| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qi Wang, Jing Peng, Yang Liu, Yang Tian, Jie Li, Yao-Yao Ren, Jian Gu, Rui Ta. [Therapeutic effects of alkaloids in Tibetan medicine Bangna (Aconiti Penduli et Aconiti Flavi Radix) on osteoarthritis rats and mechanisms]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 17. 2022-09-27. PMID:36164879. |
the protein expression of inflammatory factors cyclooxygenase-2(cox-2), inducible nitric oxide synthetase(inos), tumor necrosis factor-α(tnf-α), and interleukin-1β(il-1β) in each group were detected by western blot, and the protein expression of matrix metalloprotease-13(mmp-13), aggrecan, collagen Ⅱ, fibroblast growth factor 2(fgf2) by immunofluorescence staining. |
2022-09-27 |
2023-08-14 |
rat |
| Davorin Sef, Miljenko Kovacevic, Bojan Jernej, Karlo Novacic, Marko Slavica, Jelka Petrak, Igor Medved, Milan Milosevi. Immunohistochemical analysis of MMP-9 and COX-2 expression in carotid atherosclerotic plaques among patients undergoing carotid endarterectomy: A prospective study. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 31. issue 11. 2022-09-08. PMID:36075131. |
matrix metalloproteinase-9 protein (mmp-9) and cyclooxygenase-2 (cox-2) proteins may have a role in remodelling of atherosclerotic plaques. |
2022-09-08 |
2023-08-14 |
Not clear |
| Cong Sui, Yichao Wu, Ran Zhang, Tiantian Zhang, Yang Zhang, Jiaojiao Xi, Yanyu Ding, Jiyue Wen, Yong H. Rutin Inhibits the Progression of Osteoarthritis Through DNA and cell biology. 2022-05-19. PMID:35588172. |
we found that rutin effectively reduced the expression levels of inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), tumor necrosis factor-α (tnf-α), and matrix metalloproteinase 13 (mmp-13) and increased the expression of col ii and aggrecan ( |
2022-05-19 |
2023-08-13 |
rat |
| Dinesh G Goswami, Satyendra K Singh, Omid Madadgar, Claire R Croutch, Erica L Noland, Jared Brown, Rajesh Agarwal, Neera Tewari-Sing. Mechanism of Phosgene Oxime Induced Skin Toxicity in C57BL/6 Mouse Model. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554650. |
cx exposure also led to increased expression of inflammatory mediators, cyclooxygenase-2 (cox-2), matrix metallopeptidase-9 (mmp-9), myeloperoxidase (mpo), and map kinases jnk. |
2022-05-13 |
2023-08-13 |
mouse |
| Qingyu Meng, Luya Pu, Mingran Qi, Shuai Li, Banghao Sun, Yaru Wang, Bin Liu, Fan L. Laminar shear stress inhibits inflammation by activating autophagy in human aortic endothelial cells through HMGB1 nuclear translocation. Communications biology. vol 5. issue 1. 2022-05-06. PMID:35523945. |
in this study, we found that lss could inhibit the increased expression of intercellular adhesion molecule-1 (icam-1), vascular cell adhesion molecule-1 (vcam-1), cyclooxygenase-2 (cox-2), and matrix metallopeptidase-9 (mmp-9) caused by tnf-α in an autophagy-dependent pathway in human aortic endothelial cells (haecs) and human umbilical vein endothelial cells (huvecs). |
2022-05-06 |
2023-08-13 |
human |
| Ajay Kumar Verma, Anuj Kumar Pandey, Arpita Singh, Surya Kant, Abbas Ali Mahdi, Ved Prakash, Kausar Mahmood Ansari, Rakesh Kumar Dixit, Shyam Chand Chaudhar. Increased Serum Levels of Matrix-metalloproteinase-9, Cyclo-oxygenase-2 and Prostaglandin E-2 in Patients with Chronic Obstructive Pulmonary Disease (COPD). Indian journal of clinical biochemistry : IJCB. vol 37. issue 2. 2022-04-25. PMID:35463116. |
