| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wings T Y Loo, Min Wang, L J Jin, Mary N B Cheung, G R L. Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis. Archives of oral biology. vol 56. issue 10. 2012-02-24. PMID:21481333. |
the objective of this study was to investigate the association amongst the single nucleotide polymorphisms of genes encoding for matrix metalloproteinase (mmp) 1, 3, 9 and cyclooxygenase-2 (cox-2) of subjects. |
2012-02-24 |
2023-08-12 |
human |
| Kyue Yim Lee, Youn-Jae Kim, Heon Yoo, Seung Hoon Lee, Jong Bae Park, Ho Jin Ki. Human brain endothelial cell-derived COX-2 facilitates extravasation of breast cancer cells across the blood-brain barrier. Anticancer research. vol 31. issue 12. 2012-02-22. PMID:22199296. |
moreover, expression of matrix metalloproteinase (mmp-2) mediating the transmigration was induced in hbecs by cox-2 after co-culture with breast cancer cells. |
2012-02-22 |
2023-08-12 |
human |
| Dewei Cui, Xiangbao Zhang, Yafeng F. [Expressions of COX-2 and MMP-2 in nasopharyngeal carcinoma and the their relationship with lymph node metastasis]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 22. issue 15. 2012-01-26. PMID:18950008. |
to study the expression of cyclooxygenase-2 (cox-2) and matrix metalloproteinase-2 (mmp-2) in nasopharyngeal carcinoma (npc) and their relationship with lymph node metastasis. |
2012-01-26 |
2023-08-12 |
Not clear |
| Chantale L Pinard, Dominique Gauvin, Maxim Moreau, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Eric Tronc. Measurements of canine aqueous humor inflammatory mediators and the effect of carprofen following anterior chamber paracentesis. Veterinary ophthalmology. vol 14. issue 5. 2012-01-25. PMID:21929606. |
phase i: to evaluate levels of prostaglandin e(2) (pge(2) ), nitrites and nitrates (no(x) ), tumor necrosis factor-alpha (tnf-α) and expression of inducible cyclo-oxygenase (cox-2), nitric oxide synthase (nos-2), and matrix metalloproteinases (mmp-3 and -9) in canine aqueous humor following repeated anterior chamber paracenteses (acp). |
2012-01-25 |
2023-08-12 |
Not clear |
| Chan Young Ock, Eun-Hee Kim, Hua Hong, Kyung Sook Hong, Young-Min Han, Ki-Seok Choi, Ki-Baik Hahm, Myung-Hee Chun. Prevention of colitis-associated colorectal cancer with 8-hydroxydeoxyguanosine. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 9. 2012-01-05. PMID:21733838. |
significantly decreased levels of malondialdehyde, monocyte chemotactic protein-1, matrix metalloproteinasess, cox-2, nox4, and β-catenin nuclear accumulation were responsible for cancer prevention effects of exogenous 8-ohdg. |
2012-01-05 |
2023-08-12 |
mouse |
| Georgia Papacleovoulou, Hilary O D Critchley, Stephen G Hillier, J Ian Maso. IL1α and IL4 signalling in human ovarian surface epithelial cells. The Journal of endocrinology. vol 211. issue 3. 2012-01-03. PMID:21903865. |
we also document that il4 up-regulates lysyl oxidase (lox) mrna transcripts, a key gene for extracellular matrix (ecm) deposition and inhibits il1α-induced expression of cyclooxygenase-2 (cox-2) mrna, a gene involved in breakdown of ecm, showing a further role in post-ovulatory wound healing. |
2012-01-03 |
2023-08-12 |
human |
| Flora Zagouri, Christos A Papadimitriou, Meletios-Athanassios Dimopoulos, Dimitrios Pectaside. Molecularly targeted therapies in unresectable-metastatic gastric cancer: a systematic review. Cancer treatment reviews. vol 37. issue 8. 2011-12-06. PMID:21676549. |
a number of biological agents modulating different signal transduction pathways are currently in clinical development, such as angiogenesis inhibitors and agents targeting epidermal growth factor receptor, cell cycle, matrix metalloproteinases, cyclooxygenase-2 (cox-2), mammalian target of rapamycin (mtor) or proteasome. |
2011-12-06 |
2023-08-12 |
Not clear |
