| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sun Young Park, Seon Yeong Chae, Jin Oh Park, Kyu Jin Lee, Geuntae Par. Gold-conjugated resveratrol nanoparticles attenuate the invasion and MMP-9 and COX-2 expression in breast cancer cells. Oncology reports. vol 35. issue 6. 2017-03-17. PMID:27035791. |
rev-aunps suppressed tpa-induced enzymatic activity and the expression of matrix metalloproteinase (mmp)-9 and cyclooxygenase-2 (cox-2). |
2017-03-17 |
2023-08-13 |
human |
| Tao Li, Jingtao Zhong, Xiaofeng Dong, Peng Xiu, Fuhai Wang, Honglong Wei, Xin Wang, Zongzhen Xu, Feng Liu, Xueying Sun, Jie L. Meloxicam suppresses hepatocellular carcinoma cell proliferation and migration by targeting COX-2/PGE2-regulated activation of the β-catenin signaling pathway. Oncology reports. vol 35. issue 6. 2017-03-13. PMID:27109804. |
furthermore, meloxicam suppressed the ability of hcc cells expressing higher levels of cox-2 and prostaglandin e2 (pge2) to migration via potentiating expression of e-cadherin and alleviating expression of matrix metalloproteinase (mmp)-2 and -9. |
2017-03-13 |
2023-08-13 |
human |
| Jang Won Park, Young-Pil Yun, Kyeongsoon Park, Jae Yong Lee, Hak-Jun Kim, Sung Eun Kim, Hae-Ryong Son. Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model. Colloids and surfaces. B, Biointerfaces. vol 147. 2017-02-16. PMID:27521747. |
a dose-dependent in vitro anti-inflammatory effect on pro-inflammatory cytokine markers (matrix metallopeptidase-3 (mmp-3), matrix metallopeptidase-13 (mmp-13), cyclooxygenase-2 (cox-2), a disintegrin and metalloproteinase with thrombospondin motifs-5 (adamts-5)), interleukin-6 (il-6), and tumor necrosis factor (tnf-α) was observed by confirming with real-time pcr analyses. |
2017-02-16 |
2023-08-13 |
rat |
| Yazmín K Márquez-Flores, Isabel Villegas, Ana Cárdeno, M Ángeles Rosillo, Catalina Alarcón-de-la-Lastr. Apigenin supplementation protects the development of dextran sulfate sodium-induced murine experimental colitis by inhibiting canonical and non-canonical inflammasome signaling pathways. The Journal of nutritional biochemistry. vol 30. 2017-01-09. PMID:27012631. |
our results revealed that dietary api supplementation decreased the macroscopic and microscopic damage signs of colitis; also, it was capable to down-regulate mpges, cox-2 and inos enzyme colonic expressions and to decrease serum matrix metalloproteinase (mmp-3) levels. |
2017-01-09 |
2023-08-13 |
mouse |
| Xuanbin Wang, Ning Wang, Hongliang Li, Ming Liu, Fengjun Cao, Xianjun Yu, Jingxuan Zhang, Yan Tan, Longchao Xiang, Yibin Fen. Up-Regulation of PAI-1 and Down-Regulation of uPA Are Involved in Suppression of Invasiveness and Motility of Hepatocellular Carcinoma Cells by a Natural Compound Berberine. International journal of molecular sciences. vol 17. issue 4. 2017-01-06. PMID:27092498. |
this was accompanied by a dose-dependent down-regulation of expression of cyclooxygenase-2 (cox-2), nuclear factor kappa b (nf-κb), urokinase-type plasminogen activator (upa) and matrix metalloproteinase (mmp)-9 in berberine-treated hcc cells. |
2017-01-06 |
2023-08-13 |
Not clear |
| Luminiţa Lazăr, Andrada Loghin, Eugen-Silviu Bud, Diana Cerghizan, Emőke Horváth, Előd Ernő Nag. Cyclooxygenase-2 and matrix metalloproteinase-9 expressions correlate with tissue inflammation degree in periodontal disease. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 56. issue 4. 2016-11-07. PMID:26743292. |
cyclooxygenase-2 (cox-2) and matrix metalloproteinase-9 (mmp-9) have synergistic effects in the degradation of the extra-cellular matrix. |
2016-11-07 |
2023-08-13 |
Not clear |
| Ting-Yi Chien, Steven Kuan-Hua Huang, Chia-Jung Lee, Po-Wei Tsai, Ching-Chiung Wan. Antinociceptive and Anti-Inflammatory Effects of Zerumbone against Mono-Iodoacetate-Induced Arthritis. International journal of molecular sciences. vol 17. issue 2. 2016-11-04. PMID:26901193. |
moreover, matrix metalloproteinase (mmp)-13 and cox-2 expressions of interleukin (il)-1β-stimulated primary rat chondrocytes were inhibited by zerumbone. |
2016-11-04 |
2023-08-13 |
mouse |
