| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haruta Mogami, Annavarapu Hari Kishore, Haolin Shi, Patrick W Keller, Yucel Akgul, R Ann Wor. Fetal fibronectin signaling induces matrix metalloproteases and cyclooxygenase-2 (COX-2) in amnion cells and preterm birth in mice. The Journal of biological chemistry. vol 288. issue 3. 2013-03-26. PMID:23184961. |
fetal fibronectin signaling induces matrix metalloproteases and cyclooxygenase-2 (cox-2) in amnion cells and preterm birth in mice. |
2013-03-26 |
2023-08-12 |
mouse |
| Khanh vinh quốc Luong, Lan Thi Hoàng Nguyễ. The beneficial role of vitamin D in systemic lupus erythematosus (SLE). Clinical rheumatology. vol 31. issue 10. 2013-03-25. PMID:22801788. |
vitamin d also exerts protective effects against sle through non-genomic factors, such as ultraviolet radiation (uv) exposure, matrix metalloproteinase (mmps), heme oxygenase-1 (ho-1), the prostaglandins (pgs), cyclooxygenase-2 (cox-2), and oxidative stress. |
2013-03-25 |
2023-08-12 |
Not clear |
| Sherif A Ibrahim, George W Yip, Christian Stock, Jun-Wei Pan, Claudia Neubauer, Michaela Poeter, Danute Pupjalis, Chuay Yeng Koo, Reinhard Kelsch, Roland Schüle, Ursula Rescher, Ludwig Kiesel, Martin Gött. Targeting of syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and invasiveness via a Rho-GTPase- and E-cadherin-dependent mechanism. International journal of cancer. vol 131. issue 6. 2013-03-11. PMID:22573479. |
affymetrix screening and confirmatory qpcr and western blotting analysis of syndecan-1-deficient cells revealed upregulation of atf-2, cox-2, cadherin-11, vinculin, actin γ 2, myl9, transgelin-1, rhoa/c, matrix metalloproteinase 2 (mmp2) and heparanase, and downregulation of aml1/runx1, e-cadherin, cldn1, p21waf/cip, cyclin-dependent kinase 6, tlr-4, pai1/2, collagen1alpha1, jhdm1d, mpp4, mmp9, matrilin-2 and anxa3/a10. |
2013-03-11 |
2023-08-12 |
Not clear |
| Sun Young Park, Young Hun Kim, YoungHee Kim, Sang-Joon Le. Aromatic-turmerone attenuates invasion and expression of MMP-9 and COX-2 through inhibition of NF-κB activation in TPA-induced breast cancer cells. Journal of cellular biochemistry. vol 113. issue 12. 2013-03-08. PMID:22740037. |
in the present study, we investigated the inhibitory effects of ar-turmerone on expression and enzymatic activity levels of 12-o-tetradecanoylphorbol-13-acetate (tpa)-induced matrix metalloproteinase (mmp)-9 and cyclooxygenaase-2 (cox-2) in breast cancer cells. |
2013-03-08 |
2023-08-12 |
human |
| Jie Mei, Li-Ping Jin, Ding Ding, Ming-Qing Li, Da-Jin Li, Xiao-Yong Zh. Inhibition of IDO1 suppresses cyclooxygenase-2 and matrix metalloproteinase-9 expression and decreases proliferation, adhesion and invasion of endometrial stromal cells. Molecular human reproduction. vol 18. issue 10. 2013-02-14. PMID:22638210. |
ido1, cyclooxygenase-2 (cox-2) and matrix metalloproteinases (mmps) in endometriotic ectopic stromal cells, endometriosis-derived eutopic stromal cells and normal escs (control) were detected by the in-cell western analysis. |
2013-02-14 |
2023-08-12 |
Not clear |
| Naoufal Akla, Jonathan Pratt, Borhane Annab. Concanavalin-A triggers inflammatory response through JAK/STAT3 signalling and modulates MT1-MMP regulation of COX-2 in mesenchymal stromal cells. Experimental cell research. vol 318. issue 19. 2013-02-11. PMID:22971618. |
given msc chemotaxis and cell survival are regulated, in part, by the membrane type-1 matrix metalloproteinase (mt1-mmp), an mmp also involved in transducing nf-κb intracellular signaling pathways, we tested whether stat3 regulation by mt1-mmp may also contribute to the expression balance of cox-2 in msc. |
2013-02-11 |
2023-08-12 |
human |
| Naghma Khan, Deeba N Syed, Harish Chandra Pal, Hasan Mukhtar, Farrukh Afa. Pomegranate fruit extract inhibits UVB-induced inflammation and proliferation by modulating NF-κB and MAPK signaling pathways in mouse skin. Photochemistry and photobiology. vol 88. issue 5. 2013-01-24. PMID:22181855. |