here, we measured the serum level of matrix metalloproteinase-9 (mmp-9), cyclooxygenase-2 (cox-2) and prostaglandin e-2 (pge-2) and reveal the correlation between their levels in copd subjects. |
2022-04-25 |
2023-08-13 |
human |
| Shanshan Yu, Kaixuan Cui, Peiqi Wu, Benjuan Wu, Xi Lu, Rong Huang, Xiaoyu Tang, Jianqiang Lin, Boyu Yang, Jinfeng Zhao, Qingjing He, Xiaoling Liang, Yue X. Melatonin prevents experimental central serous chorioretinopathy in rats. Journal of pineal research. 2022-04-18. PMID:35436360. |
additionally, the data also showed that intraperitoneal injection of melatonin in advance inhibited aldosterone-induced macrophage/microglia infiltration, and remarkably diminished the levels of inflammatory cytokines (il-6, il-1β, and cox-2), chemokines (ccl-3, and cxcl-1), and matrix metalloproteinases (mmp-2, and mmp-9). |
2022-04-18 |
2023-08-13 |
rat |
| Liang-Yu Zhao, Guo-Jun Xin, Yuan-Yuan Tang, Xiao-Fei Li, Yu-Zhen Li, Ning Tang, Yu-Hong M. miR-664b-3p inhibits colon cell carcinoma via negatively regulating Budding uninhibited by benzimidazole 3. Bioengineered. vol 13. issue 3. 2022-02-14. PMID:35156516. |
over-expression of mir-664b-3p could reduce the expression of proliferation-promoted proliferating cell nuclear antigen (pcna), proliferation marker protein ki-67 (ki-67), migration-promoted cyclooxygenase-2 (cox-2), matrix metallopeptidase 2 (mmp-2), and matrix metallopeptidase 9 (mmp-9), and apoptosis-inhibited protein (bcl-2) while increasing the expression of apoptosis-promoted bcl2-associated x protein (bax), caspase-3, and caspase-9 proteins. |
2022-02-14 |
2023-08-13 |
Not clear |
| Chaoran Song, Laura Rojas Lorz, Jongsung Lee, Jae Youl Ch. In Vitro Photoprotective, Anti-Inflammatory, Moisturizing, and Antimelanogenic Effects of a Methanolic Extract of Plants (Basel, Switzerland). vol 11. issue 1. 2022-01-11. PMID:35009097. |
ros activate the nf-κb and mapk signaling pathways leading to production of inflammatory molecules such as cox-2, collagen-degrading proteins such as matrix metalloproteinases (mmps), and moisture-deficiency-related proteins such as hyaluronidases (hyals). |
2022-01-11 |
2023-08-13 |
Not clear |
| Zuojie Li, Qingpeng Wang, Linming Li, Yan Chen, Jichun Cui, Min Liu, Ning Zhang, Zhifang Liu, Jun Han, Zhengping Wan. Ketoprofen and Loxoprofen Platinum(IV) Complexes Displaying Antimetastatic Activities by Inducing DNA Damage, Inflammation Suppression, and Enhanced Immune Response. Journal of medicinal chemistry. 2021-12-01. PMID:34852203. |
herein, ketoprofen (kp) and loxoprofen (lp) platinum(iv) complexes with antiproliferative and antimetastatic properties were designed and prepared by integrating chemotherapy and immunotherapy targeting cyclooxygenase-2 (cox-2), matrix metalloproteinase-9 (mmp-9), and programmed death ligand 1 (pd-l1), besides dna. |
2021-12-01 |
2023-08-13 |
Not clear |
| Shaikh Jamal Uddin, Md Fahim Hasan, Mohasana Afroz, Dipto Kumer Sarker, Razina Rouf, Muhammad Torequl Islam, Jamil A Shilpi, Mohammad S Mubara. Curcumin and its Multi-target Function Against Pain and Inflammation: An Update of Pre-clinical Data. Current drug targets. vol 22. issue 6. 2021-11-26. PMID:32981501. |
