| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K J Senthil Kumar, M Gokila Vani, Hen-Wen Hsieh, Chin-Chung Lin, Jiunn-Wang Liao, Pin-Ju Chueh, Sheng-Yang Wan. MicroRNA-708 activation by glucocorticoid receptor agonists regulate breast cancer tumorigenesis and metastasis via downregulation of NF-κB signaling. Carcinogenesis. vol 40. issue 2. 2019-12-06. PMID:30726934. |
in addition, gr agonist treatment or mir-708 mimic transfection remarkably inhibited ikkβ expression and suppressed nuclear factor-kappab (nf-κb) activity and its downstream target genes, including cox-2, cmyc, cyclin d1, matrix metalloproteinase (mmp)-2, mmp-9, cd24, cd44 and increased p21cip1 and p27kip1 that are known to be involved in proliferation, cell-cycle progression, metastasis and csc marker protein. |
2019-12-06 |
2023-08-13 |
human |
| Gene A Morrill, Adele B Kostellow, Raj K Gupt. The pore-lining regions in cytochrome c oxidases: A computational analysis of caveolin, cholesterol and transmembrane helix contributions to proton movement. Biochimica et biophysica acta. vol 1838. issue 11. 2019-11-20. PMID:25037006. |
using computational methods developed to study protein topology, membrane channels and 3d packing arrangements within transmembrane (tm) helix arrays, we find that subunit-1 (cox-1), subunit-2 (cox-2) and subunit-3 (cox-3) contribute 139, 46 and 25 residues, respectively, to channel formation between the mitochondrial matrix and intermembrane space. |
2019-11-20 |
2023-08-13 |
Not clear |
| Ajay Matta, Muhammad Zia Karim, Hoda Gerami, Peter Jun, Martha Funabashi, Greg Kawchuk, Alyssa Goldstein, Warren Foltz, Marshall Sussman, Bjorn C Eek, W Mark Erwi. NTG-101: A Novel Molecular Therapy that Halts the Progression of Degenerative Disc Disease. Scientific reports. vol 8. issue 1. 2019-11-18. PMID:30429487. |
in addition, a single intra-discal injection of ntg-101 into the injured ivd-nps resulted in sustained expression of healthy extra-cellular matrix (ecm) proteins (aggrecan, collagen 2a1) and reduced expression of inflammation associated proteins and molecules (il-1β, il-6, il-8, mmp-13, cox-2 and pge2) as compared to vehicle controls. |
2019-11-18 |
2023-08-13 |
human |
| Jianli Ren, Jian Liu, Xin Su. Correlation of COX-2 and MMP-13 expressions with gastric cancer and their effects on prognosis. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. vol 23. issue 3. 2019-09-23. PMID:30003735. |
to study the expressions of cyclooxygenase-2 (cox-2) and matrix metalloproteinase-13 (mmp-13) genes in gastric cancer, and to investigate the correlation between them and gastric cancer and their effects onprognosis. |
2019-09-23 |
2023-08-13 |
Not clear |
| Jianli Ren, Jian Liu, Xin Su. Correlation of COX-2 and MMP-13 expressions with gastric cancer and their effects on prognosis. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. vol 24. issue 1. 2019-08-19. PMID:30941969. |
to study the expressions of cyclooxygenase-2 (cox-2) and matrix metalloproteinase-13 (mmp-13) genes in gastric cancer, and to investigate the correlation between them and gastric cancer and their effects on prognosis. |
2019-08-19 |
2023-08-13 |
Not clear |
| Rong-Hui Deng, Bo Qiu, Pang-Hu Zho. Chitosan/hyaluronic acid/plasmid-DNA nanoparticles encoding interleukin-1 receptor antagonist attenuate inflammation in synoviocytes induced by interleukin-1 beta. Journal of materials science. Materials in medicine. vol 29. issue 10. 2019-07-16. PMID:30276528. |
rt-qpcr and western blot analysis demonstrated that cs/ha/pil-1ra nanoparticles were able to increase il-1ra expression in primary synoviocytes, and reduce the mrna and protein levels of matrix metalloproteinase-3 (mmp-3), matrix metalloproteinase-13 (mmp-13), cyclooxygenase-2 (cox-2) and inducible nitric oxide synthase (inos) in il-1β-induced synoviocytes. |
2019-07-16 |
2023-08-13 |
Not clear |
| Lei Fang, Xinggang Wang, Qingzhu Sun, Eleni Papakonstantinou, Chongteck S'ng, Michael Tamm, Daiana Stolz, Michael Rot. IgE Downregulates PTEN through MicroRNA-21-5p and Stimulates Airway Smooth Muscle Cell Remodeling. International journal of molecular sciences. vol 20. issue 4. 2019-05-31. PMID:30781615. |
