| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Yang, Yingjie Chu, Yuhang Wang, Xiangmei Zhao, Wenke Xu, Peirong Zhang, Xiaoyu Liu, Shujuan Dong, Wenqi He, Chuanyu Ga. siRNA-mediated silencing of Wnt5a regulates inflammatory responses in atherosclerosis through the MAPK/NF-κB pathways. International journal of molecular medicine. vol 34. issue 4. 2015-05-26. PMID:25050997. |
furthermore, the mrna and protein expression of inflammatory cytokines, including monocyte chemotactic protein-1 (mcp-1), cyclooxygenase-2 (cox-2), matrix metalloproteinase (mmp)-2 and mmp-9 was significantly downregulated in the ad-wnt5a sirna group. |
2015-05-26 |
2023-08-13 |
mouse |
| Ali Roohbakhsh, Hamideh Parhiz, Fatemeh Soltani, Ramin Rezaee, Mehrdad Iranshah. Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases. Life sciences. vol 124. 2015-05-19. PMID:25625242. |
unlike conventional anti-cancer drugs, hsd and hst inhibit tumor growth by targeting multiple cellular protein targets at the same time, including caspases, bcl-2 (b-cell lymphoma 2) and bax (bcl-2 associated x protein) for the induction of apoptosis, and cox-2 (cyclooxygenase-2), mmp-2 (matrix metalloproteinase-2) and mmp-9 for the inhibition of angiogenesis and metastasis. |
2015-05-19 |
2023-08-13 |
Not clear |
| Elena Talero, Sofia Garcia-Maurino, Virginia Motilv. Melatonin, autophagy and intestinal bowel disease. Current pharmaceutical design. vol 20. issue 30. 2015-04-13. PMID:24251670. |
these actions have been associated to a variety of mechanisms, such as reduction of t cells number, modulation of macrophage activity, suppression of nfκb activity, inhibition of cell adhesion molecules and proinflammatory cytokines , suppression of cox-2 and inos levels and the consequent synthesis of pge2 and no, reduction of matrix metalloproteinase (mmp) -2 and -9 activity, and modulation of apoptosis. |
2015-04-13 |
2023-08-12 |
human |
| K Amrutha, Pandurangan Nanjan, Sanu K Shaji, Damu Sunilkumar, K Subhalakshmi, Lakshmi Rajakrishna, Asoke Banerj. Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells--A SAR study. Bioorganic & medicinal chemistry letters. vol 24. issue 19. 2015-03-30. PMID:25190466. |
the modulation of expression of two nf-κb regulated genes involved in tumorigenesis, matrix metalloproteinase-9 (mmp-9), and cyclooxygenase-2 (cox-2) were also analyzed in these cells. |
2015-03-30 |
2023-08-13 |
Not clear |
| Y Asakawa-Tanne, S Su, R Kunimatsu, N Hirose, T Mitsuyoshi, Y Okamoto, E Tanaka, K Tanne, K Tanimot. Effects of enzymatic degradation after loading in temporomandibular joint. Journal of dental research. vol 94. issue 2. 2015-03-27. PMID:25503611. |
gene expressions of interleukin-1β (il-1β), cyclooxygenase-2 (cox-2), matrix metalloproteinases (mmps), type ii collagen, and histology were examined after prolonged cyclic loading by an active pendulum system. |
2015-03-27 |
2023-08-13 |
Not clear |
| Kyu-Shik Lee, Do-Hyung Lee, So-Young Chun, Kyung-Soo Na. Metastatic potential in MDA-MB-231 human breast cancer cells is inhibited by proton beam irradiation via the Akt/nuclear factor-κB signaling pathway. Molecular medicine reports. vol 10. issue 2. 2015-02-12. PMID:24859472. |
cyclooxygenase-2 (cox-2) and matrix metalloproteinase‑9 (mmp-9) are highly expressed in various cancers, such as colon, lung and breast cancer, and enhance cell migration and metastasis in vitro and in vivo. |
2015-02-12 |
2023-08-13 |
human |
| S C Su, K Tanimoto, Y Tanne, R Kunimatsu, N Hirose, T Mitsuyoshi, Y Okamoto, K Tann. Celecoxib exerts protective effects on extracellular matrix metabolism of mandibular condylar chondrocytes under excessive mechanical stress. Osteoarthritis and cartilage. vol 22. issue 6. 2015-01-26. PMID:24721459. |
this study evaluated the effect of celecoxib, a selective cox-2 inhibitor, on extracellular matrix (ecm) metabolism of mandibular condylar chondrocytes under cts. |
2015-01-26 |
2023-08-13 |
Not clear |