| Jin-Woo Jeong, Hye Hyeon Lee, Ki Won Lee, Ki Young Kim, Sung Goo Kim, Su Hyun Hong, Gi-Young Kim, Cheol Park, Ho Kyoung Kim, Young Whan Choi, Yung Hyun Cho. Mori folium inhibits interleukin-1β-induced expression of matrix metalloproteinases and inflammatory mediators by suppressing the activation of NF-κB and p38 MAPK in SW1353 human chondrocytes. International journal of molecular medicine. vol 37. issue 2. 2016-10-27. PMID:26707272. |
therefore, in the present study, we investigated whether mori folium water extract (mf) inhibited the catabolic effects of il-1β in vitro, and also whether it inhibited the matrix metalloproteinases (mmps), inducible nitric oxide (no) synthase (inos) and cyclooxygenase-2 (cox-2) through the attenuation of nuclear factor-κb (nf-κb) and mitogen activated protein kinase (mapk) pathways in sw1353 human chondrocytes. |
2016-10-27 |
2023-08-13 |
human |
| Tianjie Qi, Fei Xu, Xixin Yan, Shuai Li, Haitao L. Sulforaphane exerts anti-inflammatory effects against lipopolysaccharide-induced acute lung injury in mice through the Nrf2/ARE pathway. International journal of molecular medicine. vol 37. issue 1. 2016-10-14. PMID:26531002. |
moreover, treatment with sulforaphane significantly inhibited prostaglandin e2 (pge2) production, and cyclooxygenase-2 (cox-2), matrix metalloproteinase-9 (mmp-9) protein expression (as shown by western blot analysis), as well as inducible nitric oxide synthase (inos) activity in mice with lps-induced ali. |
2016-10-14 |
2023-08-13 |
mouse |
| Juan Duan, Yu Yang, Hong Liu, Peng-Cheng Dou, Sheng-Yu Ta. Osthole ameliorates acute myocardial infarction in rats by decreasing the expression of inflammatory-related cytokines, diminishing MMP-2 expression and activating p-ERK. International journal of molecular medicine. vol 37. issue 1. 2016-10-14. PMID:26549213. |
moreover, the protein expression levels of endothelial nitric oxide synthase (enos) and mitogen-activated protein kinase (mapk) cascades, including extracellular signal-regulated kinase (erk), c-jun n-terminal kinase (jnk) and p38, cyclooxygenase-2 (cox-2), as well as matrix metalloproteinase-2 (mmp-2) were all assayed by western blot analysis. |
2016-10-14 |
2023-08-13 |
rat |
| Song-sheng Shi, Hua-bin Zhang, Chun-hua Wang, Wei-zhong Yang, Ri-sheng Liang, Ye Chen, Xian-kun T. Propofol Attenuates Early Brain Injury After Subarachnoid Hemorrhage in Rats. Journal of molecular neuroscience : MN. vol 57. issue 4. 2016-08-24. PMID:26342279. |
expression of cyclooxygenase-2 (cox-2) and matrix metalloproteinase-9 (mmp-9) were determined by reverse transcription-polymerase chain reaction (rt-pcr). |
2016-08-24 |
2023-08-13 |
rat |
| Alessandro Venosa, Rama Malaviya, Hyejeong Choi, Andrew J Gow, Jeffrey D Laskin, Debra L Laski. Characterization of Distinct Macrophage Subpopulations during Nitrogen Mustard-Induced Lung Injury and Fibrosis. American journal of respiratory cell and molecular biology. vol 54. issue 3. 2016-07-12. PMID:26273949. |
time-related increases in m1 (inos, il-12α, cox-2, tnf-α, matrix metalloproteinase-9, matrix metalloproteinase-10) and m2 (il-10, pentraxin-2, connective tissue growth factor, apoe) genes, as well as chemokines/chemokine receptors associated with trafficking of m1 (ccr2, ccr5, ccl2, ccl5) and m2 (cx3cr1, fractalkine) macrophages to sites of injury, were also noted in macrophages isolated from the lung after nm. |
2016-07-12 |
2023-08-13 |
rat |
| Zhen Tao, Ming Cheng, Shu-Cai Wang, Wei Lv, Huai-Qiang Hu, Chuan-Fen Li, Bing-Zhen Ca. JAK2/STAT3 pathway mediating inflammatory responses in heatstroke-induced rats. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-06-10. PMID:26261556. |
heatstroke induced inflammation factors secretions and up-regulated levels of matrix metallopeptidase 2 and 9 (mmp2 and mmp-9) and systemic inflammatory response molecules including intercellular adhesion molecule-1 (icam-1), tumor necrosis factor-beta 1 (tnf-β1) and cyclooxygenase-2 (cox-2). |
2016-06-10 |
2023-08-13 |
rat |
| Anja Saalbach, Tobias Janik, Matthias Busch, Diana Herbert, Ulf Anderegg, Jan C Simo. Fibroblasts support migration of monocyte-derived dendritic cells by secretion of PGE2 and MMP-1. Experimental dermatology. vol 24. issue 8. 2016-05-17. PMID:25865800. |
finally, in mice initiation of inflammation by induction of an irritant contact dermatitis or a psoriasis-like skin inflammation, the expression of the pge2 generating cox-2 and the mouse collagen i degrading enzyme matrix metalloproteinases (mmp)-13 was strongly up-regulated. |