non-immune ige activated two signaling pathways: (i) signal transducer and activator of transcription 3 (stat3)→mir-21-5p→downregulating phosphatase and tensin homolog (pten) expression, and (ii) phosphatidylinositol 3-kinases (pi3k)→protein kinase b (akt)→mammalian target of rapamycin (mtor)→ribosomal protein s6 kinase beta-1 (p70s6k)→peroxisome proliferator-activated receptor gamma coactivator 1-α (pgc1-α)→peroxisome proliferator-activated receptor-γ (ppar-γ)→cyclooxygenase-2 (cox-2)→mitochondrial activity, proliferation, migration, and extracellular matrix deposition. |
2019-05-31 |
2023-08-13 |
human |
| Hua Wang, Pan Hao, Hu Zhang, Cuiping Xu, Junyan Zha. MicroRNA-223 inhibits lipopolysaccharide-induced inflammatory response by directly targeting Irak1 in the nucleus pulposus cells of intervertebral disc. IUBMB life. vol 70. issue 6. 2019-05-28. PMID:29707878. |
matrix degrading enzymes (adamts4, adamts5, mmp3 and mmp13), no reaction-associated proteins (pge2, cox-2 and inos) and the expression of nuclear factor (nf)-κb signaling-related proteins were downregulated after mir-233 overexpression. |
2019-05-28 |
2023-08-13 |
rat |
| Agnes Schröder, Ute Nazet, Dominique Muschter, Susanne Grässel, Peter Proff, Christian Kirschnec. Impact of Mechanical Load on the Expression Profile of Synovial Fibroblasts from Patients with and without Osteoarthritis. International journal of molecular sciences. vol 20. issue 3. 2019-05-13. PMID:30704030. |
then we assessed gene and protein expression of proinflammatory factors (tnfα, cox-2, pg-e2, il-6), extracellular matrix (ecm) components (col1, fn1) and glycosaminoglycans (gags) via rt-qpcr, elisa, dmmb assay and hplc. |
2019-05-13 |
2023-08-13 |
Not clear |
| Bo Zhang, Kai Jin, Ting Jiang, Lanting Wang, Shun Shen, Zimiao Luo, Yanyan Tuo, Xianping Liu, Yu Hu, Zhiqing Pan. Celecoxib normalizes the tumor microenvironment and enhances small nanotherapeutics delivery to A549 tumors in nude mice. Scientific reports. vol 7. issue 1. 2019-04-23. PMID:28855534. |
inspired by the close association between cyclooxygenase-2 (cox-2) and tumor-associated angiogenesis, as well as tumor matrix formation, we proposed that tumor microenvironment normalization by cox-2 inhibitors might improve the distribution and efficacy of nanotherapeutics for solid tumors. |
2019-04-23 |
2023-08-13 |
mouse |
| Satya Sahay, Prakash Tiwari, Manuraj Pandey, Krishna P Gupt. PI3K/Akt Pathway and miR-21 are Involved in N-Ethyl-N-Nitrosourea-Induced F1 Mouse Lung Tumorigenesis: Effect of Inositol Hexaphosphate. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 38. issue 1. 2019-03-21. PMID:30806292. |
further, mir-21 expressions were found to be modulated at the respective time as well, along with the activation of matrix metalloproteinase (mmp-9) and vascular endothelial growth factor expression. akt activation also enhanced the expression of cyclin d1, cyclooxygenase-2 (cox-2), nuclear factor-κb (nf-κbp50), and mammalian target of rapamycin (mtor). |
2019-03-21 |
2023-08-13 |
mouse |
| Mrityunjay Tyagi, Biswanath Maity, Bhaskar Saha, Ajay Kumar Bauri, Mahesh Subramanian, Subrata Chattopadhyay, Birija Sankar Patr. Spice-derived phenolic, malabaricone B induces mitochondrial damage in lung cancer cells via a p53-independent pathway. Food & function. vol 9. issue 11. 2019-03-20. PMID:30318526. |
this effect of mal b was strongly associated with the concomitant decrease in anti-apoptotic (iap1, iap2 and survivin), angiogenic (growth factors) and cancer invasiveness (matrix metalloproteinase-9, cox-2) modulating proteins. |
2019-03-20 |
2023-08-13 |
mouse |
| Lihua Li, Juan Li, Jing Yi, Hang Liu, Han Le. Dose-Effect of Irbesartan on Cyclooxygenase-2 and Matrix Metalloproteinase-9 Expression in Rabbit Atherosclerosis. Journal of cardiovascular pharmacology. vol 71. issue 2. 2019-03-14. PMID:29420356. |
our study aimed to assess the dose-effect of irbesartan on cyclooxygenase-2 (cox-2) and matrix metalloproteinase-9 (mmp-9) in rabbit atherosclerotic aorta. |
2019-03-14 |
2023-08-13 |
human |
| Sivagami Gunasekaran, Karthikkumar Venkatachalam, Nalini Namasivaya. Anti-inflammatory and anticancer effects of p-methoxycinnamic acid, an active phenylpropanoid, against 1,2-dimethylhydrazine-induced rat colon carcinogenesis. Molecular and cellular biochemistry. vol 451. issue 1-2. 2019-03-08. PMID:29980883. |
