| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun-Rong Lei, Xian-Kun Tu, Yang Wang, De-Wen Tu, Song-Sheng Sh. Resveratrol downregulates the TLR4 signaling pathway to reduce brain damage in a rat model of focal cerebral ischemia. Experimental and therapeutic medicine. vol 17. issue 4. 2020-10-01. PMID:30936996. |
additionally, the protein expression levels of toll-like receptor 4 (tlr4) and nuclear factor (nf)-κb p65 were detected using western blot analyses, the mrna expression levels of cyclooxygenase-2 (cox-2) and matrix metalloproteinase-9 (mmp-9) were examined by reverse-transcription polymerase chain reaction, and tumor necrosis factor (tnf)-α and interleukin (il)-1β blood levels were determined by elisa. |
2020-10-01 |
2023-08-13 |
rat |
| Claudia I Rivas-Ortiz, Yolanda Lopez-Vidal, Luis Jose Rene Arredondo-Hernandez, Gonzalo Castillo-Roja. Genetic Alterations in Gastric Cancer Associated with Frontiers in medicine. vol 4. 2020-09-30. PMID:28512631. |
recently, these genes (interleukin 10, il-17, mucin 1, β-catenin, cdx1, smad4, serpine1, hypoxia-inducible factor 1 subunit alpha, gsk3β, cdh17, matrix metalloproteinase 7, runx3, rassf1a, tff1, hai-2, and cox-2) have been studied in association with oncogenic activation or inactivation of tumor suppressor genes. |
2020-09-30 |
2023-08-13 |
Not clear |
| Young Yun Jung, Jong Hyun Lee, Dongwoo Nam, Acharan S Narula, Ojas A Namjoshi, Bruce E Blough, Jae-Young Um, Gautam Sethi, Kwang Seok Ah. Anti-myeloma Effects of Icariin Are Mediated Through the Attenuation of JAK/STAT3-Dependent Signaling Cascade. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:29899697. |
we found that icariin downregulated the protein expression of stat3 downstream target gene products such as bcl-2, bcl-xl, survivin, iap-1/2, cox-2, vegf, and matrix metallopeptidase 9 (mmp-9) in a concentration-dependent manner. |
2020-09-30 |
2023-08-13 |
human |
| Mahmood Rasool, Arif Malik, Sulayman Waquar, Qura Tul-Ain, Tassadaq H Jafar, Rabia Rasool, Aasia Kalsoom, Muhammad A Ghafoor, Sheikh A Sehgal, Kalamegam Gauthaman, Muhammad I Naseer, Mohammed H Al-Qahtani, Peter N Pushpara. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:30123124. |
the serum samples were further analyzed for biomarkers such as 8-hydroxydeoxyguanosine (8-ohdg), 4-hydroxynonenal (4-hne), tumor necrosis factor-alpha (tnf-α), cyclooxygenase-2 (cox-2), matrix metalloproteinase-8 (mmp-8), isoprostanes-2 alpha (isop-2α), and acetylcholine esterase (ache) using conventional enzyme linked immunosorbent assay (elisa) method. |
2020-09-30 |
2023-08-13 |
rat |
| M W Roomi, T Kalinovsky, J Cha, N W Roomi, A Niedzwiecki, M Rat. Effects of a nutrient mixture on immunohistochemical localization of cancer markers in human cervical cancer HeLa cell tumor xenografts in female nude mice. Experimental and therapeutic medicine. vol 9. issue 2. 2020-09-29. PMID:25574189. |
tumor growth was measured and immunohistochemical staining was evaluated for the following cancer markers: ki67 (proliferation); matrix metalloproteinase (mmp)-2 and -9 (invasion/metastasis); vascular endothelial growth factor (vegf) (angiogenesis); terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) and b-cell lymphoma 2 (bcl-2) (apoptosis); cyclooxygenase 2 (cox-2) and inducible nitric oxide synthase (inos) (inflammation); and glutathione s-transferase π (gstπ) (a general cancer marker). |
2020-09-29 |
2023-08-13 |
mouse |
| Kun Sun, Xiao-He Tang, Yi-Kui Xi. Paclitaxel combined with harmine inhibits the migration and invasion of gastric cancer cells through downregulation of cyclooxygenase-2 expression. Oncology letters. vol 10. issue 3. 2020-09-29. PMID:26622726. |
the expression levels of cox-2 and matrix metalloproteinase-9 (mmp-9) were analyzed by western blot analysis. |
2020-09-29 |
2023-08-13 |
human |
