| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Saha, P K Datta, H Sheng, J D Morrow, M Wada, H L Moses, R D Beaucham. Synergistic induction of cyclooxygenase-2 by transforming growth factor-beta1 and epidermal growth factor inhibits apoptosis in epithelial cells. Neoplasia (New York, N.Y.). vol 1. issue 6. 2000-08-17. PMID:10935498. |
increased expression of cox-2 and production of prostaglandins appear to provide a survival advantage to transformed cells through the inhibition of apoptosis, increased attachment to extracellular matrix, increased invasiveness, and the stimulation of angiogenesis. |
2000-08-17 |
2023-08-12 |
human |
| B K Hong, H M Kwon, B K Lee, D Kim, I J Kim, S M Kang, Y Jang, S H Cho, H K Kim, B C Jang, S Y Cho, H S Kim, M S Kim, H C Kwon, N Le. Coexpression of cyclooxygenase-2 and matrix metalloproteinases in human aortic atherosclerotic lesions. Yonsei medical journal. vol 41. issue 1. 2000-04-11. PMID:10731924. |
cyclooxygenase-2 (cox-2) is involved in the inflammatory response via the generation of prostanoids that, in turn, are involved in the production of matrix metalloproteinases (mmps). |
2000-04-11 |
2023-08-12 |
human |
| K Hatanaka, M Kawamura, M Ogino, M Saito, K Ogino, S Matsuo, Y Harad. Expression and function of cyclooxygenase-2 in mesothelial cells during late phase of rat carrageenin-induced pleurisy. Life sciences. vol 65. issue 13. 1999-10-07. PMID:10503963. |
a cox-2 inhibitor, nimesulide, lowered the intrapleural level of 6-keto-pgf1alpha and inhibited hyperplasia of the pleural matrix, suggesting that cox-2 expressed in mesothelial cells may play a role in the synthesis of extracellular matrix through formation of pgi2. |
1999-10-07 |
2023-08-12 |
rat |
| R L Shattuck-Brandt, L W Lamps, K J Heppner Goss, R N DuBois, L M Matrisia. Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms. Molecular carcinogenesis. vol 24. issue 3. 1999-05-04. PMID:10204802. |
both the matrix metalloproteinase matrilysin and the prostaglandin h synthase cyclooxygenase-2 (cox-2), are thought to play key roles in colorectal carcinogenesis. |
1999-05-04 |
2023-08-12 |
mouse |
| J L Dean, M Brook, A R Clark, J Saklatval. p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes. The Journal of biological chemistry. vol 274. issue 1. 1999-02-05. PMID:9867839. |
we have previously shown that the pyridinyl imidazole sb 203580, which inhibits it, blocks the interleukin-1 induction of cyclooxygenase-2 (cox-2) and matrix metalloproteinase 1 and 3 mrnas in fibroblasts. |
1999-02-05 |
2023-08-12 |
human |
| D A Hart, P Sciore, R Boykiw, C Ren. Pregnancy induces complex changes in the the pattern of mRNA expression in knee ligaments of the adolescent rabbit. Matrix biology : journal of the International Society for Matrix Biology. vol 17. issue 1. 1998-08-13. PMID:9628250. |
levels of mrna for matrix molecules (collagen types i and iii and the proteoglycans biglycan, decorin, versican and lumican), proteinases and inhibitors (collagenase, urokinase, pai-1 and timp-1, -2 and -3), growth factors (bfgf, igf-i, tgf-beta1 and et-1), cytokines (il-1beta and tnf) and enzymes responsible for important tissue mediators (cox-2 and inos) were assessed by semi-quantitative rt-pcr. |
1998-08-13 |
2023-08-12 |
human |
| H Satoi, N Oka, T Kawasaki, K Miyamoto, I Akiguchi, J Kimur. Mechanisms of tissue injury in vasculitic neuropathies. Neurology. vol 50. issue 2. 1998-03-16. PMID:9484378. |
in the involved vessels of all samples, numerous infiltrating cells were positive for perforin, nitric oxide synthase (m-nos), cyclooxygenase-2 (cox-2), or matrix metalloproteinase-1 (mmp-1). |
1998-03-16 |
2023-08-12 |
Not clear |
| C S Williams, R N DuBoi. Prostaglandin endoperoxide synthase: why two isoforms? The American journal of physiology. vol 270. issue 3 Pt 1. 1996-07-05. PMID:8638704. |
overexpression of cox-2 in intestinal epithelial cells results in increased adhesion to extracellular matrix proteins and inhibition of apoptosis. |
1996-07-05 |
2023-08-12 |
mouse |
| M Tsujii, R N DuBoi. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell. vol 83. issue 3. 1996-01-24. PMID:8521479. |
the rie-s cells expressed elevated cox-2 protein levels and demonstrated increased adhesion to extracellular matrix (ecm) proteins. |
1996-01-24 |
2023-08-12 |
rat |