| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rebecca A Sosa, Cathi Murphey, Niannian Ji, Astrid E Cardona, Thomas G Forsthube. The kinetics of myelin antigen uptake by myeloid cells in the central nervous system during experimental autoimmune encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950). vol 191. issue 12. 2014-02-18. PMID:24227784. |
our results show that during eae cx3cr1(+)cd11b(+) microglia were the first apcs in the cns to contain myelin ag upon induction of disease, albeit in very small numbers. |
2014-02-18 |
2023-08-12 |
mouse |
| Ting Li, Shengru Pang, Yongping Yu, Xiaoqian Wu, Jing Guo, Shengxiang Zhan. Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke. Brain : a journal of neurology. vol 136. issue Pt 12. 2014-02-10. PMID:24154617. |
we found that a small population of blood-derived cx3cr1(gfp/+) cells infiltrated the cerebral parenchyma, but these cells did not proliferate and were phenotypically distinguishable from resident microglia. |
2014-02-10 |
2023-08-12 |
Not clear |
| Ting Li, Shengru Pang, Yongping Yu, Xiaoqian Wu, Jing Guo, Shengxiang Zhan. Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke. Brain : a journal of neurology. vol 136. issue Pt 12. 2014-02-10. PMID:24154617. |
cx3cr1(gfp/+) infiltrating cells also displayed different kinetics from reactive microglia. |
2014-02-10 |
2023-08-12 |
Not clear |
| Ting Li, Shengru Pang, Yongping Yu, Xiaoqian Wu, Jing Guo, Shengxiang Zhan. Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke. Brain : a journal of neurology. vol 136. issue Pt 12. 2014-02-10. PMID:24154617. |
together, these results indicated that cx3cr1(gfp/+) infiltrating cells and reactive microglia represented two distinct populations of cells with different functions and therapeutic potentials for the treatment of stroke. |
2014-02-10 |
2023-08-12 |
Not clear |
| Jenny A Garcia, Sandra M Cardona, Astrid E Cardon. Analyses of microglia effector function using CX3CR1-GFP knock-in mice. Methods in molecular biology (Clifton, N.J.). vol 1041. 2014-01-30. PMID:23813389. |
in our case, chimeras help us to better understand the role of cx3cr1 in microglia and peripheral myeloid cells. |
2014-01-30 |
2023-08-12 |
mouse |
| Stefano Fumagalli, Carlo Perego, Fabrizio Ortolano, Maria-Grazia De Simon. CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice. Glia. vol 61. issue 6. 2013-10-29. PMID:23440897. |
we have explored the consequences of cx3cr1 deletion in ischemic (30' mcao) mice on: (1) brain infarct size; (2) microglia dynamism and morphology; (3) expression of markers of microglia/macrophages (m/m) activation and polarization. |
2013-10-29 |
2023-08-12 |
mouse |
| Stefano Fumagalli, Carlo Perego, Fabrizio Ortolano, Maria-Grazia De Simon. CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice. Glia. vol 61. issue 6. 2013-10-29. PMID:23440897. |
microglia were stationary in both cx3cr1(-/-) and cx3cr1(-/+) mice throughout the study. |
2013-10-29 |
2023-08-12 |
mouse |
| Stefano Fumagalli, Carlo Perego, Fabrizio Ortolano, Maria-Grazia De Simon. CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice. Glia. vol 61. issue 6. 2013-10-29. PMID:23440897. |
in cx3cr1(-/-) mice, they displayed a significantly higher number of ramifications >10 μm at baseline and at 24 h after ischemia compared to cx3cr1(-/+) mice, indicating that cx3cr1 deficiency impaired the development of microglia hypertrophic/amoeboid morphology. |
2013-10-29 |
2023-08-12 |
mouse |
| Jenny A Garcia, Paula A Pino, Makiko Mizutani, Sandra M Cardona, Israel F Charo, Richard M Ransohoff, Thomas G Forsthuber, Astrid E Cardon. Regulation of adaptive immunity by the fractalkine receptor during autoimmune inflammation. Journal of immunology (Baltimore, Md. : 1950). vol 191. issue 3. 2013-09-30. PMID:23817416. |
fractalkine binds cx3cr1 on microglia and circulating monocytes, dendritic cells, and nk cells. |
2013-09-30 |
2023-08-12 |
mouse |
| Masaki Ueno, Yuki Fujita, Tatsuhide Tanaka, Yuka Nakamura, Junichi Kikuta, Masaru Ishii, Toshihide Yamashit. Layer V cortical neurons require microglial support for survival during postnatal development. Nature neuroscience. vol 16. issue 5. 2013-06-27. PMID:23525041. |
cx3cr1 in microglia was required for the survival of layer v neurons. |
2013-06-27 |
2023-08-12 |
