| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ratana Lim, Gillian Barker, Courtney A Wall, Martha Lappa. Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium. Molecular human reproduction. vol 19. issue 7. 2014-01-31. PMID:23475986. |
in placenta and foetal membranes, all treatments significantly reduced lps-stimulated release and gene expression of pro-inflammatory cytokines il-6 and il-8; placenta decreased cyclooxygenase (cox-2) mrna expression, subsequent release of prostaglandins pge2 and pgf2α and expression and activity of matrix-degrading enzyme matrix metalloproteinase (mmp)-9. |
2014-01-31 |
2023-08-12 |
human |
| Shu-Zhen Chen, Yong-Su Zhe. [Molecular targets of tea polyphenols and its roles of anticancer drugs in experimental therapy]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 48. issue 1. 2014-01-16. PMID:23600134. |
tps inhibit growth factor receptor-mediated signal transduction pathway, decrease the activities of mitogen activated protein kinases and activator protein transcription factor-1, block nuclear factor-kappab signaling pathway, reduce proteasome activity, lower overexpression of cox-2, subside dihydrofolate reductase and telomerase, and inhibit dna methylation and matrix metalloproteinases. |
2014-01-16 |
2023-08-12 |
mouse |
| Xinxin Tie, Sheng Han, Lingxuan Meng, Yunjie Wang, Anhua W. NFAT1 is highly expressed in, and regulates the invasion of, glioblastoma multiforme cells. PloS one. vol 8. issue 6. 2014-01-14. PMID:23762456. |
clustering analysis and pearson correlation analysis of microarray data showed that the expression of nfat1 correlated with the expression of the invasion-related genes cyclooxygenase-2 (cox-2), matrix metalloproteinase-7 (mmp-7) and mmp-9, a result confirmed by in vitro analysis. |
2014-01-14 |
2023-08-12 |
human |
| Barbara Bellei, Angela Pitisci, Monica Ottaviani, Matteo Ludovici, Carlo Cota, Fabiola Luzi, Maria Lucia Dell'Anna, Mauro Picard. Vitiligo: a possible model of degenerative diseases. PloS one. vol 8. issue 3. 2014-01-07. PMID:23555779. |
moreover, vitiligo melanocytes produced many biologically active proteins among the senescence-associated secretory phenotype (saps), such as interleukin-6 (il-6), matrix metallo proteinase-3 (mmp3), cyclooxygenase-2 (cox-2), insulin-like growth factor-binding protein-3 and 7 (igfbp3, igfbp7). |
2014-01-07 |
2023-08-12 |
Not clear |
| Lucas D Sanches, Sergio A A Santos, Jaqueline R Carvalho, Gabriela D M Jeronimo, Wagner J Favaro, Maria D G Reis, Sérgio L Felisbino, Luis A Justuli. Protective effect of γ-tocopherol-enriched diet on N-methyl-N-nitrosourea-induced epithelial dysplasia in rat ventral prostate. International journal of experimental pathology. vol 94. issue 6. 2014-01-07. PMID:24205794. |
after 4 months, the vps were excised to evaluate morphology, cell proliferation and apoptosis, as well as cyclooxygenase-2 (cox-2), glutathione-s-transferase-pi (gst-pi) and androgen receptor (ar) protein expression, and matrix metalloproteinase-9 (mmp-9) activity. |
2014-01-07 |
2023-08-12 |
rat |
| Ching-Shu Lai, Shiming Li, Cheng Bin Liu, Yutaka Miyauchi, Michiko Suzawa, Chi-Tang Ho, Min-Hsiung Pa. Effective suppression of azoxymethane-induced aberrant crypt foci formation in mice with citrus peel flavonoids. Molecular nutrition & food research. vol 57. issue 3. 2013-12-23. PMID:23307625. |
the in vivo data have revealed for the first time that the citrus peel extract-gl-is an effective antitumor agent mechanistically downregulating the protein levels of inos, cox-2, ornithine decarboxylase, vascular endothelial growth factor, and matrix metallopeptidase 9 in colonic tissues of mice, suggesting that gl is a novel functional natural product capable of preventing inflammation-associated colon tumorigenesis. |
2013-12-23 |
2023-08-12 |
mouse |
| Qian-Hai Ding, Ye Cheng, Wei-Ping Chen, Hui-Ming Zhong, Xiang-Hua Wan. Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes. European journal of pharmacology. vol 708. issue 1-3. 2013-12-17. PMID:23396231. |
overexpression of matrix metalloproteinases (mmps), inducible nitric oxide synthase (inos) and cyclooxygenase-2 (cox-2) have long been suggested to play crucial roles in the progression of osteoarthritis. |
