| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marcelo Marcet-Palacios, Kathryn Graham, Carol Cass, A Dean Befus, Irvin Mayers, Marek W Radomsk. Nitric oxide and cyclic GMP increase the expression of matrix metalloproteinase-9 in vascular smooth muscle. The Journal of pharmacology and experimental therapeutics. vol 307. issue 1. 2003-10-23. PMID:12954809. |
interactions and possible cross talk between inducible nitricoxide synthase (inos), cyclooxygenase-2 (cox-2) and matrix metalloproteinase-9 (mmp-9), were studied in rat aortic vascular smooth muscle cells stimulated with bacterial lipopolysaccharide (lps), interferon-gamma (ifn-gamma), and phorbol 12-myristate13-acetate (pma). |
2003-10-23 |
2023-08-12 |
rat |
| R A Wagenaar-Miller, G Hanley, R Shattuck-Brandt, R N DuBois, R L Bell, L M Matrisian, D W Morga. Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction. British journal of cancer. vol 88. issue 9. 2003-07-31. PMID:12778076. |
matrix metalloproteinases (mmps) and cyclooxygenase-2 (cox-2) are expressed in both sporadic and familial adenomatous colonic polyps and tumours and have been independently shown to play causal roles in intestinal tumour formation in mouse models of colon cancer. |
2003-07-31 |
2023-08-12 |
mouse |
| Christoph Waldner, Gunhild Heise, Jutta Meyer-Kirchrath, Karsten Schrör, Bernd Grabensee, Peter Heerin. Selective cyclooxygenase-2 inhibition upregulates renal cortical alpha V integrin expression. Nephron. Experimental nephrology. vol 93. issue 2. 2003-04-04. PMID:12629275. |
as prostaglandins are known to influence cell adhesion processes, we investigated the effect of cox-2 inhibition on the expression of alpha(v) integrins, which are also enhanced in renal diseases and control the adherence between the endothelium and the extracellular matrix (ecm) in the glomerulus. |
2003-04-04 |
2023-08-12 |
Not clear |
| Min Yao, Stacia Kargman, Eugene C Lam, Colleen R Kelly, Yaxin Zheng, Pauline Luk, Elizabeth Kwong, Jilly F Evans, M Michael Wolf. Inhibition of cyclooxygenase-2 by rofecoxib attenuates the growth and metastatic potential of colorectal carcinoma in mice. Cancer research. vol 63. issue 3. 2003-03-07. PMID:12566300. |
biochemical analyses of the primary splenic tumor in rofecoxib-treated mice showed no alteration in cox-1 expression, but significant decreases in the expression of the tumor-promoting proteins cox-2, cyclin d1, cytosolic beta-catenin, matrix metalloproteinases-2 and -9, and vascular endothelial cell- derived growth factor. |
2003-03-07 |
2023-08-12 |
mouse |
| Mariam Dohadwala, Raj K Batra, Jie Luo, Ying Lin, Kostyantyn Krysan, Mehis Pold, Sherven Sharma, Steven M Dubinet. Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion. The Journal of biological chemistry. vol 277. issue 52. 2003-02-27. PMID:12393872. |
genetic inhibition of tumor cox-2 led to diminished matrix metalloproteinase (mmp)-2, cd44, and ep4 receptor expression and invasion. |
2003-02-27 |
2023-08-12 |
Not clear |
| Francis J Giles, Hagop M Kantarjian, B Nebiyou Bekele, Jorge E Cortes, Stephan Faderl, Deborah A Thomas, Taghi Manshouri, Anna Rogers, Michael J Keating, Moshe Talpaz, Susan O'Brien, Maher Albita. Bone marrow cyclooxygenase-2 levels are elevated in chronic-phase chronic myeloid leukaemia and are associated with reduced survival. British journal of haematology. vol 119. issue 1. 2002-12-13. PMID:12358901. |
cox-2 may also reduce apoptosis and reduce cellular attachment to the extracellular matrix (ecm). |
2002-12-13 |
2023-08-12 |
Not clear |
| Z Strakova, S Srisuparp, A T Fazleaba. IL-1beta during in vitro decidualization in primate. Journal of reproductive immunology. vol 55. issue 1-2. 2002-10-01. PMID:12062820. |