available pre-clinical data suggest the ameliorating effect of curcumin in pain and inflammation is rendered through the modulation of pain pathways, including inhibition of a number of pro-inflammatory mediators, inhibition of oxidative stress and cyclooxygenase-2 (cox-2), down-regulation of ca2+/calmodulin-depend protein kinase ii (camkiiα) and calcium channels like transient receptor potential (trp), modulation of metabotropic glutamate receptor-2 (mglu2), modulation of monoamine system, inhibition of jak2/stat3 signaling pathway, remodeling of extracellular matrix proteins, inhibition of apoptosis, inhibition of jnk/mapk and erk/creb signaling pathway, and activation of the opioid system. |
2021-11-26 |
2023-08-13 |
Not clear |
| Yi-Ting Chen, Chih-Chien Wang, Chia-Pi Cheng, Feng-Cheng Liu, Chian-Her Lee, Herng-Sheng Lee, Yi-Jen Pen. Interleukin-26 Has Synergistic Catabolic Effects with Palmitate in Human Articular Chondrocytes via the TLR4-ERK1/2-c-Jun Signaling Pathway. Cells. vol 10. issue 9. 2021-11-19. PMID:34572149. |
in this study, palmitate markedly synergizes the il-26-induced proinflammatory effects and matrix protease, including cox-2, il-6, and mmp-1, in hacs via the toll-like receptor 4 (tlr4)-erk1/2-c-jun signal transduction pathway. |
2021-11-19 |
2023-08-13 |
human |
| Wirginia Kukula-Koch, Dominik Szwajgier, Katarzyna Gaweł-Bęben, Marcelina Strzępek-Gomółka, Kazimierz Głowniak, Henry O Meissne. Is Phytomelatonin Complex Better Than Synthetic Melatonin? The Assessment of the Antiradical and Anti-Inflammatory Properties. Molecules (Basel, Switzerland). vol 26. issue 19. 2021-11-16. PMID:34641628. |
this work aims to assess the recently established anti-inflammatory and antioxidant potential of melatonin of plant origin extracted from the plant matrix as a phytomelatonin complex (pht-mlt), and compare its activity with synthetic melatonin (snt-mlt) when used on its own or with vitamin c. for this purpose, a cox-2 enzyme inhibitory activity test, an antiradical activity in vitro and on cell lines assays, was performed on both pht-mlt and snt-mlt products. |
2021-11-16 |
2023-08-13 |
Not clear |
| Laíla Pereira Silva, Eliziária Cardoso Santos, Bruno Arantes Borges, Marcia Paranho Veloso, Daniela Aparecida Chagas-Paula, Reggiani Vilela Gonçalves, Rômulo Dias Novae. Tagitinin F has anti-inflammatory, anti-nociceptive and anti-matrix metalloproteinase properties: An in silico, in vitro and in vivo study. Pharmacological research. vol 164. 2021-11-12. PMID:33212290. |
the paw of balb/c mice was injected with carrageenan and treated with 0.5% and 1% tag-f. excisional wounds were also produced in balb/c mice and treated with 0.5% and 1% tag-f. our results indicated a consistent concentration-dependent downregulation in 5-lipoxygenase, cyclooxygenase 1 and 2 (cox-1 and cox-2), matrix metalloproteinase 1 and 2 (mmp-1 and mmp-2) activities; as well as attenuation in prostaglandin e2 (pge2), leukotriene b4 (ltb4) and tumor necrosis factor-α (tnf-α) production in both in vitro and in vivo models. |
2021-11-12 |
2023-08-13 |
mouse |
| Zahra Bagherian, Abbas Mirshafiey, Monireh Mohsenzadegan, Mohammad M Farajollah. Evaluation of G2013 (α-L-guluronic acid) efficacy on PC-3 cells through inhibiting the expression of inflammatory factors. Clinical and experimental pharmacology & physiology. 2021-11-08. PMID:34699087. |
expression of interleukin 8 (il-8), nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb), myeloid differentiation factor 88 (myd-88), cyclooxygenase 2 (cox-2), matrix metalloproteinase-2 (mmp-2), and mmp-9 genes were studied in the pc-3 cells treated with 25 (low dose) or 50 (high dose) µg/ml of g2013 for 24 h using quantitative real-time polymerase chain reaction (qrt-pcr) technique. |