2013-12-17 |
2023-08-12 |
human |
| H Erdem, U Yildirim, A K Uzunlar, K Cam, A Tekin, M A Kayikci, C Sahiner, M Oktay, H Ankarali, L Y Aydi. Relationship among expression of basic-fibroblast growth factor, MTDH/astrocyte elevated gene-1, adenomatous polyposis coli, matrix metalloproteinase 9,and COX-2 markers with prognostic factors in prostate carcinomas. Nigerian journal of clinical practice. vol 16. issue 4. 2013-12-17. PMID:23974731. |
relationship among expression of basic-fibroblast growth factor, mtdh/astrocyte elevated gene-1, adenomatous polyposis coli, matrix metalloproteinase 9,and cox-2 markers with prognostic factors in prostate carcinomas. |
2013-12-17 |
2023-08-12 |
Not clear |
| H Erdem, U Yildirim, A K Uzunlar, K Cam, A Tekin, M A Kayikci, C Sahiner, M Oktay, H Ankarali, L Y Aydi. Relationship among expression of basic-fibroblast growth factor, MTDH/astrocyte elevated gene-1, adenomatous polyposis coli, matrix metalloproteinase 9,and COX-2 markers with prognostic factors in prostate carcinomas. Nigerian journal of clinical practice. vol 16. issue 4. 2013-12-17. PMID:23974731. |
basic fibroblast growth factor (bfgf), matrix metalloproteinase-9 (mmp-9), cyclooxygenases-2 (cox-2), and adenomatous polyposis coli (apc) are very important in tumor progression as well. |
2013-12-17 |
2023-08-12 |
Not clear |
| Ching-Shu Lai, Shiming Li, Yutaka Miyauchi, Michiko Suzawa, Chi-Tang Ho, Min-Hsiung Pa. Potent anti-cancer effects of citrus peel flavonoids in human prostate xenograft tumors. Food & function. vol 4. issue 6. 2013-12-16. PMID:23673480. |
these inhibitory effects were accompanied by mechanistic down-regulation of the protein levels of inflammatory enzymes (inducible nitric oxide synthase, inos and cyclooxygenase-2, cox-2), metastasis (matrix metallopeptidase-2, mmp-2 and mmp-9), angiogenesis (vascular endothelial growth factor, vegf), and proliferative molecules, as well as by the induction of apoptosis in prostate tumors. |
2013-12-16 |
2023-08-12 |
mouse |
| I-Ta Lee, Chuen-Mao Yan. Inflammatory signalings involved in airway and pulmonary diseases. Mediators of inflammation. vol 2013. 2013-12-03. PMID:23690670. |
moreover, many of the known inflammatory target proteins, such as matrix metalloproteinase-9 (mmp-9), intercellular adhesion molecule-1 (icam-1), vascular cell adhesion molecule-1 (vcam-1), cyclooxygenase-2 (cox-2), and cytosolic phospholipase a2 (cpla2), are associated with airway and lung inflammation in response to various stimuli. |
2013-12-03 |
2023-08-12 |
Not clear |
| Benoit Paquette, Hélène Therriault, J Richard Wagne. Role of interleukin-1β in radiation-enhancement of MDA-MB-231 breast cancer cell invasion. Radiation research. vol 180. issue 3. 2013-11-06. PMID:23927563. |
we propose that the effect of il1β on the invasiveness of the mda-mb-231 cells involves elevation of matrix metalloproteinase-9 (mmp-9) production, induction of cox-2 expression and pge2 biosynthesis. |
2013-11-06 |
2023-08-12 |
Not clear |
| Rahul A Sheth, Alexandra Kunin, Lars Stangenberg, Mark Sinnamon, Kenneth E Hung, Raju Kucherlapati, Umar Mahmoo. In vivo optical molecular imaging of matrix metalloproteinase activity following celecoxib therapy for colorectal cancer. Molecular imaging. vol 11. issue 5. 2013-09-30. PMID:22954186. |
we present an optical molecular imaging approach to measure the efficacy of the cyclooxygenase-2 (cox-2) inhibitor celecoxib on tumor growth rate through its effect on matrix metalloproteinase (mmp) activity. |
2013-09-30 |
2023-08-12 |
mouse |
| Luis Bujanda, Cristina Sarasqueta, Angel Cosme, Elizabeth Hijona, José M Enríquez-Navascués, Carlos Placer, Eloisa Villarreal, Marta Herreros-Villanueva, María D Giraldez, Meritxell Gironella, Francesc Balaguer, Antoni Castell. Evaluation of alpha 1-antitrypsin and the levels of mRNA expression of matrix metalloproteinase 7, urokinase type plasminogen activator receptor and COX-2 for the diagnosis of colorectal cancer. PloS one. vol 8. issue 1. 2013-08-20. PMID:23300952. |
evaluation of alpha 1-antitrypsin and the levels of mrna expression of matrix metalloproteinase 7, urokinase type plasminogen activator receptor and cox-2 for the diagnosis of colorectal cancer. |
2013-08-20 |
2023-08-12 |
Not clear |