mouse |
| Carsten Minten, Rachael Terry, Celine Deffrasnes, Nicholas J C King, Iain L Campbel. IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS. PloS one. vol 7. issue 11. 2013-06-20. PMID:23166780. |
analysis of microglia ex vivo revealed irf8-deficient microglia had significantly increased levels of cd45, cd11b and f4/80, but significantly decreased levels of the chemokine receptors ccr2, ccr5 and cx3cr1. |
2013-06-20 |
2023-08-12 |
mouse |
| Winnie W Pong, Samantha B Higer, Scott M Gianino, Ryan J Emnett, David H Gutman. Reduced microglial CX3CR1 expression delays neurofibromatosis-1 glioma formation. Annals of neurology. vol 73. issue 2. 2013-05-21. PMID:23424002. |
leveraging a genetically engineered mouse model of neurofibromatosis type 1 (nf1)-associated optic glioma, we now demonstrate that stromal microglia express the cx3cr1 chemokine receptor, such that reduced cx3cr1 expression decreases optic nerve microglia. |
2013-05-21 |
2023-08-12 |
mouse |
| Hayley A Mattison, Hui Nie, Huiming Gao, Hui Zhou, Jau-Shyong Hong, Jing Zhan. Suppressed pro-inflammatory response of microglia in CX3CR1 knockout mice. Journal of neuroimmunology. vol 257. issue 1-2. 2013-05-21. PMID:23499256. |
suppressed pro-inflammatory response of microglia in cx3cr1 knockout mice. |
2013-05-21 |
2023-08-12 |
mouse |
| Hayley A Mattison, Hui Nie, Huiming Gao, Hui Zhou, Jau-Shyong Hong, Jing Zhan. Suppressed pro-inflammatory response of microglia in CX3CR1 knockout mice. Journal of neuroimmunology. vol 257. issue 1-2. 2013-05-21. PMID:23499256. |
neuronal fractalkine acts via its receptor, cx3cr1, on microglia to regulate neuroinflammation. |
2013-05-21 |
2023-08-12 |
mouse |
| Hayley A Mattison, Hui Nie, Huiming Gao, Hui Zhou, Jau-Shyong Hong, Jing Zhan. Suppressed pro-inflammatory response of microglia in CX3CR1 knockout mice. Journal of neuroimmunology. vol 257. issue 1-2. 2013-05-21. PMID:23499256. |
we hypothesize that cx3cl1-cx3cr1 signaling is neuroprotective and propose that the reduced production of pro-inflammatory signals in cx3cr1(-/-)microglia may result from compensatory mechanisms and not be the direct result of cx3cr1 deficiency. |
2013-05-21 |
2023-08-12 |
mouse |
| Ji-Hua Hu, Jian-Ping Yang, Lei Liu, Cai-Fang Li, Li-Na Wang, Fu-Hai Ji, Hao Chen. Involvement of CX3CR1 in bone cancer pain through the activation of microglia p38 MAPK pathway in the spinal cord. Brain research. vol 1465. 2013-04-30. PMID:22613229. |
involvement of cx3cr1 in bone cancer pain through the activation of microglia p38 mapk pathway in the spinal cord. |
2013-04-30 |
2023-08-12 |
rat |
| Ji-Hua Hu, Jian-Ping Yang, Lei Liu, Cai-Fang Li, Li-Na Wang, Fu-Hai Ji, Hao Chen. Involvement of CX3CR1 in bone cancer pain through the activation of microglia p38 MAPK pathway in the spinal cord. Brain research. vol 1465. 2013-04-30. PMID:22613229. |
previous studies have demonstrated that fractalkine, a newly discovered chemokine, is implicated in spinal cord neuron-to-microglia activation signaling as well as mediation of neuropathic and inflammatory pain via its sole receptor cx3cr1, which is specifically expressed on microglia. |
2013-04-30 |
2023-08-12 |
rat |
| Ji-Hua Hu, Jian-Ping Yang, Lei Liu, Cai-Fang Li, Li-Na Wang, Fu-Hai Ji, Hao Chen. Involvement of CX3CR1 in bone cancer pain through the activation of microglia p38 MAPK pathway in the spinal cord. Brain research. vol 1465. 2013-04-30. PMID:22613229. |
furthermore, we demonstrated that blockade of cx3cr1 suppressed the activation of microglia and the expression of p38 mitogen-activated protein kinase (mapk) in the spinal cord in bcp rats. |
2013-04-30 |
2023-08-12 |
rat |
| Jelena Marie Kezic, Xiangting Chen, Elizabeth P Rakoczy, Paul G McMenami. The effects of age and Cx3cr1 deficiency on retinal microglia in the Ins2(Akita) diabetic mouse. Investigative ophthalmology & visual science. vol 54. issue 1. 2013-03-25. PMID:23307960. |
the effects of age and cx3cr1 deficiency on retinal microglia in the ins2(akita) diabetic mouse. |
2013-03-25 |
2023-08-12 |
mouse |
| Yochai Wolf, Simon Yona, Ki-Wook Kim, Steffen Jun. Microglia, seen from the CX3CR1 angle. Frontiers in cellular neuroscience. vol 7. 2013-03-20. PMID:23507975. |
microglia, seen from the cx3cr1 angle. |
2013-03-20 |
2023-08-12 |
Not clear |