the expression of cox-2 and matrix metalloproteinase-3 (mmp-3) genes follows after 4-6 h. the steroid hormones, particularly progesterone, which are critical for igfbp-1 expression, modulate the activity of il-1beta by down-regulating mmp-3 activity. |
2002-10-01 |
2023-08-12 |
Not clear |
| P Long, F Liu, N P Piesco, R Kapur, S Agarwa. Signaling by mechanical strain involves transcriptional regulation of proinflammatory genes in human periodontal ligament cells in vitro. Bone. vol 30. issue 4. 2002-09-17. PMID:11934644. |
this is evidenced by the fact that tens at low magnitude: (i) inhibits recombinant human (rh)il-1beta-dependent induction of cyclooxygenase-2 (cox-2) mrna expression and production of prostaglandin estradiol (pge2); (ii) inhibits rhil-1beta-dependent induction matrix metalloproteinase-1 (mmp-1) and mmp-3 synthesis by suppressing their mrna expression; (iii) abrogates rhil-1beta-induced suppression of tissue inhibitor of metalloprotease-ii (timp-ii) expression; and (iv) reverses il-1beta-dependent suppression of osteocalcin and alkaline phosphatase synthesis. |
2002-09-17 |
2023-08-12 |
human |
| Sze-Kwan Lin, Sang-Hong Kok, Mark Yen-Ping Kuo, Tzu-Jou Wang, Jeng-Tzung Wang, Flora Tzu-Chin Yeh, Michael Hsiao, Wan-Hong Lan, Chi-Yuan Hon. Sequential expressions of MMP-1, TIMP-1, IL-6, and COX-2 genes in induced periapical lesions in rats. European journal of oral sciences. vol 110. issue 3. 2002-09-06. PMID:12120711. |
after lesion induction, the mrnas encoding for matrix metalloproteinase-1 (mmp-1), tissue inhibitor of metalloproteinase-1 (timp-1), interleukin-6 (il-6), and cyclooxygenase-2 (cox-2) in the developing lesions were detected by in situ hybridization at day 5, 10, 15 and 20, respectively. |
2002-09-06 |
2023-08-12 |
rat |
| P Ottino, H E Baza. Corneal stimulation of MMP-1, -9 and uPA by platelet-activating factor is mediated by cyclooxygenase-2 metabolites. Current eye research. vol 23. issue 2. 2002-03-11. PMID:11840344. |
this study was undertaken to evaluate the significance of cyclooxygenase-2 (cox-2) activity on urokinase plasminogen activator (upa) and matrix metalloproteinases (mmps)-1 and -9 induction in cornea following platelet-activating factor (paf) treatment. |
2002-03-11 |
2023-08-12 |
Not clear |
| Joanne Archambault, Mari Tsuzaki, Walter Herzog, Albert J Bane. Stretch and interleukin-1beta induce matrix metalloproteinases in rabbit tendon cells in vitro. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 20. issue 1. 2002-03-07. PMID:11853088. |
the purpose of this study was to evaluate the production of cyclooxygenase ii (cox-2) and matrix metalloproteinases (mmps) by tendon cells exposed to cyclic strain and inflammatory cytokines in vitro. |
2002-03-07 |
2023-08-12 |
rabbit |
| T Sakai, F Kambe, H Mitsuyama, N Ishiguro, K Kurokouchi, M Takigawa, H Iwata, H Se. Tumor necrosis factor alpha induces expression of genes for matrix degradation in human chondrocyte-like HCS-2/8 cells through activation of NF-kappaB: abrogation of the tumor necrosis factor alpha effect by proteasome inhibitors. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 16. issue 7. 2002-01-18. PMID:11450703. |
treatment of the cells with tnf-alpha markedly increased the levels of matrix metalloproteinase 1 (mmp-1), mmp-3, intercellular adhesion molecule 1 (icam-1), and cyclo-oxygenase 2 (cox-2) messenger rnas (mrnas). |
2002-01-18 |
2023-08-12 |
human |
| T Sakai, F Kambe, H Mitsuyama, N Ishiguro, K Kurokouchi, M Takigawa, H Iwata, H Se. Tumor necrosis factor alpha induces expression of genes for matrix degradation in human chondrocyte-like HCS-2/8 cells through activation of NF-kappaB: abrogation of the tumor necrosis factor alpha effect by proteasome inhibitors. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 16. issue 7. 2002-01-18. PMID:11450703. |