2021-11-08 |
2023-08-13 |
Not clear |
| Xinlan Qu, Yuan Fang, Siying Zhuang, Yuanzhen Zhan. Micro-RNA miR-542-3p suppresses decidualization by targeting ILK pathways in human endometrial stromal cells. Scientific reports. vol 11. issue 1. 2021-11-01. PMID:33785768. |
moreover, mir-542-3p overexpression caused down-regulation of the angiogenic factors vascular endothelial growth factor (vegf), cyclooxygenase-2 (cox-2) and matrix metalloproteinase-9 (mmp-9), and the supernatant of hescs overexpressing mir-542-3p inhibited the formation of tubular structures in human umbilical vein endothelial cells (huvecs), suggesting that mir-542-3p inhibits angiogenesis of huvecs. |
2021-11-01 |
2023-08-13 |
mouse |
| b' Sanda Smu\\xc4\\x91 Orehovec, Anto Dujmovi\\xc4\\x87, Davor Mijatovi\\xc4\\x87, Marko Mance, Bo\\xc5\\xbeena \\xc5\\xa0ar\\xc4\\x8devi\\xc4\\x8. Immunohistochemical Expression of Matrix Metalloproteinase-1 and Cyclooxygenase-2 in Cutaneous Squamous Cell and Basal Cell Carcinoma. Acta dermatovenerologica Croatica : ADC. vol 291. issue 1. 2021-10-25. PMID:34477058.' |
the cyclooxygenase-2 (cox-2) and matrix metalloproteinase-1 (mmp-1) enzymes have both been linked to the development of these diseases but their exact significance is unknown. |
2021-10-25 |
2023-08-13 |
Not clear |
| Zhang Xuyin, Ding Jingxin, Tao Xiang, Jia Luoqi, Hua Keqi. Biomarker expression in normal fimbriae: Comparison of high- and low-grade serous ovarian carcinoma. Oncology letters. vol 4. issue 5. 2021-10-21. PMID:23162641. |
the fimbriae of normal appearance [without serous tubal intraepithelial carcinoma (stic)] from 28 patients with high-grade oscs and 24 patients with low-grade oscs were assessed for the expression of 6 markers [e-cadherin, matrix metalloproteinase-2 (mmp-2), phospho-akt (pakt), cyclooxygenase-2 (cox-2), vascular endothelial growth factor (vegf) and p53] using immunohistochemistry. |
2021-10-21 |
2023-08-12 |
Not clear |
| Yao Hua, Limei Zhou, Weidong Yang, Wenji An, Xiaolin Kou, Jian Ren, Hailang Su, Rong Chen, Zhengping Zhang, Jianjun Zou, Zhihong Zha. Y-2 reduces oxidative stress and inflammation and improves neurological function of collagenase-induced intracerebral hemorrhage rats. European journal of pharmacology. vol 910. 2021-10-04. PMID:34536364. |
further study demonstrated that y-2 could reduce inflammatory response and oxidative stress by decreasing the levels of myeloperoxidase (mpo), ionized calcium-binding adaptor protein-1 (iba-1), inflammatory cytokines and oxidative products, inhibit transcription factor nuclear factor-κb (nf-κb) activation, cyclooxygenase-2 (cox-2) and matrix metallopeptidase 9 (mmp-9) expression in brain tissue around in the core regions of hematoma. |
2021-10-04 |
2023-08-13 |
rat |
| Muskan Bhatia, Mihir Bhalerao, Natália Cruz-Martins, Dileep Kuma. Curcumin and cancer biology: Focusing regulatory effects in different signalling pathways. Phytotherapy research : PTR. vol 35. issue 9. 2021-09-29. PMID:33837579. |
in fact, mmps are responsible for the degradation of the cell-extracellular matrix, which can lead to the diseased condition and many different pathways contribute to its activity, such as jak/stat, nf-κb, mapk/erk, cox-2, ros, tgf-β, among others. |
2021-09-29 |
2023-08-13 |
Not clear |