pfe consumption also inhibited uvb-induced protein expression of (1) cox-2 and inos, (2) pcna and cyclin d1 and (3) matrix metalloproteinases-2,-3 and -9 in mouse skin. |
2013-01-24 |
2023-08-12 |
mouse |
| Ji-Wei Bai, Zhe Wang, Song-Bai Gui, Ya-Zhuo Zhan. Loss of 15-hydroxyprostaglandin dehydrogenase indicates a tumor suppressor role in pituitary adenomas. Oncology reports. vol 28. issue 2. 2013-01-24. PMID:22580984. |
the inhibition of cell proliferation was accompanied by the decreased expression of cox-2, matrix metalloproteinase-9 (mmp-9) and b cell leukemia/lymphoma-2 (bcl-2). |
2013-01-24 |
2023-08-12 |
rat |
| Khanh vinh quôc Lu'o'ng, Lan Thi Hoàng Nguyê. Thiamine and Parkinson's disease. Journal of the neurological sciences. vol 316. issue 1-2. 2013-01-22. PMID:22385680. |
thiamine has also been implicated in pd through its effects on l-type voltage-sensitive calcium channels (l-vscc), matrix metalloproteinases (mmps), prostaglandins (pgs), cyclooxygenase-2 (cox-2), reactive oxygen species (ros), and nitric oxide synthase (nos). |
2013-01-22 |
2023-08-12 |
Not clear |
| Marcello Ferretti Fanelli, Ludmilla T Domingos Chinen, Maria Dirlei Begnami, Wilson Luis Costa, José Humberto T Fregnami, Fernando A Soares, André Luis Montagnin. The influence of transforming growth factor-α, cyclooxygenase-2, matrix metalloproteinase (MMP)-7, MMP-9 and CXCR4 proteins involved in epithelial-mesenchymal transition on overall survival of patients with gastric cancer. Histopathology. vol 61. issue 2. 2013-01-16. PMID:22582975. |
to assess the correlation between tumour progression and epithelial-mesenchymal transition (emt), we assayed the expression levels of selected molecules involved in emt [cd44, transforming growth factor (tgf)-α, cyclooxygenase-2 (cox-2), matrix metalloproteinase (mmp)-7, mmp-9 and c-x-c chemokine receptor (cxcr4)], and correlated these with overall patient survival (os) and disease stage. |
2013-01-16 |
2023-08-12 |
Not clear |
| D B Vendramini-Costa, J E Carvalh. Molecular link mechanisms between inflammation and cancer. Current pharmaceutical design. vol 18. issue 26. 2013-01-16. PMID:22632748. |
these cells produce a variety of cytotoxic mediators such as reactive oxygen and nitrogen species (ros and rns respectively), serine and cysteine proteases, membrane perforating agents, matrix metalloproteinase (mmp), tumor necrosis factor α (tnfα), interleukins (il-1, il-6, il-8), interferons (ifns) and enzymes, as cyclooxygenase-2 (cox-2), lipooxygenase-5 (lox-5) and phospholipase a2 (pla2), which activate or are activated by transcription factors as nuclear factor κb (nf-κb) and signal transducers and activators of transcription-3 (stat3). |
2013-01-16 |
2023-08-12 |
Not clear |
| Neera Tewari-Singh, Anil K Jain, Swetha Inturi, David A Ammar, Chapla Agarwal, Puneet Tyagi, Uday B Kompella, Robert W Enzenauer, J Mark Petrash, Rajesh Agarwa. Silibinin, dexamethasone, and doxycycline as potential therapeutic agents for treating vesicant-inflicted ocular injuries. Toxicology and applied pharmacology. vol 264. issue 1. 2012-11-19. PMID:22841772. |
nm (100nmol) exposure of the corneas for 2h (cultured for 24h), showed increases in epithelial thickness, ulceration, apoptotic cell death, epithelial detachment microbullae formation, and the levels of vegf, cyclooxygenase-2 (cox-2) and matrix metalloproteinase-9 (mmp-9). |
2012-11-19 |
2023-08-12 |
rabbit |
| I-Ta Lee, Chuen-Mao Yan. Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases. Biochemical pharmacology. vol 84. issue 5. 2012-10-15. PMID:22587816. |
many of the known inflammatory target proteins, such as matrix metalloproteinase-9 (mmp-9), intercellular adhesion molecule-1 (icam-1), vascular cell adhesion molecule-1 (vcam-1), cyclooxygenase-2 (cox-2), and cytosolic phospholipase a(2) (cpla(2)), are associated with nadph oxidase activation and ros overproduction in response to pro-inflammatory mediators. |
2012-10-15 |
2023-08-12 |
Not clear |
