Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Yang Liu, Xun Sun, Lianlei Wang, Yiming Dou, Ye Tian, Tianyu Yu, Yiming Zhang, Qingqian Zhao, Jiayi Lu, Yinyin Feng, Jiayu Wang, Xinyu Liu, Yuna Shang, Chunju Li, Qiang Yan. Sequential Targeted Enzyme-Instructed Self-Assembly Supramolecular Nanofibers to Attenuate Intervertebral Disc Degeneration. Advanced materials (Deerfield Beach, Fla.). 2024-09-02. PMID:39221659. |
1 (flurbiprofen-gffyplglageeeergd) reduces the expression of inflammation-related genes and proteins and the polarization of m1 macrophages by competitively inhibiting cox-2 and increases the expression of extracellular matrix proteins col-2 and aggrecan. |
2024-09-02 |
2024-09-04 |
Not clear |
Chuang-Yu Lin, Parichart Naruphontjirakul, Te-Yang Huang, Yi-Chia Wu, Wei-Hsuan Cheng, Wen-Ta S. The Exosomes of Stem Cells from Human Exfoliated Deciduous Teeth Suppress Inflammation in Osteoarthritis. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201248. |
the results showed that the exosomes successfully inhibited the pro-inflammatory factors, including tnf-α, il-6, inos, no, cox-2 and pge2, induced by il-1β and the degrading enzyme of the extrachondral matrix (mmp-13). |
2024-08-29 |
2024-09-01 |
human |
Anupam Bishayee, Amanda Penn, Neha Bhandari, Riley Petrovich, Lindsay K DeLiberto, Jack T Burcher, Sandra Maria Barbalho, Siddavaram Nagin. Dietary plants for oral cancer prevention and therapy: A review of preclinical and clinical studies. Phytotherapy research : PTR. 2024-08-28. PMID:39193857. |
these agents were also found to regulate cellular growth signaling pathways by action on extracellular signal-regulated kinase and mitogen-activated protein kinase, inflammation via modulation of cyclooxygenase (cox)-1, cox-2, and nuclear factor-κb p65, and metastasis through influence of cadherins and matrix metalloproteinases. |
2024-08-28 |
2024-08-30 |
Not clear |
Agata Wojtkowska, Anna Małek, Sławomir Giziński, Rafał Sapierzyński, Anna Rodo, Justyna Sokołowska, Katarzyna A Zabielska-Koczywąs, Anna Wojtalewicz, Magdalena Walewska, Ewa Kautz, Magdalena Ostrzeszewicz, Roman Lechowsk. Comparison of MMP-2, MMP-9, COX-2, and PGP Expression in Feline Injection-Site and Feline Noninjection-Site Sarcomas-Pilot Study. Animals : an open access journal from MDPI. vol 14. issue 14. 2024-07-27. PMID:39061572. |
this study aimed to determine the differences in the expression of the selected proteins (matrix metalloproteinase-2 (mmp-2), matrix metalloproteinase-9 (mmp-9), cyclooxygenase-2 (cox-2), and p-glycoprotein (pgp)) and their correlation with the mitotic count in fiss and non-fiss, in order to characterize their immunohistochemical features. |
2024-07-27 |
2024-07-29 |
Not clear |
Hongri Ruan, Tingting Zhu, Tiantian Wang, Yingchao Guo, Yun Liu, Jiasan Zhen. Quercetin Modulates Ferroptosis via the SIRT1/Nrf-2/HO-1 Pathway and Attenuates Cartilage Destruction in an Osteoarthritis Rat Model. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000568. |
in vitro, que inhibited the expression of il-1β-induced chondrocyte matrix metalloproteinases (mmp3 and mmp13) and inflammatory mediators such as inos and cox-2. |
2024-07-13 |
2024-07-15 |
rat |
Alaa H Sayed, Nadia S Mahmoud, Ola A M Mohawed, Hanaa H Ahme. Combined effect of pantoprazole and mesenchymal stem cells on experimentally induced gastric ulcer: implication of oxidative stress, inflammation and apoptosis pathways. Inflammopharmacology. 2024-04-23. PMID:38652367. |
moreover, the treated groups (panto, adscs and adscs + panto) displayed significant down-regulation (p < 0.05) in gastric nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb), tumor necrosis factor alpha (tnf-α), cyclooxygenase-2 (cox-2), intercellular adhesion molecule-1 (icam-1), matrix metallopeptidase 9 (mmp-9) and caspase-3 along with significant up-regulation (p < 0.05) in vascular endothelial growth factor (vegf) and peroxisome proliferator-activated receptor gamma (pparγ) genes expression compared to the untreated gu group. |
2024-04-23 |
2024-04-26 |
rat |
Samia Mahmoud Manawy, Eman Mohamed Faruk, Rabab Fawzy Hindawy, Mahmoud M Hassan, Diaa M G Farrag, Mansour A E Bashar, Hanan Fouad, Rania Abubaker Bagabir, Dina Allam Abdelmaksoud Hassan, Ahmed Mohammed Zaazaa, Mohamed Ghazy Attia Hablas, K Mostafa Kama. Modulation of the Sirtuin-1 signaling pathway in doxorubicin-induced nephrotoxicity (synergistic amelioration by resveratrol and pirfenidone). Tissue & cell. vol 87. 2024-02-27. PMID:38412579. |
