced memory deficiency. Neurobiology of aging. vol 34. issue 12. 2014-04-02. PMID:23855980. |
chemokine fractalkine receptor (cx3cr1) is primarily located in the microglia in the brain and its role in the amyloid fibril-induced neuroinflammation and memory deficiency remains debated. |
2014-04-02 |
2023-08-12 |
rat |
| Christopher N Parkhurst, Guang Yang, Ipe Ninan, Jeffrey N Savas, John R Yates, Juan J Lafaille, Barbara L Hempstead, Dan R Littman, Wen-Biao Ga. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. vol 155. issue 7. 2014-02-26. PMID:24360280. |
to address this question, we generated cx3cr1(creer) mice expressing tamoxifen-inducible cre recombinase that allow for specific manipulation of gene function in microglia. |
2014-02-26 |
2023-08-12 |
mouse |
| Christopher N Parkhurst, Guang Yang, Ipe Ninan, Jeffrey N Savas, John R Yates, Juan J Lafaille, Barbara L Hempstead, Dan R Littman, Wen-Biao Ga. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. vol 155. issue 7. 2014-02-26. PMID:24360280. |
using cx3cr1(creer) to drive diphtheria toxin receptor expression in microglia, we found that microglia could be specifically depleted from the brain upon diphtheria toxin administration. |
2014-02-26 |
2023-08-12 |
mouse |