| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rashmi Choudhary, Howard Li, Robert A Winn, Amber L Sorenson, Mary C M Weiser-Evans, Raphael A Nemenof. Peroxisome proliferator-activated receptor-gamma inhibits transformed growth of non-small cell lung cancer cells through selective suppression of Snail. Neoplasia (New York, N.Y.). vol 12. issue 3. 2010-06-24. PMID:20234816. |
this was associated with the increased expression of e-cadherin and decreased expression of cox-2 and matrix metaloproteinases. |
2010-06-24 |
2023-08-12 |
Not clear |
| Eun-Jung Lee, Myung-Shin Jeon, Byung-Dong Kim, Jeong-Han Kim, Young-Guen Kwon, Hyangkyu Lee, Yun Sang Lee, Jeong-Hee Yang, Tae-Yoon Ki. Capsiate inhibits ultraviolet B-induced skin inflammation by inhibiting Src family kinases and epidermal growth factor receptor signaling. Free radical biology & medicine. vol 48. issue 9. 2010-06-16. PMID:20123015. |
capsiate inhibited uvb-induced cyclooxygenase-2 (cox-2) expression, extracellular signal-related kinase 1/2 phosphorylation, nuclear translocation of nf-kappab, and the expression of proinflammatory cytokines and potent angiogenic factors, including vascular endothelial cell growth factor and matrix metalloproteinase-2 (mmp-2) and mmp-9. |
2010-06-16 |
2023-08-12 |
human |
| George L Tipoe, Tung Ming Leung, Emily C Liong, Thomas Yue Huen Lau, Man Lung Fung, Amin A Nanj. Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice. Toxicology. vol 273. issue 1-3. 2010-06-11. PMID:20438794. |
the mrna expression levels of tnf-alpha, cox-2, inos, alpha-smooth muscle actin (alpha-sma), transforming growth factor (tgf-beta(1)), pro-collagen-i, matrix metalloproteinases (mmp-2, -9) and their inhibitors (timp-1, -2) were determined by rt-pcr. |
2010-06-11 |
2023-08-12 |
mouse |
| Esin Atik, Bulent Akansu, Sevgi Bakaris, Nedim Aba. Expression of cyclooxygenase-2 and its relation to histological grade, inducible nitric oxide synthase, matrix metalloproteinase-2, CD-34, Caspase-3, and CD8 in invasive ductal carcinoma of the breast. Saudi medical journal. vol 31. issue 2. 2010-06-02. PMID:20174726. |
to assess by immunohistochemistry the cyclooxygenase-2 (cox-2) expression in invasive ductal carcinoma and its possible correlation with the histological grade, inducible nitric oxide synthase (inos), matrix metalloproteinase-2 (mmp2), and other common immunohistochemical parameters (cd-34, caspase-3, and cd8). |
2010-06-02 |
2023-08-12 |
Not clear |
| C M Kershaw-Young, R J Scaramuzzi, M R McGowan, A A Pitsillides, C P D Wheeler-Jones, M Khali. The effect of estradiol on COX-2, EP2, and EP4 mRNA expression and the extracellular matrix in the cervix of the hypogonadotrophic, ovariectomized ewe. Theriogenology. vol 73. issue 5. 2010-05-18. PMID:20031195. |
the effect of estradiol on cox-2, ep2, and ep4 mrna expression and the extracellular matrix in the cervix of the hypogonadotrophic, ovariectomized ewe. |
2010-05-18 |
2023-08-12 |
Not clear |
| Neelam Sharma-Walia, Arun George Paul, Virginie Bottero, Sathish Sadagopan, Mohanan Valiya Veettil, Nagaraj Kerur, Bala Chandra. Kaposi's sarcoma associated herpes virus (KSHV) induced COX-2: a key factor in latency, inflammation, angiogenesis, cell survival and invasion. PLoS pathogens. vol 6. issue 2. 2010-04-27. PMID:20169190. |
infected hmvec-d and tive-ltc cells secreted a variety of ics, gfs, angiogenic factors and matrix metalloproteinases (mmps), which were significantly abrogated by cox-2 inhibition either by chemical inhibitors or by sirna. |
2010-04-27 |
2023-08-12 |
human |
| Anggakusuma, Yanti, Jae-Kwan Hwan. Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells. Journal of dermatological science. vol 57. issue 2. 2010-04-08. PMID:19914807. |
in photoaging uvb irradiation promotes degradation of the extracellular matrix (ecm) by matrix metalloproteinases (mmps) and, in inflammation, uvb irradiation promotes the expression of inducible cyclooxygenase (cox-2), leading to overproduction of inflammatory mediators. |
2010-04-08 |
2023-08-12 |
Not clear |