thus, it is shown that the activation of p65/p50 nf-kappab by tnf-alpha plays a cardinal role in inducing the expression of mmp-1, mmp-3, icam-1, and cox-2 genes, which are involved in matrix degradation and inflammatory reaction in chondrocytes, leading to chondrocytic chondrolysis. |
2002-01-18 |
2023-08-12 |
human |
| M R Pan, L Y Chuang, W C Hun. Non-steroidal anti-inflammatory drugs inhibit matrix metalloproteinase-2 expression via repression of transcription in lung cancer cells. FEBS letters. vol 508. issue 3. 2001-12-26. PMID:11728453. |
recent studies show that up-regulation of cyclooxygenase-2 (cox-2) in human cancer cells induces activation of matrix metalloproteinases (mmps) and increase of metastatic potential. |
2001-12-26 |
2023-08-12 |
human |
| S J Warden, J M Favaloro, K L Bennell, J M McMeeken, K W Ng, J D Zajac, J D War. Low-intensity pulsed ultrasound stimulates a bone-forming response in UMR-106 cells. Biochemical and biophysical research communications. vol 286. issue 3. 2001-09-27. PMID:11511078. |
using a novel us-cell coupling method, us was found to stimulate expression of the immediate-early response genes c-fos and cox-2 and elevate mrna levels for the bone matrix proteins alp and oc. |
2001-09-27 |
2023-08-12 |
human |
| R W Kelly, A E King, H O Critchle. Cytokine control in human endometrium. Reproduction (Cambridge, England). vol 121. issue 1. 2001-09-13. PMID:11226025. |
the nfkappab pathway is important in the control of cytokine synthesis and can modulate production of chemokines, matrix metalloproteinases and the inducible prostaglandin synthesis enzyme cox-2. |
2001-09-13 |
2023-08-12 |
mouse |
| V L Sylvia, F Del Toro, D D Dean, R R Hardin, Z Schwartz, B D Boya. Effects of 1alpha,25-(OH)(2)D(3) on rat growth zone chondrocytes are mediated via cyclooxygenase-1 and phospholipase A(2). Journal of cellular biochemistry. Supplement. vol Suppl 36. 2001-09-13. PMID:11455568. |
the results showed that cox-1 inhibition reduced the 1alpha,25-(oh)(2)d(3)-dependent effects on proliferation, differentiation, and matrix production, whereas inhibition of cox-2 only had an effect on proliferation. |
2001-09-13 |
2023-08-12 |
rat |
| W Dempke, C Rie, A Grothey, H J Schmol. Cyclooxygenase-2: a novel target for cancer chemotherapy? Journal of cancer research and clinical oncology. vol 127. issue 7. 2001-08-09. PMID:11469677. |
in terms of angiogenesis and invasiveness, cox-2 activity was found to increase the expression of growth factors (e.g., vdeg, pdgf, bfgf) and matrix metalloproteinases (mmps). |
2001-08-09 |
2023-08-12 |
human |
| H Parfenova, V N Parfenov, B V Shlopov, V Levine, S Falkos, M Pourcyrous, C W Leffle. Dynamics of nuclear localization sites for COX-2 in vascular endothelial cells. American journal of physiology. Cell physiology. vol 281. issue 1. 2001-07-12. PMID:11401839. |
in quiescent cells, cox-1 was detected in the perinuclear zone and the cytoplasm, while cox-2 was mainly a nuclear resident possibly connected with the nuclear matrix. |
2001-07-12 |
2023-08-12 |
human |
| Y G Song, H M Kwon, J M Kim, B K Hong, D S Kim, A J Huh, K H Chang, H Y Kim, T S Kang, B K Lee, D H Choi, Y S Jang, H S Ki. Serologic and histopathologic study of Chlamydia pneumoniae infection in atherosclerosis: a possible pathogenetic mechanism of atherosclerosis induced by Chlamydia pneumoniae. Yonsei medical journal. vol 41. issue 3. 2000-09-14. PMID:10957885. |
we hypothesized that a vascular infection with c. pneumoniae may induce a chronic inflammatory reaction in the host vascular tissue and activated inflammatory cells may express inflammatory mediators such as cyclooxygenase-2 (cox-2) and matrix metalloproteinases (mmps). |
2000-09-14 |
2023-08-12 |
Not clear |