colon of animals treated with dmh showed an increased number of aberrant crypt foci (acfs), increased nuclear translocation of transcription factor nf-κb p65 subunit, increased expression of inflammatory markers (inos, cox-2), cytokines (tumour necrosis factor-α, interleukin-6), cyclin d1, antiapoptotic protein (bcl-2), metastasis marker (matrix metalloproteinase-2 (mmp-2)) and angiogenic marker (vascular endothelial growth factor vegf) and decreased expression of pro-apoptotic proteins (bax, caspases 3 and 9). |
2019-03-08 |
2023-08-13 |
rat |
| Chunxiao Wang, Yong Song, Xin Wang, Ruijun Mao, Lijun Son. Baicalin Ameliorates Collagen-Induced Arthritis Through the Suppression of Janus Kinase 1 (JAK1)/Signal Transducer and Activator of Transcription 3 (STAT3) Signaling in Mice. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-03-04. PMID:30562763. |
the levels of tumor necrosis factor (tnf)-α, interlukin-1β (il-1β), il-6, matrix metalloproteinases (mmp)-2, mmp-9, nitric oxide synthase (inos), cyclooxygenase-2 (cox-2) and their downstream inflammatory mediators janus kinase 1 (jak1)/signal transducer and activator of transcription 3 (stat3), extracellular signal-regulated kinases 1/2 (erk1/2), p38, jun n-terminal kinases (jnk) activation were detected using enzyme-linked immunosorbent assay (elisa), and western blotting analyses. |
2019-03-04 |
2023-08-13 |
mouse |
| Jae Yong Lee, Hyunwoong Lim, Jae Won Ahn, Dongsik Jang, Seung Hee Lee, Kyeongsoon Park, Sung Eun Ki. Design of a 3D BMP-2-Delivering Tannylated PCL Scaffold and Its Anti-Oxidant, Anti-Inflammatory, and Osteogenic Effects In Vitro. International journal of molecular sciences. vol 19. issue 11. 2019-02-18. PMID:30445673. |
additionally, the bmp-2/ta/pcl scaffold significantly suppressed the mrna levels of pro-inflammatory cytokines, including matrix metalloproteinases-3 (mmp-3), cyclooxygenase-2 (cox-2), interleukin-6 (il-6), and tumor necrosis factor-α (tnf-α), in lipopolysaccharide (lps)-induced mc3t3-e1 cells. |
2019-02-18 |
2023-08-13 |
Not clear |
| Jin-Woo Jeong, Cheol Park, Hee-Jae Cha, Su Hyun Hong, Shin-Hyung Park, Gi-Young Kim, Woo Jean Kim, Cheol Hong Kim, Kyoung Seob Song, Yung Hyun Cho. Cordycepin inhibits lipopolysaccharide-induced cell migration and invasion in human colorectal carcinoma HCT-116 cells through down-regulation of prostaglandin E2 receptor EP4. BMB reports. vol 51. issue 10. 2019-02-04. PMID:30269738. |
our data indicate that cordycepin suppressed lipopolysaccharide (lps)-enhanced cell migration and invasion through the inactivation of matrix metalloproteinase (mmp)-9 as well as the down-regulation of cox-2 expression and pge2 production. |
2019-02-04 |
2023-08-13 |
human |
| Wei Wang, Jiye Wan. Toll-Like Receptor 4 (TLR4)/Cyclooxygenase-2 (COX-2) Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion by NF-κB Activation. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-11-05. PMID:30098292. |
qrt-pcr and western blot assays were performed to detect tlr4, cox-2, matrix metalloproteinase (mmp)-2, mmp-9, tissue inhibitor of matrix metalloproteinases (timp)-1, epithelial-cadherin (e-cadherin), vimentin, nf-κb (p65), and p-p65 expressions. |
2018-11-05 |
2023-08-13 |
Not clear |
| Ya Hui Zhang, Ke Ma, Jia Ren Liu, Hai Xia Wang, Wen Xia Tian, Yue Hua Tu, Wen Guang Su. γ-tocotrienol inhibits the invasion and migration of human gastric cancer cells through downregulation of cyclooxygenase-2 expression. Oncology reports. vol 40. issue 2. 2018-10-12. PMID:29901169. |
western blot analyses were performed to analyse the relative expression of cox-2, matrix metalloproteinases-2 and -9 (mmp-2 and mmp-9) proteins, and enzyme-linked immunosorbent assays (elisa) were used to determine the exocrine roles of mmp-2 and mmp-9. |
2018-10-12 |
2023-08-13 |
human |
| Bin Chen, Yi Liu, Lei Chen. IL-21 Enhances the Degradation of Cartilage Through the JAK-STAT Signaling Pathway During Osteonecrosis of Femoral Head Cartilage. Inflammation. vol 41. issue 2. 2018-10-01. PMID:29247327. |
the expression of il-21, tumor necrosis factor-α (tnf-α), cyclooxygenase (cox-2), a disintegrin and metalloproteinase with thrombospondin motifs 4 (adamts-4), matrix metalloproteinase-13(mmp-13), and aggrecan in the cartilage was detected, by immunohistochemistry and western blot analysis. |
2018-10-01 |
2023-08-13 |
Not clear |