| Sangmin Kim, Sung Hoon Kim, Sung Mo Hur, Se-Kyung Lee, Wan Wook Kim, Jee Soo Kim, Jung-Han Kim, Jun-Ho Choe, Seok Jin Nam, Jeong Eon Lee, Jung-Hyun Yan. Silibinin prevents TPA-induced MMP-9 expression by down-regulation of COX-2 in human breast cancer cells. Journal of ethnopharmacology. vol 126. issue 2. 2010-03-23. PMID:19715751. |
the expression of matrix metalloproteinase-9 (mmp-9) and cyclooxygenase-2 (cox-2) are pivotal steps in breast cancer pathogenesis. |
2010-03-23 |
2023-08-12 |
human |
| Saba Aid, Afonso C Silva, Eduardo Candelario-Jalil, Sang-Ho Choi, Gary A Rosenberg, Francesca Bosett. Cyclooxygenase-1 and -2 differentially modulate lipopolysaccharide-induced blood-brain barrier disruption through matrix metalloproteinase activity. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 30. issue 2. 2010-03-02. PMID:19844242. |
in the hippocampus and cortex of lps-treated mice, matrix metalloproteinase (mmp)-3 activity was significantly decreased in cox-1(-/-) mice, whereas in cox-2(-/-) mice the activity of both mmp-9 and mmp-3, known to mediate bbb breakdown, was increased. |
2010-03-02 |
2023-08-12 |
mouse |
| Agnes D Berendsen, Theo H Smit, X Frank Walboomers, Vincent Everts, John A Jansen, Antonius L J J Broncker. Three-dimensional loading model for periodontal ligament regeneration in vitro. Tissue engineering. Part C, Methods. vol 15. issue 4. 2010-02-17. PMID:19216643. |
cell responses were recorded by measuring expression of three sets of genes: (i) cyclooxygenase 1 and 2 (cox-1, cox-2) producing prostaglandins (signaling molecules); (ii) runx2, a transcription factor for the osteogenic lineage; and (iii) the extracellular matrix proteins osteopontin, dentin matrix protein 1, and collagen type i (col1). |
2010-02-17 |
2023-08-12 |
human |
| Ana B Fernández-Martínez, Ana M Bajo, Ana Valdehita, M Isabel Arenas, Manuel Sánchez-Chapado, María J Carmena, Juan C Priet. Multifunctional role of VIP in prostate cancer progression in a xenograft model: suppression by curcumin and COX-2 inhibitor NS-398. Peptides. vol 30. issue 12. 2010-02-17. PMID:19772879. |
the regulatory role of vip on cyclooxygenase-2 (cox-2) and vascular endothelial growth factor (vegf) expression as well as on matrix metalloproteinase-2 and 9 (mmp-2 and 9) activities was examined. |
2010-02-17 |
2023-08-12 |
mouse |
| Elzbieta Kolaczkowska, Barbara Plytycz, Bernd Arnold, Helene Piccard, Ghislain Opdenakke. Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9. Immunology. vol 128. issue 1 Suppl. 2010-01-25. PMID:19175797. |
matrix metalloproteinase-9 (mmp-9)/gelatinase b plays an important role in neutrophil infiltration during inflammation and cyclooxygenases (cox-1 and cox-2) and their products are important regulators of inflammation. |
2010-01-25 |
2023-08-12 |
mouse |
| Kuei-Hsiang Hung, Hunt-Wen Hung, Hsiao-Bai Yang, Cheng-Chan Lu, Jiunn-Jong Wu, Bor-Shyang She. Host single nucleotide polymorphisms of MMP-9 -1562/TIMP-1 372 have gender differences in the risk of gastric intestinal metaplasia after Helicobacter pylori infection. Helicobacter. vol 14. issue 6. 2010-01-11. PMID:19889076. |
helicobacter pylori infection causes chronic gastric inflammation and intestinal metaplasia (im), related with deregulation of wnt pathway and over-expressions of cox-2, matrix metalloproteinase (mmp), and tissue inhibitors of matrix metalloproteinase (timp). |
2010-01-11 |
2023-08-12 |
Not clear |
| Yoshiyuki Kimura, Maho Sumiyosh. Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice. The Journal of nutrition. vol 139. issue 11. 2010-01-06. PMID:19776181. |
furthermore, they prevented increases in the expression of matrix metalloproteinase (mmp)-2, mmp-9, and mmp-13 as well as in levels of vascular endothelial growth factor (vegf) and cyclooxygenase-2 (cox-2) in the skin. |
2010-01-06 |
2023-08-12 |
mouse |
| Claudia Seifarth, Constanze Csaki, Mehdi Shakibae. Anabolic actions of IGF-I and TGF-beta1 on Interleukin-1beta-treated human articular chondrocytes: evaluation in two and three dimensional cultures. Histology and histopathology. vol 24. issue 10. 2009-11-03. PMID:19688693. |
