| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marco Locatelli, Leonardo Boiocchi, Stefano Ferrero, Filippo Martinelli Boneschi, Mario Zavanone, Samantha Pesce, Paola Allavena, Sergio Maria Gaini, Lorenzo Bello, Alberto Mantovan. Human glioma tumors express high levels of the chemokine receptor CX3CR1. European cytokine network. vol 21. issue 1. 2011-02-14. PMID:20146987. |
the chemokine receptor cx3cr1 and its cognate ligand cx3cl1 (also known as fractalkine), are involved in central nervous system pathophysiology, in particular, in the cross-talk between neurons and microglia. |
2011-02-14 |
2023-08-12 |
human |
| Zhiqiang Liu, Carlo Condello, Aaron Schain, Roa Harb, Jaime Grutzendle. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 50. 2011-02-09. PMID:21159979. |
cx3cr1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis. |
2011-02-09 |
2023-08-12 |
mouse |
| Zhiqiang Liu, Carlo Condello, Aaron Schain, Roa Harb, Jaime Grutzendle. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 50. 2011-02-09. PMID:21159979. |
the chemokine receptor cx3cr1 is selectively expressed in microglia and is thought to modulate their activity. |
2011-02-09 |
2023-08-12 |
mouse |
| Zhiqiang Liu, Carlo Condello, Aaron Schain, Roa Harb, Jaime Grutzendle. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 50. 2011-02-09. PMID:21159979. |
to study the specific effects of microglia activation on amyloid pathology in vivo, we crossbred mice lacking cx3cr1 with the alzheimer's mouse model crnd8. |
2011-02-09 |
2023-08-12 |
mouse |
| Zhiqiang Liu, Carlo Condello, Aaron Schain, Roa Harb, Jaime Grutzendle. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 50. 2011-02-09. PMID:21159979. |
cx3cr1 deletion did not affect the degree of neuronal or synaptic damage around plaques despite increased microglia density. |
2011-02-09 |
2023-08-12 |
mouse |
| Zhiqiang Liu, Carlo Condello, Aaron Schain, Roa Harb, Jaime Grutzendle. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 50. 2011-02-09. PMID:21159979. |
modulation of microglia activity and proliferation by cx3cr1 signaling may represent a therapeutic strategy for ad. |
2011-02-09 |
2023-08-12 |
mouse |
| Angela M Wynne, Christopher J Henry, Yan Huang, Anthony Cleland, Jonathan P Godbou. Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge. Brain, behavior, and immunity. vol 24. issue 7. 2011-01-18. PMID:20570721. |
protracted downregulation of cx3cr1 on microglia of aged mice after lipopolysaccharide challenge. |
2011-01-18 |
2023-08-12 |
mouse |
| Kyung-Min Lee, Sang-Min Jeon, Hee-Jung Ch. Interleukin-6 induces microglial CX3CR1 expression in the spinal cord after peripheral nerve injury through the activation of p38 MAPK. European journal of pain (London, England). vol 14. issue 7. 2010-10-25. PMID:19959384. |
these results suggest a new mechanism of neuropathic pain, in which il-6 induces microglial cx3cr1 expression in the spinal cord through p38 mapk activation, enhancing the responsiveness of microglia to fractalkine in the spinal cord, thus playing an important role in neuropathic pain after peripheral nerve injury. |
2010-10-25 |
2023-08-12 |
rat |
| Amelia A Staniland, Anna K Clark, Rachel Wodarski, Oscar Sasso, Francesco Maione, Fulvio D'Acquisto, Marzia Malcangi. Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice. Journal of neurochemistry. vol 114. issue 4. 2010-10-06. PMID:20524966. |
mature fkn is enzymatically cleaved from neuronal membranes and activation of its receptor, cx3cr1, which is expressed by microglia, induces phosphorylation of p38 mapk. |
2010-10-06 |
2023-08-12 |
mouse |
| Yong-Jing Gao, Ru-Rong J. Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. Pharmacology & therapeutics. vol 126. issue 1. 2010-06-04. PMID:20117131. |
release of cx3cl1 from neurons is ideal to mediate neuronal-to-microglial signaling, since the sole receptor of this chemokine, cx3cr1, is expressed in spinal microglia and activation of the receptor leads to phosphorylation of p38 map kinase in microglia. |
2010-06-04 |
2023-08-12 |
Not clear |
| Athanasios Dagkalis, Carol Wallace, Benjamin Hing, Janet Liversidge, Isabel J Cran. CX3CR1-deficiency is associated with increased severity of disease in experimental autoimmune uveitis. Immunology. vol 128. issue 1. 2009-11-04. PMID:19689733. |
the role of cx3cr1 in regulating the function of monocytes and microglia was examined in mice in which cx3cr1 had been replaced by green fluorescent protein (gfp). |
2009-11-04 |
2023-08-12 |
mouse |