| Mohammad A Mohammad, Ahmed A Zeeneldin, Zakaria Y Abd Elmageed, Ebtsam H Khalil, Said M E Mahdy, Hayat M Sharada, Sabry K Sharawy, Abdel-Hady A Abdel-Waha. Clinical relevance of cyclooxygenase-2 and matrix metalloproteinases (MMP-2 and MT1-MMP) in human breast cancer tissue. Molecular and cellular biochemistry. vol 366. issue 1-2. 2012-10-09. PMID:22527932. |
the aim of our study was to evaluate the protein expression profile and prognostic significance of cyclooxygenase-2 (cox-2), matrix metalloproteinase-2 (mmp-2), mmp-9 and membrane type 1-mmp (mt1-mmp) and their interaction in operable bc patients. |
2012-10-09 |
2023-08-12 |
human |
| Beom J Lim, Sung S Jung, Song Y Choi, Choong S Le. Expression of metastasis-associated molecules in non-small cell lung cancer and their prognostic significance. Molecular medicine reports. vol 3. issue 1. 2012-10-02. PMID:21472198. |
we evaluated the expression of matrix metalloproteinase (mmp)-1, mmp-2, mmp-3, mmp-9, mmp-10, tissue inhibitor of mmps (timp)-1, timp-2, β-catenin, e-cadherin and cyclooxygenase-2 (cox-2) in 43 cases of non-small cell lung cancer (nsclc). |
2012-10-02 |
2023-08-12 |
Not clear |
| Bing Liu, Liyan Qu, Zhengming Yang, Huimin Ta. Cyclooxygenase-2 inhibitors induce anoikis in osteosarcoma via PI3K/Akt pathway. Medical hypotheses. vol 79. issue 1. 2012-09-25. PMID:22546756. |
we hypothesize that cox-2 inhibitors induce anoikis in osteosarcoma via pi3k/akt, resulted in lack of correct attachment and the down-regulations of β-catenin, trkb and e-cadherin, which play an essential role in the cell/extracellar matrix (ecm) and cell/cell adhesion. |
2012-09-25 |
2023-08-12 |
human |
| Steven J McElroy, Stuart Hobbs, Michael Kallen, Noemi Tejera, Michael J Rosen, Anatoly Grishin, Poojitha Matta, Claus Schneider, Jeffrey Upperman, Henri Ford, D Brent Polk, Jörn-Hendrik Weitkam. Transactivation of EGFR by LPS induces COX-2 expression in enterocytes. PloS one. vol 7. issue 5. 2012-09-17. PMID:22675459. |
lps induction of cox-2 requires src-family kinase signaling while lps transactivation of egfr requires matrix metalloprotease (mmp) activity. |
2012-09-17 |
2023-08-12 |
Not clear |
| Khanh L Ng, Lan Nguyễ. Role of vitamin d in Parkinson's disease. ISRN neurology. vol 2012. 2012-08-23. PMID:22619734. |
vitamin d has also been implicated in pd through its effects on l-type voltage-sensitive calcium channels (l-vscc), nerve growth factor (ngf), matrix metalloproteinases (mmps), prostaglandins (pgs) and cyclooxygenase-2 (cox-2), reactive oxygen species (ros), and nitric oxide synthase (nos). |
2012-08-23 |
2023-08-12 |
Not clear |
| A S Yar, S Menevse, E Al. The effects of resveratrol on cyclooxygenase-1 and -2, nuclear factor kappa beta, matrix metalloproteinase-9, and sirtuin 1 mRNA expression in hearts of streptozotocin-induced diabetic rats. Genetics and molecular research : GMR. vol 10. issue 4. 2012-06-06. PMID:22179968. |
we investigated cyclooxygenase-1 (cox-1), cox-2, nuclear factor κb (nf-κb), matrix metalloproteinase-9 (mmp-9), and sirtuin 1 (sirt1) mrna expression levels in heart tissue after rsv treatment in streptozotocin (stz)-induced diabetic rats. |
2012-06-06 |
2023-08-12 |
rat |
| Gautam Sethi, Muthu K Shanmugam, Lalitha Ramachandran, Alan Prem Kumar, Vinay Tergaonka. Multifaceted link between cancer and inflammation. Bioscience reports. vol 32. issue 1. 2012-02-29. PMID:21981137. |
the molecular mechanism(s) by which chronic inflammation drives cancer initiation and promotion include increased production of pro-inflammatory mediators, such as cytokines, chemokines, reactive oxygen intermediates, increased expression of oncogenes, cox-2 (cyclo-oxygenase-2), 5-lox (5-lipoxygenase) and mmps (matrix metalloproteinases), and pro-inflammatory transcription factors such as nf-κb (nuclear factor κb), stat3 (signal transducer and activator of transcription 3), ap-1 (activator protein 1) and hif-1α (hypoxia-inducible factor 1α) that mediate tumour cell proliferation, transformation, metastasis, survival, invasion, angiogenesis, chemoresistance and radioresistance. |
2012-02-29 |
2023-08-12 |
Not clear |