| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Oliver Jay Broom, Ramin Massoumi, Anita Sjölande. Alpha2beta1 integrin signalling enhances cyclooxygenase-2 expression in intestinal epithelial cells. Journal of cellular physiology. vol 209. issue 3. 2007-02-07. PMID:16972245. |
since inflammation-induced changes to the extracellular matrix could affect integrin activities, we here investigated the effect of integrin signalling on the level of cox-2 expression in the non-transformed intestinal epithelial cell lines, int 407 and iec-6. |
2007-02-07 |
2023-08-12 |
Not clear |
| Hemant Kumar Jain, V K Mourya, R K Agrawa. Inhibitory mode of 2-acetoxyphenyl alkyl sulfides against COX-1 and COX-2: QSAR analyses. Bioorganic & medicinal chemistry letters. vol 16. issue 20. 2006-12-04. PMID:16908140. |
fourth highest eigenvalue of burden matrix corresponding to atomic mass would be favorable for cox-2 inhibition and sixth lowest eigenvalue of burden matrix corresponding to sanderson electronegativities is conducive for cox-1 inhibition. |
2006-12-04 |
2023-08-12 |
Not clear |
| Teri L Larkins, Marchele Nowell, Shailesh Singh, Gary L Sanfor. Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression. BMC cancer. vol 6. 2006-11-01. PMID:16831226. |
here, we correlate the inhibition of cox-2 activity with decreased breast cancer cell proliferation, migration, invasion and matrix metalloproteinase (mmp) expression. |
2006-11-01 |
2023-08-12 |
Not clear |
| C Lianxu, J Hongti, Y Changlon. NF-kappaBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1beta-induced and TNF-alpha-induced chondrocytes. Osteoarthritis and cartilage. vol 14. issue 4. 2006-09-29. PMID:16376111. |
this study was to use nf-kappabp65-specific sirna to inhibit the expression of genes of cyclooxygenase-2 (cox-2), nitric oxide synthase-2 (nos-2) and matrix metalloproteinase-9 (mmp-9), which is paralleled with the initiation and progression of cartilage lesions in osteoarthritis (oa) model, in induced chondrocytes, and therefore to explore a new gene therapy for oa. |
2006-09-29 |
2023-08-12 |
rat |
| Arthur J Chu, Ta-Hsu Chou, Ben D Che. Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications. Frontiers in bioscience : a journal and virtual library. vol 9. 2006-09-28. PMID:15353307. |
pge2 induced by cox-2 exerts several biological properties that may be advantageous for tumorigenesis: 1) promoting angiogenesis (increased vegf, bfgf, and pdgf production), 2) anti-apoptosis mechanism (via increased bcl-2 and akt activity), 3) stimulating tumor metastasis (by increasing matrix metalloproteinases) and 4) decreased immune surveillance (decreased cytokine production and nk activity). |
2006-09-28 |
2023-08-12 |
human |
| Shalini Jain, Goutam Chakraborty, Gopal C Kund. The crucial role of cyclooxygenase-2 in osteopontin-induced protein kinase C alpha/c-Src/IkappaB kinase alpha/beta-dependent prostate tumor progression and angiogenesis. Cancer research. vol 66. issue 13. 2006-09-07. PMID:16818637. |
we have shown that osteopontin stimulates the activation of protein kinase c alpha/nuclear factor-inducing kinase/nuclear factor-kappab-dependent signaling cascades that induces cox-2 expression, which in turn regulates the prostaglandin e(2) production, matrix metalloproteinase-2 activation, and tumor progression and angiogenesis. |
2006-09-07 |
2023-08-12 |
mouse |
| Jae Ho Byun, Myung Ah Lee, Sang Young Roh, Byoung Yong Shim, Sook Hee Hong, Yoon Ho Ko, Su Jin Ko, In Sook Woo, Jin Hyoung Kang, Young Seon Hong, Kyung Shik Lee, Ah Won Lee, Gyeong Sin Park, Kyo Yeong Le. Association between cyclooxygenase-2 and matrix metalloproteinase-2 expression in non-small cell lung cancer. Japanese journal of clinical oncology. vol 36. issue 5. 2006-08-22. PMID:16735371. |