renal tissue was collected to assess matrix metalloproteinase-9 (mmp9), inflammatory and apoptotic markers: tumor necrosis factor-alpha (tnf- β, caspase-3, cyclo-oxygenase-2 (cox-2), and oxidative stress markers: nitric oxide (no), glutathione (gsh), malondialdehyde (mda), and superoxide dismutase (sod). |
2024-02-27 |
2024-03-01 |
rat |
Chaohua Deng, Nathalie Presle, Anne Pizard, Cécile Guillaume, Arnaud Bianchi, Hervé Kemp. Beneficial Impact of Eicosapentaenoic Acid on the Adverse Effects Induced by Palmitate and Hyperglycemia on Healthy Rat Chondrocyte. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339087. |
the expression of genes encoding proteins found in cartilage matrix (type 2 collagen and aggrecan) or involved in degenerative (metalloproteinases, mmps) or in inflammatory (cyclooxygenase-2, cox-2 and microsomal prostaglandin e synthase, mpges) processes was analyzed by qpcr. |
2024-02-10 |
2024-02-12 |
rat |
Hong Su, Qiuju Yan, Wei Du, En Hu, Zhaoyu Yang, Wei Zhang, Yusheng Li, Tao Tang, Shushan Zhao, Yang Wan. Calycosin ameliorates osteoarthritis by regulating the imbalance between chondrocyte synthesis and catabolism. BMC complementary medicine and therapies. vol 24. issue 1. 2024-01-23. PMID:38254101. |
while cartilage matrix degradation index cyclooxygenase-2 (cox-2), phosphor-epidermal growth factor receptor (p-egfr), and matrix metalloproteinase-9 (mmp9) expression were decreased. |
2024-01-23 |
2024-01-25 |
mouse |
Guozhong Wu, Shaik Althaf Hussain, Jayasimha Rayalu Daddam, Zhou Y. Anti-osteoarthritis, Bone Protective and Antiinflammatory Effect of Lusianthridin against Monosodium Iodoacetate Induced Osteoarthritis via Suppression of Inflammatory Pathway. Journal of oleo science. vol 73. issue 1. 2024-01-03. PMID:38171734. |
lusianthridin significantly (p < 0.001) decreased the level of cartilage oligometrix matrix protein (comp) and c-reactive protein (crp); cytokines such as tnf-α, il-1β, il-6, il-10; inflammatory parameters include 5- lipoxygenase (5-lox), cox-2, leukotriene b4 (ltb4), pge2; transforming growth factor beta (tgf-β); mmp level like mmp-1, 3, 9, 13, respectively. |
2024-01-03 |
2024-01-06 |
rat |
Ying Yu, Sang-Min Kim, Kyeongsoon Park, Hak Jun Kim, Jae Gyoon Kim, Sung Eun Ki. Therapeutic Nanodiamonds Containing Icariin Ameliorate the Progression of Osteoarthritis in Rats. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958960. |
ica/ta-nds inhibited the mrna levels of pro-inflammatory elements, including matrix metalloproteinases-3 (mmp-3), cyclooxygenase-2 (cox-2), interleukin-6 (il-6), and tumor necrosis factor-α (tnf-α), and increased the mrna levels of anti-inflammatory factors (i.e., il-4 and il-10) in lps-activated raw 264.7 macrophages. |
2023-11-14 |
2023-11-20 |
rat |
Tian Mao, Junchi Fa. Myricetin Protects Against Rat Intervertebral Disc Degeneration Partly Through the Nrf2/HO-1/NF-κB Signaling Pathway. Biochemical genetics. 2023-07-28. PMID:37507641. |
rt-qpcr, western blotting, and elisa were applied to evaluate the levels of inflammatory factors (inos, cox-2, tnf-α, il-6, pge2, and nitrite) and extracellular matrix (ecm)-associated components (mmp13, adamts-5, aggrecan, and collagen ii) in npcs. |
2023-07-28 |
2023-08-14 |
rat |
Xinyu Dou, Yunlong Ma, Qipeng Luo, Chunyu Song, Meijuan Liu, Xiao Liu, Donglin Jia, Shuiqing Li, Xiaoguang Li. Therapeutic potential of melatonin in the intervertebral disc degeneration through inhibiting the ferroptosis of nucleus pulpous cells. Journal of cellular and molecular medicine. 2023-06-17. PMID:37329158. |
current studies demonstrated that conditioned medium (cm) from the lipopolysaccharide (lps)-stimulated macrophages caused a series of changes about idd, including increased intracellular oxidative stress (increased reactive oxygen species and malondialdehyde levels, but decreased glutathione levels), upregulated expression of inflammation-associated factors (il-1β, cox-2 and inos), increased expression of key matrix catabolic molecules (mmp-13, adamts4 and adamts5), reduced the expression of major matrix anabolic molecules (col2a1 and acan), and increased ferroptosis (downregulated gpx4 and slc7a11 levels, but upregulated acsl4 and lpcat3 levels) in nucleus pulposus (np) cells. |