| Athanasios Dagkalis, Carol Wallace, Benjamin Hing, Janet Liversidge, Isabel J Cran. CX3CR1-deficiency is associated with increased severity of disease in experimental autoimmune uveitis. Immunology. vol 128. issue 1. 2009-11-04. PMID:19689733. |
resident microglia within the retina were activated equally as eau developed in mice with or without cx3cr1, as determined by changes in morphology, suggesting that the microglial cell response did not account for the differences. |
2009-11-04 |
2023-08-12 |
mouse |
| Lian Zhao, Wenxin Ma, Robert N Fariss, Wai T Won. Retinal vascular repair and neovascularization are not dependent on CX3CR1 signaling in a model of ischemic retinopathy. Experimental eye research. vol 88. issue 6. 2009-10-08. PMID:19176215. |
cx3cr1 is a chemokine receptor located specifically on microglia; its ligand, cx3cl1 (also known as fractalkine or neurotactin) displays pro-angiogenic activity both in in vivo and in vitro. |
2009-10-08 |
2023-08-12 |
mouse |
| Lian Zhao, Wenxin Ma, Robert N Fariss, Wai T Won. Retinal vascular repair and neovascularization are not dependent on CX3CR1 signaling in a model of ischemic retinopathy. Experimental eye research. vol 88. issue 6. 2009-10-08. PMID:19176215. |
our results show that: (1) cx3cr1 signaling is not required for normal vascular, microglial, and neuronal development in the retina in the first postnatal week, (2) the processes of retinal vascular repair and neovascularization following ischemia occur similarly with and without cx3cr1 signaling, (3) microglia redistribution in the retina and their association with vascular elements occurring concurrently is independent of cx3cr1, and (4) cx3cr1 does not influence the extent of neuronal cell loss in the retina following ischemia. |
2009-10-08 |
2023-08-12 |
mouse |
| Lian Zhao, Wenxin Ma, Robert N Fariss, Wai T Won. Retinal vascular repair and neovascularization are not dependent on CX3CR1 signaling in a model of ischemic retinopathy. Experimental eye research. vol 88. issue 6. 2009-10-08. PMID:19176215. |
taken together, our findings indicate that the regulatory signals exchanged between microglia and vascular elements in the ischemic retinopathy animal model are unlikely to involve cx3cr1. |
2009-10-08 |
2023-08-12 |
mouse |
| Katharine J Liang, Jung Eun Lee, Yunqing D Wang, Wenxin Ma, Aurora M Fontainhas, Robert N Fariss, Wai T Won. Regulation of dynamic behavior of retinal microglia by CX3CR1 signaling. Investigative ophthalmology & visual science. vol 50. issue 9. 2009-09-18. PMID:19443728. |
regulation of dynamic behavior of retinal microglia by cx3cr1 signaling. |
2009-09-18 |
2023-08-12 |
Not clear |
| Katharine J Liang, Jung Eun Lee, Yunqing D Wang, Wenxin Ma, Aurora M Fontainhas, Robert N Fariss, Wai T Won. Regulation of dynamic behavior of retinal microglia by CX3CR1 signaling. Investigative ophthalmology & visual science. vol 50. issue 9. 2009-09-18. PMID:19443728. |
the role of cx3cr1, a chemokine receptor expressed in microglia, in regulating microglia morphology and dynamic behavior in the resting state and after laser-induced focal injury was examined. |
2009-09-18 |
2023-08-12 |
Not clear |
| Che Liu, Defang Luo, Wolfgang J Streit, Jeffrey K Harriso. CX3CL1 and CX3CR1 in the GL261 murine model of glioma: CX3CR1 deficiency does not impact tumor growth or infiltration of microglia and lymphocytes. Journal of neuroimmunology. vol 198. issue 1-2. 2008-11-10. PMID:18508133. |
cx3cl1 and cx3cr1 in the gl261 murine model of glioma: cx3cr1 deficiency does not impact tumor growth or infiltration of microglia and lymphocytes. |
2008-11-10 |
2023-08-12 |
mouse |
| Che Liu, Defang Luo, Wolfgang J Streit, Jeffrey K Harriso. CX3CL1 and CX3CR1 in the GL261 murine model of glioma: CX3CR1 deficiency does not impact tumor growth or infiltration of microglia and lymphocytes. Journal of neuroimmunology. vol 198. issue 1-2. 2008-11-10. PMID:18508133. |
a slight increase in the tumor growth rate in cx3cr1-/- mice was evident with similar numbers of microglia and cd4+, cd8+, foxp3+, or ly49g2+ lymphocytes within tumors established in cx3cr1 +/- and -/- mice. |
2008-11-10 |
2023-08-12 |
mouse |
| Che Liu, Defang Luo, Wolfgang J Streit, Jeffrey K Harriso. CX3CL1 and CX3CR1 in the GL261 murine model of glioma: CX3CR1 deficiency does not impact tumor growth or infiltration of microglia and lymphocytes. Journal of neuroimmunology. vol 198. issue 1-2. 2008-11-10. PMID:18508133. |
these data indicate that cx3cr1 has little or no effects on either gliomagenesis or the migration of microglia and lymphocytes into gl261 tumors. |
2008-11-10 |
2023-08-12 |
mouse |