| Jie Mei, Ming-Qing Li, Ding Ding, Da-Jin Li, Li-Ping Jin, Wei-Guo Hu, Xiao-Yong Zh. Indoleamine 2,3-dioxygenase-1 (IDO1) enhances survival and invasiveness of endometrial stromal cells via the activation of JNK signaling pathway. International journal of clinical and experimental pathology. vol 6. issue 3. 2013-08-15. PMID:23411497. |
ido1 mrna expression was evaluated by quantitative real-time reverse transcription-polymerase chain reaction (real-time pcr), and protein levels of ido1, survivin, protein 53 (p53), matrix metalloproteinase (mmp)-2, mmp-9, tissue-inhibitor of metalloproteinase-1 (timp-1) and cyclooxygenase-2 (cox-2) in ido1-overexpressing and ido1-deficiency escs were analyzed by in-cell western. |
2013-08-15 |
2023-08-12 |
Not clear |
| Sun Young Park, Ji-Hee Kim, Sang Joon Lee, YoungHee Ki. Involvement of PKA and HO-1 signaling in anti-inflammatory effects of surfactin in BV-2 microglial cells. Toxicology and applied pharmacology. vol 268. issue 1. 2013-07-05. PMID:23360889. |
surfactin significantly inhibited excessive production of the pro-inflammatory mediators tnf-α, il-1β, il-6, monocyte chemoattractant protein-1 (mcp-1), prostaglandin e2 (pge2), nitric oxide (no) and reactive oxygen species (ros), and suppressed the expression of matrix metalloproteinase-9 (mmp-9), inducible no synthase (inos) and cyclooxygenase-2 (cox-2). |
2013-07-05 |
2023-08-12 |
Not clear |
| Yu-Mi Shin, Hyun-Joo Jung, Woo-Yong Choi, Chang-Jin Li. Antioxidative, anti-inflammatory, and matrix metalloproteinase inhibitory activities of 20(S)-ginsenoside Rg3 in cultured mammalian cell lines. Molecular biology reports. vol 40. issue 1. 2013-06-14. PMID:23054007. |
in the same stimulated macrophages, 20(s)-rg3 was able to suppress matrix metalloproteinase-9 (mmp-9) activity and suppress cyclooxygenase-2 (cox-2) expression. |
2013-06-14 |
2023-08-12 |
Not clear |
| Boban M Erovic, Luke Harris, Mina Jamali, David P Goldstein, Jonathan C Irish, Sylvia L Asa, Ozgur Met. Biomarkers of parathyroid carcinoma. Endocrine pathology. vol 23. issue 4. 2013-05-23. PMID:23001705. |
we constructed a tissue microarray of parathyroid carcinomas from 10 patients as well as parathyroid adenomas from 25 patients and stained the slides for 34 proteins involved in angiogenesis (platelet-derived growth factor receptor (pdgfr)-α, pdgfr-β, vascular endothelial growth factor receptor-2 (vegfr-2), and epidermal growth factor receptor (egfr)), inflammation (cyclooxygenase (cox)-1 and cox-2), cell adhesion (matrix metalloproteinase (mmp)-1, cd9, and keratin 7), cell cycle (cdc2p34, cyclin d1, retinoblastoma (rb), p27, p21, parafibromin, bmi-1, 14-3-3σ, and p53), and apoptosis (bcl-2a, mcl-1, bcl-xl, and glutathione-s-transferase-isoenzyme π (gst-π)) along with some markers of the sonic hedgehog (smo, shh, gli-1, gli-2, gli-3, and patched), mtor (akt, mammalian target of rapamycin (mtor), and forkhead box o (foxo)-1), and wnt (wisp-1, wisp-2, and β-catenin) signal transduction pathways. |
2013-05-23 |
2023-08-12 |
Not clear |
| Jung-Hee Kim, Dong Ki Park, Choong Hwan Lee, Do-Young Yoo. A new isoflavone glycitein 7-O-beta-D-glucoside 4''-O-methylate, isolated from Cordyceps militaris grown on germinated soybeans extract, inhibits EGF-induced mucus hypersecretion in the human lung mucoepidermoid cells. Phytotherapy research : PTR. vol 26. issue 12. 2013-04-09. PMID:22407817. |
the decrease in cyclooxygenase-2 (cox-2) production was correlated with reduced levels of protein and mrna of inducible matrix metalloproteinase 9 (mmp-9) and also muc5ac gene expression. |
2013-04-09 |
2023-08-12 |
human |
| N Sharma-Walia, K Patel, K Chandran, A Marginean, V Bottero, N Kerur, A G Pau. COX-2/PGE2: molecular ambassadors of Kaposi's sarcoma-associated herpes virus oncoprotein-v-FLIP. Oncogenesis. vol 1. 2013-04-04. PMID:23552603. |
we demonstrate that cox-2 inhibition, via its chemical inhibitors (ns-398 or celecoxib), reduced v-flip/k13-mediated nf-κb induction, and extracellular matrix (ecm) interaction-mediated signaling, mitochondrial antioxidant enzyme manganese superoxide dismutase (mnsod) levels, and subsequently downregulated detachment-induced apoptosis (anoikis) resistance. |
2013-04-04 |
2023-08-12 |
Not clear |