2023-06-17 |
2023-08-14 |
Not clear |
Le Su, Jilong Liu, Qiulin Yue, Song Zhang, Chen Zhao, Xin Sun, Jing Xu, Xingtao Jiang, Kunlun Li, Baojun Li, Lin Zha. Evaluation of the effects of e-cigarette aerosol extracts and tobacco cigarette smoke extracts on human gingival epithelial cells. Toxicology in vitro : an international journal published in association with BIBRA. 2023-05-10. PMID:37164182. |
the levels of matrix metalloproteinase, cox-2, and inflammatory factors were higher in hgecs treated with csc than those treated with ecac. |
2023-05-10 |
2023-08-14 |
human |
Lavanya Mude, Srikanth Jupudi, Akey Krishna Swaroop, Vyshnavi Tallapaneni, Veera Venkata Satyanarayana Reddy Karr. Molecular insights in repurposing selective COX-2 inhibitor celecoxib against matrix metalloproteinases in potentiating delayed wound healing: a molecular docking and MMPB/SA based analysis of molecular dynamic simulations. Journal of biomolecular structure & dynamics. 2023-05-09. PMID:37160705. |
molecular insights in repurposing selective cox-2 inhibitor celecoxib against matrix metalloproteinases in potentiating delayed wound healing: a molecular docking and mmpb/sa based analysis of molecular dynamic simulations. |
2023-05-09 |
2023-08-14 |
Not clear |
Le Su, Jilong Liu, Qiulin Yue, Song Zhang, Chen Zhao, Xin Sun, Jing Xu, Xingtao Jiang, Kunlun Li, Baojun Li, Lin Zha. Evaluation of the Effects of E-Cigarette Aerosol Extracts and Tobacco Cigarette Smoke Extracts on Human Gingival Epithelial Cells. ACS omega. vol 8. issue 12. 2023-04-03. PMID:37008119. |
the levels of matrix metalloproteinase, cox-2, and inflammatory factors were higher in hgecs treated with csc than those treated with ecac. |
2023-04-03 |
2023-08-14 |
human |
Connor Charles Gains, Antonios Giannapoulos, Danae Emilie Zamboulis, Jordi Lopez-Tremoleda, Hazel R C Scree. Development and application of a novel in vivo overload model of the Achilles tendon in rat. Journal of biomechanics. vol 151. 2023-03-23. PMID:36958089. |
staining for pro-inflammatory mediators (il-6 and cox-2) and matrix degradation markers (mmp-3 and -13) also suggests an initial cellular response to overload. |
2023-03-23 |
2023-08-14 |
rat |
Xiaoyi Xia, Huang Zeng, Huilei Wang, Xin Li, Shengyuan Zhang, Li Yang, Junwei H. Revealing the Active Constituents and Mechanisms of Semiliquidambar cathayensis Chang Roots Against Rheumatoid Arthritis through Network Pharmacology, Molecular Docking, and in Vivo Experiment. Chemistry & biodiversity. 2022-11-24. PMID:36424369. |
rat experiment demonstrated that the extract of sc restored body weight loss, reduced arthritis score and the indices of thymus and spleen, alleviated ankle joint histopathology, decreased the levels of rheumatoid factor (rf), c-reactive protein (crp), il-17, tnf-α, il-1β, il-6, cyclooxygenase-2 (cox-2), 5-lipoxygenase (5-lox), and matrix metalloproteinase-2 (mmp-2), whereas elevated the levels of il-4 and il-10. |
2022-11-24 |
2023-08-14 |
rat |
Mojgan Gharipour, Masoumeh Sadeghi, Shaghayegh Haghjooy-Javanmard, Homa Hamledari, Elham Khosravi, Minoo Dianatkhah, Golnaz Vasegh. Effects of selenium intake on the expression of prostaglandin-endoperoxide synthase 2 (cyclooxygenase-2) and matrix metallopeptidase-9 genes in the coronary artery disease: Selenegene study, a double-blind randomized controlled trial. ARYA atherosclerosis. vol 17. issue 2. 2022-11-07. PMID:36338532. |
cyclooxygenase-2 (cox-2) and matrix metallopeptidase-9 (mmp-9) are two of the important genes that are reported to be involved in the cardiovascular disease (cvd) development in the molecular and genetic association studies. |
2022-11-07 |
2023-08-14 |
Not clear |
Amr Negm, Azza Sedky, Hany Elsaw. Capric Acid Behaves Agonistic Effect on Calcitriol to Control Inflammatory Mediators in Colon Cancer Cells. Molecules (Basel, Switzerland). vol 27. issue 19. 2022-10-14. PMID:36235161. |
these findings elucidate the activation of cox-2 and nf-κb via disruption of the cellular outer matrix could be considered a novel molecular target suitable for colorectal cancer therapy. |
2022-10-14 |
2023-08-14 |
human |