| Aurigena Antunes de Araújo, Hugo Varela, Gerly Anne de Castro Brito, Caroline Addison Carvalho Xavier de Medeiros, Lorena de Souza Araújo, José Heriberto Oliveira do Nascimento, Raimundo Fernandes de Araújo Júnio. Azilsartan increases levels of IL-10, down-regulates MMP-2, MMP-9, RANKL/RANK, Cathepsin K and up-regulates OPG in an experimental periodontitis model. PloS one. vol 9. issue 5. 2015-01-23. PMID:24819928. |
the aim of this study was to evaluate the effects of azilsartan (azt) on bone loss, inflammation, and the expression of matrix metallo proteinases (mmps), receptor activator of nuclear factor κb ligand (rankl), receptor activator of nuclear factor κb (rank), osteoprotegerin (opg), cyclooxygenase-2 (cox-2), and cathepsin k in periodontal tissue in a rat model of ligature-induced periodontitis. |
2015-01-23 |
2023-08-13 |
rat |
| Yanli Zhang, Qiuyan Wang, Ailing Ma, Yunhong Li, Rui Li, Yin Wan. Functional expression of TLR9 in esophageal cancer. Oncology reports. vol 31. issue 5. 2015-01-12. PMID:24647486. |
cpg odn led to activation of nf‑κb and enhanced expression of matrix metalloproteinase (mmp)-2, mmp-7 and cyclooxygenase-2 (cox-2) mrna. |
2015-01-12 |
2023-08-12 |
human |
| Supachai Yodkeeree, Wilart Pompimon, Pornngarm Limtraku. Crebanine, an aporphine alkaloid, sensitizes TNF-α-induced apoptosis and suppressed invasion of human lung adenocarcinoma cells A549 by blocking NF-κB-regulated gene products. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 9. 2014-12-29. PMID:24867094. |
furthermore, crebanine suppressed the tnf-α-mediated expression of proteins that involved cancer cell invasion (matrix metalloproteinase 9 urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and intercellular adhesion molecule 1) and angiogenesis (cox-2 and vegf), all of which are known to be regulated by nf-κb. |
2014-12-29 |
2023-08-13 |
human |
| Hao Zhang, Kun Sun, Jing Ding, Huae Xu, Lingjun Zhu, Kai Zhang, Xiaolin Li, Weihao Su. Harmine induces apoptosis and inhibits tumor cell proliferation, migration and invasion through down-regulation of cyclooxygenase-2 expression in gastric cancer. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 21. issue 3. 2014-11-25. PMID:24176842. |
the expression of cox-2, proliferating cell nuclear antigen (pcna), bcl-2, bax and matrix metalloproteinase-2 (mmp-2) was detected by western blot analysis. |
2014-11-25 |
2023-08-12 |
human |
| Hsi-Lung Hsieh, Chuen-Mao Yan. Role of redox signaling in neuroinflammation and neurodegenerative diseases. BioMed research international. vol 2013. 2014-07-29. PMID:24455696. |
these proinflammatory factors act as potent stimuli in brain inflammation through upregulation of diverse inflammatory genes, including matrix metalloproteinases (mmps), cytosolic phospholipase a2 (cpla2), cyclooxygenase-2 (cox-2), and adhesion molecules. |
2014-07-29 |
2023-08-12 |
human |
| Guo-Qing Hou, Chun Guo, Guo-Hua Song, Na Fang, Wen-Juan Fan, Xu-Dong Chen, Lei Yuan, Zhen-Quan Wan. Lipopolysaccharide (LPS) promotes osteoclast differentiation and activation by enhancing the MAPK pathway and COX-2 expression in RAW264.7 cells. International journal of molecular medicine. vol 32. issue 2. 2014-06-09. PMID:23740407. |
the expression of osteoclast-related genes including tartrate-resistant acid phosphatase (trap), matrix metalloproteinase-9 (mmp-9), cathepsin k (ck), carbonic anhydrase ii (caii) and cyclooxygenase-2 (cox-2) was determined by rt-pcr. |
2014-06-09 |
2023-08-12 |
Not clear |
| I V Boulytcheva, N E Kushlinskii, Yu N Soloviev, M D Alie. Expression of molecular markers in low-grade chondrosarcomas and cartilaginous tumors with uncertain differentiation. Klinicheskaia laboratornaia diagnostika. issue 10. 2014-05-07. PMID:24640098. |