| Kun Sun, Xiao-He Tang, Yi-Kui Xi. Paclitaxel combined with harmine inhibits the migration and invasion of gastric cancer cells through downregulation of cyclooxygenase-2 expression. Oncology letters. vol 10. issue 3. 2020-09-29. PMID:26622726. |
individually ptx and hm were able to inhibit the migration and invasion of two human gastric cancer cells; however, the combination of ptx and hm exerted synergistic effects on migration and invasion inhibition, with downregulation of cox-2 and matrix metalloproteinase (mmp)-9. |
2020-09-29 |
2023-08-13 |
human |
| Yifan Wu, Zhanghong Wang, Zeng Lin, Xin Fu, Jingdi Zhan, Kehe Y. Salvianolic Acid A Has Anti-Osteoarthritis Effect Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32581777. |
we evaluated the expression of pro-inflammatory mediators and cartilage matrix catabolic enzymes in chondrocytes by elisa, griess reaction, immunofluorescence, and western blot, which includes nitric oxide (no), tumor necrosis factor-alpha (tnf-α), interleukin-6 (il-6), prostaglandin e2 (pge2), inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), mmps (mmp-3, mmp-13), and adamts-5. |
2020-09-28 |
2023-08-13 |
Not clear |
| Hongxi Li, Shujuan Xie, Huazhe Li, Rui Zhang, Hanjun Zhan. LncRNA MALAT1 mediates proliferation of LPS treated-articular chondrocytes by targeting the miR-146a-PI3K/Akt/mTOR axis. Life sciences. vol 254. 2020-07-21. PMID:31472145. |
following with malat1 silencing, the generation of cyclooxygenase-2 (cox-2), interleukin-6 (il-6) and matrix metallopeptidase-13 (mmp-13) were promoted, while the level of type ii collagen (col2) was inhibited. |
2020-07-21 |
2023-08-13 |
rat |
| Seung-Hee Cho, Byung-Joon Seung, Soo-Hyeon Kim, Ha-Young Lim, Gyu-Seok Lee, Mi-Suk Chae, Jung-Hyang Su. Renal interstitial cell tumor in a dog: clinicopathologic, imaging, and histologic features. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. vol 32. issue 1. 2020-07-08. PMID:31876249. |
the tumor cells were positive for vimentin and cox-2, but negative for pancytokeratin; the matrix stained positively with alcian blue. |
2020-07-08 |
2023-08-13 |
dog |
| Xi-Xi Wu, Xie-Lin Huang, Ru-Ru Chen, Tang Li, Hua-Jun Ye, Wei Xie, Zhi-Ming Huang, Gao-Zhong Ca. Paeoniflorin Prevents Intestinal Barrier Disruption and Inhibits Lipopolysaccharide (LPS)-Induced Inflammation in Caco-2 Cell Monolayers. Inflammation. vol 42. issue 6. 2020-03-30. PMID:31473900. |
in vitro, treatment of pf significantly inhibited lps-induced expression of cyclooxygenase-2 (cox-2), inducible nitric oxide synthase (inos), tumor necrosis factor-alpha (tnf-α) and interleukin-6 (il-6), and matrix metalloproteinase-9 (mmp-9). |
2020-03-30 |
2023-08-13 |
human |
| Kwang-Soo Lee, Seoungwoo Shin, Eunae Cho, Won Kyun Im, Sung Ho Jeon, Younghyun Kim, Deokhoon Park, Mathilde Fréchet, Hanane Chajra, Eunsun Jun. nc886, a non-coding RNA, inhibits UVB-induced MMP-9 and COX-2 expression via the PKR pathway in human keratinocytes. Biochemical and biophysical research communications. vol 512. issue 4. 2020-03-25. PMID:30685091. |
reduced nc886 expression leads to uncontrolled pkr activity and increases in the expression of inflammatory cytokines, matrix metalloproteinase-9 (mmp-9), type iv collagenase, and cyclooxygenase (cox-2), which ultimately accelerate inflammatory responses and skin aging. |
2020-03-25 |
2023-08-13 |
human |
| Yifan Wu, Zeng Lin, Zijian Yan, Zhanghong Wang, Xin Fu, Kehe Y. Sinomenine contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2/HO-1 and NF-κB signaling pathways. International immunopharmacology. vol 75. 2020-03-05. PMID:31310911. |
from our experiments, which include griess reaction, elisa, western blot, and immunofluorescence, we found that sin not only down-regulated the expression of pro-inflammatory factors induced by il-1β, including; inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), nitricoxide (no), prostaglandin e2 (pge2), tumor necrosis factor alpha (tnf-α) and interleukin-6 (il-6), but also decreased the production of il-1β-induced cartilage matrix catabolic enzymes including; adamts-5 and mmps, in mouse chondrocytes. |