| M Shakibaei, C Buhrmann, A Mobasher. Anti-inflammatory and anti-catabolic effects of TENDOACTIVE® on human tenocytes in vitro. Histology and histopathology. vol 26. issue 9. 2011-12-05. PMID:21751149. |
the effects of tendoactive® were studied in primary cultures of human tenocytes treated with il-1β for up to 72 h. expression of collagen type i, integrin β1, cyclo-oxygenase-2 (cox-2), caspase-3 and matrix metalloproteinase-1 (mmp-1) was monitored by western blotting. |
2011-12-05 |
2023-08-12 |
human |
| T Hamsa, Girija Kutta. Ipobscurine, an indole alkaloid from Ipomoea obscura, inhibits tumor cell invasion and experimental metastasis by inducing apoptosis. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 30. issue 2. 2011-11-22. PMID:21967460. |
in the present study, we demonstrate that ipobscurine, an indole alkaloid fraction isolated from ipomoea obscura, can reduce the formation of b16f-10 melanoma-induced metastatic nodules and inhibit the proliferation, migration, and invasion of b16f-10 melanoma cells in vitro, possibly by inhibiting pro-metastatic genes such as matrix metalloproteinases (mmps) and inflammatory mediators such as cyclooxygenase-2 (cox-2), inducible nitric oxide synthase (inos), and pro-inflammatory cytokines. |
2011-11-22 |
2023-08-12 |
Not clear |
| Si Hyun Bae, Seh Hoon Oh, Seung Kew Yoon, Joung Ah Park, Gi Dae Kim, Wonhee Hur, Jong Young Choi, Il Hoan Oh, Kun Ho Yoo. Proliferation of Hepatic Oval Cells via Cyclooxygenase-2 and Extracellular Matrix Protein Signaling during Liver Regeneration Following 2-AAF/Partial Hepatectomy in Rats. Gut and liver. vol 5. issue 3. 2011-11-10. PMID:21927668. |
we investigated the role of cyclooxygenase-2 (cox-2) in hocs and the relationship between cox-2 and extracellular matrix proteins in cellular proliferation. |
2011-11-10 |
2023-08-12 |
rat |
| Anil K Jain, Neera Tewari-Singh, Mallikarjuna Gu, Swetha Inturi, Carl W White, Rajesh Agarwa. Sulfur mustard analog, 2-chloroethyl ethyl sulfide-induced skin injury involves DNA damage and induction of inflammatory mediators, in part via oxidative stress, in SKH-1 hairless mouse skin. Toxicology letters. vol 205. issue 3. 2011-10-05. PMID:21722719. |
our results show a strong cees-induced phosphorylation of h2a.x and an increase in cyclooxygenase-2 (cox-2), inducible nos (inos), and matrix metalloproteinase-9 (mmp-9) levels, indicating the involvement of dna damage and inflammation in cees-induced skin injury in male and female mice. |
2011-10-05 |
2023-08-12 |
mouse |
| Elizabeth Tahanian, Luis Arguello Sanchez, Tze Chieh Shiao, René Roy, Borhane Annab. Flavonoids targeting of IκB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells. Drug design, development and therapy. vol 5. 2011-09-16. PMID:21625419. |
in this study, we sought to investigate the nuclear factor-kappa b (nf-κb) signaling pathway, a common pathway in both the regulation of matrix metalloproteinase-9 (mmp-9) and cox-2 expression, and the inhibitory properties of several chemopreventive flavonoids. |
2011-09-16 |
2023-08-12 |
human |
| Huifang Cheng, Xiaofeng Fan, Gilbert W Moeckel, Raymond C Harri. Podocyte COX-2 exacerbates diabetic nephropathy by increasing podocyte (pro)renin receptor expression. Journal of the American Society of Nephrology : JASN. vol 22. issue 7. 2011-09-12. PMID:21737546. |
in vivo, podocyte pro(renin) receptor expression increased in diabetic cox-2-transgenic mice, and treatment with a cox-2 inhibitor abrogated the upregulation of (pro)renin receptor and reduced albuminuria, foot-process effacement, and mesangial matrix expansion. |
2011-09-12 |
2023-08-12 |
mouse |
| Ravinder Tammali, Ashish Saxena, Satish K Srivastava, Kota V Raman. Aldose reductase inhibition prevents hypoxia-induced increase in hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) by regulating 26 S proteasome-mediated protein degradation in human colon cancer cells. The Journal of biological chemistry. vol 286. issue 27. 2011-09-08. PMID:21576240. |