cyclooxygenase-2 (cox-2) contributes to invasiveness of cancer through activation of several matrix metalloproteinases (mmps). |
2006-08-22 |
2023-08-12 |
Not clear |
| Santosh K Sandur, Haruyo Ichikawa, Gautam Sethi, Kwang Seok Ahn, Bharat B Aggarwa. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents. The Journal of biological chemistry. vol 281. issue 25. 2006-08-11. PMID:16624823. |
plumbagin down-regulated the expression of nf-kappab-regulated anti-apoptotic (iap1, iap2, bcl-2, bcl-xl, cflip, bfl-1/a1, and survivin), proliferative (cyclin d1 and cox-2), and angiogenic (matrix metalloproteinase-9 and vascular endothelial growth factor) gene products. |
2006-08-11 |
2023-08-12 |
Not clear |
| Bharat B Aggarwal, Haruyo Ichikawa, Prachi Garodia, Priya Weerasinghe, Gautam Sethi, Indra D Bhatt, Manoj K Pandey, Shishir Shishodia, Muraleedharan G Nai. From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer. Expert opinion on therapeutic targets. vol 10. issue 1. 2006-07-18. PMID:16441231. |
drugs used to treat most cancers are those that can block cell signalling, including growth factor signalling (e.g., epidermal growth factor); prostaglandin production (e.g., cox-2); inflammation (e.g., inflammatory cytokines: nf-kappab, tnf, il-1, il-6, chemokines); drug resistance gene products (e.g., multi-drug resistance); cell cycle proteins (e.g., cyclin d1 and cyclin e); angiogenesis (e.g., vascular endothelial growth factor); invasion (e.g., matrix metalloproteinases); antiapoptosis (e.g., bcl-2, bcl-x(l), xiap, survivin, flip); and cellular proliferation (e.g., c-myc, ap-1, growth factors). |
2006-07-18 |
2023-08-12 |
Not clear |
| Bao Hoang, Li Zhu, Yijiang Shi, Patrick Frost, Huajun Yan, Sanjai Sharma, Sherven Sharma, Lee Goodglick, Steven Dubinett, Alan Lichtenstei. Oncogenic RAS mutations in myeloma cells selectively induce cox-2 expression, which participates in enhanced adhesion to fibronectin and chemoresistance. Blood. vol 107. issue 11. 2006-06-29. PMID:16497971. |
these results indicate a selective induction of cox-2 in mm cells containing ras mutations, which results in heightened binding to extracellular matrix protein and chemotherapeutic drug resistance. |
2006-06-29 |
2023-08-12 |
Not clear |
| Almudena Gómez-Hernández, Eva Sánchez-Galán, José Luis Martín-Ventura, Cristina Vidal, Luis Miguel Blanco-Colio, Mónica Ortego, Melina Vega, Javier Serrano, Luis Ortega, Gonzalo Hernández, José Tunón, Jesús Egid. Atorvastatin reduces the expression of prostaglandin E2 receptors in human carotid atherosclerotic plaques and monocytic cells: potential implications for plaque stabilization. Journal of cardiovascular pharmacology. vol 47. issue 1. 2006-05-22. PMID:16424787. |
prostaglandin e2 (pge2), the product of cyclooxygenase-2 (cox-2) and prostaglandin e synthase-1 (mpges-1), acts through its receptors (eps) and induces matrix metalloproteinase (mmp) expression, which may favor the instability of atherosclerotic plaques. |
2006-05-22 |
2023-08-12 |
human |
| Haizhen Zhong, J Phillip Bowe. Antiangiogenesis drug design: multiple pathways targeting tumor vasculature. Current medicinal chemistry. vol 13. issue 8. 2006-05-12. PMID:16611071. |
vegfr tyrosine kinase, methionine aminopeptidase-2 (metap-2), p53, tubulin, cyclooxygenase-2 (cox-2), and matrix metalloproteinases (mmps) all directly and/or indirectly influence the angiogenic switch. |
2006-05-12 |
2023-08-12 |
Not clear |
| Xiao-Min Wang, Tian-Xia Wu, Yun-Sil Lee, Raymond A Dionn. Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clinical pharmacology and therapeutics. vol 79. issue 4. 2006-05-02. PMID:16580899. |
because matrix metalloproteinases (mmps) play an essential role in inflammatory tissue injury and their activity is regulated by cox-2-derived prostaglandin e2, we evaluated whether cox-2 inhibition is associated with mmp overexpression during acute inflammation. |