2020-03-05 |
2023-08-13 |
mouse |
| Eun Ju Shin, Ji Su Lee, Seungpyo Hong, Tae-Gyu Lim, Sanguine Byu. Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin. International journal of molecular sciences. vol 20. issue 21. 2020-03-03. PMID:31652815. |
treatment with quercetin suppressed uv-induced matrix metalloproteinase-1 (mmp-1) and cyclooxygenase-2 (cox-2) expression and prevented uv-mediated collagen degradation in human skin tissues. |
2020-03-03 |
2023-08-13 |
human |
| Yi He, Zeng Zisan, Zhenhui Lu, Li Zheng, Jinmin Zha. Bergapten alleviates osteoarthritis by regulating the ANP32A/ATM signaling pathway. FEBS open bio. vol 9. issue 6. 2020-02-25. PMID:31037830. |
we observed that bg significantly ameliorated interleukin (il)-1β-induced expression of inflammatory cytokines and mediators, including interleukin 1 (il-1), interleukin 6 (il-6), tumor necrosis factor α (tnf-α), cyclooxygenase 2 (cox-2) and matrix metalloproteinase 13 (mmp-13), maintained chondrocyte phenotype, and promoted the secretion of cartilage-specific extracellular matrix. |
2020-02-25 |
2023-08-13 |
Not clear |
| Mahshid Vashaghian, Chantal M Diedrich, Behrouz Zandieh-Doulabi, Arie Werner, Theodoor H Smit, J P Roover. Gentle cyclic straining of human fibroblasts on electrospun scaffolds enhances their regenerative potential. Acta biomaterialia. vol 84. 2020-02-20. PMID:30471477. |
mechanical loading upregulated genes involved in matrix synthesis (collagen i, iii, v and elastin), matrix remodeling (α-sma, tgf-β1, mmp-2) and inflammation (cox-2, tnf-α, il8, il1-β). |
2020-02-20 |
2023-08-13 |
human |
| Xiaojian Huang, Yang Xi, Zekai Mao, Xiangyu Chu, Rui Zhang, Xiaohu Ma, Bowei Ni, Hao Cheng, Hongbo Yo. Vanillic acid attenuates cartilage degeneration by regulating the MAPK and PI3K/AKT/NF-κB pathways. European journal of pharmacology. vol 859. 2020-01-28. PMID:31228458. |
va inhibited the expression of inflammation responses, including cyclooxygenase-2 (cox-2), inducible nitric oxide synthase (inos), matrix metalloproteinases (mmps) and aggrecanase -2(adamts5). |
2020-01-28 |
2023-08-13 |
rat |
| Ki Mo Kim, A-Rang Im, Se Kyu Park, Hyoung Seok Shin, Sung-Wook Cha. Protective Effects of Timosaponin AIII against UVB-Radiation Induced Inflammation and DNA Injury in Human Epidermal Keratinocytes. Biological & pharmaceutical bulletin. vol 42. issue 9. 2020-01-28. PMID:31270288. |
similarly, ta-iii inhibited uvb-induced cyclooxygenase-2 (cox-2), matrix metalloproteinase-9 (mmp-9) transcription level and protein expression in a dose-dependent manner at non-cytotoxic dose. |
2020-01-28 |
2023-08-13 |
human |
| Feng-Cheng Liu, Chih-Chien Wang, Jeng-Wei Lu, Chian-Her Lee, Shao-Chi Chen, Yi-Jung Ho, Yi-Jen Pen. Chondroprotective Effects of Genistein against Osteoarthritis Induced Joint Inflammation. Nutrients. vol 11. issue 5. 2019-12-30. PMID:31137797. |
our results from an in-vitro model of osteoarthritis indicate that genistein inhibits the il-1β-induced expression of the catabolic factors nitric oxide synthase 2 (nos2), cyclooxygenase 2 (cox-2), and matrix metalloproteinases (mmps). |
2019-12-30 |
2023-08-13 |
human |
| Kaori Suyama, Daisuke Sakai, Noriaki Hirayama, Yoshihiko Nakamura, Erika Matsushita, Hayato Terayama, Ning Qu, Osamu Tanaka, Kou Sakabe, Masahiko Watanab. Effects of interleukin-17A in nucleus pulposus cells and its small-molecule inhibitors for intervertebral disc disease. Journal of cellular and molecular medicine. vol 22. issue 11. 2019-12-09. PMID:30207057. |
treatment of np cells with il-17a increased expression of cyclooxygenase-2 (cox-2), il-6, matrix metalloproteinase (mmp)-3 and mmp-13. |
2019-12-09 |
2023-08-13 |
Not clear |