in addition, ar inhibition also prevented the hypoxia-induced inflammatory molecules such as cox-2 and pge2 and expression of extracellular matrix proteins such as mmp2, vimentin, upar, and lysyl oxidase 2. |
2011-09-08 |
2023-08-12 |
mouse |
| Tian Wang, Na Jiang, Bing Han, Wenbo Liu, Tongshen Liu, Fenghua Fu, Delu Zha. Escin attenuates cerebral edema induced by acute omethoate poisoning. Toxicology mechanisms and methods. vol 21. issue 5. 2011-09-06. PMID:21417632. |
treatment with escin decreased the levels of tumor necrosis factor-alpha (tnf-α), matrix metalloproteinase-9 (mmp-9), cyclooxygenase-2 (cox-2), and prostaglandin e₂ (pge₂) in the brain. |
2011-09-06 |
2023-08-12 |
rat |
| Kung-Wen Lu, Jung-Chou Chen, Tung-Yuan Lai, Jai-Sing Yang, Shu-Wen Weng, Yi-Shih Ma, Pei-Jung Lu, Jing-Ru Weng, Fu-Shin Chueh, W Gibson Wood, Jing-Gung Chun. Gypenosides inhibits migration and invasion of human oral cancer SAS cells through the inhibition of matrix metalloproteinase-2 -9 and urokinase-plasminogen by ERK1/2 and NF-kappa B signaling pathways. Human & experimental toxicology. vol 30. issue 5. 2011-08-29. PMID:20511288. |
gyp decreased the abundance of several proteins, including nuclear factor-kappa b (nf-κb), cyclooxygenase-2 (cox-2), extracellular signal-regulated kinase 1/2 (erk1/ 2), matrix metalloproteinase-9, -2 (mmp-9, -2), sevenless homolog (sos), ras, urokinase-type plasminogen activator (upa), focal adhesion kinase (fak) and rac-alpha serine/threonine-protein kinase (akt), in a time-dependent manner. |
2011-08-29 |
2023-08-12 |
human |
| Yan-Feng Xiao, Xi Chen, Shan-Xi Liu, De-Dong Wu, Li-Fen Re. [Effect of As(2)O(3) on expressions of COX-2 and matrix metalloproteinases in SGC7901 and K562 cells]. Zhongguo shi yan xue ye xue za zhi. vol 17. issue 1. 2011-08-23. PMID:19236750. |
[effect of as(2)o(3) on expressions of cox-2 and matrix metalloproteinases in sgc7901 and k562 cells]. |
2011-08-23 |
2023-08-12 |
Not clear |
| Yingxia Liu, Wenya Zhang, Xiaoning Zhang, Yongmei Qi, Dejun Huang, Yingmei Zhan. Arsenic trioxide inhibits invasion/migration in SGC-7901 cells by activating the reactive oxygen species-dependent cyclooxygenase-2/matrix metalloproteinase-2 pathway. Experimental biology and medicine (Maywood, N.J.). vol 236. issue 5. 2011-07-12. PMID:21540248. |
to identify the role of as(2)o(3) in regulating invasion/migration activity in human gastric cancer sgc-7901 cells, the effects of as(2)o(3) on cell invasion/migration activity, the expression of cyclooxygenase-2 (cox-2), prostaglandin e2 (pge2), thromboxane b2 (txb2), leukotriene b4 (ltb4), and matrix metalloproteinase-2 (mmp-2) and intracellular reactive oxygen species (ros) were examined. |
2011-07-12 |
2023-08-12 |
human |
| Eva Uzan, Bénédicte Portet, Christian Lubrano, Sandrine Milesi, Anne Favel, Laurence Lesage-Meessen, Anne Lomascol. Pycnoporus laccase-mediated bioconversion of rutin to oligomers suitable for biotechnology applications. Applied microbiology and biotechnology. vol 90. issue 1. 2011-06-20. PMID:21210103. |
they were evaluated for their antioxidant, anti-inflammatory and anti-ageing activities on specific enzymatic targets such as cyclooxygenase (cox-2) and human matrix metalloproteinase 3 (mmp-3). |
2011-06-20 |
2023-08-12 |
human |
| Wei Zhong Li, Qiu Ju Huo, Xiao Yan Wang, Fang X. Inhibitive effect of celecoxib on the adhesion and invasion of human tongue squamous carcinoma cells to extracellular matrix via down regulation of MMP-2 expression. Prostaglandins & other lipid mediators. vol 93. issue 3-4. 2011-06-14. PMID:20709621. |
the effect of cyclooxygenase 2 (cox-2) and its inhibitor on metastasis and invasion of tumor and its relationship with matrix metalloproteinase are getting more and more attention. |
2011-06-14 |
2023-08-12 |
human |