2006-05-02 |
2023-08-12 |
Not clear |
| Svetlana Pavlovic, Baoheng Du, Kazuko Sakamoto, K M Faisal Khan, Chandramohan Natarajan, Richard M Breyer, Andrew J Dannenberg, Domenick J Falcon. Targeting prostaglandin E2 receptors as an alternative strategy to block cyclooxygenase-2-dependent extracellular matrix-induced matrix metalloproteinase-9 expression by macrophages. The Journal of biological chemistry. vol 281. issue 6. 2006-04-11. PMID:16338931. |
we previously reported that macrophage engagement of vascular extracellular matrix (ecm) triggers proteinase expression through a mapkerk1/2-dependent increase in cox-2 expression and pge2 synthesis. |
2006-04-11 |
2023-08-12 |
mouse |
| Guoguang Yang, Hee-Jeong Im, James H-C Wan. Repetitive mechanical stretching modulates IL-1beta induced COX-2, MMP-1 expression, and PGE2 production in human patellar tendon fibroblasts. Gene. vol 363. 2006-03-28. PMID:16226404. |
the expression of cyclooxygenase-2 (cox-2), matrix metalloproteinase-1 (mmp-1), and the production of prostaglandin e2 (pge2) were measured. |
2006-03-28 |
2023-08-12 |
human |
| Jung-Hwan Kim, Ki Won Lee, Min-Won Lee, Hyong Joo Lee, Sung-Hoon Kim, Young-Joon Sur. Hirsutenone inhibits phorbol ester-induced upregulation of COX-2 and MMP-9 in cultured human mammary epithelial cells: NF-kappaB as a potential molecular target. FEBS letters. vol 580. issue 2. 2006-03-21. PMID:16380122. |
inappropriate upregulation of cyclooxygenase-2 (cox-2) and matrix metalloproteinases (mmps) has been implicated in the pathogenesis of various types of cancer. |
2006-03-21 |
2023-08-12 |
human |
| Ki Won Lee, Jung-Hwan Kim, Hyong Joo Lee, Young-Joon Sur. Curcumin inhibits phorbol ester-induced up-regulation of cyclooxygenase-2 and matrix metalloproteinase-9 by blocking ERK1/2 phosphorylation and NF-kappaB transcriptional activity in MCF10A human breast epithelial cells. Antioxidants & redox signaling. vol 7. issue 11-12. 2006-03-16. PMID:16356124. |
elevated levels of cyclooxygenase-2 (cox-2) and matrix metalloproteinases (mmps) are often observed in various types of cancerous and transformed cells, and hence recognized as potential molecular targets for the chemoprevention. |
2006-03-16 |
2023-08-12 |
human |
| Burkhard Hinz, Susanne Rösch, Robert Ramer, Ernst R Tamm, Kay Brun. Latanoprost induces matrix metalloproteinase-1 expression in human nonpigmented ciliary epithelial cells through a cyclooxygenase-2-dependent mechanism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 13. 2006-03-07. PMID:16076963. |
with the use of human npe cells (odm-2), the present study therefore investigated the effect of the antiglaucomatous drug latanoprost (pgf2alpha analog) on the expression of cox-2 and its association with the induction of matrix metalloproteinases (mmps). |
2006-03-07 |
2023-08-12 |
human |
| Tetsuo Ishizaki, Kenji Katsumata, Akihiko Tsuchida, Tatehiko Wada, Yasuharu Mori, Masayuki Hisada, Hideaki Kawakita, Tatsuya Aok. Etodolac, a selective cyclooxygenase-2 inhibitor, inhibits liver metastasis of colorectal cancer cells via the suppression of MMP-9 activity. International journal of molecular medicine. vol 17. issue 2. 2006-03-02. PMID:16391837. |
in addition, cox-2 mrna, matrix metalloproteinase (mmp)-9 mrna, and tissue inhibitor of mmp (timp)-1 mrna of cancer tissue were measured by means of real-time rt-pcr. |
2006-03-02 |
2023-08-12 |
mouse |
| S Soumian, R Gibbs, A Davies, C Albrech. mRNA expression of genes involved in lipid efflux and matrix degradation in occlusive and ectatic atherosclerotic disease. Journal of clinical pathology. vol 58. issue 12. 2006-02-28. PMID:16311343. |
matrix metalloproteinase 9 (mmp-9) and cyclooxygenase 2 (cox-2) are implicated in plaque instability. |
2006-02-28 |
2023-08-12 |
Not clear |