these events correlated with down-regulation of cyclooxygenase-2 (cox-2) and matrix metallo-proteinase-13 (mmp-13). |
2009-11-03 |
2023-08-12 |
human |
| Yanchao Fu, Qingyu Zhang, Chunsheng Kang, Kairu Zhang, Jing Zhang, Peiyu Pu, Guangxiu Wang, Tao Wan. Inhibitory effects of adenovirus mediated COX-2, Akt1 and PIK3R1 shRNA on the growth of malignant tumor cells in vitro and in vivo. International journal of oncology. vol 35. issue 3. 2009-10-01. PMID:19639178. |
when cox-2, akt1 and pik3r1 were dramatically downregulated, proliferating cell nuclear antigen (pcna), cyclind1 and matrix metalloproteinases (mmp-2, mmp-9) were downregulated, while tissue-inhibitor of metalloproteinase-2 (timp-2) and p53 were upregulated. |
2009-10-01 |
2023-08-12 |
mouse |
| An-Cheng Huang, Shu-Chun Hsu, Chao-Lin Kuo, Ching-Lung Liao, Kuang-Chi Lai, Tsung-Ping Lin, Shin-Hwar Wu, Hsu-Feng Lu, Nou-Ying Tang, Jai-Sing Yang, Jing-Gung Chun. Involvement of matrix metalloproteinases in the inhibition of cell invasion and migration through the inhibition of NF-[kappa]B by the new synthesized ethyl 2-[N-p-chlorobenzyl-(2'-methyl)]anilino-4-oxo-4,5-dihydrofuran-3-carboxylate (JOTO1007) in human cervical cancer Ca ski cells. In vivo (Athens, Greece). vol 23. issue 4. 2009-09-24. PMID:19567397. |
the results indicated that joto1007 inhibited the levels of son of sevenless homolog 1 (sos-1), growth factor receptor-bound protein 2 (grb2), ras homolog gene family, member a (rhoa), rho-associated, coiled-coil containing protein kinase 1 (rock-1), focal adhesion kinase (fak), phosphorylated-c-jun (p-c-jun), nuclear factor kappa b (nf-kappab) p65, cyclooxygenase-2 (cox-2), extracellular signal-regulated kinases 1/2 (erk1/2), matrix metalloproteinase-2 (mmp-2), mmp-7 and mmp-9 but promoted the levels of protein kinase c (pkc), phosphoinositide 3-kinases (pi3k), map kinase kinase kinase 3 (mekk3), mitogen-activated protein kinase kinase 7 (mkk7), c-jun and inducible nitric oxide synthases (inos), while not affecting ras, phosphorylated-erk (p-erk), p38 and c-jun n-terminal kinase 1/2 (jnk1/2), which finally led to the inhibition of migration and invasion of the ca ski cells in vitro. |
2009-09-24 |
2023-08-12 |
human |
| Laura Spencer, Christopher Mann, Matthew Metcalfe, M'Balu Webb, Cristina Pollard, Daniel Spencer, David Berry, William Steward, Ashley Denniso. The effect of omega-3 FAs on tumour angiogenesis and their therapeutic potential. European journal of cancer (Oxford, England : 1990). vol 45. issue 12. 2009-09-11. PMID:19493674. |
the conclusions drawn from this review suggest that omega-3 fas in particular eicosapentaenoic acid (epa) and docosahexaenoic acid (dha) found principally in oily fish have potent anti-angiogenic effects inhibiting production of many important angiogenic mediators namely; vascular endothelial growth factor (vegf), platelet-derived growth factor (pdgf), platelet-derived endothelial cell growth factor (pdecgf), cyclo-oxygenase 2 (cox-2), prostaglandin-e2 (pge2), nitric oxide, nuclear factor kappa beta (nfkb), matrix metalloproteinases and beta-catenin. |
2009-09-11 |
2023-08-12 |
human |
| Tetsunari Takai, Shigeru Kanaoka, Ken-ichi Yoshida, Yasushi Hamaya, Mutsuhiro Ikuma, Naoyuki Miura, Haruhiko Sugimura, Masayoshi Kajimura, Akira Hishid. Fecal cyclooxygenase 2 plus matrix metalloproteinase 7 mRNA assays as a marker for colorectal cancer screening. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 18. issue 6. 2009-09-08. PMID:19505922. |
to further improve the sensitivity, we evaluated the usefulness of the combination of cox-2 mrna and matrix metalloproteinase 7 (mmp-7) mrna assays as a marker of crc. |
2009-09-08 |
2023-08-12 |
human |
| V Sivaramakrishnan, S Niranjali Devara. Morin regulates the expression of NF-kappaB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. Chemico-biological interactions. vol 180. issue 3. 2009-07-16. PMID:19539802. |
morin regulates the expression of nf-kappab-p65, cox-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. |
2009-07-16 |
2023-08-12 |
rat |