2016-05-17 |
2023-08-13 |
mouse |
| Norimitsu Morioka, Mizuki Tomori, Fang Fang Zhang, Munenori Saeki, Kazue Hisaoka-Nakashima, Yoshihiro Nakat. Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells. Biochemical and biophysical research communications. vol 469. issue 2. 2016-05-02. PMID:26616049. |
stimulation of c6 cells with tnf (10 ng/ml) significantly increased the mrna expression of ccl2, interleukin-6 (il-6), inducible nitric oxide synthase (inos), and matrix metalloprotease (mmp)-9, but not fibroblast growth factor-2 (fgf-2), cyclooxygenase-2 (cox-2) and mmp-2. |
2016-05-02 |
2023-08-13 |
rat |
| Zhifu Li, Dongdong Meng, Guangheng Li, Jianzhong Xu, Ke Tian, Yu L. Celecoxib Combined with Diacerein Effectively Alleviates Osteoarthritis in Rats via Regulating JNK and p38MAPK Signaling Pathways. Inflammation. vol 38. issue 4. 2016-04-18. PMID:25687638. |
furthermore, the protein expression of downstream genes of jnk, including activating-transcription factor (atf-2), matrix metalloproteinase-13 (mmp-13), and cyclooxygenase (cox-2), were also significantly inhibited by clx combined with dc as compared with single treatments. |
2016-04-18 |
2023-08-13 |
rat |
| Kevin A Ingle, Vasundhara Kain, Mehak Goel, Sumanth D Prabhu, Martin E Young, Ganesh V Halad. Cardiomyocyte-specific Bmal1 deletion in mice triggers diastolic dysfunction, extracellular matrix response, and impaired resolution of inflammation. American journal of physiology. Heart and circulatory physiology. vol 309. issue 11. 2016-04-11. PMID:26432841. |
left ventricles of cbk mice exhibited (p < 0.05): 1) progressive abnormal diastolic septal annular wall motion and reduced pulmonary venous flow only at 28 wk of age; 2) progressive worsening of fibrosis in the interstitial and endocardial regions from 8 to 28 wk of age; 3) increased (>1.5 fold) expression of collagen i and iii, as well as the matrix metalloproteinases mmp-9, mmp-13, and mmp-14 at 28 wk of age; 4) increased transcript levels of neutrophil chemotaxis and leukocyte migration genes (ccl2, ccl8, cxcl2, cxcl1, cxcr2, il1β) with no change in il-10 and il-13 genes expression; and 5) decreased levels of 5-lox, ho-1 and cox-2, enzymes indicating impaired resolution of inflammation. |
2016-04-11 |
2023-08-13 |
mouse |
| b' G K Chimal-Ram\\xc3\\xadrez, N A Espinoza-S\\xc3\\xa1nchez, E M Fuentes-Panan\\xc3\\xa. A Role for the Inflammatory Mediators Cox-2 and Metalloproteinases in Cancer Stemness. Anti-cancer agents in medicinal chemistry. vol 15. issue 7. 2016-03-24. PMID:25783962.' |
in this review, we will describe the tme by focusing on how matrix metalloproteinases (mmps) and cyclooxygenase-2 (cox-2) induce stemness and sustain stem cell maintenance. |
2016-03-24 |
2023-08-13 |
Not clear |
| Yange Ma, Airong Shen, Canyu Li, Shengnan Xu, Huanhuan Guo, Shunhong Zo. [Targeted interruption of COX-2 gene by siRNA inhibits the expression of VEGF, MMP-9, the activity of COX-2 and stimulates the apoptosis in eutopic, ectopic endometrial stromal cells of women with endometriosis]. Zhonghua fu chan ke za zhi. vol 50. issue 10. 2016-03-16. PMID:26675577. |
to investigate the effect of targeted interruption of cyclooxygenase-2 (cox-2) gene by small interference rna (sirna) on the expression of cox-2, vascular endothelial growth factor (vegf) and matrix metalloproteinase-9 (mmp-9) in eutopic and ectopic endometrial stromal cells (esc) with endometriosis, and the effect on the content of 6-keto-prostaglandin-f1α (6-keto-pgf1α, metabolites of cox) and the apoptosis of eutopic and ectopic esc with endometriosis. |
2016-03-16 |
2023-08-13 |
Not clear |
| Jilei Tang, Weiding Cui, Fanglong Song, Chenjun Zhai, Hansheng Hu, Qiang Zuo, Weimin Fa. Effects of mesenchymal stem cells on interleukin-1β-treated chondrocytes and cartilage in a rat osteoarthritic model. Molecular medicine reports. vol 12. issue 2. 2016-03-10. PMID:25892273. |
total rna and protein were collected at various time-points, and western blot and reverse transcription-quantitative polymerase chain reaction analyses were used to investigate the expression of type ii collagen (col2), aggrecan, matrix metalloproteinase-13 (mmp-13) and cyclooxygenase-2 (cox-2). |
2016-03-10 |
2023-08-13 |
rat |