only a small percentage of the idh1mutations can be identified using the specific idhiri32h antibody histologic grade is the most important predictor of local recurrence and metastasis in chondrosarcoma , commonly patents die from locally recurrent tumor ofpelvis or scull, that is difficult to manage surgically association between ratio of matrix metalloproteinaise- 1 and tissue inhibitor ofmetalloproteinase- 1, expression of metalloproteinase-1, -2 and-9, col-iv, cox-2, bcl-2, bax in context with histological and clinical data could play a significant role in determining prognosis in patients with borderline cartilaginous tumors. |
2014-05-07 |
2023-08-12 |
human |
| Sun Young Park, Se Jin Park, Tae Gyeong Park, Seetharaman Rajasekar, Sang-Joon Lee, Young-Whan Cho. Schizandrin C exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microglia. International immunopharmacology. vol 17. issue 2. 2014-04-22. PMID:23859871. |
in microglia, schizandrin c significantly inhibited lipoteichoic acid (lta)-stimulated pro-inflammatory cytokines and chemokines, prostaglandin e2 (pge2), nitric oxide (no), and reactive oxygen species (ros) production, and inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), and matrix metallopeptidase-9 (mmp-9) protein expressions. |
2014-04-22 |
2023-08-12 |
Not clear |
| Ho-Joong Kim, Jin S Yeom, Yong-Gon Koh, Jee-Eun Yeo, Kyoung-Tak Kang, Young-Mi Kang, Bong-Soon Chang, Choon-Ki Le. Anti-inflammatory effect of platelet-rich plasma on nucleus pulposus cells with response of TNF-α and IL-1. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 32. issue 4. 2014-04-01. PMID:24338609. |
the response was investigated using real-time pcr for mrna expression of type ii collagen, aggrecan, matrix metalloproteinase-3 (mmp-3), and cyclooxygenase-2 (cox-2). |
2014-04-01 |
2023-08-12 |
human |
| Ho-Joong Kim, Jin S Yeom, Yong-Gon Koh, Jee-Eun Yeo, Kyoung-Tak Kang, Young-Mi Kang, Bong-Soon Chang, Choon-Ki Le. Anti-inflammatory effect of platelet-rich plasma on nucleus pulposus cells with response of TNF-α and IL-1. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 32. issue 4. 2014-04-01. PMID:24338609. |
the combination of il-1β and tnf-α led to decrease of matrix synthesis gene expression such as collagen type ii and aggrecan and increase of the degradation gene expression of cox-2 and mmp-3, compared to the control. |
2014-04-01 |
2023-08-12 |
human |
| Susanne Schiffmann, Andreas Weigert, Julia Männich, Max Eberle, Kerstin Birod, Annett Häussler, Nerea Ferreiros, Yannick Schreiber, Hana Kunkel, Manuel Grez, Benjamin Weichand, Bernhard Brüne, Waltraud Pfeilschifter, Rolf Nüsing, Ellen Niederberger, Sabine Grösch, Klaus Scholich, Gerd Geisslinge. PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis. Biochemical pharmacology. vol 87. issue 4. 2014-03-27. PMID:24355567. |
moreover, mice lacking cox-2 or ep4 in bone marrow-derived cells show a reduced expression of matrix metalloproteinase 9 (mmp9), which results in decreased infiltration of monocytes and t cells into the cns. |
2014-03-27 |
2023-08-12 |
mouse |
| Poonam Kothari, Roberto Pestana, Rim Mesraoua, Rim Elchaki, K M Faisal Khan, Andrew J Dannenberg, Domenick J Falcon. IL-6-mediated induction of matrix metalloproteinase-9 is modulated by JAK-dependent IL-10 expression in macrophages. Journal of immunology (Baltimore, Md. : 1950). vol 192. issue 1. 2014-02-27. PMID:24285838. |
we previously reported that cyclooxygenase-2 (cox-2)-dependent pge2 synthesis regulates macrophage matrix metalloproteinase (mmp)-9 expression, an endopeptidase that participates in diverse pathologic processes. |
2014-02-27 |
2023-08-12 |
Not clear |
| Manjari Mishra, Vivek Mishra, Bhushan P Chaudhuri, Vinay K Khanna, Sanjay Mehrotra, Shakir Ali, Mukul Da. Anomalies in ovary following oral exposure to oxytocin: mechanistic studies. Reproductive toxicology (Elmsford, N.Y.). vol 40. 2014-02-20. PMID:23707249. |
the mechanism may involve over-expression of pegfr followed by downstream perk1/2 and subsequently increased ovarian pge-2 along with enhanced cox-2, has-2 & tsg-6 (matrix deposition proteins) and gdf-9 (oocyte factor) proteins, suggesting that oral exposure of ot may affect the physiology and function of the ovary. |
2014-02-20 |
2023-08-12 |
human |